Shigella flexneri에 의한 집단발병의 역학적 양상

기현균,김선희,기혜영,서진종,하동룡,김은선,정재근,김성한,이복권 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

배경 : 국내에서 Shigella flexneri에 의한 감염으로 인한 집단발병은 2000년도에 국립보건원에 집단발병례가 보고된 이후 보고되지 않았으나 최근 저자 등은 S. flexneri에 의한 대규모 집단발병을 경험하여 역학적인 양상을 기술하였다. 방법 : OO회사의 직원 및 구내식당을 이용한 사람 및 가족들을 대상으로 증상여부 및 2002년 12월 23일 이후 식당이용 여부와 취식음식에 대하여 설문조사를 실시하였으며 검체를 확보하여 미생물학적 검사를 실시하였다. 결과 : 조사대상 총 258명 중 총 110명에서 증상이 발생하였으며 증상발생일의 분포는 단일정점을 보였다. 확진자는 82명으로 이중 81명은 OO의 식당을 이용한 사람이었고 1명은 식당에서 직접 조리과정에 참여한 사람이었다. 식사여부와 증상여부의 관계를 분석한 결과 특히 24일의 취식여부의 상대위험도가 가장 높았다(RR=6.46, 3.56≤95% CI≤11.75). 항균제 내성 양상은 ampicillin 내성균주가 82균주(100.0%) ampicillin-sulbactam 내성균주가 55균주(67.1%), amoxicillin-clavulanic acid에 대한 내성균주가 62균주(74.4%), trimethoprim-sulfamethoxazole 내성균주가 82균주로 나타났다(98.8%). 분리된 균주간의 연관성을 보기 위하여 실시한 PFGE 결과 본 집단발병에서 확인된 균주는 동일한 양상을 보였으나 비슷한 시기에 분리된 균주와는 서로 다른 양상을 보였다. 결론 : 본 집단발병은 국내에서 발생한 S. flexneri에 의한 집단발병 중 가장 대규모 집단발병이었다. 본 집단발병에서 확인된 균주간의 PFGE양상이 동일하였으나 기존에 국내에서 분리된 균주의 PFGE양상과는 다른 양상을 보였다. 따라서 이러한 상황을 감안한다면 S. flexneri 및 설사환자에 대한 감시체계를 강화해야 할 것이다. Background : Most of the shigellosis outbreak in Korea was caused by Shigella sonnei since late 1990's. In contrast, outbreak by Shigella flexneri were rare since late 1990's. Currently. we experienced the shigellosis outbreak by S. flexneri and described the results of investigation. Methods : We recruited employees from company "A" who had a meal at least once at the company's cafeteria from Dec 23th, 2002 to Dec 26th, 2002. We surveyed the symptoms, food items, and history of travel of eligible persons and their family members. For the microbiological examination, we collected specimen from eligible persons and their family. Collected specimens were cultured for bacteriologic agents and viruses. Epidemiological relationship among the isolates were analyzed by pulsed field gel electrophoresis (PFGE). Results : Among the eligible persons, one hundred ten were symptomatic (110/258, 42,6%). Eighty-two were confirmed bacteriologically. Day of symptom onset showed a unipolar pattern. Diarrhea was the most common symptom among the symptomatic patients (110/110, 100%). The other symptoms included abdominal pain (81.8%), tenesmus (70.0%), headache (63.6%), nausea (61.8%), febrile sense (59.1%), and vomiting (24.5%). Lunch on 24th Dec was the most significant risk factor of the outbreak (RR=6.46, 3.56≤95% Cl≤11.75). All isolates of the outbreak has the same pattern on PFGE analysis and the PFGE pattern was not similar compared with other S. flexneri isolates from Korea. Conclusion : This is the largest and unique outbreak by S.flexneri since 2000 in Korea. The outbreak has the same origin according to the PFGE pattern and epidemic characteristics. Considering rarity of S.flexneri among shigellosis in Korea, surveillance for S.flexneri should be enhanced.

