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Magnetic nanoparticles coated with iron chelator for theragnostic agent for cancer treatment
박나은,이준,김경섭,나건 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
It is important to diagnose tumor accurately for better life quality of tumor patients. For synchronous diagnosis and treatment, superparamagnetic iron oxide nanoparticles (SPIONs) have been considered as a potential agent. But it is difficult to get good therapeutic results because of some limitations, such as poor solubility and low targeting efficacy. In this study, SPIONs were prepared by coating with targeting moiety and photosensitizer conjugated hydrophobic polymer-iron chelator to overcome those limitations. Targeting moiety could be internalized selectively through their specific receptors expressed on cells and photosensitizer enabled tumor cell death by toxic reactive oxygen species (ROS) upon laser irradiation. In virtue of polymer coating on surface of SPIONs, they showed high water solubility and internalized via receptor-mediated endocytosis. In conclusion, polymer coated- SPIONs can be applied to various tumor theragnosis based on their multiple functions
Photodynamic agent conjugated with targeting moiety and polymer for metastatic cancer treatment
박나은,이상희,나건 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Photodynamic therapy induces cancer cell death by using reactive oxygen species (ROS) generated from photosensitizer. However, photosensitizers have some limitations such as poor solubility and low targeting efficiency. In this study, photosensitizer is prepared by conjugating with targeting moiety and biocompatible polymer to overcome the side effects of photosensitizers. The cancer recurrence and metastasis make it difficult to treat cancer patients. Cancer cells modify the metabolic pathway to make energy by using fat in order to survive in lymph node environment. Therefore, conjugating fatty acids to polymeric photosensitizer can be applied to the targeted metastatic cancer therapy.
Scopolamine 유발 기억력 손상 마우스 모델에서 목향(木香)의 기억력 개선 및 항산화 효과
박나은 ( Na-eun Park ),한다영 ( Da-young Han ),김상호 ( Sang-ho Kim ),정대규 ( Dae-kyoo Chung ) 대한한방신경정신과학회 2017 동의신경정신과학회지 Vol.28 No.2
Objectives: The objective of this study is to investigate the anti-amnesic effects of AR, Aucklandiae Radix, ground powder on scopolamine (Sco)-induced memory impairment in mice (C57BL/6) through its favorable acetylcholine (ACh) and acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expression, and antioxidant effect. Methods: Six groups, a total of 20 intact or 100 Sco treated mice, were selected based on their body weights and were used in this study. Half of the mice in each group were used for the passive avoidance task test and the measurements of hippocampus ACh content, AChE activity and ChAT mRNA expression. The remaining half of the mice in each group were used for the Morris water maze test and cerebral antioxidant defense system measurement. Results: Marked decreases in step-through latency times in the passive avoidance task test and increases in escape latency times in the Morris water maze test were observed with decreases in the hippocampus ACh content and ChAT mRNA expression, and increases in the hippocampal AChE activities, as a result of Sco intraperitoneal treatment, in the present study. In addition, destruction of the cerebral cortex antioxidant defense systems was observed in Sco control mice as compared with intact vehicle control mice. However, 28 days of continuous oral pre-treatment with AR ground powder at doses of 400, 200 and 100 mg/kg markedly and dose-dependently inhibited the Sco treatment-related amnesia. Conclusions: The results prove that oral administration of AR ground powder reduces Sco-induced memory impairment. This is because it can preserve ACh, related to ChAT mRNA expression, cause AChE inhibition, and activate the cerebral antioxidant defense system.