Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

사회복지사의 기업복지 유형이 삶의 질과의 관계에서 직무몰입의 조절효과

김효선(Kim, Hyo-Seon),조주복(Cho, Joo-Bog) 한국경영교육학회 2020 경영교육연구 Vol.35 No.2

[연구목적] 본 연구는 사회복지시설에 종사하는 사회복지사의 직무몰입과 삶의 질의 향상을 위한 선택적 복지제도의 정착에 대한 기초자료를 제공하여 사회복지국가 발전에 기여하는데 그 목적이 있다. [연구방법] 본 연구의 자료 수집은 대구 · 경북지역 사회복지사를 대상으로 총 300부 설문지를 배분하여 이 중 298부를 분석 자료로 활용되었다. 실증분석을 위해 요인분석, 신뢰도분석, 분산분석, t-test, ANOVA분석, SAS 등을 이용하였다. [연구결과] 첫째, 기업복지유형에 따른 선택적 복지제도가 직무몰입에 미치는 영향을 검증한 결과, 유의한 차이가 없어서 기각되었다. 둘째, 기업복지유형과 사회복지사의 삶의 질과의 차이 검증 결과, 통계적으로 유의미한 차이가 없는 것으로 나타났다. 셋째, 기업복지의 유형과 삶의 질과의 관계에서 사회복지사의 직무몰입의 조절효과를 검증한 결과, 통계적으로 유의한 조절효과가 있는 것으로 나타났다. [연구의 시사점] 본 연구는 사회복지사의 기업복지유형에 따른 선택적 복지제도는 삶의 질과의 관계에서 직무몰입이 조절효과가 있는 것으로 나타났다. 따라서 사회복지시설에서 선택적 복지제도 정착에 필요한 직무교육프로그램을 개발하고 예산편성에 반영하여 사회복지서비스를 향상시켜야 할 것이다. [Purpose] The purpose of this study is to contribute to the development of the social welfare state by providing basic data on the corporate welfare types for the improvement of job quality and quality of life of social workers in social welfare facilities. [Methodology] The data collection of this study was divided into 300 questionnaires for social workers in Daegu and Gyeongbuk, and 298 of them were used as analytical data. Factor analysis, reliability analysis, analysis of variance, t-test, ANOVA analysis, SAS were used for the empirical analysis. [Findings] First, as a result of verifying the effect on job commitment according to corporate welfare type, it was rejected because there was no significant difference. Second, as a result of verifying the difference between the corporate welfare type and the social worker’s quality of life, there was no statistically significant difference. Third, as a result of verifying the moderating effect of job involvement of social workers in the relationship between the type of corporate welfare and the quality of life, there was a statistically significant moderating effect. [Implications] This study found that job involvement had a moderating effect on the social worker’s corporate welfare type in relation to quality of life. Therefore, the social welfare service should be improved by developing job training programs necessary for the Cafeteria Plan in social welfare facilities and reflecting them in budgeting.

국내외 저명학술지에 발표된 무작위대조연구 초록의 질적 연구

김효선,김은영 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

In this study, the quality of reporting the Randomized Controlled Trial (RCT) abstracts was investigated. It was compared between abstracts in four major Korean medical journals, covered by SCI(E), and in the New England Journal of Medicine (NEJM), the most cited medical journal in 2010 (IF=53.484), published from 2007/01 to 2011/06. There were 57 abstracts in Korean SCIs and 50 in NEJM included in the investigation; among them, three from Korean SCIs and one from NEJM were excluded. A modification of CONSORT for abstract was used as criteria, including 16 checklist items. The conformity of the abstracts to each item was assessed, and the χ2 (chi-square) analysis was used to analyze the significance of difference between the two. As a result, the two groups of journals were statistically equivalent in six items; Korean journals were significantly better in two items, and NEJM were in eight. In conclusion, the quality of reporting of RCT abstracts was better in general in NEJM than in Korean SCIs. This does not mean the full RCT reports of NEJM are superior to that of Korean SCI; rather, it highlights the need for Korean journals to adopt the CONSORT for abstracts in reporting of RCT in abstracts.

