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One-pot Lignocellulosic Biomass Conversion into Value-Added Chemicals
( Jaya Gladys Tiffany ),김재훈 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Lignocellulosic biomass is an abundant renewable resource and most importantly has enormous potential to be converted into various value-added chemicals for future biorefinery application. However, selective conversion of woody biomass is extremely challenging due to its complex structure. Herein, we investigated bimetallic Cu-Ru/HZSM5 catalyst for one-pot lignocellulose conversion in aqueous environment. HZSM5 provides acid sites required for consecutive depolymerization of holocellulose, dehydration, and isomerization while Cu-Ru synergistically promote hydro-genation/genolysis. Direct conversion of lignocellulose yielded up to 24.2wt% of lignin-derived monomers, cyclopentanone and methyl-cyclopentanone at 300 °C under pressurized H2 (3MPa) for 1h. This one-pot process can be a very promising and energy-efficient approach for utilization of whole lignocellulose into versatile platform chemicals in pharmaceuticals, fragrance, and polymer industries.
Jaya Prakash, M.,Oh, Minhak,Liu, Xinfang,Han, Kwi Nam,Seong, Gi Hun,Lah, Myoung Soo Royal Society of Chemistry 2010 Chemical communications Vol.46 No.12
<P>A general strategy was developed for edge-directed self-assembly of tetragonal metal–organic polyhedra (MOPs) having a <I>C</I><SUB>4</SUB> symmetry Cu<SUP>II</SUP><SUB>2</SUB>(COO)<SUB>4</SUB> paddle-wheel as a secondary building unit, using <I>C</I><SUB>2</SUB> symmetric dicarboxylic ligands as pincer-type primary building units.</P> <P>Graphic Abstract</P><P>Augmented tetragonal metal–organic polyhedra (MOPs) were self-assembled from <I>C</I><SUB>2</SUB> symmetric bidentate ligands based on a Cu(<SMALL>II</SMALL>) paddle-wheel moiety as a secondary building unit, where the ligands occupy the edges of the tetragonal cages. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b925335a'> </P>
( Jaya Shree Jena ),( Nilotpala Pradhan ),( Rati Ranjan Nayak ),( Bishnu P Dash ),( Lala Behari Sukla ),( Prasanna K Panda ),( Barada K Mishra ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.4
Bionanotechnology has revolutionized nanomaterial synthesis by providing a green synthetic platform using biological systems. Among such biological systems, microalgae have tremendous potential to take up metal ions and produce nanoparticles by a detoxification process. The present study explores the intracellular and extracellular biogenic syntheses of silver nanoparticles (SNPs) using the unicellular green microalga Scenedesmus sp. Biosynthesized SNPs were characterized by AAS, UV-Vis spectroscopy, TEM, XRD, FTIR, DLS, and TGA studies and finally checked for antibacterial activity. Intracellular nanoparticle biosynthesis was initiated by a high rate of Ag+ ion accumulation in the microalgal biomass and subsequent formation of spherical crystalline SNPs (average size, 15-20 nm) due to the biochemical reduction of Ag+ ions. The synthesized nanoparticles were intracellular, as confirmed by the UV-Vis spectra of the outside medium. Furthermore, extracellular synthesis using boiled extract showed the formation of well scattered, highly stable, spherical SNPs with an average size of 5-10 nm. The size and morphology of the nanoparticles were confirmed by TEM. The crystalline nature of the SNPs was evident from the diffraction peaks of XRD and bright circular ring pattern of SAED. FTIR and UV-Vis spectra showed that biomolecules, proteins and peptides, are mainly responsible for the formation and stabilization of SNPs. Furthermore, the synthesized nanoparticles exhibited high antimicrobial activity against pathogenic gram-negative and gram-positive bacteria. Use of such a microalgal system provides a simple, cost-effective alternative template for the biosynthesis of nanomaterials in a large-scale system that could be of great use in biomedical applications.
