Development of a bivalent live vaccine against duck hepatitis A virus types 1 & 3 and vaccine program for breeder ducks in Korea

Jae?Hee Roh(노재희),Min Kang,Bai Wei,Se-Yeoun Cha,Jeong-Gon Cho,Hyung-Kwan Jang 한국가금학회 2017 한국가금학회 정기총회 및 학술발표회 Vol.2017 No.11

어린 오리에 치명적인 질병을 일으키는 오리바이러스성간염의 예방을 위해 혼합생백신 개발, 백신의 방어기전 연구 및 종오리백신 프로그램의 개발로 질병방어 및 제어를 목표로 연구를 진행하였다. 첫 번째, 국내에는 1형과 3형이 동시 유행하고 있으며, 최근에는 3형의 발생보고가 증가하는 추세이다. 특히 1형과 3형의 복합감염사례도 빈번히 발생하고 있다. 이런 상황에서 효율적인 질병관리를 위해 국내에 발생하는 오리간염 1형과 3형을 동시에 방어하는 혼합백신을 개발하고 그 효능을 확인하였으며, 운반 및 보관 용이성 향상을 위한 연구를 진행하였다. 두 번째, 오리감염 생백신의 3-5일 만에 조기면역을 획득하는 특성분석을 위해 세포성 및 체액성 면역반응을 평가하였다. Cytokine이 백신접종 그룹에서 증가하는 것을 확인하였고, 특히 IFN-α에서 강한 증가를 보였다. 또한 항체가 평가에서는 기존에 알려진 바와는 다르게 백신 후 3일째에 항체를 획득하였고, 10일째에는 최고수준의 항체가 수준을 나타냈다. 세 번째, 1주령이하의 어린 일령에 치명적인 질병의 특성상 모체이행항체에 의한 예방이 가장 효과적이라는 점에 착안하여 종오리백신 프로그램을 개발하고 농장에 적용하여 평가하였다. 종오리 농장 4개동 4천수의 종오리를 대상으로 백신을 실시하였으며, 모체의중화항체가(VN titer) 8 log2이상에서 후대병아리 14일령까지 100% 방어효능을 확인하였다. 모체이행항체의 전달률은 11%수준으로 나타났으며, 후대병아리의 항체가를 개체별 추적하여 계산한 결과 모체이행항체 반감기는 3-5일령임을 확인하였다. 본 연구에서는 오리에 치명적인 질병을 일으키는 오리바이러스성간염 예방을 위한 혼합생백신 개발에 관한 연구로 기존의 국내 상용화백신의 한계점을 극복하고, 국내에 유행하는 혈청형들을 단회백신으로 효과적으로 방어할 수 있는 혼합생백신을 개발하였으며, 백신의 특성상 조기면역에 대한 세포성 및 체액성 면역기전을 평가하였다. 또한 종오리백신 프로그램을 국내에 적용하여 모체이행항체에 의한 후대 병아리의 우수한 방어 효능을 확인하였다.

디지털 치료기술 산업 육성에 따른 투자와 경제적 파급효과

김재현 ( Jae-hyun Kim ),문종윤 ( Jong Youn Moon ),장지은 ( Jieun Jang ),심정연 ( Jung Yeon Sim ),신재용 ( Jaeyong Shin ) 한국보건행정학회 2020 보건행정학회지 Vol.30 No.4

The digital treatment technology industry is one of the core fostering industries of the Moon Jae-in government along with the global trend. The purpose of this study is to compare and analyze the investment and economic ripple effect on the related industries. To this end, we used the industry-related table, which is the actual measurement data for 2015 that the Bank of Korea actually measured and released every 5 years in 2019. The digital treatment technology industry was not clearly classified within Korea’s industrial classification system, so the contents of the industry-related survey were analyzed, and the digital treatment technology industry was reclassified and then analyzed. As a result of the analysis, it was analyzed that the production induction effect of the digital treatment technology-related industry in 2015 was 1.770, the value-added induction effect was 0.875, and the employment induction effect was 19.128, which was higher than that of other industries in Korea. As a result of the analysis of the economic ripple effect (scenario 1), the production inducing effect was about 370 billion won, the added value inducing effect was about 185 billion won, and the employment inducing effect was 4,044 people. The results of this study are expected to play a large role in economic revitalization as the effect of inducing production, increasing employment, and creating added value through fostering the digital treatment technology industry is expected to play a large role in activating the economy. It is expected to play a large role in providing central medical services. Therefore, it is expected that policy support for revitalizing the digital treatment technology industry through active investment support and tax benefits from the government to foster the digital treatment technology industry is necessary.

