건강한 한국 성인에서 경구개와 상악결절 부위 저작점막의 두께 측정

조익현,박정미,장문택,김형섭,김현철,Cho, Ik-Hyun,Park, Jung-Mi,Chang, Moon-Taek,Kim, Hyung-Seop,Kim, Hyun-Chul 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.3

The aim of present study was to assess the thickness of masticatory mucosa on the hard palate and tuberosity as a potential donor site for mucogingival surgery. Thickness measurement was performed in 30 dental college students who are periodontally healthy, with a recently developed, ultrasonic device(SDM). The mean age of study subjects was 23.7(range 21-29) years old and the subjects were composed of 18 males and 12 females. Eighteen standard measurement points were defined on the hard palate, located on 3 lines which ran at different distances parallel to the gingival margin. Six positions were designated on each of these 3 lines between the level of the canine and the second molar. On the tuberosity, 6 standard measurement points were defined, located on 2 lines running parallel to the gingival margin at different distances. Data were analyzed to determine differences in gender, between different positions, and between lines, by an analysis of variance. The results showed that the mucosa of the tuberosity was significantly thicker than that of the hard palate region. Gender did not influence the thickness of masticatory mucosa, either on the hard palate or the tuberosity. On the hard palate, mucosa thickness increased as the distance from the marginal gingiva increased. The mucosa over the palatal root of the maxillary first molar was significantly thinner than that at all other positions on the hard palate. Measurement error at palate was 0.25mm, at tuberosity 0.51mm. No difference in the thickness of masticatory mucosa on palate and tuberosity was found between men and women. On the hard palate, soft tissue thickness progressively increased in sites further from the gingival margin. Therefore, we may harvest more thicker graft on the tuberosity that has more masticatory mucosa thickness than hard palate, however the width may not be sufficient for using.

Expression of Myelin-Associated Glycoprotein (MAG) in the Aged Rat Cerebrum

조익현,박창현,이종환,배춘식,예상규,이법이,박승화,고기석,김진석,장병준,Cho, Ik-Hyun,Park, Chang-Hyun,Lee, Jong-Hwan,Bae, Chun-Sik,Ye, Sang-Kyu,Lee, Beob-Yi,Park, Seung-Hwa,Koh, Ki-Seok,Kim, Jin-Suk,Chang, Byung-Joon Korean Society of Electron Microscopy 2006 Applied microscopy Vol.36 No.2

신경섬유의 수초화의 초기단계에 있어서 마이엘린의 형성에 중요한 역할을 한다고 알려져 있는 마이엘린연합 당단백질(MAG)이 정상적으로 노화된 흰쥐의 대뇌에서도 발현되는지를 알아보고자 하였다. 성숙흰쥐의 대뇌피질에서 MAG가 높은 농도로 발현되었으나 노화흰쥐의 대뇌피질에서는 유의하게 감소하였다. 대뇌에서 MAG면역양성반응 세포는 두 성숙흰쥐의 대뇌피질에서 주로 돌기를 가진 큰 세포였으며 노화흰쥐의 경우에는 주로 세포질과 돌기가 거의 없는 작고 둥근 세포였다. 성숙흰쥐의 백색질내 신경로에서 MAG면역양성 반응 세포는 많이 관찰되었으나 노화흰쥐에서는 거의 관찰되지 않았다. MAG면역반응은 galatocerebroside의 면역반응과 일치하였다. 이상의 결과로부터 노화에 의한 MAG 발현의 변화는 노화시에 나타나는 희소돌기아교세포와 마이엘린 퇴행성 변화와 관계가 있을 뿐만이 아니라 MAG는 노화시에 희소돌기아교세포의 기능 연구를 위한 적절한 marker로서 사용될 수 있음을 의미하며 앞으로 이에 대한 자세한 연구가 필요할 것으로 사료된다. Myelin-associated glycoprotein (MAG) has been known to have a crucial role to the formation of myelin sheath during initial stage of myelination. In the present study, we investigated the aging-related expressional changes of MAG in the rat cerebrum. MAG expression was markedly decreased in cerebral cortex by aging. In the adult rat cerebrum, MAG-positive rolls were process-bearing cells with large nucleus, and extensively distributed. However, in the aged rat brain, MAG-positive cells showed small and round morphology with little cytoplasm and few processes. MAG was co-expressed with galatocerebroside, but not with Iba-1, or GFAP. These results suggest that the expressional change of MAG-positive cells is associated with degeneration of oligodendrocyte-myelin system by aging, and that MAG is likely to be a reliable marker for the mature oligodendrocytes in the aged rat brain.

