‘빚 권하는 사회’를 들여다보니...

이승환 (사)방송기자연합회 2010 방송기자 Vol.2 No.-

쿠싱 증후군에서 골다공증성 척추 골절의 위험 인자

이승환,박병문,송경섭,이수건,윤상필,이재철,이범석,양봉석 대한척추외과학회 2017 대한척추외과학회지 Vol.24 No.1

Study design: Retrospective study. Objectives: The goal of this study was to evaluate the risk factors of osteoporotic vertebral fractures (OVFs) in patients with Cushing syndrome. Summary of Literature review: In most reports, vertebral fractures in Cushing syndrome have been found to be related to osteoporosis. However, few studies have analyzed the clinical risk factors for OVFs. Materials and Methods: Thirty-two patients with Cushing syndrome who visited the orthopaedic department complaining of back pain were included in this study. Standing lateral X-rays were performed to evaluate the presence of vertebral fractures, and bone mineral density (BMD) was measured. Results: Of the 32 patients with Cushing syndrome with back pain, 8 (25%) were diagnosed with OVFs using morphometric criteria. The average weight and body mass index of the vertebral fracture group (VF group) were significantly higher than the values observed in the non-vertebral fracture group (non-VF group) (p=0.004, p=0.018). Lumbar BMD was significantly lower in the VF group (p=0.006). A risk factor for OVFs in Cushing syndrome was osteoporosis (odds ratio=18.56, 95% confidence interval=1.72-200.21, p=0.016) regardless of gender, obesity, menopause, or urine free cortisol levels. Conclusions: OVFs in Cushing syndrome have been associated with overweight, and overweight is an indicator of compliance in the treatment of Cushing syndrome. Therefore, weight reduction and the prevention of osteoporosis should be emphasized in patients with Cushing syndrome to prevent OVFs. 쿠싱 증후군에서 골다공증성 척추 골절의 위험 인자이승환 • 박병문 • 송경섭 • 이수건 • 윤상필 • 이재철 • 이범석 • 양봉석광명성애병원 정형외과연구 계획: 후향적 연구목적: 쿠싱 증후군에서 증상이 있는 골다공증성 척추 골절의 유병률을 조사하고, 골다공증성 척추 골절의 위험 인자를 분석하였다. 선행문헌의 요약: 쿠싱 증후군에서 척추 골절은 대부분은 골다공증과 연관이 있었다. 그러나 척추 골절의 다른 위험 인자에 대해 분석한 연구는 거의 없었다. 대상 및 방법: 요통으로 정형외과 외래에 내원한 32명의 쿠싱 증후군 환자를 대상으로 하였다. 흉요추부 기립위 측면 방사선을 촬영하여 척추 골절을 진단하였고, 척추와 대퇴 경부의 골밀도를 측정하였다. 척추 골절 그룹과 비골절 그룹의 통계학적 차이를 paired t-test를 이용해 비교하였고, 위험인자 분석을 위해 로지스틱 회귀 분석을 사용하였다. 결과: 전체 32명의 환자중 8명(25%)의 환자에서 골다공증성 척추 골절이 확인되었다. 척추 골절군의 평균 체중과 체질량 지수가 비골절군에 비해 유의하게 높았으며(p=0.004, p=0.018), 척추 골절군의 요추부 골밀도가 비골절군에 비해 유의하게 낮았다(p=0.006). 골다공증성 척추 골절의 위험 인자는 골다공증으로 나타났다(odds ratio 18.56, 95%CI 1.72-200.21, p=0.016). 결론: 쿠싱 증후군 환자에서 척추 골절의 발생은 과체중과 관련이 있으며, 과체중은 평소 쿠싱 증후군의 부적절한 치료로 인한 상태를 반영하는 지표라고할수 있다. 그러므로, 적절한 내분비적 치료를 통계 적정 체질량을 유지하고, 골다공증의 약물 치료를 병행하는 것이 쿠싱 증후군의 척추 골절 예방에 중요하다고 하겠다. 색인 단어: 쿠싱 증후군, 척추 골절, 골다공증약칭 제목: 쿠싱 증후군과 척추 골절

