급성관동맥증후군에서의 전기화학발광법을 이용한 Troponin T 및 Creatinine Kinase-MB 검사 평가

이혁민,박광일,이경률,김정호,권오헌 대한임상병리학회 2000 대한임상병리학회지 Vol.20 No.6

상악골절단술 후 외전신경마비를 동반한 경동맥 해면정맥돌루

이원학,김동률,홍광진,이정구 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Carotid cavernous sinus fistula(CCSF) is an abnormal communication at the base of the skull between the internal carotid artery and the cavernous sinus. Fistula is almost associated with extensive facial trauma as a result of direct or indirect forces. Most fistulas of traumatic origin develop as a result of fractures through the base of the skull, which cause the laceration of the internal carotid artery near the cavernous sinus. The signs and symptoms of CCSF are pulsating exophthalmosis, orbital headache, pain, orbital or frontal bruit, loss of visual acuity, diplopia and ophthalmoplegia. Angiography reveals a definite CCSF and a detachable balloon embolization is known to be the treatment of choice. Even though carotid cavernous sinus fistula is an uncommon complication after orthognathic surgery, several cases of CCSF due to congenital anomalies, pre-existing aneurysms and abnormally thickened maxillary posterior wall have been reported in the literature. We have experienced a case of CCSF after Le Fort I osteotomy for maxillary advancement in skeletal class III patient and the cause, pathogenesis, diagnosis and treatment of this case.

하악대구치의 치성감염으로 유발된 안외골막하농양의 치험례

김동률,최동주,홍광진,이정구 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

A 61-years old man with diabetes mellitus (DM) was admitted to our hospital, complaining of progressive right periorbital swelling, headache and toothache on the right lower second molar. On the first visit, moderate swelling was noticed from the right periorbital region with exophtalmos and subconjunctival effusion. Intraorally, right lower second molar had a severe periodontal disease and fistular formation on its distal area. From 3 days after hospitalization, the visual acuity of his right eye was gradually worsen and we performed CT scan. CT scan demonstrated an inflammatory change at the right orbit with subperiosteal abscess at the inferior orbital wall, which was extended from the right infiratemporal, parapharyngeal and internal pterygoid space. Patient was treated by mean of intraoral (right upper vestibular and retromolar) and extraoral(infraorbital) incision and drainage, massive anti-therapy and DM control. The patient improved gradually and finally was discharged from the hospital, but his visual loss of right side was not recovered.

膽痲疹의 原因, 症狀 및 鍼灸治療穴에 對한 文獻的 考察

金柾勳,李賢,李秉烈 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1

The following results were obtained. 1.The Urticaria is similar to the korean medical name of yeun-jin(연疹), yum-leu(염류), pung-jin-geu(風疹槐), pung-sa(風사), pung-so-yeunjin(風搖연진). 2.The most part of the causes that induce Urticaria are like that, the sup-yeul(濕熱) that caused by the sa-gi(邪氣)'s invasion, food and behavior's fault, is gathering in the gastrointestinal tract. 3.The symptomes are like that, the severe pruritic blisters are spread on the whole body, and the color of the blisters is red or white, and nausea, vomitting, abdominal pain, chest discomfort are induced with the Urticaria. 4.The Su-Chok yangmyong Kyong(手·足陽明經), Chok taeum Kyong(足太陰經) and Chok taeyang Kyong(足太陽經) are used for the acupuncture therapy of Urticaria. 5.The acupuncture points of the Kokch(曲地), Hyolhae(血海), Chok-Samni(足三里), Samumgyo(三陰交), Hapkok(合谷) are used for the acupuncture therapy of Urticaria. 6.the Pye-area(肺區), Shinmun(神門), dammajin-area(??麻疹區), Shinsangsun(腎上腺), Chimbu(枕部) are used for the acupuncture therapy of Uriticaria in the ear-acupuncture therapy of Urticaria.