Full mouth disinfection therapy의 단기간 임상 효과 연구

조익현,정의원,차정헌,김중수,이대실,김창성,김종관,최성호,Cho, Ik-Hyun,Jung, Ui-Won,Cha, Jeong-Heon,Kim, Joong-Su,Lee, Dae-Sil,Kim, Chang-Seong,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.3

The aim of this study is to determine whether full-mouth disinfection therapy(FMT) in our clinical setting would show better improvement of clinical parameters than partial mouth disinfection therapy(PMT) in chronic periodontitis and aggressive periodontitis patients. Among 12 patients, 6 were treated FMT and other 6 were treated PMT. Clinical parameters were calculated 3 months and 6 months after initial therapy. 1. There were no statistically significant differences between FMT and PMT in the reduction rate of bleeding on probing after 3 months, 6 months 2. Initial probing depth was 4-6mm, the mean probing depth after 3 months was 2.2mm vs 2.5mm(FMT vs PMT), after 6 months was 2.4mm vs 2.8mm. This was significantly lower in the FMT groups. 3. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.8mm vs 4.1mm(FMT vs PMT), and 3 to 6 months was 0.5mm vs 0.3mm. This was significantly larger in the FMT groups. 4. Initial probing depth was 4-6mm, the mean clinical attachment level after 3 months was 2.3mm vs 2.7mm(FMT vs PMT), after 6 months was 2.7mm vs 3.0mm. This was significantly lower in the FMT groups. 5. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.0mm vs 3.0mm(FMT vs PMT), and 3 to 6 months was 0mm vs -0.1mm. This was significantly larger in the FMT groups. Although the results provided us with succeccful clinical improvement in aggressive periodontitis, further research is needed to prove its additional benefit in the treatment of chronic periodontitis

Morphometric and Ultrastructural Change of Myelin-Associated Glycoprotein (MAG)-Immunoreactive Oligodendrocytes by Aging

조익현,박창현,이종환,배춘식,예상규,이법이,박승화,고기석,김진석,장병준,Cho, Ik-Hyun,Park, Chang-Hyun,Lee, Jong-Hwan,Bae, Chun-Sik,Ye, Sang-Kyu,Lee, Beob-Yi,Park, Seung-Hwa,Koh, Ki-Seok,Kim, Jin-Suk,Chang, Byung-Joon Korean Society of Electron Microscopy 2006 Applied microscopy Vol.36 No.2

정상적인 노화과정에 있어서 마이엘린연합당단백질(MAG)의 기능을 알아보고자 Sprague-Dawley 계통 흰쥐의 대뇌피질에서 MAG 면역양성반응세포(희소돌기아교세포)에 대한 형태계측학적 및 미세구조적인 분석을 시행하였다. 노화된 흰쥐의 대뇌피질(IV-VI)에서 MAG면역양성반응세포의 밀도는 정상 흰쥐에 비하여 유의하게 감소하였다. 그러나 medium과 dark 형의 희소돌기아교세포의 비율은 증가하였다. 노화된 흰쥐의 대뇌피질에서 MAG면역음성반응세포의 핵의 평균면적은 MAG면역양성반응세포의 핵의 평균면적보다 유의하게 감소하였다. MAG의 면역반응물은 노화된 흰쥐의 대뇌피질의 medium-dark형의 희소돌기아교세포의 세포질과 돌기에서 뚜렷이 감소하였고 dark형의 희소돌기아교세포에서는 거의 관찰되지 않았다. 이러한 결과는 노화에 의한 희소돌기아교세포와 마이엘린의 변성은 MAG의 감소와 관계가 있을 것으로 생각되며, 희소돌기아교세포와 마엘린 계통에서 MAG의 기능을 연구하는 기초자료로서 유용할 것으로 사료된다. To investigate the role of myelin-associated glycoprotein (MAG) in the normal aging process, aging-related morphometric and ultrastructural analyses of the MAG-positive (MAG-(+)) oligodendrocytes were carried out in the cerebral cortex of the Sprague-Dawley rats. In the aged rats, the density of MAG-(+) oligodendrocytes was significantly decreased in the cortical layer (IV-VI) compared with that of the adult rats. However, the percentage of medium and dark types of oligodendrocytes was significantly increased by aging. In the aged rats, the mean nuclear area of the MAG-(-) oligodendrocytes was interestingly reduced compared with that of MAG-(+) oligodendrocytes. In addition, MAG immunoreactive products were markedly decreased in the medium-dark type of oligodendroglial cytoplasm and processes, and were scarcely localized in the dark type of oligodendrocytes of the aged rats. These results suggest that degeneration of oligodendrocytes-myelin system by aging is associated with down regulation of MAG, and that may contribute to further understanding of the biology of MAG in the oligodendrocytes-myelin system.

