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최홍미,김형관,신효선,이승아,이희선,오규철,이승표,김용진,조구영,손대원 한국심초음파학회 2012 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.20 No.4
Takayasu’s arteritis is a chronic inflammatory disorder that mainly involves medium to large sized arteries. Although pulmonary artery involvement is reported with a prevalence of about 10% to 50%, its clinical significance is underestimated. We report here one case of Takayasu’s arteritis complicated by severe pulmonary hypertension due to right main pulmonary artery total occlusion.
흰쥐 혈액-태반 관문의 태아측 합포체성 영양세포막에서 콜린의 수송
최홍미,강영숙 숙명여자대학교 약학연구소 2006 약학논문집-숙명여자대학교 Vol.23 No.-
The placental transport of choline is very important because the fetus cannot supply it by themselves and it is required for methylation, biosynthesis of phospholipids and cell signaling. We examined the characteristics of choline transport across the placenta using rat conditionally immortalized syncytiotrophoblast cell line (TR-TBT) in vitro. The uptake of [³H]choline in TR-TBT 18d-2 cells was increased with increasing time. The choline transport process was saturable with a Michaelis-Menten constant (Km) of 130 ± 37 μM, a K_(d) of 0.826 ± 0.084 μM and a V_(max) of 826 ± 223 pmol/mg protein/min in TR-TBT 18d-2 cells. [³H]Choline uptake was significantly inhibited by an excess amount of choline itself and by hemicholinium-3, a structural analog of choline. However organic anion, nicotinic acid, did not affect [³H]choline uptake in TR-TBT 18d-2 cells. In addition, [³H]choline uptake in this cells, blood-placental barrier, was Na^(+)- and pH- dependent. These results suggest that choline may be transported by a carrier-mediated transport system in TR-TBT 18d-2 cells.
SystemC를 이용한 RISC 코어 구현에 관한 연구
최홍미,정갑천,박성모 전남대학교 전자통신기술연구소 2002 전자통신기술논문지 Vol.5 No.1
As techniques for progressing semiconductor have developed SOC(System-on-Chip) which has capacity of concentration a huge and complex system into a chip has recently drawn a great deal of attention. Therefore, creating a new alternative to traditional methods in system designing becomes necessary. The design environment on the basis of C/C ++is programmed to surmount the liabilities such as timing, clock, delay, parallel processing or reactive movements, etc, which the previous language could not properly describe. The present study investigates the design environments on the level of system and also describes core model of algorithm, function, and resister transmission levels, expecially attentive to the embodiment of RISC core. SystemC was used for the purpose of proving its effectiveness in the new design environment.
아데포비어의 안전성 및 유효성 평가를 위한 시판 후 조사
신근영,최홍미,오신영,김준형,이일섭,권영오 대한임상약리학회 2011 Translational and Clinical Pharmacology Vol.19 No.2
Background: To investigate the safety and effectiveness of adefovir in Korean patients with chronic hepatitis B, an observational study was carried out. Methods: A total of 4,393 patients with chronic hepatitis B were enrolled from February 2004 to February 2010. For the safety assessment, investigators recorded the occurrence of observed and patient-reported adverse events (AEs) throughout the course of treatment. Antiviral effectiveness was assessed by measuring the degree of symptom improvement and the reduction of HBV DNA after 12 weeks of treatment. Results: Of the 4,393 patients, 4,158 patients were evaluated for safety and 3,867 patients for effectiveness assessment. A total of 118 AEs were reported in 4,158 patients (1.8 %). The most frequent AE was hepatic failure (0.2 %) followed by coughing (0.2 %), hepatic neoplasm (0.2 %), abdominal pain (0.1 %), dyspepsia (0.1 %), nausea (0.1 %), flatulence (0.1 %), hepatic cirrhosis (0.1 %), asthenia (0.1 %), increase in sputum production (0.1 %), and varicose vein (0.1 %). The incidence of unexpected AEs was 0.9 %. Forty-nine cases of serious AE were reported in 32 patients but all of those were thought to be unrelated to adefovir according to physician’s evaluations. The rate of subjects with well effectiveness was 96.2 %. Conclusion: Adefovir was clinically well tolerated and effective in treatment of chronic hepatitis B patients.