초기 우식 병소에서 광원에 따른 형광효과 비교

전정훈,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

본 연구의 목적은 초기 우식 병소에서 광원에 따른 형광효과를 비교하는 것으로 정량 분석형 laser/light 형광법(Quantitative laser/light-induced fluorescence, QLF)을 이용하여 아르곤 레이저광, 할로겐광, 발광다이오드광(LED),플라즈마광의 형광효과를 비교하였다. 발거된 60개의 치아를 선정한 후, 인공우식용액에 노출되지 않을 부분에 nail varnish를 도포하였고 치아는 24, 48, 72시간 동안 인공우식용액에 보관되었다. 건조 후 QLF영상으로 초기 우식 부위의 광밀도 차이에 의한 탈회정도가 기록되었다. 또한 조영제를 이용하여 동일한 방법으로 실험하였고 다음과 같은 결과를 얻었다. 염료를 이용하여 같은 방법으로 실험하여 또 다른 결과를 얻었다. 1.각 군의 평균 광밀도를 볼 때, 플라즈마광이 세 군 모두에서 다른 광원들 보다 높았다.(p<0.05). 2.세 군 사이에서 평균 광밀도를 비교해 볼 때, 플라즈마광과 할로겐광이 차이를 보였다.(p<0.05). 3.조영제를 사용하였을 경우 평균 광밀도를 비교해 볼 때, 플라즈마광이 세 군 모두에서 다른 광원들보다 높았고(p<0.05), 발광다이오드광(LED)와 아르곤 레이저광을 제외한 모든 광원이 차이를 보였다(p<0.05). 4.조영제를 사용하지 않은 경우와 사용한 경우 평균 광밀돌르 비교해 볼 때, 사용한 경우에 모든 광원의 평균 광밀도 차이가 컸다. The aim of this study was to apply the quantitative light-induced fluorescence(QLF) and use of fluorescein-enhanced QLF method for quantitative assessment of early enamel demineralization in vitro, comparing effectiveness of light sources : argon laser, halogen lamp, light emitting diode (LED) and plasma arc lamp. Sixty extracted teeth were used. prepared by gentle pumicing and coating in an acid-resistant nail-varnish. except for an exposure to a demineralizing solution. Teeth were removed at regular intervals(24, 48, and 72hrs), air-dried and QLF image were taken. Mineral loss, as measured by difference of optical density. was recorded. For dye-enganced QLF a 0.075% sodium fluorescein dye was applied after QLF examination and mineral loss was recorded. The following result were obtained: 1.Comparing with mean difference of optical density. plasma arc lamp was higher than other light sources in all group(p<0.05). 2.Comparing each group with mean difference of optical density. there was significant different using plasma arc lamp and halogen lamp. 3.For use of dye-enhanced QLF. comparing with mean difference of optical density, plasma arc lamp were higher than other light sources in all group(p<0.05). 4.With this model dye-enhanced QLF compared with QLF in optical density, dye-enhanced QLF was higher than QLF in optical density. From the results presented in this paper, it was concluded that plasma light source was more effective compared with other light source for the detection and the quantification of early enamel caries.