중뇌수도관 폐쇄에 의한 S/D계통 랫드 수뇌증 1예

조익현,한규보,장병준,Cho, Ik-Hyun,Han, Kyu-Bo,Chang, Byung-Joon 대한수의학회 2002 大韓獸醫學會誌 Vol.42 No.3

Hydrocepbalus may be an acquired or a congenital condition. We have studied the macroscopic and microscopic changes in the hydrocephalus of an inbred Sprague-Dawley rat at postnatal week 8. The animal suspected with the hydrocephalus showed clinical syndromes such as depression, severe ataxia, eye abnormalities, dome-shaped head, and persistent fontanelle. With the postmortem examination, the suspected animal was clearly revealed as a severe internal hydrocephalus. In this animal, severe ventriculomegaly was limited to the third and lateral ventricles, and cortical thining was most apparent in the parieto-occipital region. With the routine histological examination, brain tissue showed aqueductal obstruction, thinning of the cerebral cortex, severe ependymal damage, subependymal edema, damage of choroid plexus of fourth ventricle, enlarged cortical vessels, and expanded ventricles. Aqueductal obstruction was observed with the appearance of simple stenosis at the level of rostral colliculus. Subsequently, the other structures of brain such as septal nucleus, caudate nucleus, and hippocampus etc. were abnormally reconstructed by hydrocephalus. This study suggests that the hydrocephalus can be taken place by primary aqueductal obstruction and this type of hydrocephalus is classified as uncommunicating type. Though the mechanism of aqueductal obstruction is not clear, the morphological studies of this case may be helpful for the further study of hydrocephalus.

6~7世紀 新羅의 經濟的 成長에 관한 一考察

趙翊鉉(Cho ik-hyun) 한국문화사학회 1999 文化史學 Vol.- No.11·12·13

원효의 행적에 관한 재검토

조익현(Ik Hyun Cho) 단국사학회 1993 史學志 Vol.26 No.1

N/A

SURF 알고리즘을 이용한 자동차 공유 애플리케이션 문제 처리 기법

조익현 ( Ik-hyun Cho ),이근호 ( Keum-ho Lee ),전유부 ( You-boo Jeon ) 한국정보처리학회 2018 한국정보처리학회 학술대회논문집 Vol.25 No.1

요즘 많은 사람이 사용하고 있는 쏘카, 그린카, 피플카, 딜카 등 카 셰어링(car sharing) 애플리케이션 방식에 대한 차량 외관 부분이 많은 문제점으로 발생하고 있다. 본 논문에서는 기존의 카 셰어링 시스템에 SURF(Speed-Up Robust Feature) 시스템 방식을 휴대폰 애플리케이션에 적용하여 카 셰어링 시스템에서 발생하고 있는 외부적인 훼손에 대하여 사용자들의 안정적인 보안 솔루션을 제공하고자 한다.

2004년 3월 4일 대설 사례에 관한 분석과 예보를 위한 제안

조익현(Ik-Hyun Cho),유희동(Hee-Dong Yoo),이우진(Woo-Jin Lee),신경섭(Kyung-Sup Shin) 한국기상학회 2004 대기 Vol.14 No.3

A heavy snowfall event occurred over the middle part of the Korean peninsula on March 4, 2004. The numerical models of KMA failed to forecast this heavy snowfall event because this event was due to small scale disturbance by low lever convergence and atmospheric instability. The analyses for this heavy snowfall have been performed to give forecasters useful suggestions for forecasting heavy snowfall events in the future. The analyses for the snowfall event were recounted by the Hourly Korean Peninsula Analysis Weather Chart (HKPAWC) presenting on the KMA intranet system. We confirmed that warm air flows of low level into south central Korea in conjunction with strong southwesterly winds played important role in the heavy snowfall event. We suggested several check points to improve the forecast of heavy snowfall events in the future through the results of the analyses.

오미자 관련 물질의 신경보호 및 면역조절 효능

조익현(Ik-Hyun Cho) 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.5