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내독소로 유도되는 Nuclear Factor Kappa B 활성화에 미치는 Src Family Kinase의 조절기전
김희재,이혜원,이희수,하종식,이지희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2
목적: Src family tyrosine kinases (TK)가 내독소로 인해 유도되는 NF-kB 활성화 신호전달체계에 연관되어 있음이 보고된 바 있다. 또한 내독소(LPS)나 TNF a와 같은 여러 자극제는 IkB-a 의 serine기 또는 tyrosine기의 인산화를 통하여 NF-kB를 활성화 시킨다고 알려진 바 있다. 이에 본 연구에서는 RAW 264.7 대식세포에 내독소 투여 시 유도되는 NF-kB활성화 및 NF-kB 의존성 염증성인자 생성에 대한 Src TK의 역할에 대해 규명하고자 한다. 방법: American Type Culture Collection 에서 구입한 생쥐의 대식세포, RAW264.를 내독소(LPS)에 노출시킨 후 damnacanthal나 PP1을 처리하여, EMSA, Nitrite assay, Western blot을 통하여Src TK가 NF-kB활성과 염증인자의 생성에 있어서 어떤 역할을 하는지에 대하여 조사하였고 내독소 투여로 인한 NF-kB활성에 있어서 Src TK의 기본적인 작용기전에 대해 조사하였다. 결과: Damnacanthal이나 PP1은 Src TK 특이적 억제제로 알려져 있는데, 본 연구에서는 Src TK의 특이적 억제제인 damnacanthal 이나 PP1을 사용하였고, RAW 264.7 대식세포에서 Src TK 특이 억제제의 전처치는 내독소로 유도되는 NF-kB활성을 차단시켰다. 또한 내독소 투여로 증가된 NO 생성은 damnacanthal이나 PP1에 의하여 억제되었다. 이런 TK kinase 억제제는 내독소로 유도되는 serine 기 인산화와 IkB-a 분해를 억제시켰다. 결론: Src kinase 특이적 억제제인 damnacanthal 그리고 PP1이 RAW 264.7세포에서 내독소로 유도되는 NF-kB활성과 Nitric Oxide 생성을 차단시켰다. 또한. Damna-canthal이나 PP1은 내독소로 유도된 serine기 인산화와 IkB-a의 분해를 억제시켰다. Objectives : Src family tyrosine kinases(TK) have been found to be involved in LPS induc-tion of signal cascades. Furthermore Lipopolysaccharide(LPS) or Tumor necrosis factor alpha (TNF-a) activate nuclear transcription factor kB(NF-kB) by inducing serine or tyrosine pho-sphorylation of the inhibitory subunit of NF-k B(I k B- a). In this study, it is our purpose to search the role of Src TK in LPS induced activation of NF-k B and NF-k B dependent induced inflam-matory factors. Methods : Nuclear extracts were prepared from RAW 264.7 cells pretreated with damnacan-thal or PP1 and then stimulate with LPS. After that, we figured out the dffects of inhibition of Src family kinases on LPS-induced activation of NF-kB by EMSA. We investigated effects of damnacanthal of PP1 on the production of NO by Griess assay and LPS-induced serine phos-phorylation and degradation of Ik B-a by Western blots in LPS-stimulated RAW263.7 cells. Results : Inhibition of Src TK with damnacanthal or PP1 blocked LPS-induced NF-kB acti-vation at the range of nanomolar concentrations. Substantial inhibition in LPS-induced production of NO was also observed in cells treated with damnacanthal or PP1. These kinase inhibitors blocked LPS-induced the serine phosphorylation, and the degradation of Ik B-a. Conclusion : we investigated the role of Src TK in NF-k B activation and production of nitric oxide (NO) in LPS stimulated RAW 264.7 macrophages and the underlying mechanism by which Src TK play a role in LPS-induction of the possible pathways leading to NF-k B activation. Src kinase specific inhibitors, damnacanthal and PP1 blocked LPS induced activating NF-k B and producing Nitric Oxide in Raw 264.7 machrophages. Moreover, Damnacanthal and PP1 inhibited LPS induced serine phosphorylation and degradation of Ik B-a.