건강보험에서 5인 미만 사업장의 직장보험 편입 효과 평가와 정책 방향

송명섭,김창보,고수경,임정수,박지연 한국사회보장학회 2002 사회보장연구 Vol.18 No.2

본 논문은 건강보험공단이 2001년 「월 이후 추진하고 있는 5인 미만 사려장의 직장보험 편입을 평가하고 향후 정책방향을 제시하는데 목적을 두고 있다. 5인 미만 사업장의 직장보험 편입은 보험 가입자의 보험료 부과의 형평성을 제고하고, 영세사업장 노동자들의 보험료 부담을 경감시키며 건강보험재정 안정 효과를 위한 것이다. 2001년 7월 이후 12월 31일까지 직장보험으로 신규편입한 대상자는 모두 약 64만명이었으나 편입이전지역보험 대상자는 약 53만명, 직장보험 대상자는 약 10만명이었다. 또한 동일 기간동안 직장보험으로 편입된 사업장은 모두 88,751개였다. 편입 전후 개인별 보험료 수준 변화를 살펴보면 보험료 부과대상 중 77.6%는 본인이 부담해야 할 보험료가 감소하였다. 대신 사업주의 보험료 부담은 상대적으로 늘어났다. 한편 2001년 7월 이후 12월까지 직장보험 편입으로 건강보험의 재정은 약 19,530백만원의 재정절감효과가 있었다. 직장보험은 7,331백만원의 보험료 수입 증가가 발생하였으며, 지역보험은 12,199백만원의 재정절감 효과가 있었다. 향후 5인 미만 사업장의 직장보험 편입이 원만히 추진되기 위해서는 피부양자 인정기준의 개선과 영세사업장 사업주의 보험료 부담을 경감시켜주기 위한 방안을 강구해야 하며, 사회적으로는 비정규직 노동자에 대한 사회보장 적용 확대를 위한 노력이 동시에 추구되어야 할 것이다. This study was conducted for the purpose of evaluating coverage of small companies with less than 5 persons by Corporate Insurance since July 2001 and of suggesting policy implication. This coverage expansion by Corporate Insurance was intended for improving equity level of contribution imposition, alleviating financial burden of employees and achieving financial stability of health insurance. While, from July 2001 to December, the number of newly covered beneficiaries was about 642 thousand persons, the number of Regional beneficiaries before the new coverage expansion by Corporate Insurance was 533 thousand persons. And the number of Corporate Insurance beneficiaries before the coverage expansion was 101 thousand persons. For the same period, the number of companies by the new coverage expansion of Corporate Insurance was 88,751. Before and after the expansion, taking into account changes of individual contribution levels, payment share levels of contribution were reduced to the 77.6% of the beneficiaries newly covered by Corporate Insurance. Instead, payment share level of contribution of employers was increased more than before. And 19,530 million won was increased in National Health Insurance Expenditure. 7,331million won was increased in Corporate Insurance revenue. Expenditure reduction effect of 12,199 million won was able to be obtained in Regional Insurance. In order to implement successfully the coverage expansion by Corporate Insurance in times ahead, employers' contribution share should be reduced, when considering low profitability levels of small companies.

매복된 견치의 Tunnel을 통한 교정적 견인

전정훈,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

매복된 상악 견치를 위한 외과적 수술을 동반하는 교정치료는 주위조직에 손상을 주지 않고 치열궁내에 적절히 위치시켜야 한다. 이를 위해 매복된 치아의 위치에 따라 다양한 외과적, 교정적 방법이 소개되었으며, 그 방법으로 window procedure, apically positioned flap, closed eruption technique, tunnel traction 등이 있다. 깊은 골연하 매복에서 사용할 수 있는 방법으로 closed eruption technique 그리고 tunnel traction이 있는데, closed eruption technique은 점막 및 치은 하방으로 지나는 견인 와이어의 자극으로 염증 발생 가능성이 높으며 치은퇴축 및 부착 치은의 소실이 발생할 수 있다. 하지만, tunnel traction은 치아의 맹출이 터널을 통해서 유도되어 각화치은에 둘러싸인 채 치조골의 중앙으로 나오게 되므로 치은퇴축이나 치주부착의 소실 없이 적절한 각화치은을 얻을 수 있으며 매복치가 치조골의 중심부로 맹출함에 따라 생리적 맹출과 같은 효과 얻을 수 있다. 본 증례는 깊은 매복을 보이는 상악 견치를 tunnel traction을 이용한 치료를 보고한 것으로, 적절한 방향을 가지고 맹출하였으며 치은퇴축이나 부착치은의 소실이 발생하지 않았다. The impacted maxillary canine is a common problem of which all dental practitioners should be aware. The surgical orthodontic treatment of impacted canines is replaced correction position in dental arch without periodontal damage. Many treatment possibilities have been considered for this goal; window procedure, apically positioned flap, closed eruption technique and tunnel traction. Prognosis for these treatment may be very uncertain in many case(infraosseous impacted tooth). Other steps are required to achieve a satisfactory periodontal outcome. Satisfactory results could be expected if the physiologic eruption pattern is restored by tunnel traction, because permanent tooth erupts through the gingiva near the crest of the ridge so that periodontal damage is reduced. This article report that the surgical orthodontic treatment using tunnel traction is obtained proper position and reduced periodontal damage in facially impacted maxillary canines.

