후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

객체 지향 데이터베이스에서 쓰기비용을 감안한 다중 선채취기법

남인길,도용석 大邱大學校 科學技術硏究所 1998 科學技術硏究 Vol.5 No.3

This paper presents a set of techniques for improving the efficiency of cache in object oriented database management system. The proposed method is divided into two steps. As the first step, we analyze the disc access frequency and pattern for various queries. Then, based on the analyzing results of the first step, we make prefetching of certain pages which have high degree of access frequency. In addition to this method, in this research, we propose a multiple prefetch caching algorithm that is based on the previous method. Basically this method delay page replacement by considering write cost for pages with information modification. Simulation results show that the proposed method consistently outperforms existent algorithms.

일측성 악하선 무형성증 2예

도남용,조성일 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

Aplasia or agenesis of the salivary gland is an uncommon disorder. Unilateral aplasia of the submandibular gland is an extremely rare disorder. Salivary gland aplasia may occur either in isolation or in association with other developmental anomalities, such as atresia of the lacrimal pucta, mandibulofacial dysostosis or congenital malformations of the temporomandibular component. Clinically, patients may be asymptomatic or may present with dryness of the mouth, difficulty in swallowing, and dental caries. The authors experienced two cases of incidentally detected unilateral aplasia of the submandibular gland demonstrated by computed tomography. So we present this cases with review of literatures.

비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할

도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

ARMAX프로세스를 위한 최적기구변수법

南炫道,崔龍雲 단국대학교 1988 論文集 Vol.22 No.-

In this paper, the recursive optinal instrumental vairable method, which estimates noise dynamics as well as system dynamics using pre-filtered data, was propsed. In case of no pre-filtering, the computational burden of this algorithm is equal to that of extended least squares(ELS) methods and less than that of the rescursive maximum likelihood(RML) method. But in case of prefiltering the computational burden of this algorithm is equal to that of the RML, but this algorithm shows faster convergence than ELS and RML algoorithms. Also, vaeious instrumental variables were proposed, and various types of prefilters were prposed to improve the performance of the proposed algorithms. Computer simulations were performed to illustrate the efficiency of the proposed methods.

비강 및 부비동 종양에서의 종양혈관형성에 관한 면역조직화학적 연구

도남용,노용훈,박선홍 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : Angiogenesis is essential for the growth of solid tumors. Microvessel density(MVD), which represent a measure of tumor angiogenesis, have been found to have prognostic significance in many tumor types for predicting an increased risk of metastasis. However, the significance of angiogenesis in sinonasal malignant tumor remains controversial. The purpose of this study was to asses the tumor vascularity using the highly specific endothelial cell marker CD34, and the expression of its related protein p53, in sinonasal malignant tumors. Materials and Methods : The study samples were obtained after surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IPs with malignant transformation(IP-MT), 16 cases of squamous cell carcinoma(SCC) in sinonasal cavity. Microvessels were stained with anti-CD34 and p53 expressions were assessed by immunohistochemical staining. Results : The degree of tumor angiogenesis in squamous cell carcinoma group was higher than in inverted papilloma group, and which reached at highest level in IP-MT(p<05). The p53 expressions were increased as tumor progressed, which was statistically significant also(p<05). Significant correlation between MVD and p53 expressions was observed in IP(p<05) but there were no correlation in IP-MT and SCC. Conclusions : These results suggest that overexpression of p53 and MVD in the sinonasal tumors seemed to be associated with tumorigenesis but further studies on tumor angiogenesis of sinonasal tumors are needed before it can be adopted as a prognostic marker.

후두 및 하인두 편평세포암종에서 E-cadherin의 면역조직화학적 발현

도남용,나한조,이도용,허준,최지윤,이홍영,임성철 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background and Objectives : The cell-cell adhesion molecule E-cadherin is necessary for the maintenance of the epithelial cellular structure. We were designed to confirm the significance of E-cadherin as a marker for differentiation and invasiveness of squamous cell carcinoma of the larynx and hypopharynx. Materials and Methods : Our study was investigated for the immunohistochemical expression of the epithelium-specific cell adhesion molecule E-cadherin in formalin fixed paraffin embedded tissue specimen of 32 cases of squamous cell carcinoma of larynx and hypopharynx. Results : The positive expression of E-cadherin was 56.3%(18 cases) in squamous cell carcinoma of the larynx and hypopharynx. Decreased E-cadherin expression was a stastistically significant correlation with a increased grade of lymph node stage and clinical stage. Reduced expression was seen in the large tumor size and poorly differentiated tumors, but these result was not statistically significant. Conclusion : The expression of E-cadherin may be related with progression of squamous cell carcinoma of the larynx and hypopharynx. But these correlation were not sufficient for the prognostic indicators in squamous cell carcinomas of the larynx and hypopharynx.

안와를 침범한 거대한 전두동 점액낭종 I 례 : 증례보고

도남용,박성용,박영균 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

The term mucocele was introduced by Rollet in 1896 and Onodi gave the first histologic description in 1901. Paranasal sinus mucocele is the slowly expanding benign lesion which can occur as a result of trauma and spontaneous obstruction of sinus ostium or ostial tract. Mucoceles most frequently ahse from the frontal sinus and anterior ethmoid air cells, Presenting with proptosis, frontal headaches and reduced ocular mobility, especially on upward gaze. Since it may destruct the adjacent bony structure by pressure, early diagnosis and proper treatment are necessary. Recently we experienced on huge mucocele involving frontal and anterior ethmoid sinus and expanding onto left orbit, which was treated with endoscopic surgical procedure.

이하선에 발생한 상피-근상피암종 1예

도남용,박성용,임태승 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Epithelial-myoepithelial carcinoma (EMC) is a uncommon disease of salivary gland, occurring predominantly in the parotid gland and shown as painless mass. EMC is a tumor composed of variable proportions of two cell types that typically form ducHike structures, It has a mixture of trabecular structure with doubleUlayered arrangement of inner ductal cells and outer myoepithelial cells. We experienced a epithelialUmyoepithelial carcinoma of the left parotid gland treated with total parotidectomy and report it with the review of the literature.