고분자 코팅된 리포좀의 입자 크기 및 열적 특성

진병석,한송희 동덕여자대학교 2003 생활과학연구 Vol.8 No.-

Polymercoated liposomes using water-soluble poly(vinyl alcohol) and chitosan were prepared in order to enhance the stability of liposome. Droplet sizes of liposomes, ranged from several hundred nm to 2㎛, dependon the consition components, preparation method, and coating. Lyotropic liquid crystalline phase transition of polymer coated liposomes were characterized by diffrential scanning calorized optical microscopy.

L-Ascorbic Acid가 포집된 베시클의 제조

진병석 생활과학연구소 2005 생활과학연구 Vol.10 No.-

L-ascorbic acid entrapped vesicles were prepared in order to delay the oxidation of L-ascorbic acid. Vesicles were composed mainly of lecithin, butylene glycol, and water, and the vesicular membranes showed hydrated liquid crystalline phase behaviors. The stabilization effect of vesicles was investigated by measuring the change of concentration of L-ascorbic acid with storage time. The concentration of L-ascorbic acid was measured with HPLC equipped with UV detector. Variations of average particle size and entrapment efficiency (EE) of vesicles with lecithin types were also investigated.

인지질 혼합물로 구성된 초음파처리 리포좀 제조 및 안정성

진병석,한송희 동덕여자대학교 2002 생활과학연구 Vol.7 No.-

Liposomes were prepared, using hydrogenated phospholipid mixture extracted from soybean, by homogenization and sonication. The stability of the liposomes was investigated by measuring the turbidity changes, which were correlated with the particle size of liposomes. The turbidity of liposome solution decreased to be finally transparent by sonication procedure. The incorporation of cholesterol into hydrogenated phospholipid also decreased the turbidity of liposome solution. The particle sizes of transparent liposome solutions were measured to be less than 100nm.

TiO2 표면 처리된 LiNi0.8Co0.15Al0.05O2의 전기화학적 특성 평가

진수진, 김직수, 박석준, 나병기 충북대학교 건설기술연구소 2013 충북대학교 건설기술연구소 논문집 Vol.32 No.1

본문참고

연신조건에 따른 PET와 PEN의 분자배향 비교

진병석 동덕여자대학교 2002 생활과학연구 Vol.7 No.-

The effects of uniaxial drawing conditions on the average and the amorphous molecular orientation of PET and PEN were investigated. The average molecular orientation functions of PET and PEN (fav), they all decreased with drawing temperature and increased with drawing rate. The amorphous orientation function (fa) of PEN also increased with drawing rate, but that of PET decreased with drawing rate. These behaviors could be explained from the relation between crystallization rate and chain relaxation rate.

액막을 이용한 지방산 분리

진병석,김동학 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.4 No.2

액막을 이용하여 지방산이 포함된 폐수로부터 지방산 분리를 시도하였다. 가스크로마토그래피와 폐수의 지방산 농도 측정 방법을 통하여 다양한 조건에서의 액막의 분리속도를 관측하였다. 분리과정 중 액막의 안정성에 필요한 계면활성제의 최적농도를 실험을 통하여 결정하고 지방산 분리 속도에 대한 여러 실험적 조건의 영향을 살펴보았다. 이들 결과에서 지방산을 폐수로부터 효과적으로 분리하는 방법이 가능함을 알 수 있다.

이상형 스테인레스강의 크롬질화물 석출과 상 방위관계 연구

최병학,김진우,고석민,조용석,김상식,이재현 국립7개대학공동논문집간행위원회 2002 공업기술연구 Vol.2 No.-

Microstructures in the directionally solidified duplex stainless steels were investigated in order to understand the effect of nitrogen addition and its precipitation in the α phase. It was found that the addition of nitrogen causes the formation of fine precipitates in α matrix and segregation phases of nitrogen in the α/γ interface. Both the fine precipitates and the segregation phases were identified as CrN(fcc, a=4.18Å), as a coherent phase related to the α-bcc matrix with crystal relationship of (200) CrN//(01￣1)α and (1￣1￣1)CrN//(3￣2￣1)α.

