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돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
Electric-field-induced spin disorder-to-order transition near a multiferroic triple phase point
Jang, Byung-Kweon,Lee, Jin Hong,Chu, Kanghyun,Sharma, Pankaj,Kim, Gi-Yeop,Ko, Kyung-Tae,Kim, Kwang-Eun,Kim, Yong-Jin,Kang, Kyungrok,Jang, Han-Byul,Jang, Hoyoung,Jung, Min Hwa,Song, Kyung,Koo, Tae Yeon Nature Publishing Group 2017 Nature physics Vol.13 No.2
<P>The emergence of a triple phase point in a two-dimensional parameter space (such as pressure and temperature) can offer unforeseen opportunities for the coupling of two seemingly independent order parameters. On the basis of this, we demonstrate the electric control of magnetic order by manipulating chemical pressure: lanthanum substitution in the antiferromagnetic ferroelectric BiFeO3. Our demonstration relies on the finding that a multiferroic triple phase point of a single spin-disordered phase and two spin-ordered phases emerges near room temperature in Bi0.9La0.1FeO3 ferroelectric thin films. By using spatially resolved X-ray absorption spectroscopy, we provide direct evidence that the electric poling of a particular region of the compound near the triple phase point results in an antiferromagnetic phase while adjacent unpoled regions remain magnetically disordered, opening a promising avenue for magnetoelectric applications at room temperature.</P>
Jang Won Young,정우진,장병국,황재석,이헌주,Hwang Moon Joo,Kweon Young Oh,Tak Won Young,Park Soo Young,Lee Su Hyun,Lee Chang Hyeong,Kim Byung Seok,Kim Si Hye,Suh Jeong Ill,Park Jun Gi 대한의학회 2020 Journal of Korean medical science Vol.35 No.29
Background: Liver cirrhosis has become a heavy burden not only for patients, but also for our society. However, little is known about the recent changes in clinical outcomes and characteristics of patients with cirrhosis-related complications in Korea. Therefore, we aimed to evaluate changes in characteristics of patients with liver cirrhosis in Daegu-Gyeongbuk province in Korea over the past 15 years. Methods: We retrospectively reviewed the medical records of 15,716 liver cirrhotic patients from 5 university hospitals in Daegu-Gyeongbuk province from 2000 to 2014. The Korean Standard Classification of Diseases-6 code associated with cirrhosis was investigated through medical records and classified according to the year of first visit. Results: A total of 15,716 patients was diagnosed with cirrhosis. A number of patients newly diagnosed with cirrhosis has decreased each year. In 2000, patients were most likely to be diagnosed with hepatitis B virus (HBV) cirrhosis, followed by alcoholic cirrhosis. There was a significant decrease in HBV (P < 0.001), but alcohol, hepatitis C virus (HCV), and non- alcoholic fatty liver disease (NAFLD) showed a significant increase during the study period (alcohol, P = 0.036; HCV, P = 0.001; NAFLD, P = 0.001). At the time of initial diagnosis, the ratio of Child-Turcotte-Pugh (CTP) class A gradually increased from 23.1% to 32.9% (P < 0.001). The most common cause of liver-related hospitalization in 2000 was hepatocellular carcinoma (HCC) (25.5%); in 2014, gastrointestinal bleeding with esophageal and gastric varices (21.4%) was the most common cause. Cases of hospitalization with liver-related complication represented 76.4% of all cases in 2000 but 70.9% in 2014. Incidence rate of HCC has recently increased. In addition, HCC-free survival was significantly lower in CTP class A than in classes B and C. Finally, there was significant difference in HCC occurrence according to causes (P < 0.001). HBV and HCV cirrhosis had lower HCC-free survival than alcoholic and NAFLD cirrhosis. Conclusion: In recent years, the overall number of cirrhosis patients has decreased. This study confirmed the recent trend in decrease of cirrhosis, especially of cirrhosis due to HBV, and the increase of HCV, alcoholic and NAFLD cirrhosis. Targeted screening for at-risk patients will facilitate early detection of liver diseases allowing effective intervention and may have decreased the development of cirrhosis and its complications.
