Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists

Yingmei Wang,Shiqian Zhang,Lihui Wei,Zhongqiu Lin,Xinyu Wang,Jianliu Wang,Keqin Hua,Manhua Cu,Jiandong Wang,Shixuan Wang,Wen Di,Yudong Wang,Ruifang An,Mingrong Xi,Ruixia Guo,Qi Zhou,Xing Xie,Fengxia X 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratorysyndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk ofbeing infected with the coronavirus and are more likely to develop severe complications, ascompared to the general population. The increasing spread of COVID-19 presents challengesfor the clinical care of patients with gynecological malignancies. Concerted efforts should beput into managing gynecological malignancies in an orderly manner by strictly implementingthe measures that are specifically developed for controlling the spread of COVID-19. We havedrafted Recommendations on Management of Gynecological Malignancies during the COVID-19 Pandemicbased on our experience on controlling COVID-19 pandemic in China. We recommendthat patients with gynecological malignancies should be managed in hierarchical andindividualized manners in combination with local conditions related to COVID-19. Medicalcare decision should be balanced between controlling COVID-19 pandemic spread and timelydiagnosis and treatment for gynecologic oncology patients.

Comparative Transcriptome Analysis of Rhizoctonia solani-resistant and -Susceptible Rice Cultivars Reveals the Importance of Pathogen Recognition and Active Immune Responses in Host Resistance

Guo-Liang Wang,Shaohong Qu,Zhengjie Yuan,Yu Zhang,Guojuan Xu,Dongling Bi,Haiyan Qu,Xiaowei Zou,Xiaoqing Gao,Haihe Yang,Haiyan He,Xuli Wang,Jiandong Bao,Shimin Zuo,Xuebiao Pan,Bo Zhou 한국식물학회 2018 Journal of Plant Biology Vol.61 No.3

Rice sheath blight (SB), caused by Rhizoctoniasolani (R. solani), is a major threat to rice productionworldwide. The molecular mechanisms of the SB resistancein rice are poorly understood. The transcriptomes of the SBresistantrice cultivar YSBR1 and the susceptible cultivarLemont were analyzed after R. solani infection. A total of7624 differentially expressed genes (DEGs) were identifiedat one or more timepoints in a cultivar. 5526 and 5618 DEGswere differentially expressed in Lemont and YSBR1,respectively. YSBR1 exhibited stronger and earlier transcriptionalresponse to R. solani than Lemont. Gene ontology enrichmentanalysis revealed that genes that encode cell wall-modifyingand glycosyl-degrading enzymes or anti-microbial proteinswere specifically induced in YSBR1 at 6 hpi. MapMananalysis revealed that more DEGs related with cell wall, β-glucanses, respiratory burst, phenylpropanoids and ligninwere highly induced by R. solani in YSBR1 than in Lemont. The results also showed that receptor-like kinases and jasmonicacid signaling may play important roles in host resistance toR. solani. This study highlights potential candidate genes andsignaling pathways involved in rice sheath resistance and canhelp to further clarify the mechanistic events underlyingresistance and susceptibility to R. solani.

Polyetheretherketone implants with hierarchical porous structure for boosted osseointegration

Zhiyong Chen,Yu Chen,Yang Wang,JiaJia Deng,Xin Wang,Qingqing Wang,Yuehua Liu,Jiandong Ding,Lin Yu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Good osseointegration is the key to the long-term stability of bone implants. Thermoplastic polyetheretherketone (PEEK) has been widely used in orthopedics; however, its inherent biological inertia causes fibrous tissue to wrap its surface, which leads to poor osseointegration and thus greatly limits its clinical applications. Methods Herein, we developed a facile yet effective surface modification strategy. A commonly used sulfonation coupled with “cold pressing” treatment in the presence of porogenic agent formed a three-dimensional hierarchical porous structure on PEEK surface. Subsequently, the effects of porous surface on the in vitro adhesion, proliferation and differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) were evaluated. Finally, the osteoinduction and osseointegration of surface-porous PEEK implant were examined in the rat distal femoral defect model. Results In vitro results showed that the surface modification did not significantly affect the mechanical performance and cytocompatibility of PEEK substance, and the porous structure on the modified PEEK substrate provided space for cellular ingrowth and enhanced osteogenic differentiation and mineralization of BMSCs. In vivo tests demonstrated that the surface-porous PEEK implant could effectively promote new bone formation and had higher bone-implant contact rate, thereby achieving good bone integration with the surrounding host bone. In addition, this modification technique was also successfully demonstrated on a medical PEEK interbody fusion cage. Conclusion The present study indicates that topological morphology plays a pivotal role in determining implant osseointegration and this facile and effective modification strategy developed by us is expected to achieve practical applications quickly.

