Prophylthiouracil에 의한 antineutrophil cytoplasmic autoantibodies 양성 급성 사구체 신염 1예

황석재(Seok Jae Hwang),김영설(Young Seol Kim),나학렬(Hak Reol Naa),오승준(Seung Joon Oh),양인명(In Myung Yang),김진우(Jin Woo Kim),최영길(Young Kil Choi),양문호(Moon Ho Yang) 대한내과학회 2000 대한내과학회지 Vol.58 No.3

Vasculitis is a rare complication of antithyroid drugs. Recently it was reported in association with ANCA. In most cases, the ANCA was specific for myeloperoxidase. The glomerulonephritis was key clinical manifestation in majority of cases. When antithyroid drugs were discontinued, clinical disease generally improved and ANCA titers were tended to fall. We experienced a 44 year old woman who presented with gross hematuria and generalized edema, after she had been treated with prophylthiouracil for 6 week for thyrotoxicosis. Renal biopsy was done, which showed mesangial proliferative glomerulonephritis. Indirect immunoflurorescence staining showed highly positive perinuclear pattern of ANCA in her serum. Prophylthiouracil associated ANCA positive glomerulonephritis was suspected. After cessation of prophylthiouracil and administration of prednisolone, renal function recovered gradually and ANCA titers were reduced. We hereby report a case of prophylthiouracil associated ANCA positive glomerulonephritis with a brief review of literature.(Korean J Med 58:330-334, 2000)

균혈증, 안내염 및 전립선농양이 합병된 Klebsiella pneumoniae 간농양 1예

황석재,나학열,서환조 대한감염학회 1998 감염 Vol.30 No.6

저자들은 평소에 건강했던 72세 남자 환자에서 균혈증, 안내염 및 전림선농양이 합병된 Klebsiella pneumoniae 간농양 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다. Metastatic infections were rare complications of Klebsiella pneumoniae lever abscess and bacterremia. However, over the past 15 years, they have become prevalent infectious complications in diabetic patients in Taiwan. A 72-year old man was admitted to Kyung-Hee University Hospital with fever, chill, dysuria, and frequency. On rectal examination the prostate gland was tender. Abdominal sonogram showed liver abscess. On hospital day 3, orbital pain, eyelid edema, conjunctival chemosis, hypopyon, and absence of light perception were noted in the right eye. K. pneumoniae was isolated from blood culture. The antimicrobial susceptibility test showed susceptibility to all antibiotics, except ampicillin. He was treated with ceftrizxone and astromicin intravenously for 3 weeks and follow un-transrectal sonogram revealed formation of prostatic abcess. We report a case of K. pneumoniae liver abscess complicated with bacteremia, endophthalmitis, and prostatic abscess.

소음인(少陰人) 곽란(藿亂) 병증(病證)에 대한 고찰(考察)("동무유고(東武遺稿)", "동의수세보원(東醫壽世保元)" 초본권(草本卷), 갑오본(甲午本), 신축본(辛丑本)을 중심으로)

석재화,함통일,황민우,고병희,송일병,이수경,Soek, Jae-Hwa,Ham, Tong-Il,Hwang, Min-Woo,Koh, Byung-Hee,Song, Il-Byung,Lee, Soo-Kyung 사상체질의학회 2005 사상체질의학회지 Vol.17 No.2

