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( Myon-hee Lee ),( Srivalli Swathi Mamillapalli ),( Brett D. Keiper ),( Dong Seok Cha ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.2
Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification. [BMB Reports 2016; 49(2): 93-98]
Survival of Korean Cancer Patients Diagnosed in 1995
Jong-Myon Bae,Young-Joo Won,Kyu-Won Jung,Kyung-Ae Suh,Young-Ho Yun,Myung-Hee Shin,Yoon-Ok Ahn,Duk-Hee Lee,Hai-Rim Shin,Don-Hee Ahn,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5
Purpose: To produce the nationwide 5-year survivalrates of Korean cancer patients by primary cancer site.Materials and Methods: The study subjects were cancerpatients diagnosed in 1995, as documented by the KoreaCentral Cancer Registry (KCCR) Program. This data wascollected in 120 (93%) of 129 nationwide intern- andresident-training hospitals and 75 (94%) of the 80 Koreanuniversity hospitals. Follow-up was performed by obtaininginformation upon vital status (i.e., whether living ordead) from the government administered whole populationfiles. Cumulative observed survival rate (OSR) wascalculated by using the life table method and the relativesurvival rate (RSR) was computed using the life-time tablefor the years 1995, 1997, and 1999.Results: Of the 55,042 study subjects, the OSR for allKorean cancer patients was 61.4% at 1 year and 38.1%at 5 years. The RSR for all cancers was 62.5% at 1 yearand 41.4% at 5 years, and the 5-year RSRs for all cancersin men and women were 32.6% and 53.2%, respectively.Conclusion: This is the first nationwide report upon5-year cancer survival by primary site in Korea. Menshowed a lower survival rate than women in most malignancies.Pancreatic and thyroid cancer had the lowestand highest 5-year survival rates, respectively. (Cancer Res Treat. 2002;34:319-325)
이경철(Kyung-Chul LEE),이진면(Jin Myon Lee),오지택(Ji-Taek Oh),김정현(Jeong-Hyun Kim),이상근(Sang-Keun Lee),박선희(Seon-Hee Park) 한국철도학회 2012 한국철도학회 학술발표대회논문집 Vol.2012 No.10
철도정책 수립 시 산업통계가 기본적으로 요구되나 국내에는 철도산업을 종합적으로 포괄하는 통계체계가 아직 구축되어 있지 않다. 본 연구는 철도산업 통계체계구축 필요성 관련 논의를 확산시키기 위한 기초 연구로 우선 활용이 가능한 정부 승인통계 중 전국 사업체 조사, 광업·제조업 조사, 도·소매업조사, 운수업조사 결과를 분석하여 철도산업의 구조적 특성변화를 분석하였다. 결과를 요약하면, 철도산업은 2,187개의 기업에서 약 56천인을 고용하였다(08년). 철도장비 제조업은 년간 출하액이 3조296억원(09년)으로 국내 전체 제조업의 0.29% 수준이며, 철도관련 수송용 기계 및 장비 도매업의 매출액은 9,496억원(08년)으로 전체 도소매업의 0.15%, 철도운수업은 매출액 6조3537억원(09년) 으로 전체 5% 수준이다. 철도산업 내부에서는 철도운송업, 철도건설업, 철도차량제조업의 순으로 부가가치규모가 크고, 경제적인 위상이 높은 것으로 파악되었다. This article aims to develop discussions on the necessity of official statistics system for railroad industry which is indispensable in planning, every five years, the Railroad Industry Development Plan. To reach this goal, it was necessary to define the scope of railroad industry and extract railroad industry related figures from the surveys of the Korea National Statistics Office : census on establishments, mining & manufacturing, wholesale & retail, and transport. Railroad Industry employed 56 thousand workers in 2,187 establishments in 2008. Railroad equipments manufacturing occupied, in 2009, 0.29% of country‘s whole manufacturing by the market price. Sales of Railroad transport related machineries and equipments, in 2008, were 0.15% in the nation"s wholesale and retail takings. The share of Railroad transport sales were 5% in whole domestic transport sales. Within railroad industry, added value was important in the order of rail transport, rail construction and manufacturing of rolling stocks.
Hai-Rim Shin,Yoon-Ok Ahn,Jong-Myon Bae,Myung-Hee Shin,Duk-Hee Lee,Choong-Won Lee,Heechoul Ohrr,Don-Hee Ahn,Jacques Ferlay,Dornald Maxwell Parkin,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.6
Purpose: We estimated the incidence of cancer inKorea.Materials and Methods: The indicence of cancer wasestimated using national mortality data, and the incidencedata from four frontier regional cancer registries,including Kangwha, Seoul, Busan and Deagu. These fourregistries served a population about seventeen million,which is almost 38% of entire population in Korea.Results: The overall age-standardized incidence rates(ASR) were 287.0 and 163.1 per 100,000 for males andfemales, respectively. Among males, stomach cancer wasthe most frequent (ASR 69.6), followed by lung cancers,including bronchus cancer (ASR 54.5), liver cancer (ASR47.0) and colo-rectal cancer (ASR 25.2). The most frequentsites of cancer in females, by rank order, were stomach(ASR 26.8), breast (ASR 20.1), uterine cervix (ASR 18.0),colo-rectum (ASR 15.9), lung (ASR 13.0) and liver (ASR12.0).Conclusion: It is hoped that these results will providevaluable leads for cancer research and cancer control inKorea. (Cancer Res Treat. 2002;34:405-408)