노년기 치매와 우울증의 유병률 및 위험인자

서국희,김장규,연병길,박수경,유근영,양병국,김용식,조맹제 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

경기도 연천군에 거주하는 만 65세이상 노인 1,037명을 대상으로 1996년 12월부터 1997년 8월까지 9개월간에 걸쳐 치매와 노년기 우울장애의 유병률과 위험인자에 관한 이 단계 역학조사(일차선별검사후 이차 진단적 면접)를 수행하였다. 다단계 층화집락표본추출에 의한 확률표본법으로 대상자 선정을 하였고, 반응률은 85.2%이 었다. 일차선별검사에는 노인정신장애 평가척도 한국어판(K-PAS)을 사용하였고, 일상생활 능력척도(ADL) 및 수단적 일상생활 능력척도(IADL)를 사용하여 기능을 평가했고, 지지도 척도(APGAR)를 사용하여 사회적 지지정도를 평가하였다. 이차 진단적 면접에서는 진 신장애의 진단 및 통계편람 제3판 개정판(DSM-III-R)의 진단기준을 따라 임상 진단을 확정하였다. 감별진단 및 장애 정도의 평가를 위하여 보조적인 진단도구들을 사용하였다. 1) 연령 보정된 치매의 유병률(%)[95% 신뢰구간]은 6.83[6.12∼7.54](남자 6.34[5.29∼7.40], 여자7.09[6.14∼8.04]이었다. 이중 알쯔하이머형 치매의 유병률(%)[95% 신뢰구간]은 4.17[3.61∼4.74] (남자 2.42[1.76∼3.08], 여자 5.31[4.48∼6.14]이었고, 혈관성치매의 유별률(%)[95% 신뢰구간]은2.38[1.95∼2.81](남자 3.46[2.67∼4.25], 여자 1.63[1.16∼2.10])이었다. 2) 연령 보정된 우울장애의 유병률(%)[95% 신뢰구간]은 10.99[10.11∼11.87](남자 7.59[6.44∼8.73], 여자 13.46[12.20∼14.73])이었다. 진단별로는 주요 우울장애의 유병률(%)[95% 신뢰구간] 이 7.50[6.76∼8.26](남자 4.42[3.54∼5.31], 여자 9.78[8.68∼10.88]), 기분부전장애의 유병률(%)[95% 신뢰구간]이 2.02[1.62∼2.42](남자 1.37[0.86∼1.87], 여자 2.46[1.88∼3.03], 달리 특정되지 않은 우울장애 유병률 (%)[95% 신뢰구간]이 1.49[1.15∼1.83](남자 1.85[1.47∼2.23], 여자 1.28[0.96∼1.60])이었다. 3) 알쯔하이머형 치매의 통계적으로 유의한 5가지 위험인자는 85셍상의 고령(O.R.= 10.27), 무학(O.R.= 4.01), 흡연[흡연년수 0.1∼30년(O.R.= 3.11), 흡연년수 30년 이상 (O.R.= 4.60)], 알코올남용(O.R.= 2.98)과 치매의 가족력 (O.R.= 4.85)이었다. 4) 혈관성 치매의 통계적으로 유의한 3가지 위험인자는 '무학' (O.R.= 3.78), 흡연[40년 이상 흡연년수 (O.R.= 11.15)]과 '뇌졸중의 과거력 (O.R.= 26.76)'이었다. 5) 우울장애의 통계적으로 유의한 3가지 위험인자는 '75∼79세 연령군' (O.R.= 2.87), '뇌졸중의 과거력' (O.R.= 3.33)과 '우울장애의 가족력' (O.R.= 7.16)이었다. 중심단어:알쯔하이머형 치매·혈관성 치매·우울장애·유병률·위험인자·흡연. An epidemiological survey was conducted to estimate the prevalence of and identify the risk factors of dementia and depression in the elderly between December 1997 and August 1998 in Yonchon County, Korea. A total of 1,037 elderly aged 65 years and over underwent a two phase diagnocstc procedure. Multiple stage, random cluster sampling method was used to select the subjects. Response rate was 85.4%. For the Ist stage screening survey, the Korean Psych-ogeriatric Assessment Scale was used as a primary screening tool, which had already been standardized in Korea, and functioning and social support were assessed by ADL, IADL and APGAR. At the 2nd stage, diagnoses were confirmed according to the DSM-Ⅲ-R. And several other scales were used as supporting information for differential diagnoses and for evaluating severity. 1) Age-sex adjusted prevalence(%)[95% C.I] of dementia was 6.83[6.12-7.54](male 6.34 [5.29-7.40], female 7.09[6.14-8.04]). Prevalence of the dementia of the Alzheimer's type was 4.17[3.61-4.74](male 2.42[1.76-3.08], female 5.31[4.48-6.14]) and that of the va-scular dementia was 2.38[1.95-2.81](male 3.46[2.67-4.25],female 1.63[1.16-2.10]). 2) Age-sex adjusted prevalence(%)[95% C.I.] of depressive disorder was 10.99[10.11-11.87](male 7.59[6.44-8.73], female 1346[12.20-14.73]. Among depressive disorders, prev-alence(%)[95% C.I.] of major depressive disorder was 7.50[6.76-8.26](male 4.42[3.54-5.31], female 9.78[8.68-10.88]), that of dysthymic disorder was 2.02[1.62-2.42](male 1.37[0.86-1.87], female 2.46[1.88-3.03]) and that of depressive disorder NOS was 1.49[1.15-1.83](male 1.85[1.47-2.23], female 1.28[0.96-1.60]). 3) Five statistically significant risk factors of the dementia of the Alzheimer's type were identified : age over 85(O.R. = 10.27), illiteracy (O.R. = 4.01), alcohol abuse (O.R. = 2.98), smoking [0 < pack year ≤30(O.R. = 3.11), pack year>30(O.R. = 4.60)] and family history of dementia (O.R. = 4.85). 4) Three statistically significant risk factors of the vascular dementia were identified : illiteracy (O.R. = 3.78), history of CVA(O.R. = 26.76) and smoking over 40 pack year(O.R. = 11.15). 5) Three statistically significant risk factors of the depressive disorder were identifed : age between 75 and 79(O.R. = 2.87), past history of CVA(O.R. = 3.33) and family history of depressive disorder(O.R. = 7.16). KEY WORDS:Dementia of the Alzheimer's Type·Vascular dementia·Depressive disorder·Prevalence·Risk factor·Smoking.

