Magnetic Interaction in FeCo alloy Nanotube Array

D. Zhou1,T. Wang,M.G. Zhu,Z.H. Guo,W. Li,F. SLi 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists

Yingmei Wang,Shiqian Zhang,Lihui Wei,Zhongqiu Lin,Xinyu Wang,Jianliu Wang,Keqin Hua,Manhua Cu,Jiandong Wang,Shixuan Wang,Wen Di,Yudong Wang,Ruifang An,Mingrong Xi,Ruixia Guo,Qi Zhou,Xing Xie,Fengxia X 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratorysyndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk ofbeing infected with the coronavirus and are more likely to develop severe complications, ascompared to the general population. The increasing spread of COVID-19 presents challengesfor the clinical care of patients with gynecological malignancies. Concerted efforts should beput into managing gynecological malignancies in an orderly manner by strictly implementingthe measures that are specifically developed for controlling the spread of COVID-19. We havedrafted Recommendations on Management of Gynecological Malignancies during the COVID-19 Pandemicbased on our experience on controlling COVID-19 pandemic in China. We recommendthat patients with gynecological malignancies should be managed in hierarchical andindividualized manners in combination with local conditions related to COVID-19. Medicalcare decision should be balanced between controlling COVID-19 pandemic spread and timelydiagnosis and treatment for gynecologic oncology patients.

Numerical simulation Analysis of Tip Clearance Flow in a Centrifugal Compressor

Zhou, Shuiqing,Wang, Jun,Wang, Chuanghua,Li, Ye Korean Society for Fluid machinery 2014 International journal of fluid machinery and syste Vol.7 No.1

In order to research the relationship between the tip clearance and leakage flow of centrifugal compressor, a high speed centrifugal compressor was investigated by using CFD. A numerical study on the effect of four different rotor tip clearance sizes of centrifugal compressor, which were 0.5times, 1 times, 1.5times and 2.0times of the design tip clearance, was carried out. Efficiency and pressure ratio curves were obtained under different mass flow. The reasons of the clearance vortex and the factors of vortex size were analyzed. The result indicated that with the increase of tip clearance size, the performance of the compressor changed obviously, the performance parameters such as efficiency and pressure ratio tended to decrease obviously. While, the leakage flow does not always lead to leak vortex. The strength of the vortex increased with the tip clearance. The size of leak vortex was affected by the pressure difference between the suction side and the pressure side of blade tip.

Construction of a Protein-Protein Interaction Network for Chronic Myelocytic Leukemia and Pathway Prediction of Molecular Complexes

Zhou, Chao,Teng, Wen-Jing,Yang, Jing,Hu, Zhen-Bo,Wang, Cong-Cong,Qin, Bao-Ning,Lv, Qing-Liang,Liu, Ze-Wang,Sun, Chang-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.

Distortional buckling of cold-formed lipped channel columns subjected to axial compression

Wang-Bao Zhou,Lizhong Jiang 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.3

Cold-formed lipped channel columns (CFLCCs) have been widely used in light gauge steel constructions. The distortional buckling is one of the important buckling modes for CFLCCs and the distortional buckling critical load depends significantly on the rotational restrain stiffness generated by the web to the lipped flange. First, a simplified explicit expression for the rotational restraint stiffness of the lipped flange has been derived. Using the expression, the characteristics of the rotational restraint stiffness of the lipped flange have been investigated. The results show that there is a linear coupling relationship between the applied forces and the rotational restraint stiffness of the lipped flange. Based on the explicit expression of the rotational restraint stiffness of the lipped flange, a simplified analytical formula has been derived which can determine the elastic distortional buckling critical stress of the CFLCCs subjected to axial compression. The simplified analytical formula developed in this study has been shown to be accurate through the comparisons with results from the distortional buckling analyses using the ANSYS finite element software. The developed analytical formula is easy to apply, and can be used directly in practical design and incorporated into future design codes and guidelines.

HOCl Oxidation-modified CT26 Cell Vaccine Inhibits Colon Tumor Growth in a Mouse Model

Zhou, Rui,Huang, Wen-Jun,Ma, Cong,Zhou, Yan,Yao, Yu-Qin,Wang, Yu-Xi,Gou, Lan-Tu,Yi, Chen,Yang, Jin-Liang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Despite progress in elucidating mechanisms associated with colorectal cancer and improvement of treatment methods, it remains a frequent cause of death worldwide. New and more effective therapies are therefore urgently needed. Recent studies have shown that immunogenicity of whole ovarian tumor cells and subsequent T cell response were potentiated by oxidation modification with hypochlorous acid (HOCl) in vitro and ex vivo. These results prompted us to investigate the protective antitumor response with an HOCl treated CT26 colorectal cancer cell vaccine in an in vivo mouse model. Administration of HOCl modified vaccine triggered robust antitumor immunity to autologous tumor cells in mice and prolonged survival period significantly. In addition, increased necrosis and apoptosis were found in tumor tissue from the oxidation group. Interestingly, ELISPOT assays showed that specific T cell responses were not elicited in response to the immunizing cellular antigen, in contrast to raising sera antibody titer and antibody binding activity shown by ELISA assay and flow cytometry. Further evaluation of the mechanisms underlying HOCl modified vaccine mediated humoral immunity highlighted the role of antibody-dependent cell-mediated cytotoxicity. These results combined with previous studies suggest that HOCl oxidation modified whole cell vaccine has wide applicability as a cancer vaccine because it can target both T cell- and B cell-specific responses. It may thus represent a promising approach for the immunotherapy of colorectal cancer.

