人蔘이 自然發生高血壓쥐에 있어서 血壓 및 血漿 Renin 活性度에 미치는 影響에 關한 實驗的 硏究

孫宜錫,朴陞哲,許鳳烈,李禎均,林憲吉,咸駿洙,梁忠模,韓哲洙,朴贊雄,金海中 대한의학협회 1979 대한의학협회지 Vol.22 No.9

대두 식이섬유를 이용한 특수 영양식품의 유효성 평가

한재흠,이균희,손현수,이윤복,박점선,오만진 충남대학교 농업과학연구소 2008 농업과학연구 Vol.35 No.1

In the development of enteral foods for the patients with diarrhea, soybean hull, by-products of soybean processing, was used to prepare crude dietary fiber extracts (soybean hull fiber, SHF). Total dietary fiber content of SHF is 85% and their composition are 86.1% cellulose, 8.1% hemi-cellulose, and 4.7% lignin. The effects of SHF on the prevention of diarrhea were studied in animal. Spraque-Dawley (SD) rats were fed AIN93G diets containing 5% dietary fiber for 3days simultaneously inducing diarrhea with the phenolphthalein Mg citrate solution. On day 4, feces were collected at different time point. Dietary fibers used for the animal study were SHF, soybean cotyledon fiber (SCF), psyllium husk fiber (PHF), and chicory fiber (CF). α-cellulose was used as a control. Body weight gain, calorie consumed and food efficiency ratio among the experimental groups were not different. However, water content in the feces of SHF group was significantly lower by 10%, compared with other groups at 24hrs. time point. This effect was even greater in the feces collected later than 24 hrs. time point. SHF seems to have a greater effects on slow the symptom of diarrhea. Based on the previous results, enteral food enriched with SHF were prepared and its effect was compared with other commercially available products from domestic or imported ones. Weight changes among experimental groups were not different, but the moisture content of feces consumed SHF enriched products were lower than that of other products. Approximately 10% decrease in water content was observed from feces collected at 24 hr time point. According to the sensory evaluation, overall acceptability of the enteral food enriched with SHF was 3.24 out of 5 indicating that taste of this product is acceptable. 대두가공에 부산물로부터 얻어지는 대두 식이섬유를 이용하여 설사환자를 위한 경장 영양 식이를 개발하기 위하여 쥐에게 투여한 후 체중증가율, 변의 수분감소, 사료효율 등을 측정하여 다음과 같은 결과를 얻었다. 대두피 중의 식이섬유함량은 85% 이었고 cellulose 가장 높았으며 hemi-cellulose, lignin의 순 이었다. 대두 식이섬유가 대조구에 비하여 체중 감소율은 약간 낮았고 사료효율은 약간 높았다. 대두 식이섬유를 섭취시킨 쥐가 치커리 식이섬유, 차전자 피에 비하여 24시간 후의 변의 수분함량은 10% 낮았다. 대두 식이섬유를 첨가한 경장영양식이로 사육한 쥐의 체중변화와 사료효율은 3제품 간에 차이가 없었으나 다른 하나의제품은 대조군에 비하여 낮았다. 대두 식이섬유를 이용하여 가공한 경장영양식이 다른 상업용 제품에 비하여 실험쥐의 변 수분함량은 10% 이상 낮았다.

아기들의 영양공급원으로서 대두 유아식의 적합성과 유용성

손헌수,이윤심,신해철,성효실 한국콩연구회 2001 韓國콩硏究會誌 Vol.18 No.2

Soybean has been cultivated and consumed in Asia for a long time. Because soy cultivation has a long history in Asian countries, soy products-tofu, soymilk, and soy infant formula-are staples in most Asian families. In USA, the first use of soy formula feeding was in 1909. In 1929, Hill and Stuart recommended soy formula for infants with allergy to cow milk-based protein. Since then, the use of soy formula in USA has steadily increased, approximately 20-25% of formula fed infants in 1998. American Academy of Pediatrics recommended that soy formula is safe and effetive alternatives to provide appropriate nutrition for normal growth and development. It means that soy formula is adequate and/or equivalent to cow milk-based formula in nutrition feeding for normal infants. Also, soy formula has advantage over cow milk-based formula. Because soy formula are lactose-free, they are appropriate for use in infants with galactosemia and lactose intolerance. For infants with acute diarrhea, soy formula can reduce duration of liquid stools. For most infants with documented IgE-mediated allergy to cow milk protein, soy formula feeding do well.