화악산 일대의 곤충 개체군의 분석

정선우,진정효,전주아 昌原大學校 基礎科學硏究所 2000 基礎科學硏究所論文集 Vol.12 No.-

The insect fauna from the district of Mt. Hwaak was studied. Specimens were collected from April to October of 1998. The total specimens were classified into 9 orders, 70 families, and 300 species. In Dermaptera, 1 families 1 species were identified. In Odonata, 1 families 3 species were collected, and 7 families 13 species were contained in Homoptera. In Hemiptera, 11 families 22 species were classified, and 5 families 10 species were classified in Orthoptera. Diptera held 6 families 9 species, Hymenoptera had 8 families 20 species, and Coleoptera had 8 families 44 species. And we could classified 23 families 176 species in Lepidoptera.

물/극성유기용매 혼합욕에서 폴리에스테르의 염색

유효선,김은아 한국의류학회 1998 한국의류학회지 Vol.22 No.1

Polyester filaments were dyed with disperse dye in dyebath containing water and water miscible organic solvents : acetone, 1,4-dioxane, DMF. In case of Acetone and 1,4-dioxane, the equilibrium dyeuptake was maximun at the volume fraction 0.05. The equilibrium dye uptakes were decreased as volume fraction of organic solvents were increased. When the volume fractions of water miscible organic solvents were varied, dye uptake was increased constantly with dyeing time. In dyebath containing water and water miscible organicsolvent, the dyeuptake was increased quickly during initial 40∼60 min. and slowly increased there after. The slope of C_t/C_∞ to √t was greater in dyebath containing water and water miscible organic solvents than dyebath containing water. The differences of the slope with volume fractions of water miscible organic solvent were not shown big.

市販 衣類製品의 消費者 問題에 關한 實證的 硏究 : centering around outer wear outerwear를 中心으로

전효순,차옥선 漢陽大學校 韓國生活科學硏究所 1985 韓國 生活 科學 硏究 Vol.- No.3

Clothing goods are one of the most important necessaries that are consumed in large quantities with various kinds and uses, while they several problems. First, consulter have difficulties in choice since a number of synthetic fibers appear. Second, it is very difficult to presuppose the changes in quality in the process of consumption. Third, it is difficult to estimate the goods because they are not only utility goods but also fashionable goods. And the last, it is hard to see where the responsibility for quality lies owing to the complexity of manufacturing process and distribution structure. The aim of this study is to analyze the problems not in the place of producer or dealer of clothing goods but in the place of consumer, and to propose their remedied. This study is based on the findings of questionnaires drawn up on the basis of references and the 439 claims related to the clothings which were submitted to three comsumer's complaint centers. The concrete aims of this study areas follows: (1) to define consumer's problems by looking into documentary records and to research the necessity of consumerism. (2) to analyze consumer's thoughts by questioning housewives and making a survey of their attitudes toward the use and the choice of clothing goods in the market. (3) to study the claims submitted to consumer's complaint centers and to compare them with the conditions of latent dissatisfaction on the questionnaires, in order to examine the problems about the quality of clothing goods in the market and the actual conditions of dealings. PROCEDURE The research was carried out from july 10 to july 15, 1983 on 600 housewives. They were randomly selected from parents of students of 5 primary schools in Seoul. The questionnaire designed by the researcher consists of 25 questions. The questions were made on the model of face-validity tests of professors, and seven of the questions were prestested. The statistical methods used are frequency, percentile and χ3 test. FINDINGS AND CONCLUSIONS A survey upon consumer's attitude toward clothing goods revealed that the younger housewives took more interest than the older ones in making complaints against the prior clothings, but the older ones had more experiences in making complaints. On the whole, however, consumer's attitude toward clothing goods seems to be in a lower level. The frequency of checking the garment label of clothing goods was comparatively high and tended to increase in proportion to the education and income level of the participants. The degree of perception on the safety of clothing goods is generally low and also tends to increase in proportion to the education and income level of the participants. The research on the actural conditions of consumer's complaints against clothing goods revealed the following facts. Among the claims submitted to consumer's complaint center, those against poor quality ranked first, and those against laundry, service, label, price and safety came after in order. But on the questionnaire, price problem took the firstplace. The lack of strength and the unsound sewing was the main concern of the complaints against poor quality, the fading color and the contraction against laundry, the refusal of exchange against service, the faulty indication of care and no indication against travel, and the difference of price among the shops against price. From the result of the above study, I propose several devices as follows: (1) For the more reasonable use and choice of clothings, we need consumer education based upon tile end-use of clothing goods. (2) Producers should concentrate their efforts on the management for consumer by taking good care of consumer's complaints aginst poor clothings. (3) The authorities concerned should give the administrative consideration for the protection from consumer's damage of clothing goods by suoolement of the regulations related to the quality control over clothings, the safety and the improvement in destribution structure.