조세제도, 가려진 진실

이승환 (사)방송기자연합회 2012 방송기자 Vol.8 No.-

[취재보도 부문_제166회 이달의 방송기자상] 모든 죽음에는 이유가 있다 : 〈‘숨진 참고인 이재명 법카 바꿔치기 당사자였다’ 연속보도〉 2022년 7월 28일~29일 보도 JTBC 박창규, 이가혁, 이승환, 박현주, 이해선 기자

이승환 (사)방송기자연합회 2022 방송기자 Vol.68 No.-

[지역보도부문/기획다큐_제71회 이달의 방송기자상] 농촌 산모들에게 행복한 임신·출산을

이승환 (사)방송기자연합회 2014 방송기자 Vol.20 No.-

국소 신세포암으로 근치적 신적출술을 시행 받은 환자에서 술전 증상의 예후적 중요도

이승환,오철영,한웅규,양승철 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.12

치매관련 유전자 검사의 임상적 고찰

이승환,박건우 대한노인병학회 2008 Annals of geriatric medicine and research Vol.12 No.1

Dementia is the progressive or chronic dysfunction of cortical or subcortical functions that results in complex cognitive decline and Alzheimer's disease is the most common etiology of dementia. Currently, causal genetic mutations such as amyloid precursor protein, presenilin 1, presenilin 2 in familial Alzheimer's disease and many susceptible genes including polymorphysm of apolipoprotein E have been reported. Furthermore, genetic testings are available in person at risk for Alzheimer's disease. However, besides from results of genetic testing, there are many issues such as economics, ethics, psychological and legal. So clinician should be considered these complexities before ordering genetic test for patients with/without Alzheimer's disease.

대장암의 복강경 수술에 있어서 개복전환 위험인자

이승환,이길연,박순도,박선진,이석환 대한대장항문학회 2009 Annals of Coloproctolgy Vol.25 No.6

Purpose: Recently, laparoscopic surgery has been performed with increasing frequency in cases of various diseases, including colorectal cancer. However, in some cases, laparoscopic surgery should be converted to open procedures because of several factors. In this study, we tried to find the causes of and the risk factors for conversion to open procedures during colorectal cancer surgery. Methods: From June 2002 to May 2008, laparoscopic surgery in 324 patients who were diagnosed as having colorectal cancer was performed by two surgeons. Patients were divided into two groups, non-conversion and conversion groups. We investigated the differences in age, sex, presence of preoperative colonic obstruction, tumor invasion (pT stage), and so on between the two groups. Results: Of the 324 patients, 20 patients experienced an open conversion: 5 of 28 patients who had a colonic obstruction and 15 of 296 patients who had no obstruction (P=0.021). The causes of conversion during the surgery were tumor invasion, peritoneal adhesion, hemorrhage, and cancer perforation. There were 8 conversions out of 92 patients from June 2002 to May 2005 and 12 out of 232 from June 2005 to May 2008 (P=0.231). In regards to the degree of tumor invasion, 9 of 32 who were stage pT4 experienced a conversion to an open procedure (P<0.001). In multivariate analysis, the presence of a colonic obstruction and pT4 stage were meaningful risk factors for conversion to an open procedure. Conclusion: From this study, we can predict a higher rate of conversion to an open procedure in patients with locally advanced colon cancer, especially when a colonic obstruction is present. Therefore, a careful laparoscopic approach is needed in such patients. Purpose: Recently, laparoscopic surgery has been performed with increasing frequency in cases of various diseases, including colorectal cancer. However, in some cases, laparoscopic surgery should be converted to open procedures because of several factors. In this study, we tried to find the causes of and the risk factors for conversion to open procedures during colorectal cancer surgery. Methods: From June 2002 to May 2008, laparoscopic surgery in 324 patients who were diagnosed as having colorectal cancer was performed by two surgeons. Patients were divided into two groups, non-conversion and conversion groups. We investigated the differences in age, sex, presence of preoperative colonic obstruction, tumor invasion (pT stage), and so on between the two groups. Results: Of the 324 patients, 20 patients experienced an open conversion: 5 of 28 patients who had a colonic obstruction and 15 of 296 patients who had no obstruction (P=0.021). The causes of conversion during the surgery were tumor invasion, peritoneal adhesion, hemorrhage, and cancer perforation. There were 8 conversions out of 92 patients from June 2002 to May 2005 and 12 out of 232 from June 2005 to May 2008 (P=0.231). In regards to the degree of tumor invasion, 9 of 32 who were stage pT4 experienced a conversion to an open procedure (P<0.001). In multivariate analysis, the presence of a colonic obstruction and pT4 stage were meaningful risk factors for conversion to an open procedure. Conclusion: From this study, we can predict a higher rate of conversion to an open procedure in patients with locally advanced colon cancer, especially when a colonic obstruction is present. Therefore, a careful laparoscopic approach is needed in such patients.