Preparation, structure, and properties of cellulose nanofibril/silk sericin composite film
Jang, Mi Jin,Park, Byung-Dae,Kweon, HaeYong,Jo, You-Young,Um, In Chul Korean Society of Sericultural Science 2015 International Journal of Industrial Entomology Vol.31 No.1
Recently, sericin has attracted increasing attention in biomedical and cosmetic research because of its useful properties including acceleration of wound healing, improvement of cell attachment, and inhibition of ultraviolet-B induced apoptosis. However, sericin films have poor mechanical properties, which restricts the application to those fields. In this study, cellulose nanofibril (CNF)/sericin composite films were fabricated by solvent casting, and the effects of ultrasonication time and CNF content on the solution turbidity, molecular conformation, and film mechanical properties of sericin film were examined. As the ultrasonication time increased, the turbidity of the CNF/sericin suspension decreased. Conversely, as the CNF content increased, the turbidity increased. However, ${\beta}$-sheet crystallization and mechanical properties remained almost unchanged by varying the ultrasonication time and CNF content, indicating that CNF is not effective to improve the mechanical properties of sericin films.
Yoo, Byung-Wook,Park, Jae-Hyoung,Jin, Joo-Young,Jang, Yun-Ho,Kim, Yong-Kweon IOP 2009 JOURNAL OF MICROMECHANICS AND MICROENGINEERING - Vol.19 No.5
<P>This paper describes a self-alignment method whereby a mirror actuation voltage, corresponding to a specific tilting angle, is unvarying in terms of misalignment during fabrication. A deep silicon etching process is proposed to penetrate the top silicon layer (the micromirror layer) and an amorphous silicon layer (the addressing electrode layer) together, through an aluminum mask pattern, in order to minimize the misalignment effect on the micromirror actuation. The size of a fabricated mirror plate is 250 × 250 × 4 µm<SUP>3</SUP>. A pair of amorphous silicon electrodes under the mirror plate is about half the size of the mirror plate individually. Numerical analysis associated with calculating the pull-in voltage and the bonding misalignment is performed to verify the self-alignment concepts focused upon in this paper. Curves of the applied voltage versus the tilt angle of the self-aligned micromirror are observed using a position sensing detector in order to compare the measurement results with MATLAB analysis of the expected static deflections. Although a 3.7 µm misalignment is found between the mirror plate and the electrodes, in the direction perpendicular to the shallow trench of the electrodes, before the self-alignment process, the measured pull-in voltage has been found to be 103.4 V on average; this differs from the pull-in voltage of a perfectly aligned micromirror by only 0.67%. Regardless of the unpredictable misalignments in repetitive photolithography and bonding, the tilting angles corresponding to the driving voltages are proved to be uniform along the single axis as well as conform to the results of analytical analysis.</P>
Yoo, Byung-Wook,Park, Jae-Hyoung,Jang, Yun-Ho,Kim, Yong-Kweon IOP 2008 JOURNAL OF MICROMECHANICS AND MICROENGINEERING - Vol.18 No.3
<P>This paper describes the design, fabrication and testing of a one-axis micromirror in order to suppress the electric charging problem related to its actuation. The electrostatically-actuated torsional micromirror is of the parallel-plate type. Since the dielectric around the electrodes below the mirror plates is highly exposed, we installed gold shields in the floating state around the electrodes, so as to cover the exposed dielectric surface. The gold shields played a leading role in limiting the electric field between the electrodes. This effect was characterized and the tilting angle stability was measured by observing the micromirror performance with and without the floating field-limiting shields. Drift measurements of these two types of micromirrors were made using a position-sensing detector (PSD). The micromirror with the field-limiting shields, namely micromirror type A, showed a tilting angle drift of 0.005° at 83% of the pull-in voltage, while a tilting angle drift of 0.5° was measured at the same percentage of the pull-in voltage for the micromirror without the field-limiting shields, namely micromirror type B. At 97.7% of the pull-in voltage, the pull-in phenomenon occurred after 220 s for micromirror type B due to the charging effect. On the other hand, micromirror type A showed no pull-in phenomena with elapsed time at a bias of 97.7% of the pull-in voltage due to the resolution of the charging effect.</P>
장부림(Jang, Boo-Rim),민동국(Min, Dong-Kook),전병권(Jun, Byung-Kweon) 한국주거학회 2019 한국주거학회 학술대회논문집 Vol.31 No.2
Mokpo is an ocean city which is harmonious the ocean sightseeing resources and culture & arts resources. There are Yudalsan Mountain on the west, Samhakdo Island on the south, Gatbawi Island on the east and it is rising as ocean sightseeing city land mark by opening cable car on the sea, however, the necessity of urban regeneration is seriously necessary because of superannuated coal terminal at the Samhakdo Island on the south and distant facilities and insufficient management of the surroundings of Marina Port. A deliberate proposal is attempted in the terms of urban regeneration of Mokpo area by introducing waterfront concept as the solution of the problem recognizing the problem on the Mokpo Marina Port only.