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Hippocampus-dependent Task Improves the Cognitive Function after Ovariectomy in Rats
천송희 질병관리본부 2017 Osong Public Health and Research Persptectives Vol.8 No.3
Objectives: Estrogen is an important hormone for cell growth, development, and differentiation by transcriptional regulation and modulation of intracellular signaling via second messengers. The reduction in the estrogen level after ovariectomy may lead to cognitive impairments associated with morphological changes in areas of the brain mediate memory. The aim of the present study was to find out the effect of tasks on the cognitive function after ovariectomy in rats. Methods: The animals used in the experiment were 50 Sprague-Dawley female rats. This study applied a hippocampus-independent task (wheel running) and a hippocampus-dependent task (Morris water maze) after ovariectomy in rats and measured the cognitive performance (objectrecognition and object-location test) and growth-associated protein 43 (GAP-43) and neurotrophin 3 (NT-3) expression in the hippocampus, which is an important center for memory and learning. Results: There were meaningful differences between the hippocampus-independent and hippocampus- dependent task groups for the object-location test and GAP-43 and NT-3 expression in the hippocampus, but not the object-recognition test. However, the hippocampus-independent task group showed a significant improvement in the object-recognition test, compared to the control group. Conclusion: These results suggest that hippocampus-dependent task training after ovariectomy enhances the hippocampus-related memory and cognitive function that are associated with morphological and functional changes in the cells of the hippocampus.
근육열상에 대한 초기 전기자극이 C-fos와 TGF-β1 발현에 미치는 영향
천송희(Cheon Song-Hee),김훈(Kim Hoon) 한국체육과학회 2009 한국체육과학회지 Vol.18 No.1
Pain is the sign to protect body from injurious stimuli. Muscle pain related with exercise results in muscle weakness and range of motion (ROM) decrease. Inappropriate application of the treatment for painful condition induces many poor outcomes. The purpose of this study was to investigate effects of early electrical stimulation on pain and healing process after muscle tearing of rats. Male Sprague-Dawley rats (N=30), ages from 8 to 10 weeks and weight from 270 to 350 g were used for this study. Muscle injuries were produced on the right gastrocnemius muscles. Electrical stimulation was applied to experimental group (N=15) on injured site at 1, 2 and 3 day. The expressions of c-fos on spinal cord and transforming growth factor β1(TGF-β1) at injured site by immunohistochemistry were used for the result of pain and muscle healing, respectively. Between experimental and control group, the c-fos and TGF-β1 expressions after muscle tearing were significant different. Both groups were observed changes of c-fos and TGF-β1 expressions with the lapse of time, but the expressions were more significant in experimental group than in control, and this differences were remarkable at 1 day after muscle tearing. These results suggest that early electrical stimulation after muscle tearing is essential factor for early phase after muscle tearing. In conclusion, electrical stimulation was contributed to pain control and muscle healing and could be used for muscle tearing treatment.
운동훈련이 미만성 축삭손상을 일으킨 흰쥐의 해마에 미치는 영향
천송희(Song-Hee Cheon) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.1
