Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability

정인하,구대정,이미연,문선준,권혜미,박세은,이은정,이원영 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.4

Background: Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease(NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This studyaimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes. Methods: We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), whichwas defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participantswere classified according to the baseline body mass index and weight difference over 4 years. Results: On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed asignificantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI],1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR,1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLDcompared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53). Conclusion: Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable bodyweight.

Increased Risk of Cardiovascular Disease and Mortality in Patients with Diabetes and Coexisting Depression: A Nationwide Population-Based Cohort Study

정인하,권혜미,박세은,한경도,박용규,김양현,이은정,이원영 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.3

Background: Previous studies have suggested that depression in patients with diabetes is associated with worse health outcomes. The aim of this study was to evaluate the risk of cardiovascular disease (CVD) and mortality in patients with diabetes with comorbid depression. Methods: We examined the general health check-up data and claim database of the Korean National Health Insurance Service (NHIS) of 2,668,615 participants with type 2 diabetes mellitus who had examinations between 2009 and 2012. As NHIS database has been established since 2002, those who had been diagnosed with depression or CVD since 2002 were excluded. The 2,228,443 participants were classified into three groups according to the claim history of depression; normal group (n=2,166,979), transient depression group (one episode of depression, n=42,124) and persistent depression group (at least two episodes of depression, n=19,340). The development of CVD and mortality were analyzed from 2009 to 2017. Results: Those with depression showed a significantly increased risk for stroke (transient depression group: hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.15 to 1.26) (persistent depression group: HR, 1.54; 95% CI, 1.46 to 1.63). Those with depression had an increased risk for myocardial infarction (transient depression group: HR, 1.25; 95% CI, 1.18 to 1.31) (persistent depression group: HR, 1.38; 95% CI, 1.29 to 1.49). The persistent depression group had an increased risk for all-cause mortality (HR, 1.66; 95% CI, 1.60 to 1.72). Conclusion: Coexisting depression in patients with diabetes has a deleterious effect on the development of CVD and mortality. We suggest that more attention should be given to patients with diabetes who present with depressive symptoms.

1950-60년대 한국건축의 기술적 담론에 관한 연구

정인하 대한건축학회 2006 대한건축학회논문집 Vol.22 No.1

This study want to provide the broad perspective on the discourse of technology in the 1950-60's Korean architecture. In order to accomplish this objective, we would like to propose 3 processes of study as follows;1) It's important to put Korean architects and structural experts in the central place of technological discourse, because they were the first Koreans who searched for the optimal possibilities in introducing the advanced technology of western countries.2) By shedding lights on the material conditions in the 1950-60's including production of architectural materials, the capability of construction, and economy, we will make clear the gap which existed between ideas and reality 3) Taking into consideration the interaction between architects and material condition, we will reveal the outline of technological discourse in the 1950-60's Korean architecture.