Elimination of the State-of-Charge Errors for Distributed Battery Energy Storage Devices in Islanded Droop-controlled Microgrids

Wang, Weixin,Wu, Fengjiang,Zhao, Ke,Sun, Li,Duan, Jiandong,Sun, Dongyang The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.4

Battery energy storage devices (ESDs) have become more and more commonplace to maintain the stability of islanded power systems. Considering the limitation in inverter capacity and the requirement of flexibility in the ESD, the droop control was implemented in paralleled ESDs for higher capacity and autonomous operation. Under the conventional droop control, state-of-charge (SoC) errors between paralleled ESDs is inevitable in the discharging operation. Thus, some ESDs cease operation earlier than expected. This paper proposes an adaptive accelerating parameter to improve the performance of the SoC error eliminating droop controller under the constraints of a microgrid. The SoC of a battery ESD is employed in the active power droop coefficient, which could eliminate the SoC error during the discharging process. In addition, to expedite the process of SoC error elimination, an adaptive accelerating parameter is dedicated to weaken the adverse effect of the constraints due to the requirement of the system running. Moreover, the stability and feasibility of the proposed control strategy are confirmed by small-signal analysis. The effectiveness of the control scheme is validated by simulation and experiment results.

On Block-decoupling of Boolean Control Networks

Lei Wang,Jiandong Zhu,Yifeng Li 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.1

In this paper, two block-decoupling problems of Boolean control networks (BCNs), one of which is related to system decomposition and the other is not, are investigated by using the method of the semi-tensor product of matrices. Necessary and sufficient graphic conditions for block-decoupling of BCNs in the two cases are obtained. Moreover, a logical coordinate transformation is constructed to achieve block-decoupling related to system decomposition when the corresponding graphic conditions are satisfied. Finally, two illustrative examples are provided to illustrate the theoretical results.

RFID Bi-Directional Authentication Protocol Based on Dynamic Coupled Integer Tent Map

Liu Jiandong,Zhang Xiao,Wang Yequan,Shang Kai 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.3

To meet the special needs of RFID, it is proposed to use a coupled dynamic integer tent map lattices model (DCML) to implement a Hash function and a random number generation scheme. The scheme is featured with fast operation. Based on this, this paper proposes RFID bi-directional authentication protocol. This has strictly proved by BAN logic. This protocol can resolve eavesdropping, illegal access, location tracking, impersonation and replay attack.

Efficient Immobilization of Enzymes on Amino Functionalized MIL-125-NH2 Metal Organic Framework

Zichen Wang,Yang Liu,Jinhong Li,Guoqing Meng,Daoyu Zhu,Jiandong Cui,Shi Ru Jia 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.1

As a series of metal organic framework (MOFs), materials of institute lavoisier frameworks (MILs) are expected to be excellent supports for enzyme immobilization due to their good water-stability and acid tolerance. However, enzyme loading on MIL-125-NH2 is very low due to small pore size and few amino groups on the surface of the MIL-125-NH2. In this work, catalase (CAT) was immobilized on the MIL-125-NH2 and amino functionalized MIL-125-NH2 by adsorption (CAT@MIL-125-NH2) and covalent binding (CAT@Amino MIL-125-NH2), respectively. Compared with the CAT@MIL-125-NH2 and free CAT, the CAT@Amino MIL-125-NH2 displayed high activity recovery, good pH stability, stability against denaturants, and thermostability. Furthermore, activity recovery of CAT@Amino MIL-125-NH2 was 56% higher than CAT@MIL-125-NH2. The CAT@Amino MIL-125-NH2 still retained 50% residual activity for 14 days at room temperature, whereas free CAT lost activity after storage for 1 day at the same storage conditions. Furthermore, the CAT@Amino MIL-125-NH2 maintained 62% of its initial activity after 4 consecutive uses, showing good reusability. The results showed that the amino functionalized MIL- 125-NH2 is an excellent carrier of enzyme immobilization.

