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관상피내암, 관상피내암을 포함한 침윤성 유관암 및 점액성암에서 HER-2/neu와 Paxillin의 발현 양상
한선욱,최윤영,우희두,손두민,배상호,강길호,김성용,백무준,임철완,이문수,김창호,이민혁,노진혁,조현득,오미혜,김의한,조무식 한국유방암학회 2008 Journal of breast cancer Vol.11 No.3
Purpose : We purpose to determine the correlation of HER-2/neu and paxillin expression in ductal carcinoma in situ(DCIS), invasive ductal carcinoma with ductal carcinoma in situ(IDC with DCIS) and mucinous carcinoma. Method : To evaluate the expression of HER-2/neu and paxillin, the immunohistochemical staining was performed for 13 cases of DCIS, 13 cases of IDC with DCIS and 6 cases of mucinous carcinoma. Results : The DCIS and IDC were associated with infiltration of the inflammatory cells, especially in the comedo type and solid type of tumor. In cases with infiltration of the inflammatory cells, HER-2/neu and paxillin were strongly expressed. When comparing the expression level of HER-2/neu from adjacent normal tissue between DCIS and IDC with DCIS, expression of HER-2/neu was similar to that of normal tissue adjacent to DCIS. However, in the adjoining normal ductal epithelial cells, paxillin was highly expressed in cells of all of the tumor types, and especially for IDC with DCIS. HER-2/neu and paxillin were not expressed in mucinous carcinoma cells in all cases. Conclusion : HER-2/neu in the DCIS and IDC with infiltration of inflammatory cells shows higher expression than non-inflammatory DCIS and IDC. If normal duct epithelial cells show a high level of HER-2/neu expression, the epithelial cells have a high probability of transformation into anaplastic cells. However, paxillin appears to have no value as a prognostic factor. The difference of expression of HER-2/neu between IDC with DCIS and DCIS suggests a different origin of tumor cells. The growth pattern of mucinous carcinoma cell is different from the that of DCIS or IDC cell, which grow slowly.
Hyalinizing Trabecular Tumor of the Thyroid Gland
한선욱,이진형,우희두,조현득,송민수,김성용,박래경 대한갑상선-내분비외과학회 2012 The Koreran journal of Endocrine Surgery Vol.12 No.2
A Hyalinizing Trabecular Tumor (HTT) is a very rare tumor. We report one case that was confirmed to be HTT after an operation. A 44-year-old female visited our hospital with about a 1.3-cm-sized mass on the left thyroid. Fine Needle Aspiration Biopsy (FNAB) indicated papillary thyroid cancer. After a left hemithyroidectomy, a frozen section biopsy reported the possibility of HTT. Therefore, we did not proceed with the surgery. According to the final report, she was diagnosed with HTT. Five lymph nodes were dissected and were found to be benign. Thyroid transcription factor-1 and neuron specific enolase were positive, and in addition calcitonin was negative. Ki-67 was recorded to be less than 5%. She was discharged without any complication. HTT is benign in most cases, but the possibility of malignancy should be considered. Because it is hard to differentiate between it and PTC or MTC, an accurate diagnosis through histologic examination of specimens and surgical resection is necessary.
유방암에서 mTOR 및 pAkt의 발현과 에스트로겐/ 프로게스테론 수용체와의 연관성 및 예후에 관한 분석
한선욱,김성용,이문수,강길호,김지선,임철완,이지현,이현주,오미혜,이민혁 한국유방암학회 2013 Journal of Breast Disease Vol.1 No.1
Purpose: The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway is a critical signaling pathway downstream of the growth factor receptor tyrosine kinase that regulates cell growth and survival. Rapamycin, an inhibitor of the mTOR, possesses antitumor activity against many tumors including breast cancer, especially against estrogen receptor (ER) positive breast cancer cell lines. In this study, the expression of mTOR and pAkt in breast cancer, its association with ER/progesterone receptor (PR) and prognosis were examined. Methods: Formalin fixed paraffin-embedded 170 cases of the breast cancer were immunohistochemically stained, using rabbit monoclonal antibody mTOR and rabbit monoclonal antibody pAkt. Based on this, the expression pattern of ER/PR and mTOR/pAkt were analyzed, and outcomes were also investigated. Results: mTOR expression was positive in 110 of 170 cases (64.7%) and pAkt expression was positive in 130 of 170 cases (76.5%). In correlation between clinicopathologic factors and mTOR/pAkt expression, mTOR expression was correlated with ER/PR positive and pAkt expression was correlated with age (>65), postmenopause. But there is no statistically significant in correlation between survival and mTOR/pAkt expression. Conclusion: The expression of pAkt was correlated with postmenopausal women and increased age, and we found the expression of ER/PR increased mTOR. The results provide a rationale basis for future clinical development of mTOR inhibitor combined ER inhibitor in breast cancer.
한국현대상업건축(韓國現代商業建築)에서 나타난 비물질적(非物質的) 표현(表現) 특성(特性)에 관한 연구(硏究)
한선욱,장미현,김정재,Han, Sun-Wook,Jang, Mi-Hyun,Kim, Jung-Jae 한국건축역사학회 2002 건축역사연구 Vol.11 No.1
Contemporary architecture is developing aspects of variety design in form and material. The various architectural trends even change classical materiality. This concept has the background of current idea - digital, information, imagination with paradigm. So this study aims to show the present status of the expressions in the contemporary architecture in Korea under its dematerialized situation. And like this, we know for study about the relation between dematerialization and current architecture, still more Korean present condition. In chapter one, the background, purpose and method of study are explained. In chapter two, this study inquires the general concept of dematerial. In the process of searching for the forming basic background this study understands the characteristic. In chapter three, this study inquires the aspect of dematerialized expression in modern architect. In chapter four, with characteristics drawn in chapter three, this study show the present status of the expressions in the contemporary architecture in Korea under its dematerialized situation. In chapter five, a synthetic conclusion is presented.
현대주택 외관에 나타난 비물질적 표현 특성에 관한 연구 -1990년 이후 국내 사례를 중심으로-
한선욱,김정재 한국주거학회 2002 한국주거학회 논문집 Vol.13 No.5
Contemporary architecture shows complex aspects of various design in form and material. Such trends even change classical materiality and this concept is believed to be the background of current ideas - digital, information, imagination with paradigm. This study inquires the general concept of dematerial. In the process searching for the forming basic background this study understands the characteristic. With characteristics drawn in chapter three, this study show the present status of the architectural expressions in the contemporary house in Korea under its dematerialized situation. And like this, we know fur study about the relation between dematerialization and current architecture, still more Korean present condition.