유기성 폐기물과 알칼리 안정화제가 첨가된 연안 양식장 퇴적물 조비료의 영양성분 조성

김정배,강창근,이근섭,박정임,이필용 한국환경과학회 2002 한국환경과학회지 Vol.11 No.12

To utilize coastal aquaculture ground bottom sediment in which concentrations of harmful pollutants are low and organic content is high as an organic fertilizer alkaline stabilizers such as CaO, Oyster shell, Mg(OH)_2 were added to the bottom sediment organic additives of livestock or food wastes. Nutritive qualities of crude fertilizers were measured to examine effects of alkaline stabilizers and organic waste additions. The Mg(OH)_2-added crude fertilizer had significantly lower total carbon(T-C) and nitrogen(T-N) content, reflecting the dilution effect due to great amount of Mg(OH)_2 addition. However, the addition of oyster shell had no significant effect on the T-C and T-N content of the fertilizer. P_2O_5 and K_2O content was considerably higher in the mixed of aquaculture ground bottom sediment and livestock wastes than in the mixture of the sediments and food wastes, resulting from higher P_2O_5 and K_2O content in livestock wastes. Addition of Mg(OH)_2 increased the content of MgO in the crude fertilizer but significantly reduced the content of other nutritive elements such as P_2O_5, K_2O and CaO. Addition of oyster shell as an alkaline stabilizer seemed to have the advantage of saving time and expenses for dryness due to role as a modulator of water content. Moreover, additions of effect Mg(OH)_2 decreased the concentrations of heavy metals in the fertilizer by the dilution while additions of oryster shell had no influence on heavy metal concentrations in the fertilizer.

다공성 활성탄의 표면 개질 및 이산화티탄 고정

주창식,박흥재,정갑섭 한국환경과학회 2003 한국환경과학회지 Vol.12 No.9

For the purpose of surveying any possibility of anchoring titanium dioxide on activated carbons to promote their activities as catalysts and/or adsorbents, two activated carbons were oxidized with ammonium peroxydisulfate and followed by anchoring titanium dioxide. The anchoring of titanium dioxide on the oxidized activated carbons were performed via the adsorption of tetrabutyltitanate, hydrolysis with deionized water, and calcination. The effect of oxidizing and anchoring treatment on the surface element composition, surface area, and pore texture were analyzed by XPS, BET and TPD. The oxidation of activated carbons with ammonium peroxydisulfate introduced carboxyl groups on the surface of activated carbons and these carboxyl groups promoted the anchoring of titanium oxide on the activated carbons. However, the treatments affected the surface area and the porosity of activated carbons.