1. Objectives This study is to find changes of Dongmu Lee Je-Ma's conception about Soeumin Gwakran(곽란(藿亂)) Disease through comparing with his writings such as ${\ulcorner}$DongMuYooGo${\lrcorner}$, ${\ulcorner}$, ${\ulcorner}$SooSe Bowon Sasang chobon guen${\lrcorner}$, ${\ulcorner}$SooSe Bowon Gabobon${\lrcorner}$ and ${\ulcorner}$SooSe Bowon Sinchucbon${\lrcorner}$. 2. Methods We compared conceptions, symptom, mechanism and treatment of Soeumin Gwakran(곽란(藿亂)) Disease in ${\ulcorner}$DongMuYooGo${\lrcorner}$, ${\ulcorner}$SooSe Bowon Sasang Chobonguen${\lrcorner}$, ${\ulcorner}$SooSe Bowon Gabobon${\lrcorner}$ and ${\ulcorner}$SooSe Bowon Sinchucbon${\lrcorner}$ 3. Results and Conclusions (1) In ${\ulcorner}$DongMuYooGo${\lrcorner}$ and ${\ulcorner}$SooSe Bowon Sasang Chobonguen${\lrcorner}$, Dongmu Lee Je-Ma?s conception about soeumin Gwakran(곽란(藿亂)) Disease is yet based on previous traditional medicine based on ${\ulcorner}$DongEuiBoGam${\lrcorner}$ (2) In ${\ulcorner}$SooSe Bowon Gabobon${\lrcorner}$, Seupgwakran(습곽란(濕藿亂)) is described within the catego of Taeum syndrome(태음병(太陰病)), and Geongwakran(건곽란(乾藿亂)) is described within the catergory of Soeum syndrome(소음병(少陰炳)). But conception about Soeurnin Gwakran(곽란(藿亂)) Disease is not yet definitely settled. (3) In ${\ulcorner}$SooSe Bowon Sinchucbon${\lrcorner}$, Geongwakran(건곽란(乾藿亂)) is described within a severe case of Taeum syndrome(태음병(太陰病)) ? Dongmu Lee Je-Ma? s conception about Soeurnin Gwakran(곽란(藿亂)) Disease is changed.

기능성소화불량의 식적설문지 개발과 신뢰도 및 타당도 검정

황미니,하나연,고석재,박재우,김진성 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.3

Objectives: Several pattern diagnosis questionnaires have been developed to objectify the process of pattern diagnosis in Korean medicine. In this context, this study aimed to develop a food retention questionnaire for functional dyspepsia (FRQ-FD) by modifying the previously developed food retention questionnaire (FRQ) and to verify its reliability and validity. Furthermore, this study aimed to identify the optimal cut-off value of the FRQ-FD for standardization and use in clinical situations. Methods: To develop the FRQ-FD, we extracted the major symptoms of food retention pattern for functional dyspepsia from Chinese/Korean medicine textbooks and requested an importance survey from experts using the Delphi method. The first draft of the FRQ-FD was composed of 25 questions comprising 8 questions from the textbooks and the Delphi method and 17 questions from the FRQ already developed in 2013. To analyze its reliability, validity, and optimal cut-off value, 60 subjects were enrolled in this study from June 25 to August 13, 2018. Thirty patients were diagnosed as both functional dyspepsia and food retention pattern, and 30 healthy participants were not. All participants were requested to fill up the FRQ-FD, Stomach Qi Deficiency Questionnaire (SQDQ), Scale for Stomach Qi Deficiency pattern (SSQD), visual analog scale (VAS) for dyspepsia, Nepean Dyspepsia Index-Korean version (NDI-K), and functional dyspepsia-related quality of life (FD-QoL). Results: No statistically significant differences were found in sex distribution, age, and body mass index between the patient group and the control group. As five questions affected the reliability negatively and three questions affected the clinical validity negatively, we decided to exclude the eight questions upon further investigation. The Cronbach’s α coefficient of the revised FRQ-FD (17 items) was 0.899, and its clinical validity was verified. Construct validity was analyzed by factor analysis and produced five factors. Statistically significant positive correlations were found between the revised FRQ-FD and the other dyspepsia scales, namely, SQDQ, SSQD, VAS, NDI-K, and FD-QoL. VAS and NDI-K especially had strong positive correlations with FRQ-FD. Conclusions: The FRQ-FD developed in this study can provide fundamental reliability and validity for a pattern diagnosis questionnaire. FRQ-FD can help to diagnose food retention pattern in functional dyspepsia patients. Further studies are required to inspect several statistical factors.