근대 이후 빠리의 도시계획과 사회주거의 변천

정인하 프랑스문화학회 1996 프랑스 문화읽기 Vol.1 No.1

Depuis le Moyen-Age, Paris est le centre politique et culturel de la France. Cette vine s'est de´veloppe´e en suivant pas a` pas l'histoire de la France qu'elle re´sume d'une certaine manie`re. De la conception me´die´vale a` la conception de la ville moderne, Paris a connu, au cours des XIXe et XXe sie`cles, de grands changements architecturaux et urbanistiques. Cette e´tude porte sur le logement social et l'urbanisrne de Paris depuis les temps modernes. L'analyse qui y est conduite a pour finalite´ de mettre en e´vidence l'attitude que les Franais, Bans le domaine de l'urbanisme parisien, ont adopte´e afin de re´pondre aux nouveaux enjeux ne´s de la Re´volution industrielle et de la modernisation. Pour cela, nous aeons chaisi d'etudier successivement la re´novation urbaine de Paris conduite par Haussmann sous le Second Empire, la vision architecturale de Le Corbusier a` travers la Ville radieuse, la construction des villes nouvelles autour de Paris, enfin l'histoire du logement social a` Paris depuis le XIXe sie`cle. Le projet d'Haussmann visa, dans une perspective fonctionnelle et utilitaire, a` ame´liorer la circulation de fair, de l'eau, des personnes et des biens en re´organisant l'ancien tissu urbain parisien par de nombreuses perce´es qui modifie`rent sensiblement la topographie de Paris. Le Corbusier propose un type ide`al de vine correspondant aux nouvelles exigences de la re´alite´ moderne. Et la construction des vines nouvelles autour de Paris depuis les anne´es 1960 est un nouvel essai pour cre´er un environnement urbain a` dimension humaine. Le logement social apparai^t comme le but essentiel que les architectes et les technocrates du minise`tre du Plan ont assigne´ a` cette urbanisation des Trente Glorieuses. Dans bien des grandes vines franc¿aises, mais aussi a` l'e´tranger, le logement social devient l'une des principales pre´occupations des urbanistes. Dans cette perspective, l'histoire du logement social et de l'urbanisme de Paris offre un point de vue dont les villes du tiers-monde, y compris les villes core´ennes, pourraient s'inspirer dans leur gestion quotidienne des proble`mes urbains.

이상의 초기시에 나타난 한국근대건축의 '근대성'탐구

정인하 한국건축역사학회 1999 건축역사연구 Vol.8 No.1

김수근에 대한 일본건축의 영향과 한국건축의 이념형의 탐구

정인하 한국건축역사학회 1996 건축역사연구 Vol.5 No.2

투시도법과 디지털 표현방식의 비교를 통한 비표상적 건축에 관한 연구

정인하,Jung, In-Ha 한국건축역사학회 2003 건축역사연구 Vol.12 No.2

After a digital modelling method has been introduced into architectural design in 1990s, a radical change was taken place in generating architectural form and space. Many architects have a view that digital modelling method is the most Important invention in the visual presentation since the moment that architect Philippo Brunelleschi experimented initially the linear perspective. Therefore, in this study, comparing between perspectiva artificialis and digital modelling method, we clarify 1) the relationship of architectural design and presentation method, 2) the practical and philosophical background inherent in digital modelling method which played key role in developing non-representational architecture, 3) and the principles of non-representational architecture like diagram, folding, and trace.

미셀 푸코와 만프레도 타푸리의 역사이론 비교연구 -건축, 이데올로기, 권력의 계보학-

정인하,Jung, In-Ha 한국건축역사학회 1999 건축역사연구 Vol.8 No.3

This study tries to compare the architectural thought of Michel Foucault with that of Manfredo Tafuri in order to make clear the architectural identity as a social institution. In Michel Foucault's case, the archeology of discourse and the geneology of power were central method to understand the history of occidental society since the Renaissance. Four him, architecture is assumed as a mechanism of operation which make the power effectively radiate in th space. He thinks that a new discursive space was arranged since the 18th century in Europe, the architecture played a role to coordinate divers powers. Mafredo Tafuri, architetural historian, depends on the criticism of ideology in search of the relation between the economic system of capitalism and modern architecture and urbanism. He thinks that all architecture is an institution. And any attempt to overthrow the institution, is bound to see itself turned into a positive contribution and into an ideology, So all architectural attempts to conceal the contradiction of capitalism are negated. This different perspective on architecture exposes many points of dispute: historical periodization, disciplinary limit of architecture, understanding of Enlightenment architecture, utopia and heterotopia, etc.

주한 프랑스대사관의 시지각적 장면 구성과 조형적 특징에 관한 연구

정인하 대한건축학회 1998 大韓建築學會論文集 Vol.14 No.1

ANOVA법에 의한 Plasma Deposit 공정변수분석

정인하,박희성,이철용,강권호,문제선,배기광,양명승,박현수 한국분말야금학회 1998 한국분말야금학회 학술대회논문집 Vol.1998 No.1