장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

Biodegradable poly(lactic acid)/poly(butylene adipate-co-terephthalates) active food packaging films containing quaternary ammonium chitosan as antibacterial agents

Seo-Eun Lee,Se-Eun Jeong,Ha-Young Choi,Seong-Eun Kim,Jun Kyun Oh 한국산업식품공학회 2022 학술대회 및 심포지엄 Vol.2022 No.11

Encapsulated essential oil-loaded environment-friendly biodegradable polymer-based hydrogel with antimicrobial activity against foodborne pathogens

Se-Eun Jeong,Seo-Eun Lee,Ha Young Choi,Seong Eun Kim,Jun Kyun Oh 한국산업식품공학회 2022 학술대회 및 심포지엄 Vol.2022 No.11

페그인터페론 알파-2a에 무반응인 환자에서 페그인터페론 알파-2b로 치유된 만성 C형 간염 1예

서광원,김태균,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2007 仁濟醫學 Vol.28 No.-

페그인터페론과 리바비린의 병합요법은 현재 만성 C형 간염의 표준치료로서 유전자형과 체중에 따라 치료기간과 용량에 약간의 차이가 있고 치료기간도 24주, 48주로 단순화 되어있다. 현재의 치료가 기존의 인터페론과 리바비린의 병합요법보다 효과가 많이 높아졌으나 임상에서 치료에 무반응인 환자들을 볼 수 있다. 만성 C형간염 치료 시 무반응인 경우도 환자에게 맞는 맞춤형 치료를 시도해 봄으로써 지속적 바이러스 반응을 높일 수 있을 것으로 생각되어 적정치료를 위한 노력들이 계속되고 있다. 저자들은 페그인터페론 알파-2a로 치료하다가 무반응인 환자에서 페그인터페론 알파-2b로 바꾸어 치료후 바이러스 지속반응을 보인 환자 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Combination therapy with peginterferon(PEG-IFN) and ribavirin is standard treatment for patients with chronic hepatitis C. Nonresponse to treatment is defined as the failure to achieve a 2-log(IU/ml) decline in serum HCV RNA during the first 12 weeks of the therapy. Nonresponders rarely have further decline in serum HCV RNA with the continued therapy and are unlikely to respond during retreatment. The length and shape of each polyethylene glycol(PEG) moiety are crucial in determining the effect on pharmacokinetic and phamacodynamic properties. PEG-IFN alfa-2b has the advantage of weight-adjusted dosing and better extravascular tissue infiltration. We report here a case of an obese women who was a nonresponder to previous treatment with PEG-IFN alfa-2a during the first 16 weeks, but achieved a sustained viral response to PEG-IFN alfa-2b during the next 16 weeks for chronic hepatitis C infection.

Effects of Decoction and Powder of Sipjotang with Jujubae fructus or Licorice on Liver and Kidney

Seo, In-Gyo,Zhao, Rong-Jie,Park, Eun-Young,Park, Sang-Mi,Choi, Song-I,Kim, Han-Kyun,Park, Sook-Jahr,Kwon, Young-Kyu,Kim, Sang-Chan The Physiological Society of Korean Medicine and T 2007 동의생리병리학회지 Vol.21 No.1

The effects of Jujubae Fructus and Licorice extracts on the main components of Sijotang Euphorbiae Kansui Radix, Daphinis Genkwa Flos, Euphonrbiae Pekinensis Radix (KWD) treatment [KWD decoction (KWDD) and KWD powder (KWDP)] related toxicities were examined in the kidney and the liver. To select more suitable extract which effectively reduce KWD-treatment related toxicities in the body, blood biochemical and histopathological changes induced by KWD were analyzed in the rats which received treament of KWD + Jujubae Fructus or KWD + Licorice. In the present study, no KWD-treatment related blood biochemical and histopathological change in the liver was detected. However, increase of tubules containing hyaline casts and atrophic tubules in the kidney was detected as the indicators of KWDD treatment related nephrotoxicity. Addition of Jujubae Fructus (KWDDJ) or Licorice (KWDDL) extracts effectively inhibited the nephrotoxcity induced by KWDD treatments. More ameliorated effects were acquired by addition of Jujubae Fructus extract (KWDDJ) than Licorice (KWDDL). In KWDP treatment, there was no significant difference in the number of tubules containing hyaline casts in all drug treated groups compared to normal or control group except for high dose of KWDP. Both of Jujubae Fructurs and Licorice reduced high dose of KWDP treatment related nephrotoxicity, and there was no significant difference between KWDPJs and KWDPLs. It is concluded that addition of Jujubae Fructus is more suitable than Licorice in reducing the nephrotoxicty of KWDD, also it is more suitable to taking Sipjotang in the form of powder than decoction.