[논문] 술탄 갈리예프의 무슬림 민족공산주의

이승환 부산대학교 인문학연구소 2011 코기토 Vol.- No.69

술탄 갈리예프는 비러시아계 무슬림 민족인 볼가 따따르인으로 러시아 혁명기에 활동한 마르크스주의자였고 반(反)식민 혁명가이자 이론가였다. 1917년 4월 바히토프와 함께 무슬림 민족 공산주의를 제창한 술탄 갈리예프는 10월 혁명 발발 직후 볼셰비키에 가입하였고 볼셰비키 조직 내의 영향력 있는 위치에서 러시아 내 민족 문제의 해결과 러시아 혁명의 수호에 앞장섰다. 그가 볼셰비키 내의 무슬림 민족위원회 위원장으로 활동하던 1918년 당시, 혁명 러시아는 어려움에 봉착하고 있었다. 서구의 자본주의 국가들은 러시아 내전에 간섭하여 백군을 직접 지원하고 있었고 혁명 러시아를 국제적으로 봉쇄하고 있었다. 볼셰비키 지도부는 이러한 고립에서 벗어나기 위하여 서구에서의 프롤레타리아 혁명을 기다리고 있었다. 하지만 결국 서구에서 프롤레타리아 혁명은 일어나지 않았고 혁명 러시아는 세계 사회주의 혁명의 실현이라는 전망을 상실해가고 있었다. 술탄 갈리예프는 동방 전술을 통해 혁명 러시아에 새로운 전망을 제시하고자 하였다. 술탄 갈리예프의 동방 전술은 프롤레타리아 민족 이론과 프롤레타리아 민족 독재 이론, 공산주의에 이르는 무슬림적 방식으로 더욱 구체화 된다. 프롤레타리아 민족 이론은 식민지의 사회주의 혁명을 이끌 주체를 정의한 것이었고, 프롤레타리아민족 독재이론은 식민지의 혁명을 세계 혁명으로 전화시키는 데 필요한 개념이었다. 또한 술탄 갈리예프는 식민지 동방에서의 사회주의 혁명을 성공적으로 수행하기 위하여 동방에서의 혁명 전술이 그 지역의 문화와 역사를 충분히 고려해야 한다고 주장했다. 이는 맑스주의의 유럽중심주의를 인식하고, 그것을 극복하고자 했다는 점에서 큰 의미가 있다. 이 같은 술탄 갈리예프의 이론들은 1960년대 식민지 해방운동의 국면에서 비서구의 마르크스주의자들 뿐 아니라 유럽의 포스트 마르크스주의 사상가들에게도 많은 영향을 미치게 된다. 그간 러시아혁명의 역사는 언제나 서구의 혁명가들을 중심으로 구성되어 왔다. 역사가들은 러시아 혁명을 레닌, 스탈린, 트로트키와 같은 인물들의 사상과 활동을 중심으로 서술했으며 술탄 갈리예프와 이슬람 민족공산주의자들을 철저히 외면해왔던 것이다. 이는 서구 마르크주의자들의 오만이었다. 제국주의가 본격적으로 시작된 이래 마르크스주의는 유럽뿐 아니라 억압과 착취가 존재하는 곳 그 어디에서든 해방을 위한 철학으로서의 역할을 해왔으며 그 중심에 비서구의 마르크스주의자들의 헌신적인 노력과 실천이 있었다. 그리고 비서구 마르크스주의의 역사적 전통, 그 시작에 술탄 갈리예프가 위치한다. Sultan Galiev was the most highest ranked muslim bolsheviks and most influential national communist in 1920’s USSR. He was a Marxist and Tatar nationalist. When he was chairman of Islam National Commit, USSR faced the a few difficult problems. Bolsheviks expected Proletarian Revolution in West Europe for escape these problem. They thought Russia Revolution was prologue of World socialist revolution. But Western Proletariat did not uprise. Sultan Galiev indicated new revolutional vision for Bolsheviks. He argued that Bolsheviks find their ally not West but East. This was his Eastern strategy. The Eastern strategy was composed of about three theory. Those are the Proletarian Nation, the Proletarian dictatorship over colonial Metropolises and the Muslim way to socialism. Sultan Galiev argued that the world was divided into oppressor nation and oppressed nation. All colonized nation was Proletarian nation. Therefore they will be subject of world socialist revolution. And the proletarian nations should have dictatorship over non revolutionary nation like western Europe nations for abolition world imperialism. These thesis are rereading of Marx-Leninist revolutionary theory for imperialist and colonialist world. The national communist seek to national way to communism. Sultan Galiev argued that Muslim people had their own way to achieve communist society. It would be Islamic and communistic way. After 1923 Stalin seized power of Russian communist party and Soviet Govermant. Stalin purge Sultan Galiev on Russian communist party and In 1928 liquidated all national communist in Soviet Union. After liquidation of national communist stalin argued that Stalinist is host of marxist revolutionary theory and eliminated all memories and contribution of Sultan Galiev and national communist. But ideas of Sultan Galiev and muslim national communist were revived in 1960’s when colonial liberation revolution had arisen strongly.