현역 군인 발생을 중심으로 본 2000년도 국내 삼일열 말라리아 발생 현황

박재원,김영아,염준섭,유정식,양병국,채종일 대한감염학회 2001 감염 Vol.33 No.4

Background : Since 1997, the annual case occurrence of vivax malaria in the Republic of Korea have exceeded 1,000 cases since 1997. The military is thought to be an important source of the current outbreak. We collected various informations about malaria cases (soldiers, veterans and civilians) which occurred in 2000, and analyzed the characteristics of the current outbreak. Methods : Informations about malaria cases of soldiers, veterans and civilians, including name, age, sex, day of onset, region, etc., were collected through the National Institute of Health. Results : Out of total 4,141 cases, 1,288 (31.1%) occurred in the military, 1,273 (30.7%) occurred among the veterans, and 1,580 (38.2%) occurred among civilians. The monthly case occurrence reached its peak in early August. Areas such as Cheolwon, Yeoncheon and Paju showed the highest prevalence. Conclusion : It is considered that the current malaria outbreak has escaped from the exponential growth phase, however, more attention should be paid to prevent further spreading of malaria infection. (Korean J Infect Dis 33:280∼284, 2001)

Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats

Byung Keun Yang,Guk Nam Kim,Yong Tae Jeong,Hun Jeong,Pradeep Mehta,Chi Hyun Song 한국균학회 2008 Mycobiology Vol.36 No.1

Anti-inflammatory Activity of Salvia plebeia extract in LPS-stimulated RAW 264.7 Cells

Byung Soon Hwang,Hee sun Yang,Ji Yeong Kim,Mi Jang,Su Hyun Kwon,Hae Ju Kang,Gi-Chang Kim,In Guk Hwang 한국식품영양학회 2020 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2020 No.10

[P10-24] Hypoglycemic Effects of Polymers Obtained from Fruiting Bodies, Mycelia, and Culture Broth of Coriolus versicolor in STZ-induced Diabetic Rats

Guk Nam Kim,Byung Keun Yang,Yong Tae Jeong,Hun Jeong,Yu Sun Jeong,Sang Min Kim,Rezuanul Islam,Pradeep Mehta,Chi Hyun Song 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10

Assessment of tissue characteristics of noncalcified coronary plaques by 64-slice computed tomography in comparison with integrated backscatter intravascular ultrasound

Yang, Woo-In,Hur, Jin,Ko, Young-Guk,Choi, Byung-Wook,Kim, Jung-Sun,Choi, Donghoon,Ha, Jong-Won,Hong, Meonong-Ki,Jang, Yangsoo,Chung, Namsik,Shim, Won-Heum,Cho, Seung-Yun Lippincott Williams Wilkins, Inc. 2010 Coronary artery disease Vol.21 No.3

BACKGROUND: The ability of 64-slice computed tomography (CT) angiography to differentiate plaque types remains unclear. We evaluated whether the density of noncalcified coronary plaques by 64-slice CT angiography correlates with plaque components assessed by integrated backscatter intravascular ultrasound (IB-IVUS). METHODS: Eighty-six patients [stable angina/acute coronary syndrome (ACS) 67/19, mean age 62±11 years] who showed significant coronary artery stenosis (≥50% diameter stenosis) by 64-slice CT angiography underwent coronary angiography and were evaluated using IB-IVUS. RESULTS: A total of 92 noncalcified coronary plaques on CT angiography were evaluated with IB-IVUS. There was a positive correlation between CT density and calcified tissue content (r=0.41, P<0.001). However, the CT density of plaques did not correlate with other tissue components. Patients with ACS showed more lipid (43.1±13.2 vs. 35.8±13.5, P=0.03) and less soft fibrous tissue (50.5±11.7 vs. 56.5±12.0, P=0.05) by IB-IVUS than those with stable angina. However, the mean CT density of plaques in ACS was not different from that in stable angina (140.6±88.5 vs. 113.1±80.9, P=0.19). CONCLUSION: Except for calcified tissue, CT angiography failed to differentiate plaque types of noncalcified tissue. Therefore, the role of 64-slice CT angiography in identifying lipid-rich plaques remains limited.