PVD 방법에 의한 TiN barrier metal 형성과 공정개발

염병렬,박형호,최치규,이종덕,김건호,이정용,서경수,강민성 濟州大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.10 No.2

Ar과 N₂?가스가 혼합된 분위기에서 반응성 스퍼터링 방법에 의하여 TiN 박막을 증착하였다. N₂ 가스의 농도는 화학양론적으로 TiN이 형성되는 조건에 맞도록 조절하였으며, 기판의 온도는 실온에서 부터 700℃의 범위내로 유지하였다. (111) texture 구조를 가지면서 화학양론적으로 Ti??N??인 박막은 기판의 온도가 600℃ 이상에서 형성되었고, 기판의 온도가 600℃ 이하에서는 형성된 박막은 N-과다형이었다. XRD, XPS 및 RBS 분석 결과 TiN 박막의 조성비는 기판의 온도에서 다소 의존하였으나 약 5% 이내에 불과하였다. TiN 박막의 면저항은 기판온도의 증가에 따라 감소하였고, 기판온도가 600℃에서 증착된 TiN 박막의 면저항능 14.5Ω/□ 였고, Ar―가스 분위기에서 700℃로 30초간 열처리한 후는 8.9Ω/□ 이었다. 따라서 반응성 스퍼터링방법에 의하여 형성되는 양질의 TiN 박막은 기판온도가 600℃이상이 최적조건임을 알았다. Titanium nitride (TiN) films were prepared by reactive sputter deposition in mixed gas of Ar+N₂?. The volume percentage of N₂ in the working gas was chosen so as to grow stoichiometric TiN films and the substrate temperature during film growth was set from room temperature to 700℃. stoichiometric Ti??N?? films with (111) texture were grown at temperatures over 600℃, while films prepared at temperatures below 600℃ showed N-rich TiN. The composition x and y in the Ti??N?? films determined by XPS and RBS varied within 5% with the substrate temperature. The sheet resisstance of the TiN films decreases as the substrate temperature increased. TiN film prepared at 600℃ showed 14.5Ω/□, and it decreased to 8.9Ω/□ after the sample was annealed at 700℃, 30 sec in Ar-gas ambient by RTA. By far, high quality stoichiometric TiN films by reactive sputtering in the mixed gas ambient could be prepared at substrate temperature over 600℃.

뮤코펙트 정(염산암브록솔 30mg)에 대한 암브렉트 정의 생물학적 동등성

유정연,정선경,최미희,한상범,이경률,이희주 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

A bioequivalence study of Ambrect^(™) tablets (Dong Wha Pharm. Ind. Co., Ltd.) to Mucopect^(™) tablets(Boe-hringer Ingelheim Korea, Ltd.) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the ambroxol hydorchoride dose of 30 ㎎ in a 2×2 crossover study. There was a one-week wash out period between the doses. Plasma concentrations of ambroxol were monitored by a high-performance liquid chromatography for over a period of 24 hours after the administration. Aug_(t)(the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compilied from the plasma concentraction-time data. Analysis of variance was carried out using logarithmically transformed AUC_(T) and C_(max). No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the AUC_(t) ratio and the C_(max) ratio for Ambrect^(™)/Mucopect^(™) were 0.89-1.01 and 0.89-1.02, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstarated the bioequivalence of Ambrect^(™) and Mucopect^(™) with respect to the rate and extent of absorption.

제올라이트촉매상에서의 톨루엔과 메탄올의 측쇄알킬화반응

朴憲烈,金正基,李寅善 중앙대학교 기술과학연구소 1988 기술과학연구소 논문집 Vol.18 No.-

The side-chain alkylation of toluene with methanol was studied experimentally over cation-exchanged X and Y zeolites. According to the experimental results, the higher conversions have been obtained at 420℃ and reactant mole ratio=6(toluene/methanol) and over K-exchanged X-zeolite, the yields of styrene and ethylbenzene were 5.7%, 4.4% respectively that were remarkably higher compared with those over KY-zeolite, and also the yield of products over KX-zeolite was higher than over CaX-zeolite since the potassium ion over X-zeolite enhances the catalytic due to its basic tendency compared with the calcium ion. The reaction path was suggested for this reaction using both the acidic and basic sites on the surface.