Elimination of the State-of-Charge Errors for Distributed Battery Energy Storage Devices in Islanded Droop-controlled Microgrids

Weixin Wang,Fengjiang Wu,Ke Zhao,Li Sun,Jiandong Duan,Dongyang Sun 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.4

Battery energy storage devices (ESDs) have become more and more commonplace to maintain the stability of islanded power systems. Considering the limitation in inverter capacity and the requirement of flexibility in the ESD, the droop control was implemented in paralleled ESDs for higher capacity and autonomous operation. Under the conventional droop control, state-of-charge (SoC) errors between paralleled ESDs is inevitable in the discharging operation. Thus, some ESDs cease operation earlier than expected. This paper proposes an adaptive accelerating parameter to improve the performance of the SoC error eliminating droop controller under the constraints of a microgrid. The SoC of a battery ESD is employed in the active power droop coefficient, which could eliminate the SoC error during the discharging process. In addition, to expedite the process of SoC error elimination, an adaptive accelerating parameter is dedicated to weaken the adverse effect of the constraints due to the requirement of the system running. Moreover, the stability and feasibility of the proposed control strategy are confirmed by small-signal analysis. The effectiveness of the control scheme is validated by simulation and experiment results.

Experimental Investigation of the Mechanical Behaviour of Wall-Beam-Strut Joints for Prefabricated Underground Construction

Tingjin Liu,Jiandong Lu,Di Wang,Hongyuan Liu 한국콘크리트학회 2021 International Journal of Concrete Structures and M Vol.15 No.1

Prefabricated construction is becoming increasingly prevalent, however, it is rarely applied in underground constructions, except for tunnel linings, due to the difficulties that arise in jointing various prefabricated components in underground conditions. To solve the vertical location problem of embedded mechanical couplers during the construction of wall–beam–strut joints for a prefabricated metro station, a new connection using welded steel plates is proposed. In this paper, four full-scale specimens of wall–beam–strut joints connected using welded steel plates and mechanical couplers were experimentally tested under monotonic and low-reversed cyclic loading conditions. The testing results were analysed in terms of the ultimate bearing capacity, failure mode, hysteresis, skeleton curve, stiffness degradation, energy dissipation and strain of the reinforcement bars. Notably, the two kinds of joints had similar ultimate bearing capacities and failure modes, but the crack distributions on the tops of the waler beams were different. For the specimens with the welded steel plate connection, tensile horizontal cracks first appeared on the top surface of the beam, where the welded steel plate was located, and then coalesced gradually; however, this cracking pattern was not observed during the experimental test of the specimens connected with the mechanical couplers. Furthermore, it was determined that the energy dissipation and ductility of the welded steel plate connection were better than those of the mechanical coupler connected joint, because the steel plate could redistribute the internal force in the joint and increase the stiffness. It was concluded that the proposed welded steel plate connection could be more favourable than the mechanical coupler connection in the construction of a prefabricated metro station in Guangzhou. Moreover, the results obtained from these experiments could provide guidelines for the corresponding connections employed in underground-prefabricated structures.

Preparation and Properties of Halogen-Free Flame Retardant and High Refractive Index Optical Resin via Click Chemistry

Chaoyun Luo,Jiandong Zuo,Fuquan Wang,Yanchao Yuan,Feng Lin,Jianqing Zhao 한국고분자학회 2018 Macromolecular Research Vol.26 No.4

Halogen-free flame retardant tri(acryloyloxyethyl) phosphate (TAEP) optical resin was prepared using hydroxy ethyl acrylate (HEA) and phosphorus oxychloride and the chemical structure was characterized by Fourier transform infrared spectrometer and proton nuclear magnetic resonance spectrometer. Optical resins mixed by pentaerythritol tetrathioglycolic and TAEP with different S and P contents were obtained via click chemistry curing. The curing performance, thermal stability and flame retardant performance of the optical resins were analyzed by differential scanning calorimeter, thermogravimetric analyzer, and vertical burning tester, respectively. Additionally, the burned residual morphology of samples was investigated by scanning electronic microscopy, and the refractive indices of the optical resins were measured by an Abbe refractometer. The results revealed that increasing S content could improve the refractive indices of the resins; whereas, the flame retardant performances decreased. The optical resins with S content of 2% and P contents of 7.37% had refractive indices of 1.4935 and UL 94 V-0 flame retard level, respectively. The optical resins had good thermal stability and the 5% decomposition temperature reached up to 200.1 ℃.