식이 단백질의 급원에 따른 당뇨쥐의 혈당 및 혈청지질에 미치는 영향
이수진,김영진,박수정,김희정,이윤희,유영상 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.2
This study was designed to find out the effects of soybean protein and milk protein between nondiabetic and diabetic rats. The experimental results are summarized as follows. 1. Total food intake was higher in diabetic soybean protein group than other groups but it was not significant. 2. The change of body weight was lower in diabetic soybean protein group than other groups and the soybean protein was effective to maintain the ideal body weight. 3. The effects of lowering total cholesterol and glucose in serum was higher in soybean protein groups than the milk protein groups.
Effect of pulverizing method on the particle size of matured silkworm powder
( Su-bae Kim ),( Kee-young Kim ),( Sang-deok Ji ),( Seong-wan Kim ),( Nam-suk Kim ),( You-young Jo ),( Jong-gil Kim ),( Young-guk Kim ),( Hui-yeon Koo ),( Hyung-chul Moon ),( Young-seek Seok ),( Hyun- 한국잠사학회 2018 International Journal of Industrial Entomology Vol.37 No.2
Recently matured silkworm powder was developed by RDA. In this study, the effect of pulverizing method on the particle size of matured silkworm powder was examined. FESEM was performed to observe the morphology and to measure the particle size of silkworm powder. Particle morphology of air-jet mill pulverized powder was round and smooth, however, those of roller-mill and hammer-mill pulverized mature silkworm was more harsh and square. Particle size was varied with pulverizing technique as follows; 1.1 μm (air-jet mill), 10 μm (roller mill), and 120 μm (hammer mill), respectively. A proximate analysis results of air-jet mill powder showed that crude protein, crude lipid, crude fiber, and ash was 73%, 12%, 1.95%, and 3.4%, respectively. According to our results, air-jet mell technique might be used to make a tiny matured silkworm powder.
Effect of pulverizing method on the particle size of matured silkworm powder
Kim, Su-Bae,Kim, Kee-Young,Ji, Sang-Deok,Kim, Seong-Wan,Kim, Nam-Suk,Jo, You-Young,Kim, Jong-Gil,Kim, Young-Guk,Koo, Hui-Yeon,Moon, Hyung-Chul,Seok, Young-Seek,Lee, Hyun-Tai Korean Society of Sericultural Science 2018 International Journal of Industrial Entomology Vol.37 No.2
Recently matured silkworm powder was developed by RDA. In this study, the effect of pulverizing method on the particle size of matured silkworm powder was examined. FESEM was performed to observe the morphology and to measure the particle size of silkworm powder. Particle morphology of air-jet mill pulverized powder was round and smooth, however, those of roller-mill and hammer-mill pulverized mature silkworm was more harsh and square. Particle size was varied with pulverizing technique as follows; $1.1{\mu}m$ (air-jet mill), $10{\mu}m$ (roller mill), and $120{\mu}m$ (hammer mill), respectively. A proximate analysis results of air-jet mill powder showed that crude protein, crude lipid, crude fiber, and ash was 73%, 12%, 1.95%, and 3.4%, respectively. According to our results, air-jet mell technique might be used to make a tiny matured silkworm powder.
Kim, Su-Mi,Ryu, Seung-Hee,Park, Hui-Don,Kim, Sung-Su,Kim, Jeong-Hwan,Kim, Jong-Sang The Korean Society of Food Science and Nutrition 1998 Preventive Nutrition and Food Science Vol.3 No.3
There is extensive evidence suggesting the protective role of fruits and vegetables against chemically induced carcinogenesis. We have tested the ability of a representative range of Korean vegetables to act as blocking agents against neoplastic initiation by determining the induction level of quinone reductase , an anticarcinogenci marker enzyme, in hepalclc 7 cells exposed to vegetable extracts. Among thirty vegetables tested, Arcitum lappa(Burdock), Brassica juncea (Mustard leaf), Pteridium aguilinum (Bracken) and Chrysanthemum cornoratium(Crown daisy) caused a significant induction of quinone teductase activity with a limited increase in arylhdrocarbon hydroxylase activity. Combination of crown daisy with burdock had synergistic effect on quinone reductase induction. Quinone reductase-inducing activity was found mostly in hesane and ehtylactate fractions of MeOH extract of crown daisy while it ws not quinone reductase activity in liver, kideny, lung, and small intestine, confirming the presence of potent QR inducer (s) in crown daisy. These sata suggest that some vegetables including crown daisy induced QR merits further investigation as a potential cancer preventive agent in human.
