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진병석,곽효정,이상묵 한국공업화학회 2005 응용화학 Vol.9 No.1
EGCG entrapped ethosome vesicles were prepared in order to delay the oxidation of EGCG. Vesicles were composed mainly of lecithin, ethanol, and water, and the vesicular membranes showed hydrated liquid crystalline phase behaviors. The stabilization effect of vesicles was investigated by measuring the change of concentration of EGCG with storage time. The concentration of EGCG was measured with HPLC equipped with UV detector. Variations of average particle size and entrapment efficiency (EE) of vesicles with lecithin types were also investigated.
진병석,유지연 동덕여자대학교 2001 생활과학연구 Vol.6 No.-
Liposomes are self-assembling colloidal vesicles composed of phospholipid bilayers in which drugs or bioactive materials are encapsulated. Liposomes have been widely employed as an effective delivery system for drugs and cosmetics, but there are still some problems about the low stability of liposomes. In this study, various relavant informations on the charaterisics of liposome were presented. Also, factors influencing the stability of liposomes were analyzed and a general overview of the stability problems of liposomes was given.
HPC와 프로필렌 글리콜로 구성된 수화 액정형 베시클의 형성에 관한 연구
진병석 동덕여자대학교 2004 생활과학연구 Vol.9 No.-
Hydrated liquid crystalline vesicles, composed mainly of HPC and propylene glycol, were prepared. Liquid crystalline phase behavior and thermal phase transition of the vesicles were investigated by the polarized optical microscopy equipped with hot stage. The formation of vesicular droplet was also observed by SEM. Average droplet sizes of the vesicles, which were all below 1μ, depended on lipid constituent composition and propel glycol content. Encapsulation efficiency of the vesicle was much higher than that of liposome. This was caused by the two step process for preparation and the hydrophilic constitution of propylene glycol in vesicle.
Ethosome의 구성성분 조성 및 제조조건이 입자의 크기 및 포집효율에 미치는 영향
진병석,이상묵 한국공업화학회 2004 응용화학 Vol.8 No.1
Calcein entrapped ethosomes, which are vesicular system composed mainly of phospholipid, ethanol, and water, were prepared with varying the composition of constituent components and preparation condition. Entrapment efficiency of the ethosome is decreased as the added amount of ethanol increased. The ethosome should be prepared above 60℃ for high entrapment efficiency. Incorporation of cholesterol into lecithin decreased the entrapment efficiency and increased the droplet size of the ethosome.