질환의 예방과 치료에서 대두의 생리적 기능에 대한 최근의 연구

손헌수,정형근,이윤심,신해철 한국콩연구회 2000 韓國콩硏究會誌 Vol.17 No.1

For long time, soybean has been used as important food in Orient because of high protein content and quality. Recently, many studies have shown incidence rate of degenerative chronic diseases -cancer, atherosclerosis, osteoporosis- is higher in the Western people who consumed more animal foods compared to Asian. It has been known that the reduction of Cancer, cardiovascular disease, and osteoporosis is associated with the diet rich in soybean products. Soybean include many kinds of anti-disease components, such as isoflavone, protein, trypsin inhibitor, phytic acid, and saponin. Isoflavone is similar in structure to estrogen and has estrogenic and anti-estrogenic activity. Genistein, which inhibits protein tyrosine kinase, angiogenisis and DNA topoisomerase, has potent anti-cancer activity. Antioxidant activity of isoflavone prevent the oxidation of LDL-cholesterol, as a result, lower the risks of cardiovascular disease. The estrogenicity of isoflavone similar in structure to ipriflavone of osteoporosis drug has been shown to be quiet beneficial to bone health. Soy protein equivalent in nutrition quality to cow milk protein not only have hypocholesterolemic effect, approved by FDA bat also prevent bone calcium from excreting through kidney. Some scientists are studying anti-cancer function of phytic acid and trypsin inhibitor.

분리 대두 단백을 이용한 영양음료의 특성과 그의 이용 방안

손헌수,최은정,조경환 한국콩연구회 1990 韓國콩硏究會誌 Vol.7 No.2

As the result of the rapid development of industry and economy, social structure is becoming complex and our dietary pattern is being westernized. Accordingly, intake of carbohyd-rated have decreased while that of animal protein and lipid have increased. These changes in dietary pattern lead to increase in cerebral blood vessel disease and cardiovascular disease caused by imbalancing animal food intake. As the result, vegetable protein, such as soy protein, is of growing interest as soy protein have an excellent nutritive value and function. However beany flavor, texture and heat instability limited its wider usage. We tried to overcome these defects of soy protein, and developed completely balanced liquid nutritional product. This product provides the balance of nutrients with caloric distribution of protein(25%) : fat(20%) : carbohydrate(55%), and the ratio of animal protein(sodium caseinate) and soy protein(isolated soy protein) is 6 : 4 according to the recommendation of FAO, and is enriched to the appropriate levels of minerals and vitamins.

대두 이수플라본이 인간에 미치는 영향 분석

손헌수,정형근,이윤심,신해철 한국콩연구회 2000 韓國콩硏究會誌 Vol.17 No.2

Soybean has been consumed in South Asia as a variety of traditional soyfood products. Epidemiologic evidence suggests that high intake of soy foods may protect against breast, prostate, colon cancer, atherosclerosis and osteoporosis. Based on many experimental studies, Food Drug Administration(FDA) authorized a health claim related to soy protein consumption. Diet low in saturated fat and cholesterol that include 25 grams of soy protein a day may reduce the risk of heart disease. But recently, Doerge and Sheehan concern that while isoflavones which have effects similar to the female hormones estrogen may help to prevent a range of condition including high cholesterol, they also lead to health problems in animals including alteration in sexual development of fetus, induction of thyroid disorders, increase of breast cancer and brain aging in elderly men. The FDA said the concerns were not supported by conclusive scientific research. While chemicals in soy do exert hormonal effects, the impact is $quot;very limited$quot; and much lower than that of natural or synthetic estrogens. We discuss the beneficial effects or adverse effects of isoflavones.

Poster Session : PS 1621 ; Miscellaneous : Genetic Polymorphisms in Superoxide Dismutase Genes (SOD1, SOD2 and SOD3) and Maculopapular Eruption Induced by Antituberculosis Drugs

( Sang Heon Kim ),( Sang Hoon Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ),( Jae Hyung Lee ),( Byoung Hoon Lee ),( Youn Seup Kim ),( Jae Seuk Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Maculopapular eruption is the most common adverse reactions to antituberculosis drugs (ATD), often leading to discontinuation of the medication. While the mechanisms of ATD-induced MPE are not well understood, oxidative stress induced by the ATD metabolites could play a role in drug-induced MPE. We aimed to examine if the genetic polymorphisms in superoxide dismutase genes (SOD1, SOD2 and SOD3) were associated with MPE induced by ATD. Methods: We enrolled 75 patients with ATD-induced MPE and 237 ATD-tolerant control by regular monitoring of adverse reactions to ATD. Genotyping was performed 4 single nucleotide polymorphisms (SNP) in SOD1 (rs2070424), SOD2 (rs4880) and SOD3 (rs2536512 and rs1799895) in patients with ATD-induced MPE and patients tolerant to ATD. Genotype-phenotype association was examined by logistic regression analysis adjusting for gender and age. Results: In SOD1, there was signifi cant association between rs2070424 (Ivs3-251A/G) and ATD-induced MPE (P = 0.019, OR = 2.42, 95% CI 1.16-5.05), with higher frequency of genotype, GA + GG, in patients with ATD-induced MPE compared with ATD-tolerant controls. The other polymorphisms in SOD2 and SOD3 did not show signifi cant difference of genotypes between case and control group. Conclusions: Intron SNP rs2070424 of SOD1 (Ivs3-251A/G) showed signifi cant association with ATD-induced MPE. These fi ndings suggest that this genetic variant may increase the risk of ATD-induced MPE.

