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서중석,이우승,김현,김호덕,라봉진 중앙대학교 의과대학 의과학연구소 1998 中央醫大誌 Vol.23 No.4
It has been demonstrated that brief period of ischemia and reperfusion (ischemic preconditioning, IP) enhances recovery of post-ischemic contractile dysfunction and reduces incidences of reperfusion-induced arrhythmia or infarct size after a prolonged ischemia. Recent studies suggest that IP triggers activation of protein kinase C (PKC). In the present study, the author teated this hypothesis with PKC activator, phorbol ester (PMA, 0.01 nM) or inhibitor, calphostin C (200 nM) to measure the left ventricular function and infarct size; and assessed whether hemodynamics are related with each other or not. Hearts isolated from New Zealand White rabbits (1.5-2.0 kg body weight) were perfused with Tyrode solution by Langendorff technique. After stabilization of baseline hemodynamics, the hearts were subjected to 45 min global ischemia followed by 120 min reperfusion with IP (IP group, n=7) or without IP (ischemic control group, n=7). IP was induced by single episode of 5 min global ischemia and 10 min reperfusion. In the PMA-treated group (n=13), the heart was subjected to perfusion with Tyrode solution containing PMA for 5 min after stabilization of the baseline, washing out (for 10 min with normal perfusion), and 45 min ischemia and 120 min reperfusion; in the calphostin C-treated preconditioned group (n=15), calphostin C was given for 15 min from 5 min before IP regimen. Left ventricular function including developed pressure (LVDP), dP/dt, heart rate, left ventricular end-diastolic pressure (LVEDP) and coronary flow (CF) was measured. Iinfarct size was determined by staining with tetrazolium salt and planimetry. Data were anaalyzed by one-way analysis of variance and Tukey's post-hoc test; and linear regression between hemodynamic values. In comparison with the ischemic control group, IP signifivantly increased the recovery of the left ventricular function including left ventricular developed pressure, contractility, and coronary flow. However, enhancement of the functional recovery disappeared by calphostin C or PMA treatment. IP and PMA also reduced infarct size (from 38 to 10-20%, p<0.05). However, calphostin C blocked infarct reduction effect of IP. These results suggest that in isolated Langendorff-perfused rabbit heart model, IP could improve post-ischemic contractile dysfunction, as well as it has an infarct size-liniting effect; these cardioprotective effect of IP may be related, at least in part, to trigger activation of PKC, however, there are any relationship between hemodynamics.
김응석,이정호,김중훈 대한상하수도학회 2003 상하수도학회지 Vol.17 No.2
In domestic sewer rehabilitation works, the numerical weighting based on number of sewer defect is used to determine the propriety of rehabilitation order. In case of the decision standard in each defect contents of inside and outside of the country, the weight for determining sewer rehabilitation order is composed of several distribution of marks, not considering the weight in each sewer defects. In this study, the fifteen defect contents are determined suitable for domestic situation based on the sewer defect data of inside and outside of the country. Also, we select persons in charge of the business to calculate the detail weight and pose questions about important level of each sewer defect contents. The results of using Delphi method which is a question survey method apply the AHP and calculate the weight in each sewer defect. The appropriate marks matrix of sixteen sewer defects is made for laying precise decision standard of sewer condition through the result of analysis. The marks matrix of sixteen sewer defects can solve the complicated decision making problems of sewer rehabilitation works.
신양호,김귀현,이진복,엄현석,이중근,박진석 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1
본 논문에서는 고성능 표면탄성파 필터의 최적 설계를 위하여 다양한 IDT(interdigital transducer) 구조의 필터를 제작하고 각각의 주파수 응답특성을 비교 분석하였다. 기본 구조외에 MSC(micro strip-coupler), double split, reflector, ground line 등의 구조를 일반적으로 널리 사용되고 있는 Y-Z cut l-N(LiNbO3) 기판 위에 형성시켰다. 제작된 소자의 중심주파수, 통과 대역, 삽입손실등을 측정하였으며, 주파수 응답에 기초한 기존 모델의 효용성을 논의하였다. Effects of IDT structures on frequency responses of SAW filters are investigated to achieve a high performance SAW filter, Various types of IDTS, such as MSC(multistrip-coupler), double split, reflector, and ground line, are designed and patterned on a widely used Y-Z cut LN(LiNbO3) substrate. Center frequencies, band widths, and insertion losses are measured and compared. Invalidity of the conventional model based on the impulse response model is also discussed.
직장암환자에서 복회음병합절제술(Miles' operation) 후 발생한 지속적인 배뇨장애의 치료
박희석,김기찬,정호중 고신대학교 의학부 1998 高神大學校 醫學部 論文集 Vol.13 No.1-2
Bladder dysfunction is one of the serious postoperative complications after rectal cancer surgery. To get sufficient objective data and factors for adequate management of bladder dysfunction following rectal cancer surgery, we reviewed medical records of 122 patients who had abdominoperineal resection of rectum (Miles' operation) for rectal cancer. The incidence of bladder dysfunction in 122 rectal cancer patients was 18.9 percent (23 patients). Among 23 patients with bladder dysfunction, 10 patients were referred to our rehabilitation service and their bladder was areflexic type neurogenic bladder at referred time. In 10 patients referred to our rehabilitation service, 8 patients(80.0% got the balanced bladder and 2 patients(20.0% ) failed, and the interval between beginning of bladder training and establishment of balanced bladder in 8 patient was 13.4±6.8 days. In 13 patients did not referred to our service, only 3 patients(23.1% ) got the balanced bladder and 10 patients(76.9%) failed. To improve the life quality of the rectal cancer patients with neurogenic bladder following abdominoperineal resection of rectum, early proper rehabilitative managements including bladder training were should be given.
자발성 뇌출혈 환자의 일상생활동작 수행에 영향을 미치는 인자
정호중,진기은,박희석 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2
The Modified Barthel Index (MBI) and the Functional Independence Measure (FIM) have been used widely as evaluating tools for Activities of Daily Living (ADL) of the disabled. To obtain the guideline for the evaluation and planning of rehabilitative management, we performed this study by comparative analysis of MBI and FIM about the factors affecting ADL of the spontaneous intracerebral hemorrhage patients. The mean scores of MBI and FIM were 46.0 and 68.9 at the beginning of rehabilitation therapy, and 75.4 and 94.4 at discharge, respectively. Thus the average scores of improvement of MBI and FIM were 29.5and 25.5, respectively, each of which was statistically significant (p<0.05). The mean FIM score at discharge of the patient group with initial MBI score above 50 was significant higher than that of the group with initial MBI score equal to or below 50 (109.6 versus 85.9, p<0.05). According to the amount of initial intracerebral hemorrhage. MBI and FIM scores at discharge were found significantly different by 20cc (p<0.05). In conclusion. MBI and FIM scores are found to be useful to evaluate the factors affecting ADL in patients with spontaneous ICH.