Su-Mi Kim,Seung Hee Ryu,Hui-Don Choi,Sung-Su Kim,Jeong-Hwan Kim,Jong-Sang Kim 한국식품영양과학회 1998 Preventive Nutrition and Food Science Vol.3 No.3
There is extensive evidence suggesting the protective role of fruits and vegetables against chemically induced carcinogenesis. We have tested the ability of a representative range of Korean vegetables to act as blocking agents against neoplastic initiation by determining the induction level of quinone reductase, an anticarcinogenic marker enzyme, in hepa1c1c7 cells exposed to vegetable extracts. Among thirty vegetables tested, Arctium lappa (Burdock), Brassica juncea (Mustard leaf), Pteridium aguilinum (Bracken) and Chrysanthemum coronarium (Crown daisy) caused a significant induction of quinone reductase activity with a limited increase in arylhydrocarbon hydroxylase activity. Combination of crown daisy with burdock had synergistic effect on quinone reductase induction. Quinone reductase-inducing activity was found mostly in hexane and ethylacetate fractions of MeOH extract of crown daisy while it was not detected in n-butanol and water fractions. Animal study using SD rats demonstrated that crown daisy intake induced quinone reductase activity in liver, kidney, lung, and small intestine, confirming the presence of potent QR inducer(s) in crown daisy. These data suggest that some vegetables including crown daisy induced QR merits further investigation as a potential cancer preventive agent in human.
Su-Hwan Lee,Hui-Su Bae,Yang-Yeol Oh,Sang-Hun Lee,Yeong-Joo Kim,Sun Kim,Jin-Hee Ryu,Kang-Ho Jung,Choong-Geun Lee,Jae-Hyeon Kim,Yeong-Doo Kim,Weon-Young Choi,Jae-Yeong Cho,Kyoung-Bo Lee,Keon-Hui Lee,Ki- 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6
It is known that the poor soil fertility of newly reclaimed saline soils is due to the lack of organic matter and available mineral nutrients for crop production. The effect of green manuring with Sesbania aculeata in combination with five rates of urea-N treatments (N0. N25, N50, N75, N100) on the productivity of a subsequent whole-crop barley and the fertility of the reclaimed saline soil in Saemangeum was evaluated in the field during 2013-2014 growing season. Sesbania was grown during summer season (June to October). The amount of Sesbania incorporated was 16.2 Mg ha<SUP>-1</SUP>. Sesbania contributed to 393 kg N ha<SUP>-1</SUP> to the soils when ploughed down and incorporated before whole-crop barley cultivated. The performances of whole-crop barley following sesbania incorporation were significantly affected by a combination of Sesbania manuring and different N rates. The N fertilizer equivalence without N fertilizer following Sesbania was 42.6% (63.9 kgN ha<SUP>-1</SUP>), compared with N100(150 kg N ha<SUP>-1</SUP>) in fallow soils. The whole-crop barley yield responded to N fertilizer rates in both sesbaniaamended and fallow soil. The yield response to nitrogen rates in fallow soil was linear (Y=0.0586X+3.3011, R<SUP>2</SUP> =0.9534), whereas that in sesbania-amended soils was quadratic (Y= -0.001X<SUP>2</SUP>+0.1322X+5.7143, R<SUP>2</SUP>=0.9576). The yield of whole-crop barley in sesbania-amended with increasing N rates was increased up to SN75 (115 kgN) 10.3 Mg ha<SUP>-1</SUP>. Apparent N recovery (ANR) of whole-crop barely showed decreased with sesbania plus increasing rates of N fertilizer. Despite higher yield with sesbania manuring plus increasing N rates, the contributions of N from Sesbania with increasing N rates to whole-crop barley were decreased, whereas those from fertilizer increment due to excessively mineralized Nitrogen. Considering yield, ANR, N contribution from Sesbania and nitrogen fertilizer, the optimum N rate was N50 rate following sesbania incorporation.
대간간학회지 제6차 춘계학술대회 초록집 : 포스터 전시 ; 부분 비장색전술로 확진 및 부분 관해된 특발성 문맥압항진증 1예
김수영 ( Kim Su Yeong ),김병호 ( Kim Byeong Ho ),이승훈 ( Lee Seung Hun ),오주형 ( O Ju Hyeong ),이상목 ( Lee Sang Mog ),김교영 ( Kim Gyo Yeong ),김윤화 ( Kim Yun Hwa ),이주희 ( Lee Ju Hui ),동석호 ( Dong Seog Ho ),김효종 ( Kim Hy 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)