생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

비정질 인듐갈룸ᅳ아연-산화물 박막트랜지스터 기반의 AMOLED 화소 회로

이재표(Jae-Pyo Lee),유경민(Kyeong-Min Yu),장진녕(JinNyoung Jang),홍문표(MunPyo Hong),배병성(Byung Seong Bae) 호서대학교 공업기술연구소 2013 공업기술연구 논문집 Vol.32 No.2

본 논문은 비정질 인둠ᅳ갈f ᅳ아연-산화물 박막트랜지스터 (a-IGZO TFT)를 이용하여 능동형 유기발광다이오드 (AMOLED)용 문턱전압(Vth )을 보상하는 화소 회로를 제안하였다. 산화물 TFT는 n-채널 TFT로써, 우리는 n-채널 TFT 특성으로 회로를 최적화하였다. 제안된 화소 회로는 회로 시뮬레이션 뿐만 아니라 회로 분석을 이용하여 확인되었다. 제안된 화소 회로는 AMOLED에서 구동 TFT의 문턱전압 변화를 보상할 수 있다. 제안된 화소 회로를 이용함으로써, 문턱전압 보상은 달성되었다. rhis paper proposes a tnresnold voltage compensation pixel circuit for active-matrix organic light-emitting diode (AM OLED) using amorphous indium-gaUiimi-zinc-oxide thin-film transistors (a-IGZO TFTs), Oxide TFT is an n-channel TFT; therefore, we optimized the circuit for the n-channel TFT characteristics. The proposed pixel circuit was verified using circuit analysis as well as circuit simulations. The proposed circuit could compensate for the threshold voltage variations o f drive TFT in AM OLED. Using the proposed pixel circuit, threshold voltage compensation was achieved.

계통연계 인버터의 Inductor 최적화 기법을 통한 LCL Filter의 설계

장재하(Jae-ha·Jang),김경화(Kyeong-hwa·Kim) 한국조명·전기설비학회 2014 한국조명·전기설비학회 학술대회논문집 Vol.2014 No.5

전해산성수를 이용한 새로운 내시경 소독 시스템(Cleantop WM-1??)의 소독효율

이준행,이풍렬,송재훈,이남용,임윤정,장재권,김영호,김재준,백승운,이종철,최규완 대한감염학회 2001 감염 Vol.33 No.2

Background : Electrolyzed acid water (EAW) is a new liquid chemical germicide containing a mixture of oxidizing species and prepared by mixing a small amount of salt with tap water in an electrolyzer. We attempted an in-use evaluation of the high-level disinfection capability of Cleantop WM-1□, a new endoscope reprocessing system using EAW. Methods : Forty-seven flexible endoscopes were randomly collected just after upper endoscopic examinations and were disinfected using Cleantop WM-1□. Parts of the endoscopes without contact to EAW were disinfected with 75% ethyl alcohol. Immediately after the disinfection procedure, samples were taken from the biopsy channel (S-1), tip of the insertion tube (S-2), the umbilical cord (S-3), and the angulation knob (S-4). Results : In EAW-disinfected parts of the endoscopes, the culture-positive rates were 4.3% (2/47) in S-1 samples and 12.8% (6/47) in S-2 samples. In ethyl alcohol-disinfected area, the culture-positive rates were 2.1% (1/47) in S-3 samples and 25.5% (12/47) in S-4 samples. The colony counts of culture-positive samples ranged from 1 to 144. Pseudomonas aerugi-nasa was recovered from the angulation knob of an endoscope, but other contaminating organisms were mostly : normal flora or opportunistic pathogens. Conclusion : Although part of the endoscopes disinfected with 75% ethyl alcohol were contaminated with more organisms than EAW-disinfected areas, Cleantop WM-1□ showed a relatively good disinfection efficacy in reprocessing patient-used endoscopes. (Korean J Infect Dis 33:133∼138, 2001)

카이로프랙틱 도수요법에 의한 경추성 두통의 치료

장재호,사공은성 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Purpose : Cervicogenic headache is a neck induced headache syndrome. Chiropractic Spinal Manipulation Therapy (CSMT) is non-invasive treatment method for painful lesion. CSMT is considered to relief the pain and increase the range of motion of cervical spine without complications. Materials and Methods : A follow-up observation has been made by retrospective study after applying chiropractic spinal manipulation therapy on 28 cases of cervicogenic headache patients who visited our hospital from April 2005 to April 2007. Every patiens had performed Short-Form McGill Pain Questionnaire, Neck Disability Index, and SF-36 Questionnaire. Results : 28 patients average age was 37(14∼73). Female patient was 23 out of 28 and 5 was male patients. The average duration of treatment was 13.6 weeks. The Short-Form McGill Pain Questionnaire, in which questions about the level of pain in general and the Pain Relating Index (PRI), was 11.7 in average before chiropractic spinal manipulation and 3.7 in average after manipulation (P=0.196). The Visual Analog Scale (VAS 0-10) showed pain decrement from 6.1 to 3.1 after manipulation (P=0.126). PPI showed improvement from 2.75 to 0.5 after manipulation(P=0.1). In the Neck Disability Index, which questions the physical disability due to pain, the decrement in average was 14.6 to 4 after manipulation. The results of SF-36 Questionnaire, which deals with the patient's general health showed decrement from 57.8. to 69.4(P=0.317) after manipulation. Conclusion : CPMT has pain relieving effects in cervicogenic headache and also shows increased neck range of motion after treatment. Therefore, CSMT can be a one of useful treatment method for cervicogenic headache.