유산소 리듬 운동프로그램이 노인의 혈압, 심박수 및 생활만족도에 미치는 효과

우선혜,김효정,박영숙 대한보건협회 2001 대한보건연구 Vol.27 No.3

The purpose of this study was to test the effects of aerobic rhythmical exercise program on blood pressure, pulse and the life satisfaction of the elderly. This quai-experimental study was designed as a non-equivalent control group pretest-posttest study. The subjects were 36 subjects(experimental group: 19 subjects, control group: 17 subjects), aged between 65 and 73 years who have normal cognition, sensory function and cerebellum function. Aerobic rhythmical exercise program was developed on the basis of aerobic exercise, Korean tradititional dance and music by the author. The blood pressure, pulse rate and life satisfaction were measured prior to and following the experimental treatment. Data were analyzed with x^2-test, t-test, mean, standard deviation, percentage of change and ANCOVA test using SAS program. The results were as follows. 1. There was no significant difference of systolic blood pressure between experimental and control group following the aerobic rhythmical exercise program(F=1.39, P=0.247). 2. The diastolic blood pressure of the experimental group was significantly lower than that of control group following the aerobic rhythmical exercise program(F=2.96, p<0.1). 3. There was no significant difference of resting heart rate between experimental and control group following the aerobic rhythmical exercise program(F=0.07, P=0.793). 4. The life satisfaction of the experimental group was significantly higher than that of control group following the aerobic rhythmical exercise program(F=9.94, p<0.01). On the basis of the above findings, aerobic rhythmical exercise program is effective in reducing diastolic blood pressure and promoting life satisfaction of the elderly. Thus, this program can be recommended as an effective nursing intervention for the elderly.

호텔산업 식음료조직의 서비스품질이 고객만족에 미치는 영향

김효선 大邱大學校 社會科學硏究所 2007 社會科學硏究 Vol.13 No.1

The F&B(food and beverage) sector of the hotel industry is not only an important competition factor to add value to the hotel but also plays a vital role in increasing the incomes and employments of a county. Since intangible human services work as a vital factor to this F&B sector, this sector makes decisions to purchase by entirely depending on service quality. In addition hotel rooms are limited in increasing sales on account of their restriction as a product. Hence, this sector is in fact a very important asset on which the hotel depends for sales. This study is to offer the direction for the improvement of the F&B sector of the hotel industry by considering the above-stated elements. Therefore, so as to measure customer satisfaction by hotel image such as service types, reliability, responsiveness, confidence, sympathy, etc. and to measure customer purchase behavior which is displayed their favorable attitude and approaches. This study used SAS statistic package in the demonstrative analysis. The results of analysis are summarized as follows: 1. Service quality should be improved to increase customers' satisfaction and to create customers' favorable reaction. 2. CRMS(customer relation management system) should be built up in order to efficiently manage customers's satisfaction by improving the modern image of the food and drink business places in clean environments. 3. Incentives should be granted to customers who eat or drink in the shops of the hotel. Thus, in the hotel industry, the F&B service quality should be improved to create customers' favorable attitude through their satisfaction and to lead them to purchases, which will surely contribute to the improvement of profitability.