흡연상태와 호기 중 일산화탄소 농도

임병국,김성원,강재헌,양윤준 대한가정의학회 2001 Korean Journal of Family Medicine Vol.22 No.5

Research Hypolipidemic Effects of Biopolymers Extracted from Culture Broth, Mycelia, and Fruiting Bodies of Auricularia auricula-judae in Dietary-induced Hyperlipidemic Rats

Hun Jeong,Byung Keun Yang,Yong Tae Jeong,Guk Nam Kim,Yu Sun Jeong,Sang Min Kim,Pradeep Mehta,Chi Hyun Song The Korean Society of Mycology 2007 Mycobiology Vol.35 No.1

운 경험과 손 씻기의 상호작용이 다양성 추구 행동에 미치는 효과

양덕모 ( Deok-mo Yang ),이국희 ( Guk-hee Lee ),이병관 ( Byung-kwan Lee ) 한국감성과학회 2017 감성과학 Vol.20 No.2

기존의 선행연구들에서 사람들의 다양성 추구행동에 미치는 요인들에 많은 관심을 가져왔음에도 불구하고, 행운과 불운 그리고 체화된 인지의 상호작용이 다양성 추구행동에 미치는 효과에 관한 연구는 없었다. 행운과 불운의 경험은 소비자의 정보처리에 영향을 미치며, 손 씻기에 의한 체화된 인지는 행운 · 불운의 경험을 역전시키는 요인으로 두 요인이 다양성 추구행동에 미치는 효과를 이해하는 것은 소비자의 선택과 제품구매를 포함한 전반적인 소비자 행동연구에 중요한 역할을 할 것이다. 이에 본 연구는 운 경험 (행운 vs. 불운)과 손 씻기 여부 (있음 vs. 없음)의 상호작용이 다양성 추구행동에 미치는 영향을 검증하였다. 참가자들은 행운과 불운을 경험한 후, 손을 씻거나, 씻지 않았고, 떠먹는 요구르트의 맛을 얼마나 다양하게 선택하는지에 대한 과제를 수행하였다. 분석 결과, 운 점화와 손 씻기의 상호작용효과가 발견되었다. 구체적으로, 행운 조건의 경우, 손을 씻은 참가자와 손을 씻지 않은 참가자의 다양성 추구 행동에는 차이가 없었다. 반면에 불운 조건에서는 손을 씻은 참가자가 손을 씻지 않은 참가자보다 다양성 추구 행동이 더 높게 나타났다. 본 연구의 결과는 소비자심리와 마케팅 분야에 폭넓은 이론적, 실무적 시사점을 줄 것으로 기대한다. Although previous studies have emphasized factors affecting people`s variety-seeking behavior, research has not been performed to examine the interaction effect of good-bad luck and embodied cognition (hand washing) on variety-seeking behavior. Experience of good and bad luck affects consumer information processing and hand washing is known to reverse the experience of luck. Understanding the interaction effect of good/bad luck and hand washing on variety seeking behavior will shed important light on consumer behavior including choice and product purchase. To do this, a study was performed to investigate the effects of good/bad luck priming and hand washing on variety seeking behavior. Participants were primed with good or bad luck and then were asked to either wash their hands or not. After that, they were led to choose yogurt for the next seven days and the dependent measure was the number of different tastes of yogurt participants picked up. An interaction effect of luck priming and hand washing was found. Results indicate that, in good luck condition, there was no difference in variety seeking behavior between hand washing participants and non-hand washing participants. However, in bad luck condition, hand washing participants chose less diverse tastes of yogurt than non-hand washing participants. Implications of the study findings for the field of consumer psychology and marketing are discussed.

A Fatal Case of Disseminated Tuberculosis Coincident with Measles-Rubella Vaccination

Hae-Kwan Cheong,Byung-Guk Yang,Young Mo Sohn,Il-Hoon Kwon,Jun Chul Kim,Hangmi Kim,Jung Ran Kim 한국역학회 2010 Epidemiology and Health Vol.32 No.-

The authors report a fatal case of disseminated tuberculosis in a 14-yr-old girl, which developed immediately after a measles-rubella (MR) vaccination. Despite a markedly accelerated clinical course which led to death within two weeks, the authors could not identify any possible cause of the tuberculosis aggravation in this case, with the exception of the MR vaccination. The possible role that MR vaccination had on the clinical course of tuberculosis in this case is discussed.