일령에 따른 닭 태자 샘위의 조직학적 변화에 관한 연구

장재우,이형식,구세광 慶山大學校 基礎科學硏究所 1999 基礎科學 Vol.3 No.1

닭 태자의 샘위에서 일령에 따른 크기, 조직학적 변화를 관찰하기 위하여 부란 10일부터 부화직후에 걸쳐 10개군으로 구별하고 일반 조직학적 관찰을 실시하였던 바 다음과 같은 결과를 얻었다. 샘위는 전 연령에 걸쳐 긴 방추형으로 복강의 상부에서 관찰되었으며 크기는 부란 10일경에 직경 1.70±0.05mm, 길이 2.40±0.08mm로 관찰된 후 일령에 따라 증가하여 부화직후에는 직경 6.61±0.77mm, 길이 14.21±1.03mm로 관찰되었다. 조직학적으로 닭 태자의 샘위의 상피는 부란 초기 거짓중층원주상피로 구성되었으며 이후 단층원주상피로 분화되고 발생초기 상피의 함입에 의하여 proventricular gland가 형성되며 복합관상샘으로 분화되었다. 또한 점막상피는 다시 분화되어 부란 후기에 gastric gland를 형성하였다. To investigate, histological changes in the proventriculus of the chicken embryos with incubation periods. Samples were taken from 10 groups(10 days of incubation to hatching), and stained with H-E. The findings were as follows. The proventriculus of chicken embryos were observed by long spindle shaped in upper abdominal cavity and the size were detected that 1.70 ± 0.05mm in diameter and 2.40 ± 0.08mm in length at 10 days of incubation, after that the size were increased with incubation periods and in hatching, the size were reached at 6.61±0.77mm in diameter and 14.21±1.03mm in length. Histologically, the epithelium of the proventriculus were pseudostratified columnar epithelium in early incubation periods and after that these epithelia differentiated to simple columnar epithelium. The proventricular glands were made by invagination of surface epithelium in early incubation periods and after that these glands were differentiated to compound tubular gland type. In late incubation periods, the surface epithelium were differentiated twice and made gastric glands. The tunica muscularis and serosa were relatively well developed throughout all incubation periods but muscularis mucosa were observed after hatching.

천연염료를 이용한 무늬염법

장영호,이재범 한국공예학회 1999 조형디자인연구 Vol.2 No.2

The natural dye substance largely consists of plant, animal and minerals materials, which we can easily and naturally be obtained all around us. It has been widely used all around the world for numerous years. The natural dye substance appears to have a lot of benefits that enable the dyed material to show natural merits which in turn enables the dyed materials to exhibit their natural colors. It may have a little bit of a damaging effect on the human body itself. , in comparison to the synthetic substances. It also causes hardly any environmental pollution because of the natural chemicals and costs much less to dispose of. on the other hand it also has disadvantages, that is it's difficult to get various kinds of patterns on the cloth. The dyeing process is done by full saturation, which is only available for commercial use because of the low ratio of dyeing success. The product of the dye substance is limited, the reliability of the dyed material is low, and it is easy to make dark and light colors. For the reasons mentioned above, the use of the natural dye is decreasing except for special uses. Nowadays it is very difficult to come across this method because of he appearance of synthetic dye substances. The dyeing process by saturation into the natural dye substance is done by putting the material, ready for dyeing, into the dye-water once or several times repeatedly. It also has several problems, which include, the complexity of the dyeing process, the low reliability of the dyeing substance and the dependence on manual work done by observing with the naked eye. Eventually, these problems caused the slow down of industrialization. Furthermore, the mixed use of dye substances and it's catalyst caused to develop the natural dye substance and to increase the dye's adhesiveness to the material. Those are the disadvantages of it's use. This is the method to study silk screen printing by using natural dye substance to make a specific patterns on the clothing using various methods. The silk screen printing needs to have the material dyed by the saturation method. Then the silk screen is printed by subtracting the colors to make another shade of color without using any additional dye substance. It only uses the natural dye substance mixture and it's catalyst. It will help to print specific patterns on the material. Therefore it's effects are available for using in various kinds of silk screen printing and to make different kinds of patterns equal to the natural dye substance method, which is both saturating and then printing.

근대이후 중국무술발달사 연구

장재이 대한무도학회 2000 대한무도학회지 Vol.2 No.1

This study is to examine the meaning of martial arts history in China by examining the development of Chinese martial arts after the modern times. We have investigated the martial arts before and after People's Republic of China. As a result, the study is summarized as follows. First, the Chinese martial arts after the modem times are effectively applied to a variety of fields such as school, private, and military martial arts. Second, the Chinese martial arts have many kinds, but Wushu was developed into an athletic game or sports. Third, the Chinese martial arts have been harmoniously developed m both sports martial arts and private martial arts (dancing type). Fourth, the Chinese arts have been developed further into Asia and the world as its development and management is more standardized.