http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mesothelin Expression in Gastric Adenocarcinoma and Its Relation to Clinical Outcomes
한송희,장선희,주미,김한성 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.2
Background: Although surgical resection with chemotherapy is considered effective for patients with advanced gastric cancer, it remains the third leading cause of cancer-related death in South Korea. Several studies have reported that mesothelial markers including mesothelin, calretinin, and Wilms tumor protein 1 (WT1) were positive in variable carcinomas, associated with prognosis, and were evaluated as potential markers for targeted therapy. The aim of this study was to assess the immunohistochemical expression of mesothelial markers (mesothelin, calretinin, and WT1) in gastric adenocarcinoma and their relations to clinocopathological features and prognosis. Methods: We evaluated calretinin, WT1, and mesothelin expression by immunohistochemical staining in 117 gastric adenocarcinomas. Results: Mesothelin was positively stained in 30 cases (25.6%). Mesothelin expression was related to increased depth of invasion (p = .002), lymph node metastasis (p = .013), and presence of lymphovascular (p = .015) and perineural invasion (p = .004). Patients with mesothelin expression had significantly worse disease-free survival rate compared with that of nonmesothelin expression group (p = .024). Univariate analysis showed that mesothelin expression is related to short-term survival. None of the 117 gastric adenocarcinomas stained for calretinin or WT1. Conclusions: Mesothelin expression was associated with poor prognosis. Our results suggest that mesothelin-targeted therapy should be considered as an important therapeutic alternative for gastric adenocarcinoma patients with mesothelin expression.
한송희,이주호,최성순,이관훈 한국신뢰성학회 2014 한국신뢰성학회 학술대회논문집 Vol.2014 No.5
부식과 대기 중 습기에 대한 내성이 우수하며 연성이 좋은 Au는 반도체 패키지 등에서 전도도 (conducting path) 형성을 위한 wire 소재로서 널리 채택되고 있다. 그러나 Au는 가격 변동이 커서 최근에는 Cu가 wire의 재료로써 많이 채택되어 사용되고 있다. Cu wire는 내식성과 전도율이 우수하지만, 표면에 산화막이 쉽게 형성 되므로 환원성 분위기 등을 이용하여 표면에 산화막이 없는 ball을 형성하는 것이 중요하다. 본 논문에서는 Cu wire surface에 형성된 abnormal layer 를 분석하여 Cu wire의 corrosion 원인을 규명하고자 하였다.
한송희,김미림,정율리,윤보라,장미정,김선미,강은영,김은규,박소연 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1
Purpose: The management of benign intraductal papilloma (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial. This study was performed to evaluate the rate of upgrading to malignancy or high-risk lesions after excision and to identify factors associated with upgrading using a large series of benign IDP cases without atypia. Methods: We included patients who were diagnosed as having benign IDP without atypia on CNB and underwent surgical or vacuum-assisted excision between 2010 and 2015. We analyzed the clinical, radiologic, and histopathologic features of IDPs that were upgraded to malignancy or high-risk lesions after excision. Results: A total of 511 benign IDPs without atypia diagnosed via CNB were identified, of which 398 cases were treated with excision. After reviewing these cases, four cases of high-risk lesions in adjacent tissue on CNB, two cases which were revealed as papilloma with atypia, and nine cases of malignancy in the same breast were excluded. In the remaining 383 cases, the rate of upgrading to malignancy and high-risk lesions after excision was 0.8% and 4.4%, respectively. The presence of concurrent contralateral breast cancer, the presence of symptoms, and multifocality were factors significantly associated with upgrading to malignancy on subsequent excision. Surgical excision rather than vacuum-assisted excision was significantly associated with upgrading to high-risk lesions or malignancy. Conclusion: The rate of upgrading to malignancy for benign IDP without atypia was very low, suggesting that close clinical and radiologic observation may be sufficient for patients with benign IDP without atypia on CNB under proper settings.
한송희,이주호,이관훈 한국신뢰성학회 2017 한국신뢰성학회 학술대회논문집 Vol.2017 No.5
기존 자원고갈 및 급격한 환경오염으로 인한 신재생에너지 필요성이 갈수록 대두되고 있다. 그 중 태양광은 무공해․무한한 에너지원으로 가장 먼저 상용화가 진행되고 있다. 그러나 최근 태양광 발전 시장은 규모의 경제를 통한 원가 경쟁력 확보가 중요시되어 원가 절감의 일환으로 변환효율의 향상, 제작비용의 절감, 태양전지 공정의 간소화 등의 연구가 진행되고 있는 실정이다. 태양전지의 효율을 향상하기 위해서는 소수 캐리어의 높은 수명이 필수조건인데, 웨이퍼(wafer)가 빛에 노출되면 소수 캐리어의 수명이 줄어들어 시간이 경과함에 따라 변환 효율이 점점 감소하는 문제가 발생한다. 본 연구에서는 변환 효율을 개선하기 위해 절삭 손상된 웨이퍼 표면에 클리닝 공정 후 MCLT(Minority Career Life Time) 측정으로 비교평가하였다. 에칭 전부에 따른 MCLT의 변환 효율개선이 기대되는 시료를 주사전자현미경을 이용해 표면분석하였고, TEM(투과전자현미경)으로 내부 구조를 확인하였다.
한국어판 소아당뇨환자의 삶의 질 측정 도구 (PedsQLTM 3.0)의 신뢰도 및 타당도
한송희,박기수,김건엽,고철우,김흥식,박용훈,김진경,김혜숙,최광해,황진복,이원기,감신 한국모자보건학회 2013 한국모자보건학회지 Vol.17 No.2
Objectives: Type 1 diabetes mellitus (T1DM) in childhood has impacts on patients' daily lives. The Pediatric Quality of Life Inventory (PedsQLTM) 3.0 Diabetes Module is a questionnaire of health-related quality of life (HRQOL) specified for T1DM. This study was aimed to assess the reliability and validity of the Korean-translated version of the PedsQLTM 3.0 Diabetes Module in children and adolescents with T1DM. Methods: One hundred and two patients (aged 8~18 years) with T1DM and their parents, who were outpatients from 5 teaching and university hospitals in Daegu, Korea, participated in this study. Child self-reports and parent-proxy reports of the Korean version of the PedsQLTM 3.0 Diabetes Module were completed. As a health index, hemoglobin A1c and self-health status were collected. Results: More than 90% of the items were answered and the missing rate was minimized, which supported a good face validity and feasibility. The internal consistency of the PedsQLTM 3.0 Diabetes Module, Korean version, reached or exceeded Cronbach's alpha values of 0.70 for both child self reports and parent-proxy reports. The test-retest was highly correlated (r=0.82, 0.87) and the intraclass correlation coefficient (ICC) exceeded 0.6 in all sub-scales for child self-reports and mostly for parent-proxy reports. Children's HRQOL for child self-report was correlated with hemoglobin A1c and self-helath status (r=-0.33, 0.32). Conclusions: In summary, this study represented that the Korean version of the PedsQLTM 3.0Diabetes Module was feasible, reliable and valid for measuring the specific HRQOL in patients aged 8~18 with T1DM. Furthermore, a larger study to compare the Diabetes Module with the PedsQL Generic Core Scales is needed.