Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants

Che´rif Rabhi,Guillaume Arcile,Le´on Cariel,Christine Lenoir,Je´rome Bignon,Joanna Wdzieczak-Bakala,Jamal Ouazzani 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex® technology. The extracts were mixed to reach quantifiable amounts of active compounds identified by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) analysis. The mixture of extracts was incubated with resting cells of the fungus Beauveria bassiana ATCC 7159. The fermentation promoted the fluidization of the starting dense mixture, while HPLC monitoring evidenced the disappearance of glucogallin from E. officinalis extract and the concomitant increase in gallic acid content. Topical exposure of the chick embryo chorioallantoic membrane (CAM) to the nonfermented extract led to the extensive necrosis and destruction of the treated membrane. However, the fermented extract was shown to be free of any toxicity. Furthermore, compared with the untreated CAM, the fermented sample reduced CAM vascularization, suggesting its antiangiogenic potency. The innocuity of the fermented extract was demonstrated using the in vivo LD50 test, the morphological examination of internal organs of treated rats, as well as the evaluation of blood biomarkers of liver damage (aspartate aminotransferase and alanine aminotransferase). The fermented extract was developed as a nutraceutical antiangiogenic treatment of age-related macular degeneration and commercialized in an oral form named Ethnodyne-Visio™.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

제주 우수 수영 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe the annual effect of training of periodically anaerobic and erobic motor ability for Che-Ju representive team of elementary, middle and high school athletes, first the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events, second individually fitness scientific analysis. prescription. proper management of athlete will be necessary to apply.

의료소비자의 관계혜태 지각이 관계의 질 및 행동의도에 미치는 영향

허철선(Che이-Seon Heo),유광우(Kwang-Woo Yoo) 한국무역연구원 2014 무역연구 Vol.10 No.1

Medical institutions are important to develop and maintain enduring relationship with medical service conswners. So, this research aims to find out the effect of medical service conswners perception of relational benefits on relationship quality and behavioral intention. On the basis of the literature review, the research model is established. This research has been done through the survey utilizing medical service consumers in Gangwondo, and the effective 368 questionnaires are tested for the research model. The main findings are as follows. First, among 5 key dimensions of relational benefits, psychological, customization, economic, and information benefits except social benefits have significant effects on relationship satisfaction. Also, medical institutions type and medical service consumers type as moderating variables are included concurrently, and the significant differences are found in other 4 benefits except relationship between social benefits and relationship satisfaction. Second, relationship satisfaction relates positively to relationship commitment and behavioral intention. But the normative commitment, one of 3 key dimensions of relationship commitment, has no significant effects on recommendation to others. Third, the revisit intention has significant effect on recommendation to others. Finally, the findings reveal that the overall goodness fit index of the model is comparatively good and model set in this research is significant. At the end of the research, managerial implications, limitations and future research directions are suggested.

의료 화상을 위한 전처리 필터들의 특성에 관한 연구

강명아,최종주,정종필,정채영,정남채 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

There has been no fixed rule of pre-processing course required to do image processing that it was barely possible to find the proper pre-processing course, only to process with experience till now. In this paper, lots of application method of pre-processing algorithm, only available by the non-typified and experiential method, shall quantify and the algorithm method of algorithm according to the rule shall calculate the frequency of the value of each pixel gray level and the histogrm of the image. And then average it to all pixel number and finally set a high-ranking or optional % standardized by the average value in teh standard value. The result of a experiment showed the Median filter is superior to the Mean filter in all image of the smoothing filter. The sobel filter extracted feature. The laplacian filter presented sectional feature which not showed in original image.

Micro-sociology의 건축적 적용에 관한 연구

林采震 홍익대학교 산업기술연구소 1994 産業技術 Vol.4 No.-

Based on the theory of sociometry, which initiated by Moreno, this study explore the possibility of expanding the theory into utilization in architectural planning. Because the main concern of the study is human behaviors in the institution setting. the patient area of a hospital has been chosen. After observations of the patient area (i.e single two-persons fur- six- and larger ward) some of the findings are as follows. 1) Social interactions are most frequent within the ward 2) Inter -ward interactions are influcened by distance and 3) Gender and social background in the group significantly interfere the interactions. The study, therefore, concludes that the size of ward and the characteristics of group significantly affects the human behaviors.

이차원 보증정책의 비용분석 모형

김제승,이영규 尙志大學校 生産技術硏究所 1999 生産技術論叢 Vol.7 No.-

A two-dimensional warranty policy is characterized by a region in a two-dimensional plane with one axis representing time or age and the other representing item usage, such as the age and mileage of an automobile. This paper proposes a new two-attributes warranty policy that the failed product is free-replaced by producer in the replacement and minimally free-repaired by producer in the repair regions. We obtain expressions for the expected warranty costs under some assumptions about usage and failure and illustrate through numerical examples.