조경식물의 식재와 이용 : 원주시와 횡성군을 중심으로

원종화,정진형,김창섭,이기의 江原大學校 森林科學硏究所 2005 Journal of Forest Science Vol.21 No.-

본 연구에서는 강원도 원주시와 횡성군애에 식재 활용 되고 있는 조경 식물의 이용 상황을 조사 분석하여 현재 어떠한 식물이 어떻게 이용되고 있는가를 파악함으로서 그 이용방법에 대한 개선 방안을 모색하고 아울러 원주시와 횡성군의 아름다운 경관 형성을 위한 관리 방법 등을 제시하였다. This study was executed to find out how to improve the planting and use of landscaping plants in Weonju and Hoengseong. 1. The number of street trees were 22.068 and the species number were 10 species in Weonju in 2004. The major species of street trees were Ginkgo biloba(58%), Prunus sargentii(15%), Zelkova serrata(9%), Prunus armeniaca var, ansu(8%), and Acer palmatum(6%). The ratio of native species versus exotic were 50:50. In Hoengseong, the number of street trees was 13,500 and the specise number were 15 species. The major species of street trees were Prunus sargentii(42%), Ginkgo biloba(23%), Acer triflorum(12%) Prunus armeniaca var, ansu(6%), and Prunus mume(4%). The ratio of native species versus exotic were 67:33. The species of which planting frequency within two areas was very high were Ginkgo biloba and Prunus sargentii. 2. It is necessary to select tree species suitable for the characteristics of the locality and to raise distinctive street trees that contribute to the tourist industry. For the purpose, the appropriate street trees in two areas are Cornus controversa, Quercus aliena, Zelkova serrata. Prunus padus, Sorbus alnifolia, Sorbus comixta, Albizzia julibrissin, Acer triflorum. Styrax japonica, Chionanthus retususm Celtis sinensism, Prunus yedoensis, Malus sieboldii, Crataegus Pinnatifida, Prunus armeniaca var. ansu and Pyrus pyrifolia etc.. 3. Appropriate pruning adds to the aesthetic and prolongs the useful life, it also requires less managing of insects and diseases to maintain good healthy of street tees. Street trees were not properly pruned due to electric lines and shortage of pruning information. The pruning was controlled by Korea Electric Power Co, which has no pruning information. Pruning must be maintained by a professional landscape company to maintain good shape such as with Bonsai. The shrubs planting zone between street trees and other trees, and preservation plates were established for healthy of street trees. They have to be repaired and maintained well to keep better environmental conditions. The proper fertilization, the control of pests and diseases, the installation of drainpipe and the use of soil brought from another place were needed to improve the planting, use and maintenance of landscape plants. 4. The species number of school trees and flowers of 102 schools in Weonju and Hoengseong were 17species, 16species respectively. The major species of school trees in Weonju were Juniperus chinensis(24%), Ginkgo biloba(17%), Pinus densiflora(14%), Zelkova serrata(14%), and Pinus koraiensis(9&), and those of school trees in Hoengseong were Pinus koraiensis(44%), Abies holophylla(25%), Juniperus chinensis(8%), and Ginkgo binloba(8%). The major species of school flowers in Weonju were Rosa centifolia(47%), Forsythia koreana(24%), Magnolia kobus(12%), and Rhododendron schlippenbachii(6%), and those of school flowers in Hoengseong were Forsythia koreana(36%), Rhododendron schlippenbachii(33%), Magnolia kobus(6%) and Dicentra spectabilis(6%). 5. The species number of the protection trees designated by Woenju and Hoengseong were 15 species. The major species of protection trees were Zelkova serrata(100 trees), Ginkgo biloba(18) Pinus densiflora(7), Quercus spp.(5), Juniperus chinensis(4) and Alnus japonica(4). 6. The landscape plants planted around 2004 in weonju were Prunus yedoensis(2,563trees), Betula platyphylla var, japonica(2,000), Abies holophylla(1,785), Diospyros kaki(1,100), Prunus sargentii(880) and Prurus armeniaca var. arsu(708) etc.. The shrubs planted were Rhododendron obutusum(21,559 plants), Rosa certjfolia(7,150), Rhododendron yedoense var. poukhanense(5,950), Forsythia koreana(3,000) and Ligustrum obtusifolium(2,500) etc.. The landscape plants planted in Hoengseong Acer triflorum(928trees), Prunus yedoensis(455), Zelkova serrata(327), Thuja orientalis(261), Prunus sargentii(257), Pinus koraiensis(200), Prunus persica for, rubro-plena(200) and Pyrus pyrifolia(200) etc.. The shrubs planted were Rhododendron yedoense var, poukhanense(15,936). Syringa dilatata(10,090). Forsythia koreana(9,660). Cercis chinensis(3,200). Buuxus microphylla var, koreana(2,600) and Rosa centifolia(1,868) etc.. 7. The species numbers of the herbaceous planted in 2004 in Weonju were 24 species and the ratio of native species versus exotic were 7:17. The major species of perennial plants were Aster koraiensis(30,656 plants), Coreopsis drummondii(7,656), Rudbeckia bicolor(6,000), Chrysanthemum morifolium(4,850) and Chrysanthemum zawadskii var, latilobum(4,312). The major species of annuals and biennials were Cosmos bipinnatus(672,000plants), Zinnia elegans(35,600), Petunia hybrida(26,920), Viola tricolor(23,000), Helianthus annuus(17,000), and Geranium cinereum var, pubcaulescens(5,200). In Hoengseong, the numbers of herbaceous plants were 906,310 plants and the species numbers were 15 species. The major species of perennials plants were Aster koraiensis(70,480 plants), Hemerocallis fulva(20,070), and Phlox drummodii(18,000). The major species of annuals and biennials were Phlox hybrida(174,000 plants), Cosmos bipinnatus(125,000), Zinnia elegans(109,000), Tagetes patula(96,700), Vinca rosea(89,000) and Calendula officinalis(70,000). 8. Through these result, it was thought that the diversification of planting species, the selection of plants suitable to each space and the generalization of use of native species were needed.

