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Lee, E.H.,Seo, Y.J.,Ahn, H.C.,Kang, Y.M.,Kim, H.E.,Lee, Y.M.,Choi, B.S.,Lee, J.H. North-Holland Pub ; Elsevier Science Ltd 2010 FEBS letters Vol.584 No.21
The Yaba-like disease viruses (YLDV) are members of the Yatapoxvirus family and have double-stranded DNA genomes. The E3L protein, which is essential for pathogenesis in the vaccinia virus, consists of two domains: an N-terminal Z-DNA binding domain and a C-terminal RNA binding domain. The crystal structure of the E3L orthologue of YLDV (yabZα<SUB>E3L</SUB>) bound to Z-DNA revealed that the overall structure of yabZα<SUB>E3L</SUB> and its interaction with Z-DNA are very similar to those of hZα<SUB>ADAR1</SUB>. Here we have performed NMR hydrogen exchange experiments on the complexes between yabZα<SUB>E3L</SUB> and d(CGCGCG)<SUB>2</SUB> with a variety of protein-to-DNA molar ratios. This study revealed that yabZα<SUB>E3L</SUB> could efficiently change the B-form helix of the d(CGCGCG)<SUB>2</SUB> to left-handed Z-DNA via the active-mono B-Z transition pathway like hZα<SUB>ADAR1</SUB>1.
간호 대학생의 성 지식, 성 태도와 성 건강 간호 장애감 간의 관계
김다연,김은아,노수경,류아인,박나은,박지혜,서정민,심효정,주성민,한진실,이건정,박수민 이화여자대학교 간호과학대학 2017 이화간호학회지 Vol.- No.51
Purpose: The purpose of this study was to investigate correlation among sexual knowledge, attitude and Barriers to patient’s sexual health of nursing undergraduate students and to provide objective data to promote sexual health-care. Method: Using a descriptive correlation, 304 nursing undergraduate students were recruited through convenience random sampling from August 1st to December 20th, 2016. Data were analyzed using average, standard deviation, percentage, t-test, ANOVA, Scheffe test, Pearson’s correlation and Multiple linear regression analysis using the SPSS 21.0 program. Results: The correlation between Sexual knowledge and Sexual attitude is statistically significant(r=.289, p<.01). As the level of sexual knowledge is higher, the sexual attitude is more open. And, Sexual knowledge(r=-.307,p<.01) and Sexual attitude(r=.180,p=.002) had a negative relationship with Barriers to patient’s sexual health. Also, Sexual knowledge was the greatest influencing factor on Barriers to patient’s sexual health. Conclusion: This study showed as the level of Sexual knowledge is higher, the Sexual attitude is more open. As the degree of Sexual knowledge is lower, the Sexual attitude is more conservative, and Barriers to patient’s sexual health is more higher. Also, Sexual knowledge is the most influential factor on Barriers to patient’s sexual health.
Kim, H.Y.,Baik, J.E.,Ahn, K.B.,Seo, H.S.,Yun, C.H.,Han, S.H. Pergamon Press 2017 Molecular immunology Vol.82 No.-
<P>Streptococcus gordonii, a Gram-positive commensal in the oral cavity, is an opportunistic pathogen that can cause endodontic and systemic infections resulting in infective endocarditis. Lipoteichoic acid (LTA) and lipoprotein are major virulence factors of Gram-positive bacteria that are preferentially recognized by Toll-like receptor 2 (TLR2) on immune cells. In the present study, we investigated the effect of S. gordonii LTA and lipoprotein on the production of the representative inflammatory mediator nitric oxide (NO) by the mouse macrophages. Heat-killed S. gordonii wild-type and an LTA-deficient mutant (Delta ltaS) but not a lipoprotein-deficient mutant (Delta lgt) induced NO production in mouse primary macrophages and the cell line, RAW 264.7.S. gordonii wild-type and Delta ItaS also induced the expression of inducible NO synthase (iNOS) at the mRNA and protein levels. In contrast, the Delta lgt mutant showed little effect under the same condition. Furthermore, S. gordonii wild-type and Delta ItaS induced NF-kappa B activation, STAT1 phosphorylation, and IFN-beta expression, which are important for the induction of iNOS gene expression, with little activation by Delta lgt. S. gordonii wild-type and Delta ltaS showed an increased adherence and internalization to RAW 264.7 cells compared to Delta lgt. In addition, S. gordonii wild-type and AIMS, but not Delta lgt, substantially increased TLR2 activation while none of these induced NO production in TLR2-deficient macrophages. Triton X-114-extracted lipoproteins from S. gordonii were sufficient to induce NO production. Collectively, we suggest that lipoprotein is an essential cell wall component of S. gordonii to induce NO production in macrophages through TLR2 triggering NF-kappa B and STAT1 activation. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy
Seo, Y.,Chae, M. K.,Han, S. A.,Lee, E. J.,Lee, J. H.,Yoon, J. S. Birkha@user 2017 Inflammation research Vol.66 No.6
<P>S1P has an important role in the pathological inflammatory process of GO, which is mediated through the SphK1-S1P- S1P receptor pathway. SphK1 inhibitors and S1P receptors or antagonists could be potential approaches for controlling the inflammatory process of GO.</P>
Song, M.R.,Lee, J.E.,Lee, S.Y.,Seo, J.,Park, K.M.,Lee, S.S. Elsevier 2006 Inorganic Chemistry Communications Vol.9 No.1
S<SUB>2</SUB>O<SUB>x</SUB> macrocyclic ligands with (L<SUP>1</SUP>: x=3 and L<SUP>2</SUP>: x=4) and without (L<SUP>3</SUP>: x=3 and L<SUP>4</SUP>: x=4) dibenzo-subunit were employed as extractants. All of the ligands shows silver(I) selectivity and the silver picrate was more extractable with L<SUP>1</SUP> and L<SUP>2</SUP> when compared with L<SUP>3</SUP> and L<SUP>4</SUP>. The enhanced extractability for the silver picrate by L<SUP>1</SUP> and L<SUP>2</SUP> was revealed due to the additional stabilization of the complexes, [Ag(L)picrate], by anion-ligand π-π interaction between the picrate ion and one benzo-subunit in the ligand.