Heinrich Heine 詩論 : 特히 "Neue Gedichte"를 中心으로

轉在弘 釜山大學校 師範大學 1978 교사교육연구 Vol.5 No.1

Welch ein Lied! "Eine gewaltige Lust ergreift mich! Wa˝hrend ich sitze, und schreibe, erklingt Musik unter meinem Fenster, und an dem elegischen Grimm der lang-gezogenen Melodie, erkenne ich jene Marseiller Hymne, womit der scho˝ne Barbaroux und seine Gefa˝hrten die. Stadt Paris begru˝Bten, jener Kuhreigen der Freiheit, bei dessen To˝nen die Schweizer in den Tuilerien das Heimweh bekamen, jener triumphierende Todesgesang der Gironde, das alte su˝Be Wiegenlied-Es durehschauert mich mit Feuer und Freude, und entzU˝ndet in mir die glU˝henden Sterne der Begeisterung und die Raketen des Spottes. Ja, diese sollen nicht fehlen, bei dem groBen Feuerwerk der Zeit. Klingende Frammenstro˝me des Gesanges sollen sich ergieBen von der Ho˝he der Freiheitslust, in ku˝hnen Kaskaden, wie sich der Ganges herabstU˝rzt vom Himalaya! Und du, holde Satyra, Tochter der gerechten Themis und des bocksfu˝Bigen Pan, leih mir deine Hu˝lfe, Du bist ja mu˝tterlicher Seite dem Titanengeschlechte entsprossen, und hassest gleich mir die Feinde deiner Sippschaft, die schwa˝chlichen Usurpatoren des Olymps. Leih mir das Schwert deiner Mutter. damit ich sie richte, die verhaBte Brut, und gib mir die Picke-lflo˝te deines Vaters, damit ich sie zu Tode pfeife-">>schrieb Heinrich Heine die Spa˝tere Nachschrift der'〉Reisebilder'<<schon im November 1830. Nachdem Heine den Reisestoff auf die beschriebene Weise aufgearbeitet hatte, war er in politischer Hinsicht fu˝r ihn abgeschlossen. Heines Bedu˝rfnis nach Variation lieB eine einfache Wiederholung nicht zu. So arbeitete er mit neuem Stil das>'Neuer Fru˝hling'<1828/31von der Neuen Gedichte in Hamburg auf. Die Chance fu˝r eine. Realisierung ist hier gro˝Ber. In dieser Phase ist ihm die politisch-gesellschaftliche Aufgabe wichtiger als die dichterische. Denn Heine mo˝chte als politischer Befreier in die Geschichte eingehen. Auch an seinen Werk Neuer Fru˝hling<' wendet sich das Technische von Metrik, Sprache und Form.

홍삼 추출물이 감마선에 조사된 생쥐의 혈액상에 미치는 변화

장재철,전철,김동윤,김동조 群山大學校自然科學硏究所 1990 自然科學硏究 Vol.5 No.-

홍삼 추출물이 감마선에 조사된 생쥐의 혈액상에 미치는 변화를 알아보기 위하여 생리적 식염수군을 대조구로 하여, 홍삼추출물 투여구와 홍삼추출물 투여후 5Gy 감마선 전신조사구 및 5Gy 감마선만을 전신조사한 구 등 4구로 분류하였다. 홍삼 추출물 투여에 의한 감마선에 조사된 생쥐의 적혈구 수, 백혈구 수 및 혈소판 수는 회복되어졌으면 반면, 생쥐의 무게나 혈색소량은 거의 유의성이 없었다. 홍삼 추출물 투여구와 생리적 식염수 투여구에 5Gy 방사선 조사구의 백혈구수는 현저히 회복되었다. 이러한 결과는 홍삼 추출물이 방사선에 조사된 생쥐의 혈액상에 방호적인 효과와 회복 효과가 있다고 생각되었다. This study was carried out obtain changes of red ginseng extract on the blood in the gamma ray post-irradiated mice. The experimental groups were control(saline), ginseng, ginseng and wholebody irradiated(??), and wholebody irradiated(??). Gamma ray post-irradiation recoverd by the red ginseng extract were observed in erythrocyte, leucocyte and thrombocyte, while the ginseng extract did not affect weight and hemoglobin. Leucocyte of ginseng and wholebody irradiated groups were significantry recoverd. This results thought that red ginseng extract group before radiation injury have the protective effect and the recovry effects on the mice blood.

퍼망간네이트-옥살산에 의한 아크릴아마이드 수용성중합에서의 첨가제 효과

이채주,이종광 慶尙大學校 1986 論文集 Vol.25 No.2

The polymerization of Acrylamide initiated by MnO4-H2C2O4 redox pair has been studied in aqueous media at 35±0.2℃ in nitrogen armosphere. The rate of polymerization is independent of activator concentration (2×10-3 to 4.5×10-3 mole/1) expect at very high (above 6.3×10-3 mole/1) concentration. The initial rate of polymerization has been found to be proportional to nearly 1.17 power of low catalyst concentration (2.3×10-4 to 6.25×10-4 mole/1) and nearly the first power of low monomer concentration (1.47×10-3 to 3.3×10-3 mole/1). The overall energy of activation has been found to be 10.99kcal/mole within the temperature range 30-50℃. The effects of various additives have been studied. Organic solvents and salts depress the initial rate but small amounts of manganous salts(MnSO4, MnCl2) increase the initial rate to a considerable extent. A complexing agent(NaF) and anionic and cationic surfactants show marked influence on the rate of polymerization. The intrinsic viscosity in aqueous acrylamide solution at 30±0.1℃ was 1.01 and the molecular weight of the polyacrylamide was 63,900.