자가공명영상을 이용한 정신분열병 환자의 뇌량 면적 측정

박홍석,이정섭,황성혜,김창현 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 본 연구에서는 정신분열병의 병태생리에 뇌량이 관여하는지 확인하기 위해 초발 및 만성 정신분열병 환자, 대조군의 뇌량의 영역을 측정하였다. 방 법 : 국립의료원에 입원한 23명의 정신분열병 환자(남자 15명, 여자 8명)와 단순 두통 또는 어지럼증을 호소하여 내원한 23명의 외래환자를 대조군으로 하여 뇌자기공명영상을 얻었으며, 남자는 26명, 여자는 20명 이었다. 환자군중 초발군은 13명, 만성군은 10명이었다. 정중시상평면에서 뇌량을 7개 영역으로 구분하여 NIH Image 1.60프로그램으로 분석하였으며, 정중시상평면의 대뇌면적도 구하였다. 이렇게 구한 각 뇌량척도들은 t-test를 이용하여 대조군과 비교하였으며, 성별에 따른 차이는 ANOVA를 이용하였으며, 이후 대뇌면적을 공변량으로 하여 ANCOVA를 시행하였다. 또한 초발군과 만성환자군, 대조군의 비교는 나이와 대뇌면적을 공변량으로하여 MANCOVA를 시행하였다. 결 과 : 환자군과 대조군 사이의 총뇌량의 평균면적과 각 7부분의 평균면적을 비교한 결과 환자군이 제 3, 제 6 뇌량영역을 제외하곤 대조군에 비해 평균면적이 작은 것으로 나왔지만 통계적 유의성은 없었다. 성별에 따라 비교한 결과 통계적 유의성은 관찰되지 않았지만 남자환자는 대조군에 비해 작고, 여자환자의 경우에는 큰 것으로 확인됐다. 초발과 만성환자군으로 나누어 대조군과 비교해 본 결과, 통계적 유의성은 없었으나 초발환자군이 만성환자군에 비해 모든 뇌량척도가 작았고, 만성환자군은 대조군보다 총뇌량의 평균면적이 컸으나 초발군은 대조군 보다 작았다. 결 론 : 본 연구의 결과 정신분열병 환자에서 유의한 뇌량의 형태적 이상을 확인하지는 못했지만 이전 연구들에서도 다양한 결과들을 보고하고 있으며, 이는 정신분열병이 생물학적 및 임상적으로 각기 다른 표현형을 가지고 있다는 가설로 설명할 수 있다. Objectives : This study was performed to determine whether the corpus callosum is involved in pathophysiology of schizophrenia and measured corpus callosal areas of first episode, chronic schizophrenic patients and controls. Methods : We obtained the brain magnetic resonance imaging of 23 schizophrenic inpatients(15 males, 8 females) and 23 controls(11 males, 12 females) with simple headache or dizziness. Among the schizophrenic group, first episode patients were 13, chronic patients were 10. In mid-sagittal plane, the corpus callosum was divided into 7 areas and the cerebral area was measured. This data was analyzed with NIH image 1.60 software. We compared the corpus callosal areas of schizophrenics with controls by t-test and by ANOVA according to sex. Thereafter, ANCOVA was performed with mid-sagittal cerebral area as covariant. Comparison of first episode, chronic schizophrenics and controls was carried out by MANCOVA that was adjusted with age and mid-sagittal cerebra area. Results : The schizophrenics, compared with controls, had smaller corpus callosal areas except for the 3rd, 6th callosal area, but statistical significance was absent. According to sex, male schizophrenics had insignificantly smaller total callosal areas than male controls and female schizophrenics had larger ones. In comparison of first episode, chronic schizophrenic patients and controls, first episode patients had smaller every corpus callosal areas than chronic ones, chronic ones had larger total callosal area than controls and first episode ones had smaller total area than controls, but statistical significances were absent also. Conclusion : Our study did not reveal the structural abnormality of corpus callosum in schizophrenic patients, but many controversial results have been reported in other studies. This inter-study inconsistency could be explained by the hypotheses of not only clinical but also biological different phenotypes within the schizophrenia.