자가면역성 뇌척수염 흰쥐의 활성화된 신경아교세포에서 증가된 osteopontin의 발현

박석재,황인선,김규범,신태균,지영흔,Park, Suk-jae,Hwang, In-sun,Kim, Gyu-beom,Shin, Tae-kyun,Jee, Young-heun 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.3

Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). Autoimmune inflammation is maintained by secretion of a large number of protein. Previous studies have suggested that transcripts encoding osteopontin (OPN) are frequently detected in the mRNA population of MS plaques. To elucidate the functional role of OPN in initiation and development of EAE, we examined the expression and localization of OPN in the spinal cord during acute EAE. We demonstrated that OPN significantly increased at the early stage of EAE and slightly declined thereafter by western blot analysis. An immunohistochemical study revealed that OPN was constitutively expressed in some glial cells (microglia, astrocytes) of white matter and neurons in the CNS of control rats. OPN expression was shown to be increased in the same cells at the early and peak stage of EAE. To identity cells expressing OPN by double-immunofluorescence labeling, we labeled rat spinal cord sections for OPN with a monoclonal OPN antibody and with mAbs for astrocyte (GFAP), microglia/macrophage (OX42)-specific markers. The major cell types of OPN-expressing cells were activated astrocytes and microglia in the adjacent inflammatory lesions. Interestingly, OPN was mainly expressed in the end feet of astrocytes around vascular cell adhesion molecule-1 (VCAM-1) expressing endothelial cells of CNS blood vessel. These findings suggest that increased levels of OPN in activated glial cell may play an important role in the recruitment of inflammatory cells into the CNS parenchyma during EAE.

사상체질진단 두면부 분석프로그램의 Upgrade 연구 : 성별.연령별 특징

석재화,윤종현,이준희,황민우,조용진,고병희,이의주,송일병,Seok, Jae-Hwa,Yoon, Jong-Hyun,Lee, Jun-Hee,Hwang, Min-Woo,Cho, Yong-Jin,Kho, Byung-Hee,Lee, Eui-Ju,Song, Il-Byung 사상체질의학회 2007 사상체질의학회지 Vol.19 No.3

1. Objectives Facial features are the important personal characteristics. As a study of all the standardization research about the morphology of face and head, this study was carried out to find the differences according to sex, age. 2. Methods We have collected 1140 cases of patients of the Sasang constitutional Department of Kyung-Hee Medical Center and Kangnam Kyung-Hee Oriental Hospital. we took pictures their frontal view, lateral view of face and measured height, breaths and projected length of face with Face Features Measurement Program(FFMP) and analyzed shape differences of face according to sex, age. 3. Results We got the morphologic characteristics of face according to sex, age. And we will upgrade the Sasangin Classification System by this Morphologic study of Head and Face. 4. Conclusions 1) The morphologic characteristics of face according to sex (1) A man's head is longer and wider than a woman's in most measurement. (2) A woman's eye is bigger in height than man's. (3) A woman's face is looked full-filled than man's. (4) A man's polion is higher than pupil but a woman's polion is lower than pupil. 2) The morphologic characteristics of face according to age (1) Young age's forehead is longer and higher than old age's. (2) Young age's eyebrow is wider than old age's (3) Young age's eye is bigger in height than old age's (4) Old age's nose is longer, wider and lower than young age's (5) Old age's ear is longer than young age's (6) Old age's bigonial breath is wider than young age's (7) Old age's low face is extinguished than you age's

3차원 안면자동인식기(3D-AFRA)의 안면 표준점 인식 정확도 검증

석재화,조경래,조용범,유정희,곽창규,황민우,고병희,김종원,김규곤,이의주,Seok, Jae-Hwa,Cho, Kyung-Rae,Cho, Yong-Beum,Yoo, Jung-Hee,Kwak, Chang-Kyu,Hwang, Min-U,Kho, Byung-Hee,Kim, Jong-Won,Kim, Kyu-Kon,Lee, Eui-Ju 사상체질의학회 2007 사상체질의학회지 Vol.19 No.1