New Technique of Intracorporeal Anastomosis and Transvaginal Specimen Extraction for Laparoscopic Sigmoid Colectomy

Wang, Zheng,Zhang, Xing-Mao,Zhou, Hai-Tao,Liang, Jian-Wei,Zhou, Zhi-Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: Despite the growing acceptance of laparoscopic colon surgery, an abdominal incision is needed to remove the specimen and perform an anastomosis. Recently, natural orifice specimen extraction (NOSE) and intracorporeal anastomosis have been proposed to minimize abdominal wall trauma and improve the quality of laparoscopic colon resections Objective: To evaluate the feasibility and safety of a new approach combining intracorporeal delta-shaped anastomosis and transvaginal specimen extraction for totally laparoscopic sigmoid colectomy. Materials and Methods: Mobilization of bowel and dissection of lymph nodes were performed laparoscopically. After both proximal and distal incisal edges about 10.0 cm distance from sigmoid neoplasm were transected with an Endoscopic Linear Cutter-Straight, a small incision about 1.0 cm was created on the each colon wall of the contralateral side of the mesentery. Then anvils of an Endoscopic Linear Cutter-Straight were inserted into each colon through the small incisions, and incision and anastomosis between the walls of each colon were performed with a linear stapler. A V-shaped anastomosis was made on the wall and the remnant openings was reclosed with the Endoscopic Linear Cutter-Straight. The culdotomy was enlarged with laparoscopic ultrasound dissector. Transvaginal extraction of specimens was accomplished through a wound protector. Results: Surgery was performed for 11 patients with sigmoid cancer. No intraoperative complications or conversions occurred. The mean operating time was 132 min. All the patients were treated laparoscopically without any postoperative complications. Conclusions: The procedures of intracorporeal delta-shaped anastomosis and transvaginal specimen extraction are safe and oncologically acceptable for selected colon cancer cases.

Recent progress in the synthesis of luminescent copper clusters

Zhou, Shaochen,Wang, Fu,Wang, Chuanyi Techno-Press 2016 Advances in nano research Vol.4 No.2

Luminescent metallic clusters have attracted great interest due to their unique optical, electronic and chemical features. Comparing with intensively studied Au and Ag Clusters, Cu clusters are superior in the aspects of cost and wide industrial demanding. However, tiny copper clusters are extremely prone to aggregate and undergo susceptibility of oxidation, thereby the synthesis of fluorescent zero valent copper clusters is rather challenging. In this review, synthetic strategies towards luminescent copper clusters, including macromolecule-protection and micro molecule-capping, have been systematically surveyed. Both "bottom-up" and "top-down" synthetic routes are found to be effective in fabricating luminescent copper clusters, some of which are quite stable and possess decent luminescence quantum yields. In general, the synthesis of fluorescent copper clusters remains at its infant stage. A great deal of effort on developing novel and economic synthetic routes to produce bright and stable copper clusters is highly expected in future.

Settlement behavior and controlling effectiveness of two types of rigid pile structure embankments in high-speed railways

Wang, Changdan,Zhou, Shunhua,Wang, Binglong,Guo, Peijun,Su, Hui Techno-Press 2016 Geomechanics & engineering Vol.11 No.6

In this study, a series of geotechnical centrifugal tests were conducted to investigate the effectiveness of settlement control of two types of rigid pile structure embankments (PRSE) in collapsible loess under high-speed railway embankments. The research results show that ground reinforcement is required to reduce the post-construction settlement and settlement rate of the embankments. The rigid pile structure embankments using rigid piles can substantially reduce the embankment settlement in the construction of embankments on collapsible loess, and the efficiency in settlement reduction is affected by the pile spacing. The pile-raft structure embankments (PRSE) have much stronger ability in terms of the effectiveness of settlement control, while the pile-geogrid structure embankments (PGSE) provides rapid construction as well as economic benefits. Rational range of pile spacing of PRSE and PGSE are suggested based on the requirements of various railways design speeds. Furthermore, the time effectiveness of negative skin friction of piles and the action of pile-cap setting are also investigated. The relevant measures for improving the bearing capacity and two parts of transition zone forms as positive control mean have been suggested.

Potent antibacterial and antibiofilm activities of TICbf-14, a peptide with increased stability against trypsin

Wang Liping,Liu Xiaoyun,Ye Xinyue,Zhou Chenyu,Zhao Wenxuan,Zhou Changlin,Ma Lingman 한국미생물학회 2022 The journal of microbiology Vol.60 No.1

The poor stability of peptides against trypsin largely limits their development as potential antibacterial agents. Here, to obtain a peptide with increased trypsin stability and potent antibacterial activity, TICbf-14 derived from the cationic peptide Cbf-14 was designed by the addition of disulfide-bridged hendecapeptide (CWTKSIPPKPC) loop. Subsequently, the trypsin stability and antimicrobial and antibiofilm activities of this peptide were evaluated. The possible mechanisms underlying its mode of action were also clarified. The results showed that TICbf-14 exhibited elevated trypsin inhibitory activity and effectively mitigated lung histopathological damage in bacteria-infected mice by reducing the bacterial counts, further inhibiting the systemic dissemination of bacteria and host inflammation. Additionally, TICbf-14 significantly repressed bacterial swimming motility and notably inhibited biofilm formation. Considering the mode of action, we observed that TICbf-14 exhibited a potent membrane-disruptive mechanism, which was attributable to its destructive effect on ionic bridges between divalent cations and LPS of the bacterial membrane. Overall, TICbf-14, a bifunctional peptide with both antimicrobial and trypsin inhibitory activity, is highly likely to become an ideal candidate for drug development against bacteria.