전두근ㆍ근막피판을 이용한 선천성 안검하수의 교정

변진석,조병채,백봉수 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

Ptosis of the upper eyelid is one of common deformities of the eye region. To obtain the best surgical result in ptosis, it is necessary to select the appropriate operation for each case according to levator function, degree of ptosis, its etiology and other factors. For the correction of the congenital ptosis with very poor or absent levator function, frontalis suspension with various many materials and direct transplantation of the frontalis muscle have been used by many authors. Each of the above has its specific virtues and inherent shortcomings. On the basis of comparative study of the conventional techniques and anatomical study of the eyebrow region, we designed a superiorly based frontalis myofascial flap. The orbital portion of the orbicularis oculi muscle was included in the distal end of the frontalis myofascial flap to lengthen the flap. According to our results, this technique of frontalis myofascial flap has several advantages compared to Song's direct frontalis transplantation : (1) the operation can be done under a local anesthesia at the out-patient department with simple procedure and less bleeding. (2) the forehead wrinkles are to not disturbed, (3) this procedure needs only a single incision and does not disturb the important anatomic structures around the eyebrow region.

전기화상후 Prostaglandin F2a와 Thromboxane B2의 증가에 대한 Flurbiprofen, Prednisolone 및 Gabexate mesilate의 억제효과

조병채,김인규,변진석,백봉수 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

This study was conducted to clarify the inhibitory effect of flurbiprofen, prednisolone, and gabexate mesilate on the synthesis of prostaglandin F2a and thromboxane B2 in the tissue of electrical burn. one hundred sixty Sprague-Dawley rats, 250gm of body weight in average, were divided into 4 groups of control, flurbiprofen, prednisolone and gabexate mesilate administred group. Fourty rats of the each group were subdivided into 1st, 2nd, 4th, 7th postburn day with 10 rats in each subgroup. Ten rats were used for normal values of prostaglandin F2a and thromboxane B2. Flurbiprodfen 30mg/kg was given per mouth, and prednisolone acetate 5mg/kg and gabaxate mesilate 50mg/kg were administred intramuscularly 5 minutes after burn injury and then once a day. All but bone tissue of within 2cm area of the current entry were harvested and ground into homogenate. The levels of prostaglandin F2a and thromoboxane B2 were measured by Radioimmunoassay. The results were as followings: In normal rat tissue, the level of prostagland F2a and thromboxane B2 were 15.8±1.8 and 17.6±2.8ng/mg protein in each. In the control group the levels of both prostaglandin F2a and thromboxane B2 increased abruptly to 5 times and 7 thimes in the first day and maintained the same level in the second day. After then they rapidly decreased and returned to a near normal level in the fourth day. The increase of thromboxane B2 was more remarkable than that of prostaglandin F2a. In the flurbiprofen group, the level of thromboxane B2 was not inerease but kept at a normal level. The average level of prostaglandin F2a in the post-burn first and second day was 59.5% lower than of the control group. The average level on the post-burn first and second day was 61% lower in thromboxane B2 and 33% lower in prostaglandin F2a in the prednisolone group, and 68% lower in throboxane B2 and 48% lower in prostaglandin F2a in the gabexate mesilate group, compared to the control group. These findings suggest that electrically injured tissue is vigrously progressive due to rapid increase of thromboxane B2 and prostaglandin F2a, as inflammatory mediators, in the post-burn first and second day, is nonprogressive after the post-burn fourth day. The flurbiprodfen was the most effective of the three drugs(flurbiprofen, gabexate mesilate, prednisolone in order of effectiveness) to suppress the synthesis of thromboxane B2 prostaglandin F2a of the electrieally injured tissue.

생체분해성 안과제형의 안구내흡수정도와 안독성

민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.