東南鑛山의 地質과 鑛床成因에 對한 硏究

徐正律,李在英 慶北大學校 自然科學大學 1983 自然科學論文集 Vol.2 No.-

This work deals with geology and ore deposits at the Dongnam mine. dongnam mine is located at 128°46'∼18°49'E, 37°16'∼37°18'N in Mureong-ri, Nam-myun, Jeongseon-gun, Gangweon-do, Korea. Geology of the mine consists of Cambrian slate(Myobong Formation), Ordovician limestone (Poongchon and Hwajeol Formation), Cretaceous (?) granitic intrusives, and Quaternary alluvium deposits. General trend of strike and dip of bedding plane in sedimentary rocks is N10°∼45°E, 5°∼30°SE, and joints in granitic intrusives strike NS-N30°E, dipping 70°∼80°NW. Main lineament of the study area shows a trend of NNE-SSW. Granitic intrusives, diorite and quarts porphyry, are classified depending on the predominent normative minerals and chemical compositions: diorite into diorite-tonalite-monzodiorite-granodiorite, and quartz porphyry into granite-quartz monzonite-granite. The petrochemical nature of source magma inferred from Niggli value is semi-femic, intermediate alkaline and c-normal for diorite, and salic, alkali-rich and c-poor for quartz porphyry. Sedimentary rocks were thermally metamorphosed by the granitici ntrusives to form mostly albiteepidote hornfels from pelitic Myobons slate and hornblende hornfels from Poongchon limestone. Contact metasomatic deposits of magnetite and hematite were formed in the country rocks in the border zone with the intrusives, hydrothermal Pb-Zn-Mn deposits along the fault shear zoneand a stockwork deposit of molybdenite in the diorite itself. The molybdenite deposit is thought to be formed in the early solidified margin by the residual mineralized solution of the intrusive itself. Molybdenite bearing skarn is plotted in the triangualr diagram of diopside-hedenbergite-johannsenite within the same compositional region as the copper-bearing skarn of general porphyry copper deposits. The wallrock alteration is potassic in diorite and propylitic in quartz porphyry. As shown in ACF and AKF triangular diagrams quartz porphyry belongs to epidote-chlorite-calcite and kaolinite-muscovite-chlorite facies. The sequence and stage of mineralization is: igneous intrusion→skarnization→Fe oxide→Fe sulphide→rhodochrosite→calcite→supergene enrichment of Mn oxide. The Dongnam mine has 4 types of ore deposite: contact metasomatic deposits at the border zone of limestone with the granitic intrusives, hydrothermal filling and replacement deposits along the fault shear zone, and disseminated hydrothermal stockwork deposit in the diorite itself. Main ore minerals are composed mainly of magnetite and hematite in the contact metasomatic deposits, and Mn carbonates, galena, sphalerite and molybdenite in the hydrothermal deposits. Mn oxides are enriched at surface by surpergene oxidation of primary Mn carbonates.

Dictyostelium discoideum의 세포융합

최호형,이기현,서정열 公州大學校 基礎科學硏究所 1996 自然科學硏究 Vol.5 No.-

Dictyostelium discoideum에서 세포 융합율을 높이기 위한 최적조건들을 찾기 위해서 세포 융합율이 빛, 온도, pH 그리고 ?? 의해 어떻게 영향을 받는지를 조사하였다. 빛이 있는 조건 하에서 배양시킨 HN₁과 NC₄를 혼합하였을 때 융합율은 10% 낮아졌다. 빛이 있는 조건하에서 배양된 HN₁과 빛이 없는 조건하에서 배양된 NC₄를 혼합하였을 때 융합율은 위와 같다. 그러나 빛이 없는 조건하에서 배양된 HN₁과 NC₄를 혼합하였을 때 융합율은 60% 높아졌다. 10℃ ~ 25℃ 사이에서 모든 세포들은 융합할수 있지만 시간적인 차이를 보였다. pH 5.5-6.5에서 융합율이 가장 높으며 ?? 농도는 500μM 일때 가장 효과적이고 200μM의 농도는 영향을 미치지 못했다. 그러므로 D. discoideum에서 세포융합을 증진시키는 최적조건들은 : 빛이 없는 조건하에서 HN₁과 NC₄를 배양시키고, pH 5.5, 20℃ 또는 25℃의 온도 그리고 500μM의 ?? 농도이다. In order to find the optimum conditions to raise the rate of cell fusion in Dictyostelium discoideum, we investigated how the rate of cell fusion was affected by light, temperature, pH and ??. When HM₁ and NC₄ cultured in light were mixed, the fusion rate of these was lower by 10%. When HM1 cultured in light and NC4 cultured in dark were mixed, the fusion rate was the same as above. But when HM₁and NC₄both cultured in dark were mixed, the fusion rate was 60% higher. In the range of 10℃∼25℃, all cells can fuse but there was a difference of time. The fusion rate was the highest in pH 5.5∼6.5, and the concentration of ?? was the maximum effective at 500μM and had no effect at 200μM. Therefore, the optimum conditions to elevate the cell fusion rate in D. discoideum were : HM₁and NC₄, that both cultured in dark, pH 5.5, temperature of 20℃ or 25℃ and 500μM ??.