特用資源植物의 硏究 : 한국임학회지에 게재된 논문을 중심으로 Based on the Articles Published in the Journal of Korean Forestry

이재선,김철우,배찬호,송재모,강효진,황석인,문흥규 江原大學校 森林科學硏究所 2003 Journal of Forest Science Vol.19 No.-

한국임학회지 (1962년의 1호~2002년의 91권 6호)에 게재된 특용자원식물 관련 논문에서 식·음용식물, 약용식물, 사료식물, 조경식물, 섬유식물, 산업용식물 및 밀원식물로 분류하고 그 내용에 따라 입지환경, 생태, 생리, 번식, 조림(또는 무육, 재배), 유전·육종, 분류(또는 식별), 병·충해와 방제, 동물피해와 방제, 성분분석, 식생정보, 생물공학, 경영·경제 및 총설로 나누었다. 총 1,434편의 발표 논문 중 유용식물자원을 대상으로 한 논문은 27.6%를 차지하는 396편이었고, 내용은 식생정보 60편(15.2%), 생리 56편(14.1%), 유전·육종 56편(14.1%), 번식 53편(13.4%) 및 생태 37편(9.3%)이었다. 조림(무육·재배)은 11편(2.8%)으로 특용자원식물의 규모경영이 이루어지지 않고 있음을 시사하고 있으며, 이것은 경영·경제 분야가 6편(1.5%)인 것과 맥을 같이 하고 있었다. 연구대상 식물은 잣나무(42편), 아까시나무(23편), 밤나무(14편) 및 은행나무(14편) 순으로 높았고, 이 식물들과 관련한 연구내용은 번식, 생리, 유전·육종, 생태 및 병·충해 순이었다. 연구의 목적, 내용, 결과 및 대상식물 등을 고려하여 보면, 1) 초본식물에 대한 보다 많은 연구, 2) 타산업 또는 학분 분야와의 공동연구, 3) 자원 보전적 연구 및 4) 연구주체자 간의 연구결과의 공유 등이 매우 요망된다. The articles, published in the Journal of Korean Forestry from Number 1(1962) to number 6, Volume 91(2002), were surveyed and investigated for the research trend analysis about resource-plants for special use or purpose, i.e edible plants, medicinal plants, feed resource, landscape plants, fiber plants, industrial usage, and bee plants. If the purpose or subject matter of the research was construction or furniture timber production, mushrooms and/or pulp and Paper, such research was not included in this study. These articles were classified again depending on the content of research into 14 categories : habitat environment, ecology, physiology, propagation, silviculture(tending and culture), genetics and breeding, identification, insect and disease control, animal-related research, cemponent analysis, vegetation survey, biotechnology, management, and review. Among the total 1,434 articles published, 396 ones (27,6%) were related with plants for special use or purpose. Vegetation survey was 60(15.2%) ; physiology 56(04.1%) ; genetics and breeding 56(14.1%) ; propagation 53(13.4%) ; and ecology 37(9.3%). Siviculture research field included 11 articles (2.8%), which indicates that the management of resource-plants is to far from economic income as seen in the low number of management research filed articles, i. e., only 6 reports(1.5%). Korean white Pine was most popular for research and included 42 articles ; Robinia pseudoacacia 23 Castanea crenata 14 : and ginkgo tree 14, Research related with these species had focused mainly or propagation, physiotogy, genetics and breeding, ecology and pest control. Based on this survey and analysis, the followings are suggested : 1. More research is required on forest herbaceous plants. 2. Cooperative research work with other industrial and/or scientific area is recommendable for commercialization including medicine, cosmetics, and food etc. 3. Research resource-plant conservation. which includes biology, social education and policy, should be supported for next generation. 4. Mutual correspondence and information exchange about the research results between researchers and institutes is more necessary than now.

인용구문'-다고 하는'과 '-다는'의 특성

김선효 서울대학교 언어교육원 2004 語學硏究 Vol.40 No.1

The two goals of this thesis are to ascertain syntactic and semantic differ- ences between '-dako hanin' and '-danin' of the Korean quotation construction markers and to reveal that '-danin' can be a syntactic unit after grammaticalizational processes. First of all, we examined that '-danin' was abbreviated into '-dako hanin' synchronically.'-dako hanin' combines with the compliment head noun, which have communicative meanings. Second, the semantic meaning of '-dako hanin' has an indirectness of the statements, '-donin' has probability of the statements. Third, '-danin' can be one of the adnominal endings in Korean, because '-danin' and adnominal ending'-(i)n' have same syntactic phenomena.