Park, E.W.,Kim, J.H.,Lim, H.T.,Seo, B.Y.,Cho, I.C.,Lee, J.G.,Oh, S.J.,Cheong, I.C.,Lee, J.H.,Jeon, J.T. S. Karger AG 2004 CYTOGENETIC AND GEN0ME RESEARCH Vol.108 No.4
<P> </P><P>Copyright © 2005 S. Karger AG, Basel</P>
Kim, J.H.,Lee, Y.S.,Park, E.W.,Seo, B.Y.,Cho, I.C.,Lee, J.G.,Oh, S.J.,Lee, J.H.,Jeon, J.T. S. Karger AG 2004 CYTOGENETIC AND GEN0ME RESEARCH Vol.108 No.4
<P> </P><P>Copyright © 2005 S. Karger AG, Basel</P>
Seo, S.,Lee, K.G.,Shin, J.S.,Chung, E.K.,Lee, J.Y.,Kim, H.J.,Lee, K.T. Pergamon Press 2016 Bioorganic & medicinal chemistry letters Vol.26 No.19
Previously, we found that ethyl acetate extract fraction of Aster glehni exhibited anti-hyperuricemic effects in animal models and also five new caffeoylglucoside derivatives were isolated from this fraction. In this work, we evaluated the anti-inflammatory effects of these caffeoylglucoside derivatives and found that 6'-O-caffeoyldihydrosyringin (2, CDS) most potently inhibited the LPS-induced production of nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) in RAW 264.7 macrophages. In addition, CDS was found to concentration-dependently reduce the production of NO, PGE<SUB>2</SUB>, and the pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) induced by LPS in macrophages. Consistent with these observations, CDS concentration-dependently inhibited LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) expression at the protein level and also iNOS, COX-2, TNF-α, and IL-6, IL-1β expression at the mRNA level. Furthermore, CDS suppressed the LPS-induced transcriptional activities of nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) as well as the phosphorylation of p65 and c-Fos. Taken together, these results suggest that the anti-inflammatory effect of CDS is associated with the downregulation of iNOS, COX-2, TNF-α, IL-1β, and IL-6 expression via the negative regulation of NF-κB and AP-1 activation in LPS-induced RAW 264.7 macrophages.
서혜린,신효경,윤수진,이은주,정혜원,최수민,신수진,이미선 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52
Purpose: The purpose of this study was to understand the life experiences of North Korean nursing students at a university in South Korea Methods: The participants of this study were 7 North Korean defector nursing students. The data were collected through individual in-depth interviews. All interviews were audio-taped and verbatim transcripts were made for the analysis. The collected data were analyzed through the van Manen's Hermeneutical Phenomenological method (1990). Results: On the analysis of 7 research participant’s interview, their life can be expressed as ‘The concealment of oneself from being seen as stranger’, ‘Having hard time learning due to academic background differences’, ‘Receiving support in South Korea and trying to give to society’, ‘Satisfied with the systems different from the North Korea’, ‘Still influenced by life in North Korea.’ Conclusion: This study provided a deep understanding of the life experiences of North Korean defector students who majored in nursing. In addition, this study suggested a need for development of support programs for North Korean defector nursing students and additional nursing education methods for them. Also this study is significant that it provides a basis to help South Koreans better understand North Korean defector nursing students’ life. Therefore, this study can relieve the difficulties of North Korean defector nurses when they perform their duties with South Korean nurses.