Jaya Gautam,Suhrid Banskota,이현지,이유정,전용현,김정애,정병선 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Triple-negative breast cancer (TNBC) is a highly metastatic breast cancer with poor prognosis. In the present study, we demonstrated that Src, a non-receptor tyrosine kinase, might provide an effective therapeutic strategy to overcome TNBC invasion and metastasis, which are mediated via the synergistic action of the lysosomal enzyme cathepsin S (CTSS) and gelatinase MMP-9. Knock-down of MMP-9 and CTSS using siRNAs resulted in a synergistic suppression of MDA-MB-231 cell invasion, which was similarly observed with pharmacological inhibitors. During the screening of new drug candidates that suppress both CTSS and MMP-9, BJ-2302, a novel 7-azaindolin-2-one derivative, was discovered. Src, an upstream activator of both pathways (PI3K/Akt and Ras/Raf/ERK) responsible for the expression of CTSS and MMP-9, was identified as a high-affinity target of BJ-2302 (IC90: 3.23 μM) through a Src kinase assay and a drug affinity responsive target stability (DARTS) assay. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Unlike Z-FL-COCHO (potent CTSS inhibitor), BJ-2302 did not induce any cytotoxicity in MCF-10A normal breast epithelial cells. Additionally, BJ-2302 (1 mg/kg) strongly suppressed TNBC cell proliferation in vitro and tumor growth in a xenograft mouse tumor model. The anti-metastatic and anti-tumor effects of BJ-2302 were superior to those of Z-FL-COCHO (1 mg/kg) or batimastat (30 mg/kg), a pan-MMP inhibitor. In summary, inhibition of Src kinase suppressed TNBC tumor growth and metastasis, and Src inhibitors such as BJ-2302 may constitute a novel therapeutic tool to treat breast cancer that expresses high levels of CTSS and MMP-9.
New Species of Termitomyces (Lyophyllaceae, Basidiomycota) from Sabah (Northern Borneo), Malaysia
( Jaya Seelan Sathiya Seelan ),( Chong Shu Yee ),( Foo She Fui ),( Mahadimenakbar Dawood ),( Yee Shin Tan ),( Min-ji Kim ),( Myung Soo Park ),( Young Woon Lim ) 한국균학회 2020 Mycobiology Vol.48 No.2
The genus Termitomyces (Lyophyllaceae, Basidiomycota) is often associated with fungus-feeding termites (Macrotermitinae) due to their strong symbiotic relationships. The genus is widely found exclusively in certain regions of Africa and Asia. They are recognized as edible mushroom within Southeast Asia as well. But it is often misidentified based on morphology by the local communities especially in Malaysia for Chlorophyllum molybdites which is a highly poisonous mushroom. Thus, it is necessary to study the genus for Malaysia with the synergy of using both morphological and molecular identification. In this study, we aim to describe another new species as an addition to the genus Termitomyces found within Sabah, Malaysia. We generated two new sequences (nrLSU and mtSSU) for the new species and a total of 28 nrLSU and mtSSU sequences were retrieved from GenBank for the phylogenetic analysis using maximum likelihood and Bayesian inferences. We identified that the new collection from Sabah province is a new species and named as Termitomyces gilvus based on the termites found in the mound. A phylogeny tree made from the concatenated genes of LSU and mtSSU suggests that T. gilvus is closely related to T. bulborhizus from China. According to our results, the combination of molecular and morphology proved to be a robust approach to re-evaluate the taxonomic status of Termitomyces species in Malaysia. Additional surveys are needed to verify the species diversity and clarify their geographic distribution.
Jaya, Ranganathan,Kumar, Rangarajan Sundaresan Mohan,Srinivasan, Ramasamy Korean Academy of Oral and Maxillofacial Radiology 2013 Imaging Science in Dentistry Vol.43 No.3
It has been a challenge to establish the accurate diagnosis of developmental tooth anomalies based on periapical radiographs. Recently, three-dimensional imaging by cone beam computed tomography has provided useful information to investigate the complex anatomy of and establish the proper management for tooth anomalies. The most severe variant of dens invaginatus, known as dilated odontome, is a rare occurrence, and the cone beam computed tomographic findings of this anomaly have never been reported for an erupted permanent maxillary central incisor. The occurrence of talon cusp occurring along with dens invaginatus is also unusual. The aim of this report was to show the importance of cone beam computed tomography in contributing to the accurate diagnosis and evaluation of the complex anatomy of this rare anomaly.