Silicoater technique을 이용한 veneered stainless steel crown 수복의 임상적 평가

이상호,이창섭,김왕근,정연화 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

광법위한 치질파괴가 있는 상악유전치를 갖는 소아에서 silicoater technique에 의한 veneered stainless steel crown으로 수복 후 3∼12개월 동안 주기적 검사와 수복물의 평가 결과, 다음과 같은 결론을 얻었다. 1. 행동조절이 어려운 소아에서 chair time을 감소시킴으로써 행동조절에 도움을 주었다. 2. 유지력,내구성,심미성이 우수하였으므로 유전치부의 광법위한 치질손상시 유용한 수복방법이다. Restoration of severly carious, malformed or traumatically fractured primary incisors is one of the most difficult challenges in restorative dental care for preschloers. In restoring primary anterior teeth, four types of complete coverage crowns have been attempted over the years. Stainless steel crowns, open-faced stainless steel crowns, acid-etched crowns(strip crowns), and preformed polycarbonate crowns have been the choeces. While these restorations have beem accepatable for many patients, they all have very distinct limitations. The ideal full coronal restoration for a primary incisor requires durability, retention, and esthetics. This paper reported veneered stainless steel crown restoration of primary anterior teeth by silicoacter technique. Veneered stainless steel crown restoration by silicoater technique is considered to be a durable, retentive, and esthetic restoration.

간질환자의 정신병리와 생활사건 및 대처방식

이응천,이정섭,김창현,조필자 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

The authors assessed the differences of psychopathology, life-event and coping strategies between 71 epileptic patients and 74 chronic ill patients. To Investigate the relationship between psychiatric symptoms, stresses and coping strategies in epileptic patients and controls, Scale of Symptom checklist-90-revision(SCL-90-R), Multidimentional Coping Scale(MCS) and Life-event(SLE) were applied to the patients. Collected data were processed with SPSS/PC ver employing Chi-square test, t-test and Pearson correlation analysis. Summary of the result were as follows : 1) Epileptic patients, compared with chronic ill controls, showed significant difference in the item of the paranoid ideation of the SCL-90-R and in the item of perseverance of the MCS. 2) Chronic ill controls, compared with epileptic patients, had significant correlation with SCL-90-R and life-event, and these findings suggest that Epileptic patients have blunted coping strategies due to chronic illness and early onset age. 3) Among epileptic patients, the ones with early onset(≤18-year-old) showed significantly high scores in the obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism, additional items of the SCL-90-R and attention shift to production, emotional support seeking, emotional expression, acceptance, emotional pacification, self-criticism, positive comparison, active coping of the MCS. 4) In coping strategies adopted by epileptic patient, the ones with long duration of illness(>5years) showed significant difference at the emotional support seeking, emotional pacification, acceptance, religious seeking, positive comparison of the MCS. The epileptic patients treated with polypharmacy showed significantly high scores in the somatization, obsessive-compulsive, phobic anxiety, paranoid ideation of the SCL-90-R. In conclusion, we suggest that epileptic patients have simillar psychopathology and coping strategies with chronic ill patients. The epileptic patients with early-onset had more potential psychopathology and passive coping strategy than late-onset patients.

Gene Expression Analysis of the Bromobenzene Treated Liver with Non-hepatotoxic Doses in Mice

Lim, Jung-Sun,Jeong, Sun-Young,Hwang, Ji-Yoon,Park, Han-Jin,Cho, Jae-Woo,Song, Chang-Woo,Kim, Yang-Seok,Lee, Wan-Seon,Moon, Jin-Hee,Han, Sang-Seop,Yoon, Seok-Joo The Korean Society of Toxicogenomics and Toxicopro 2005 Molecular & cellular toxicology Vol.1 No.4

Bromobenzene (BB) is well known hepatotoxicant. Also, BB is an industrial solvent that arouses toxicity predominantly in the liver where it causes centrilobular necrosis. BB is subjected to Cytochrome P450 mediated epoxidation followed by either conjugation with glutathione, enzymatic hydrolysis or further oxidation. In this study, we focused on BB-induced gene expression at non-hepatotoxic dose. Mice were exposed to two levels of BB, sampled at 24 h, and hepatic gene expression levels were determined to evaluate dose dependent changes. When examining the toxic dose of BB treated group in other previous studies, genes related to heat shock protein, oxidative stress, and drug metabolism are expressed. Compared to these results, our study, in which non-toxic dose of BB was administrated, showed similar patterns as the toxic conditions above. The purpose of the study was to select genes that showed changes in relation to the differing dose through confirmation of the difference within transcriptomic boundaries, but those that are not detected by the existing classic toxicology tools in non-hepatotoxic dose.