이성대상포진의 증상에 따른 안면신경마비의 정도와 예후

신시옥,송창근,이동욱,최영석,진흥률,신정우,윤희석 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.1

연구목적: 이성대상포진에 동반되는 안면신경마비는 Bell's palsy와는 달리 예후가 더 나쁘고 그 마비가 완전히 회복되지 않는 경우가 더 많다.본 연구에서는 이성대상포진에서 발현되는 증상들의 유무가 치료 전 안면신경마비의 정도 및 치료 후 예후와 상관관계가 있는지를 관찰하여 예후의 예측인자에 대해 분석하였다. 재료 및 방법: 지난 1992년 1월부터 1999년 6월까지 이성대상포진으로 진단받고 본원에 입원하여 고용량 부신피질호르몬제와 항바이러스제인 acyclovir의 병합투여로 동일한 치료를 받은 30명의 환자를 대상으로 후향적으로 의무기록을 분석 및 고찰하였으며, 치료 전 안면마비의 정도와 치료 후 마비의 회복 정도를 이통, 이명, 난청, 현훈 등의 증상의 유무와 치료 시작 시기, 그리고 안면신경의 electroneuronography(ENoG) 값에 따라 비교하였다. 결과: 이성대상포진수포가 안면신경마비 보다 먼저 발현된 경우에 안면신경마비의 치료 전 grade가 통계적으로 유의하게 좋았다(p<0.05).이통, 청력손실, 그리고 현훈의 유무에 따른 안면신경마비의 정도는 상관관계가 없었고 예후에도 차이가 없었다.이명의 유무에 따른 치료 전 안면신경마비의 정도는 상관관계가 없었으나 치료 후 완전회복율은 이명이 있었던 군에서 통계적으로 유의하게 높았다(p=0.003<0.05).완전회복군과 불완전회복군 사이의 치료 전 ENoG의 수치는 통계적으로 유의하게 예후와 상관이 있었다(p=0.037<0.05). 결론: 좀더 많은 수의 환자를 연구에 포함하여 증상에 따른 예후의 차이를 연구하는 것이 필 요하며 또한 ENoG 값이 10%에서 40% 사이인 환자들의 치료 방법에 대한 고려와 이성대상포진수포가 안면신경마비보다 먼저 생긴 환자에서 치료 전 마비정도가 경미했던 이유에 대한 연구가 필요할 것으로 생각된다. Purpose: Herpes zoster oticus generally has a poor prognosis, leaving many patients with permanent facial nerve dysfunction, compare to Bell's palsy.Acyclovir and prednisolone have been widely used for the treatment of herpes zoster oticus.This retrospective study was conducted to suggest the prognostic factors according to various symptoms. Materials and Methods : Clinical studies were retrospectively performed on 30 patients with herpes zoster oticus who were treated with acyclovir and prednisolone in the Chungbuk National University Hospital between 1991 and 1999.The authors analyze the pre-treatment grade and prognosis of facial nerve palsy according to symptoms(the existence of otalgia, tinnitus, hearing loss, and vertigo), the treatment onset, and electroneuronography ( ENoG ). Results : Of thirty patients who have been diagnosed as herpes zoster oticus, there is no significant difference in the pre-treatment grade of facial nerve palsy according to the existence of vesicle, otalgia, tinnitus, vertigo, and hearing loss.Of 25 patients who have facial nerve palsy, the recovery from the palsy is complete in 14 patients(56%).There is no significant difference in the pre-treatment grade of facial nerve palsy according to the existence of otalgia, tinnitus, vertigo, and hearing loss.The pre-treatment grade of facial palsy is better when the vesicles precede facial in the group with tinnitus than without tinnitus.A significant difference of the prognosis according to the onset of treatment and other symptoms are not found.ENoG is better in the group that facial nerve palsy is completely recovered than incomplete recovery group. Conclusion : Reliable prognostic factor according to symptoms is not found, ENoG is the only prognostic factor.