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        • KCI등재

          Expression of Myelin-Associated Glycoprotein (MAG) in the Aged Rat Cerebrum

          조익현,박창현,이종환,배춘식,예상규,이법이,박승화,고기석,김진석,장병준,Cho, Ik-Hyun,Park, Chang-Hyun,Lee, Jong-Hwan,Bae, Chun-Sik,Ye, Sang-Kyu,Lee, Beob-Yi,Park, Seung-Hwa,Koh, Ki-Seok,Kim, Jin-Suk,Chang, Byung-Joon Korean Society of Electron Microscopy 2006 Applied microscopy Vol.36 No.2

          신경섬유의 수초화의 초기단계에 있어서 마이엘린의 형성에 중요한 역할을 한다고 알려져 있는 마이엘린연합 당단백질(MAG)이 정상적으로 노화된 흰쥐의 대뇌에서도 발현되는지를 알아보고자 하였다. 성숙흰쥐의 대뇌피질에서 MAG가 높은 농도로 발현되었으나 노화흰쥐의 대뇌피질에서는 유의하게 감소하였다. 대뇌에서 MAG면역양성반응 세포는 두 성숙흰쥐의 대뇌피질에서 주로 돌기를 가진 큰 세포였으며 노화흰쥐의 경우에는 주로 세포질과 돌기가 거의 없는 작고 둥근 세포였다. 성숙흰쥐의 백색질내 신경로에서 MAG면역양성 반응 세포는 많이 관찰되었으나 노화흰쥐에서는 거의 관찰되지 않았다. MAG면역반응은 galatocerebroside의 면역반응과 일치하였다. 이상의 결과로부터 노화에 의한 MAG 발현의 변화는 노화시에 나타나는 희소돌기아교세포와 마이엘린 퇴행성 변화와 관계가 있을 뿐만이 아니라 MAG는 노화시에 희소돌기아교세포의 기능 연구를 위한 적절한 marker로서 사용될 수 있음을 의미하며 앞으로 이에 대한 자세한 연구가 필요할 것으로 사료된다. Myelin-associated glycoprotein (MAG) has been known to have a crucial role to the formation of myelin sheath during initial stage of myelination. In the present study, we investigated the aging-related expressional changes of MAG in the rat cerebrum. MAG expression was markedly decreased in cerebral cortex by aging. In the adult rat cerebrum, MAG-positive rolls were process-bearing cells with large nucleus, and extensively distributed. However, in the aged rat brain, MAG-positive cells showed small and round morphology with little cytoplasm and few processes. MAG was co-expressed with galatocerebroside, but not with Iba-1, or GFAP. These results suggest that the expressional change of MAG-positive cells is associated with degeneration of oligodendrocyte-myelin system by aging, and that MAG is likely to be a reliable marker for the mature oligodendrocytes in the aged rat brain.

        • KCI등재

          Full mouth disinfection therapy의 단기간 임상 효과 연구

          조익현,정의원,차정헌,김중수,이대실,김창성,김종관,최성호,Cho, Ik-Hyun,Jung, Ui-Won,Cha, Jeong-Heon,Kim, Joong-Su,Lee, Dae-Sil,Kim, Chang-Seong,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.3

          The aim of this study is to determine whether full-mouth disinfection therapy(FMT) in our clinical setting would show better improvement of clinical parameters than partial mouth disinfection therapy(PMT) in chronic periodontitis and aggressive periodontitis patients. Among 12 patients, 6 were treated FMT and other 6 were treated PMT. Clinical parameters were calculated 3 months and 6 months after initial therapy. 1. There were no statistically significant differences between FMT and PMT in the reduction rate of bleeding on probing after 3 months, 6 months 2. Initial probing depth was 4-6mm, the mean probing depth after 3 months was 2.2mm vs 2.5mm(FMT vs PMT), after 6 months was 2.4mm vs 2.8mm. This was significantly lower in the FMT groups. 3. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.8mm vs 4.1mm(FMT vs PMT), and 3 to 6 months was 0.5mm vs 0.3mm. This was significantly larger in the FMT groups. 4. Initial probing depth was 4-6mm, the mean clinical attachment level after 3 months was 2.3mm vs 2.7mm(FMT vs PMT), after 6 months was 2.7mm vs 3.0mm. This was significantly lower in the FMT groups. 5. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.0mm vs 3.0mm(FMT vs PMT), and 3 to 6 months was 0mm vs -0.1mm. This was significantly larger in the FMT groups. Although the results provided us with succeccful clinical improvement in aggressive periodontitis, further research is needed to prove its additional benefit in the treatment of chronic periodontitis