미만성 축삭손상(diffuse axonal injury)은 외상성 뇌손상의 일반적인 형태이며, 인지 장애의 주요 원인으로 생각되어 진다. 흔들린 아기 증후군(shaken baby syndrome)과 같이 뇌에 전단력이 심하게 가해졌을 때도 신체 장애 뿐만 아니라 인지 장애가 특징적으로 나타난다. 신체 활동은 건강 증진과 더불어 기억 및 학습과 관련된 해마의 기능 향상에도 영향을 미친다. 본 연구의 목적은 흰쥐를 대상으로 미만성 축삭손상을 일으킨 후 반복적인 운동 훈련을 통해 운동 수행력을 관찰하고 해마에서 GAP-43의 발현을 통해 축삭 재생의 변화를 관찰하는 것이었다. 실험동물은 운동 훈련을 적용시키는 실험군과 대조군으로 구분하였고, 각각의 군을 다시 1일, 7일 및 14일군으로 구분하였다. 그 결과, 운동 훈련을 적용시킨 실험군이 대조군보다 운동 수행력의 향상이 더 유의했으며, 해마에서 GAP-43의 발현도 같은 양상을 나타냈다. 이러한 차이는 7일군과 14일군보다 1일군과 7일군 사이에 더 크게 나타났다. 그러므로 미만성 축삭손상 후 운동 훈련은 운동 수행력의 향상에 영향을 미치며, 인지와 관련된 해마의 구조적 변화도 야기 시키는 것으로 생각된다. Diffuse axonal injury(DAI) is a common form of traumatic brain injury and thought to be a major contributor to cognitive dysfunction. Physical activity has been shown to beneficial effects on physical health and influences in hippocampus which is an important location for memory and learning. The purpose of this study was to investigate the effect of motor training on motor performance and axonal regeneration in hippocampus through the immunoreactivity of GAP-43 after diffuse axonal injury in the rats. The experimental groups were applied motor training(beam-walking, rotarod, and Morris water maze) but control groups were not. The time performing the motor tasks and GAP-43 immunohistochemistry were used for the result of axonal recovery. There were meaningful differences between experimental groups and control groups on motor performance and GAP-43 immunohistochemistry. The control groups showed increasing tendency with the lapse of time, but experimental groups showed higher. Therefore, Motor training after DAI improve motor outcomes which are associated with dynamically altered immunoreactivity of GAP-43 in axonal injury regions, particularly hippocampus, and that is related with axonal regeneration.
감각통합치료가 주의력에 문제가 있는 자폐스펙트럼아동에게 미치는 영향
김보경,박신희,방현선,천송희,한재화,전병진 대한작업치료학회 2010 대한작업치료학회지 Vol.18 No.4
목적 : 본 연구는 주의력에 문제가 있는 자폐스펙트럼아동에게 감각통합치료를 적용하여 주의집중력에 미치는 영 향을 전산화신경인지검사를 통하여 알아보고자 하였다. 연구방법 : 대전광역시의 주간보호센터에 있는 만 10세와 12세의 자폐스펙트럼아동을 2명을 대상으로 회기 당 30 분씩 총 13회의 감각통합치료를 실시하였다. 연구 설계는 AB 단일실험연구를 사용하였고, 주의집중력의 변화는 치료 전, 중, 후 3회에 걸쳐 전산화신경인지 검사를 통하여 지속 및 선택적 주의집중력을 측정하였다. 모든 치료 회 기 동안 선택적 주의집중을 확인하기 위해서 별지우기 검사를 실시하였다. 자료 분석은 회기별 변화정도를 시각적 그래프로 제시하였다. 연구결과 : 별 지우기 검사와 전산화 신경인지기능검사를 통하여 감각통합치료 후 주의 집중력을 측정하였을 때, 전 반적으로 주의 집중력이 향상되었다. 결론 : 감각통합치료가 자폐스펙트럼아동의 주의집중력에 긍정적인 영향을 미치는 결과를 보임으로써 작업치료 임 상에서 주의집중력 향상을 위하여 감각통합치료가 사용할 수 있다
흰쥐의 피부화상 후 저강도 레이저 조사가 Substance P의 발현에 미치는 영향
구현모,이선민,남기원,김석범,천송희,강종호,김진상,Koo Hyun-Mo,Lee Sun-Min,Nam Ki-Won,Kim Souk-Boum,Cheon Song-Hee,Kang Jong-Ho,Kim Jin-Sang 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3
This study was performed to investigate the effect of low power laser irradiation on Substance P(SP) expression in the burned skin of the rats. Burns of about 3cm in diameter were created with $75^{\cric}C$ water on the back of the rats, and the lesion of experimental group were irradiated on days 1, 2, 3 and 4 postwounding. Control leasions were not irradiated. After burns, low power laser irradiation was applied by using 1000Hz, 830nm GaAlAs(Gallium-aluminum-arsenide) semiconductor diode laser. The expression of evaluated Substance P(SP) immunohistochemistry on rabbit anti-SP The results of this study wereas follows 1. The Substance P was expressed in the lamina I and II of dorsal horn of spinal cord. In expression of SP, the lesion of control group made SP to more induce significantly than experimental leasions. 2. SP immunoreactivity in burned leasion of spinal cord were decreased markedly 4 days after burns, and decreased gradually from 1 day to 2 days in burns which is laser irradiation These data suggest that low power laser have a pain release effect in the burned skin of the rats.