Physicians' Agreement on and Implementation of the 2019 European Alliance of Associations for Rheumatology Vaccination Guideline: An International Survey

Seo Philip,Winthrop Kevin,Sawalha Amr Hakam,최세림,황우창,박현아,Lee Eun Bong,Park Jin Kyun 대한류마티스학회 2023 대한류마티스학회지 Vol.30 No.1

Objective: To evaluate the perspective of healthcare professionals towards the 2019 European Alliance of Associations for Rheumatology (EULAR) vaccination guideline in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods: Healthcare professionals who care for patients with AIIRD were invited to participate in an online survey regarding their perspective on the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD. Level of agreement and implementation of the 6 overarching principles and 9 recommendations were rated on a 5-point Likert scale (1~5). Results: Survey responses of 371 healthcare professionals from Asia (42.2%) and North America (41.6%), Europe (13.8%), and other countries were analyzed. Only 16.3% of participants rated their familiarity with the 2019 EULAR guideline as 5/5 (“very well”). There was a high agreement (≥4/5 rating) with the overarching principles, except for the principles applying to liveattenuated vaccines. There was a high level of agreement with the recommendations regarding influenza and pneumococcal vaccinations; implementation of these recommendations was also high. Participants also reported a high level of agreement with the remaining recommendations but did not routinely implement these recommendations. Conclusion: The 2019 update of EULAR recommendations for the vaccination of adult patients with AIIRD is generally thought to be important by healthcare professionals, although implementation of adequate vaccination is often lacking. Better education of healthcare providers may be important to optimize the vaccination coverage for patients with AIIRD.

Factors Contributing to the Preference of Korean Patients with Crohn’s Disease When Selecting an Anti-Tumor Necrosis Factor Agent (CHOICE Study)

Eun Soo Kim,Kyeong Ok Kim,Byung Ik Jang,이창균,Hyo Jong Kim,Kang-Moon Lee,김유선,Chang Soo Eun,Sung-Ae Jung,Suk-Kyun Yang,Jun Lee,Tae-Oh Kim,Yunho Jung,Geom Seog Seo,Soon Man Yoon,IBD Study Group of the Kor 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.3

Background/Aims: Two comparable anti-tumor necrosis factor (TNF) agents with different routes of administration (intravenous [iv] infliximab [IFX] vs subcutaneous [sc] adalimumab [ADA]) are available for patients with Crohn’s disease (CD) in Korea. This study aimed to identify the preferences of Korean CD patients for a specific anti-TNF agent and the factors contributing to the decision. Methods: A prospective survey was performed among anti-TNF-naive CD patients in 10 tertiary referral hospitals. A 16-item questionnaire addressed patient preferences and the factors contributing to the decision in favor of a particular anti-TNF agent. A logistic regression was conducted to assess predictive factors for ADA preference. Results: Overall, 189 patients (139 males; mean age, 32.47±11.71 years) completed the questionnaire. IFX and ADA were preferred by 63.5% (120/189) and 36.5% (69/189) of patients, respectively. The most influential reason for choosing IFX was ‘doctor’s presence’ (68.3%, 82/120), and ADA was “easy to use” (34.8%, 24/69). Amid various clinicodemographic data, having a >60-minute travel time to the hospital was a significant independent predictive factor for ADA preference. Conclusions: A large number of anti-TNF-naive Korean patients with CD preferred anti-TNFs with an iv route of administration. The reassuring effect of a doctor’s presence might be the main contributing factor for this decision.

Anti-diabetic effect of Yukmijihwangtang-Jahage in obese Zucker rats

Seo,Eun Kyung,Kim,Kyoung Sook,Lee,Tae Kyun,Lee,Young Choon,Kim,Cheorl Ho 한국생명과학회 2000 한국생명과학회 학술발표회 Vol.29 No.-

The effect of the traditional herbal medicine Yukmijihwangtang-Jahage (YJ) on the improvement of insulin resistance and lipid profile was studied using a model for non-insulin dependent diabetes mellitus, lean (Fa/-) and obese (fa/fa) Zucker rats. Yukmijihwangtang-Jahage feeding for 4 weeks resulted in a significant decrease in the concentration of plasma triglyceride in both lean and obese Zucker rats. Furthermore, Yukmijihwangtang-Jahage markedly decreased both plasma cholesterol and fasting plasma insulin levels, and significantly decreased the postprandial glucose level at 30 min during oral glucose tolerance test in obese Zucker rats. Although there was no statistical significance, the crude glucose transporter 4 protein level of Yukmijihwangtang-Jahage dieted obese rats tended to increase when compared to that of obese control rats. Therefore, the present results suggested that Yukmijihwangtang-Jahage may be useful in prevention and improvement of metabolic disorders characterized by hyperinsulinemia states such as non-insulin dependent diabetes mellitus, syndrome X and coronary artery disease,

e-Poster : SP1 transcription factor is modified by O-GlcNAcylation in keratinocyte differentiation (초)

( Eun Jin Lee ),( Kyung Cheol Sohn ),( Dong Kyun Hong ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Young Joon Seo ),( Jeung Hoon Lee ) 대한피부과학회 2010 초록집 Vol.48 No.20