        • SCIESCOPUSKCI등재

          건강한 한국 성인에서 경구개와 상악결절 부위 저작점막의 두께 측정

          조익현,박정미,장문택,김형섭,김현철,Cho, Ik-Hyun,Park, Jung-Mi,Chang, Moon-Taek,Kim, Hyung-Seop,Kim, Hyun-Chul 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.3

          The aim of present study was to assess the thickness of masticatory mucosa on the hard palate and tuberosity as a potential donor site for mucogingival surgery. Thickness measurement was performed in 30 dental college students who are periodontally healthy, with a recently developed, ultrasonic device(SDM). The mean age of study subjects was 23.7(range 21-29) years old and the subjects were composed of 18 males and 12 females. Eighteen standard measurement points were defined on the hard palate, located on 3 lines which ran at different distances parallel to the gingival margin. Six positions were designated on each of these 3 lines between the level of the canine and the second molar. On the tuberosity, 6 standard measurement points were defined, located on 2 lines running parallel to the gingival margin at different distances. Data were analyzed to determine differences in gender, between different positions, and between lines, by an analysis of variance. The results showed that the mucosa of the tuberosity was significantly thicker than that of the hard palate region. Gender did not influence the thickness of masticatory mucosa, either on the hard palate or the tuberosity. On the hard palate, mucosa thickness increased as the distance from the marginal gingiva increased. The mucosa over the palatal root of the maxillary first molar was significantly thinner than that at all other positions on the hard palate. Measurement error at palate was 0.25mm, at tuberosity 0.51mm. No difference in the thickness of masticatory mucosa on palate and tuberosity was found between men and women. On the hard palate, soft tissue thickness progressively increased in sites further from the gingival margin. Therefore, we may harvest more thicker graft on the tuberosity that has more masticatory mucosa thickness than hard palate, however the width may not be sufficient for using.

        • KCI등재

          JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

          조익현,한평림,이강우,Hye-Yeong Ha 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.8

          We previously reported that mice lacking JSAP1(jsap1-/-) were lethal and the brain of jsap1-/- at E18.5 exhibited multiple types of developmental defects, which included impaired axon projection of the corpus callosum and anterior commissures. In the current study,we examined whether the early telencephalic commissures were formed abnormally from the beginning of initial development or whether they arose normally, but have been progressively lost their maintenance in the absence of JSAP1. The early corpus callosum in the brain of jsap1+/+ at E15.5-E16.5 was found to cross the midline with forming a distinct U-shaped tract, whereas the early axonal tract in jsap1-/- appeared to cross the midline in a diffuse manner, but the lately arriving axons did not cross the midline. In the brain of jsap1-/- at E17.5, the axon terminals of lately arriving collaterals remained within each hemisphere, forming an early Probst’s bundle-like shape. The early anterior commissure in the brain of jsap1+/+ at E14.5-E15.5 crossed the midline, whereas the anterior commissure in jsap1-/-developed, but was deviated from their normal path before approaching the midline. The axon tracts of the corpus callosum and anterior commissure in the brain of jsap1-/- at E16.5-E17.5 expressed phosphorylated forms of FAK and JNK, however, their expression levels in the axonal tracts were reduced compared to the respective controls in jsap1+/+. Considering the known scaffolding function of JSAP1 for the FAK and JNK pathways, these results suggest that JSAP1 is required for the pathfinding of the developing telencephalic commissures in the early brains.