COVID-19 Vaccine Induced Systemic Inflammatory Response Syndrome

( Sang-heon Kim ),( Soo Jin Lee ),( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-Yong Moon ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

To protect people from coronavirus disease 2019 (COVID-19), various types of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered. Adverse reactions to COVID-19 vaccines include various local and systemic adverse reactions which may occur immediately or weeks later. Here we report a case of systemic inflammatory response syndrome induced by COVID-19 vaccine. A 65-year-old man with a history of hypertension presented with 5 days of fever. On admission, he was febrile to 38.3℃ with mild dyspnea when experiencing febrile sensation. Six days ago, he was vaccinated with the BNT162b2 mRNA COVID-19 vaccine. Fever with chill developed one day after vaccination and persisted. Chest radiography and a CT scan showed bilateral pleural effusion. Abdomen CT showed interstitial edematous pancreatitis at pancreas tail and perinephric infiltration. PET/CT revealed diffuse hypermetabolic infiltration or activity in mediastinal fat tissue, pericardial and peritoneal thickening. Laboratory Results documented leukocytosis, elevated levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and C-reactive protein. There was no evidence of possible infectious diseases or rheumatic diseases after a full examination and consultation with the specialists. With the administration of high-dose oral corticosteroids, fever and pleural effusion disappeared gradually. These findings suggest systemic inflammatory response syndrome induced by COVID-19 mRNA vaccine.

Thematic Poster : TP-80 ; Incidence of Venous Thromboembolism in Head and Neck Surgery and Usefulness of Caprini Score in Korean Patients

( Sang Heon Kim ),( Sang Hoon Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ),( Jae Hyung Lee ),( Byoung Hoon Lee ),( Youn Seup Kim ),( Jae Seuk Park ),( Young Koo Jee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Postoperative venous thromboembolism (VTE) is a fatal condition in patients undergoing surgical procedure. The incidence of VTE and the usefulness of Caprini risk scoresfor predicting VTE in head and neck surgery have not been well established in Korean patients. Methods: In a prospective design, we enrolled subjects who underwent head and neck surgery from January to March 2013. Clinical characteristics and Caprini score were assessed at the day of operation. The development of VTE was monitored for the following 3 months after surgery. Results: Of 364 enrolled subjects, nine patients were identified to have VTE. The 3-month incidence rate of VTE in head and neck surgery was 2.5%. Three of these patients were in fatal condition requiring emergency embolectomy and one of them underwent extracorporeal membrane oxygenation before embolectomy. Caprini score in VTE patients was significantly higher than those without VTE (8.1 ± 5.1 vs. 3.9 ± 1.9, P = 0.048). Receiver-operating characteristic curve analysis revealed that the diagnostic accuracy of Caprini score was high with an area under the curve of 0.868 ±0.035. Conclusion: The incidence of VTE in patients with head and neck surgery was 2.47%. The Caprini risk score was useful in selecting high risk patients for VTE in head and neck surgery.

비궤양성소화불량 환자에서 위전도검사의 임상적 의의 - 위배출검사와의 연관성

박수헌,최규용,김재광,정규원,김부성,최명규,한준열,선희식,박두호,손형선,채현석 대한소화기학회 1998 대한소화기학회지 Vol.30 No.4

Background/Aims: In the pathogenesis of nonulcer dyspepsia, disordered motility of the proximal gastrointestinal tract is thought to play an important role in the genesis of this symptom. Gastric myoelectrical activity can be recorded in a noninvasive way by cutaneous electrodes. It is suggested that abnormal myoelectrical activity of the stomach, especially tachygastria, is involved in impaired gastric motility. Although the application of the electrogastrogram in clinical diagnosis has been very limited up till now, a great deal of research interest has been expended on the clinical usefulness of the electrogastrogram, However, copared with other electrophysiological studies, the electrogastrogram has a relatively short history. The aim of this study was to evaluate the clinical usefulness of the electrogastrogram compared with scintigraphic gastric ernptying study. Methods: Eleven nonulcer dyspepsia patients and nine healthy individuals were studied. Subjects fasted at least 8 hours before testing and rested comfortably ir a supine position during the study. Electrogastrogram signals were obtained before and after ingestion of a radionuclide tagging test meal. Two hours of scintigraphic gastric emptging study were performed while the electrogastrogram was simultaneously recorded. Results: Fasting 3 cycle per minute in nonulcer dyspepsia was significantly decreased compared to that of healthy volunteer(77.1±8.4% vs 96.6±0.9%, P=0.0044). Postprandial tachygastria in nonulcer dyspepsia was significantly increased compared to that of healthy volunteer(5.8±1.6% vs 14.3±2.7%, P=0.0203). Postprandial 3 cycle per minute and period dominant power were correlated with T_½ of scintigraphic gastric emptying study(r= -0.73972, P=0.00162, r=-0.64401, P=0.00957, respectively). Conclusions: This study suggests that postprandial 3 cycle per minute and period dominant power of cutaneous electrogostrogram may be useful in the detection of gastric motility disorder.