건강한 한국인 자원자에서 말레인산 이르소글라딘의 약동학적 특성에 관한 연구

이승환,임경수,김정렬,김재우,김보형,조주연,윤서현,신상구,장인진,유경상 대한임상약리학회 2009 Translational and Clinical Pharmacology Vol.17 No.1

Background : Irsogladin maleate, increasing gastric mucosal blood flow and cAMP in mucosal epithelial cells, is being marketed for the treatment of gastric ulcer and gastritis. The object of this study was to evaluate the pharmacokinetic characteristics and safety profiles of irsogladin maleate in Koreans. Methods : An open-label, dose-escalation, parallel group study was conducted in 28 healthy male Korean volunteers. Irsogladin maleate was administered as a single dose of 4 mg (n=16), 8 mg (n=6) or 16 mg (n=6). Serial blood samples for pharmacokinetic analysis were taken over 504 h. Plasma concentration of irsogladin was measured by high performance liquid chromatography – tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters were determined using noncompartmental methods. Laboratory tests, ECGs, vital signs and physical examinations were performed for clinical safety evaluation. Results : Maximum observed irsogladin plasma concentration (Cmax) (mean ± SD) of 4 mg, 8 mg and 16 mg dosage group were 82.9 ± 12.5 μg /L, 161.4 ± 25.9 μg /L and 292.6 ± 51.2 μg /L, respectively. Area under the plasma concentration versus time curve from dosing to the last quantifiable concentration (AUClast) of three dosage groups were 12694.4 ± 2906.2 μg *h/L, 24970.0 ± 5253.8 μg *h/L, 47125.3 ± 8676.7 μg *h/L, respectively. Apparent clearance (0.30 ± 0.07L/h, 0.31 ± 0.10 L/h, 0.31 ± 0.06 L/h, respectively) was unaffected by dosage. The 95% CI of slope of Dose-Cmax and Dose-AUClast linear regression were 15.4 – 19.6 and 2485.2 – 3262.0. All adverse events reported were mild and no clinically significant abnormalities of safety evaluation were observed. Conclusions : The pharmacokinetic characteristics of Irsogladin maleate after single dose administration was explored in healthy Korean volunteers. Irsogladin maleate displayed linear plasma pharmacokinetics over the dose range 4 - 16 mg. Irsogladin maleate was well tolerated after single dose administration in Koreans.