        • KCI등재

          Morphometric and Ultrastructural Change of Myelin-Associated Glycoprotein (MAG)-Immunoreactive Oligodendrocytes by Aging

          조익현,박창현,이종환,배춘식,예상규,이법이,박승화,고기석,김진석,장병준,Cho, Ik-Hyun,Park, Chang-Hyun,Lee, Jong-Hwan,Bae, Chun-Sik,Ye, Sang-Kyu,Lee, Beob-Yi,Park, Seung-Hwa,Koh, Ki-Seok,Kim, Jin-Suk,Chang, Byung-Joon Korean Society of Electron Microscopy 2006 Applied microscopy Vol.36 No.2

          정상적인 노화과정에 있어서 마이엘린연합당단백질(MAG)의 기능을 알아보고자 Sprague-Dawley 계통 흰쥐의 대뇌피질에서 MAG 면역양성반응세포(희소돌기아교세포)에 대한 형태계측학적 및 미세구조적인 분석을 시행하였다. 노화된 흰쥐의 대뇌피질(IV-VI)에서 MAG면역양성반응세포의 밀도는 정상 흰쥐에 비하여 유의하게 감소하였다. 그러나 medium과 dark 형의 희소돌기아교세포의 비율은 증가하였다. 노화된 흰쥐의 대뇌피질에서 MAG면역음성반응세포의 핵의 평균면적은 MAG면역양성반응세포의 핵의 평균면적보다 유의하게 감소하였다. MAG의 면역반응물은 노화된 흰쥐의 대뇌피질의 medium-dark형의 희소돌기아교세포의 세포질과 돌기에서 뚜렷이 감소하였고 dark형의 희소돌기아교세포에서는 거의 관찰되지 않았다. 이러한 결과는 노화에 의한 희소돌기아교세포와 마이엘린의 변성은 MAG의 감소와 관계가 있을 것으로 생각되며, 희소돌기아교세포와 마엘린 계통에서 MAG의 기능을 연구하는 기초자료로서 유용할 것으로 사료된다. To investigate the role of myelin-associated glycoprotein (MAG) in the normal aging process, aging-related morphometric and ultrastructural analyses of the MAG-positive (MAG-(+)) oligodendrocytes were carried out in the cerebral cortex of the Sprague-Dawley rats. In the aged rats, the density of MAG-(+) oligodendrocytes was significantly decreased in the cortical layer (IV-VI) compared with that of the adult rats. However, the percentage of medium and dark types of oligodendrocytes was significantly increased by aging. In the aged rats, the mean nuclear area of the MAG-(-) oligodendrocytes was interestingly reduced compared with that of MAG-(+) oligodendrocytes. In addition, MAG immunoreactive products were markedly decreased in the medium-dark type of oligodendroglial cytoplasm and processes, and were scarcely localized in the dark type of oligodendrocytes of the aged rats. These results suggest that degeneration of oligodendrocytes-myelin system by aging is associated with down regulation of MAG, and that may contribute to further understanding of the biology of MAG in the oligodendrocytes-myelin system.

        • KCI등재

          Applications of molecular markers in the discrimination of Panax species and Korean ginseng cultivars (Panax ginseng)

          조익현,김영창,김동휘,김기홍,현태경,류호진,방경환 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4

          The development of molecular markers is one of the most useful methods for molecular breeding and marker-based molecular associated selections. Even though there is less information on the reference genome, molecular markers are indispensable tools for determination of genetic variation and identification of species with high levels of accuracy and reproducibility. The demand for molecular approaches for marker-based breeding and genetic discriminations in Panax species has greatly increased in recent times and has been successfully applied for various purposes. However, owing to the existence of diverse molecular techniques and differences in their principles and applications, there should be careful consideration while selecting appropriate marker types. In this review, we outline the recent status of different molecular marker applications in ginseng research and industrial fields. In addition, we discuss the basic principles, requirements, and advantages and disadvantages of the most widely used molecular markers, including restriction fragment length polymorphism, random amplified polymorphic DNA, sequence tag sites, simple sequence repeats, and single nucleotide polymorphisms.

        • 國立大學 博物館의 現況과 活性化 方案

          조익현 한국대학박물관협회 2003 한국대학박물관협회 학술대회 Vol.48 No.-

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