1. Objectives The Face is an important standard for the classification of Sasang Contitutions. Now We are developing 3D Automatic Face Recognition Apparatus to analyse the facial characteristics. This apparatus show us 3D image of man's face and measure facial figure. We should examine accuracy of position recognition in 3D Automatic Face Recognition Apparatus(3D-AFRA). 2. Methods We took a photograph of Face status with Land Mark by using 3D-AFRA. And We scanned Face status by using laser scanner(vivid 700). We analysed error average of distance between Facial Definition Points. We compare the average between using 3D-AFRA and using laser scanner. So We examined the accuracy of position recognition in 3D-AFRA at indirectly. 3. Results and Conclusions The error average of distance between Right Pupil and The Other Facial Definition Points is 0.5140mm and the error average of distance between Left Pupil and The Other Facial Definition Points is 0.5949mm in frontal image of face. The error average of distance between Left Pupil and The Other Facial Definition Points is 0.5308mm and the error average of distance between Left Tragion and The Other Facial Definition Points is 0.6529mm in laterall image of face. In conclusion, We assessed that accuracy of position recognition in 3D-AFRA is considerably good.

자발적으로 소실된 특발성 후복막 혈종 1예

황유정 ( Yu Jeong Hwang ),진석재 ( Suk Je Jin ),정용진 ( Yong Jin Jeong ),명형준 ( Hyung Joon Myung ),신혜영 ( Hae Young Shin ),김호동 ( Ho Dong Kim ),주영은 ( Young Eun Joo ) 대한소화기학회 2021 대한소화기학회지 Vol.78 No.5

A 54-year-old man was transferred from another hospital due to a hematoma in the third portion of the duodenum on abdomen CT. He had been admitted for 2 weeks due to vomiting at another hospital. He had abdominal discomfort and nausea without abdominal pain when he visited the Gwangyang Sarang Hospital. Other than a distended abdomen and mild general abdominal tenderness, the results of physical examination were unremarkable. Abdominal CT revealed an approximately 9 cm thick walled hematoma at the anteroinferior site of the duodenal third portion. Upper endoscopy revealed stenosis of the third portion of the duodenum without mucosal lesions. The endoscope was not advanced through the narrowed duodenal lumen. A retroperitoneal hematoma was diagnosed, and his state was classified as subacute rather than acute based on the duration. The surgeon did not recommend surgical treatment. Urgent treatment was unnecessary; he was managed conservatively. The size of the hematoma decreased from 9.0 cm to 5.8 cm on the following CT. He could begin to eat food on the 26th admission day, and he was discharged on the 31st admission day. The hematoma disappeared entirely on the following CT. This paper describes a rare case of idiopathic retroperitoneal hematoma with a spontaneous resolution. (Korean J Gastroenterol 2021;78:295-299)

악심(惡心) 구토(嘔吐)를 주소(主訴)로 하는 소양인(少陽人) 표병증(表病證) 환자(患者)의 치험(治驗) 일례(一例)

석재화,황민우,최경주,이갑수,고병희,송일병,이수경,Seok, Jae-Hwa,Hwang, Min-Woo,Choi, Kyung-Ju,Lee, Kab-Soo,Koh, Byung-Hee,Song, Il-Byung,Lee, Soo-Kyung 사상체질의학회 2005 사상체질의학회지 Vol.17 No.3

1. Objectives This case is to report that a Soyangin patient with nausea and vomiting treated by Soyangin's Constitutional medications 2. Methods This patient was treated by several Constitutional medications and acupuncture treatment according to the result of Sasang Constitutional diagnosis with western management. We used Visual analogue scale(VAS) for the assessment of nausea and vomiting. 3. Results and Conclusions This patient's chief complants were nausea and vomiting. So he was treated by Soyangin's Constitutional medications(especially Hyeongbangpaedok-san, Dojeokganggi-tang and Hyeongbangsabaek-san) and showed a positive response about his symptom. But then we consider that studies about that case like this are more needed.

서울시내 일부 종합병원에서 K. pneumoniae로 분리동정된 인돌 양성균주에 대한 조사 연구

맹석재,리도현,황선철 한림대학교의료원 1981 人間科學 Vol.5 No.6