http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
도연실 ( Yeon Sil Do ),이진영 ( Jin Young Lee ),김형진 ( Hyung Jin Kim ),김응호 ( Eung Ho Kim ),채지영 ( Ji Young Chai ),전찬홍 ( Chan Hong Jeon ),차훈석 ( Hoon Suk Cha ),고은미 ( Eun Mi Koh ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.1
Sarcoidosis is a systemic granulomatous disorder of unknown cause. The isolated noduar type muscular sarcoidosis without other systemic involvement is very rare in Korea. We report a case of sarcoidosis presented with myofasciitis. A 46-year-old man visited hospital with painful nodular swelling on the right arm for 1 month. We performed a humerus MRI and it revealed irregular shaped subcutaneous mass infiltrating along the fascial plane. The biopsy of triceps mass showed non-caseating granuloma of muscle and fascia. To find out the cause of granuloma, we checked chest CT scan and found out some enlargement of mediastinal lymph nodes. The biopsy also demonstrated non-caseating granulomas. It had no cancerous component and culture for microorganisms were all negative. He was diagnosed as sarcoidosis and given NSAID. On follow up evaluation, the size of mass was decreased.
류마티스 섬유모세포양 활막세포에서 저산소증 및 사이토카인에 의한 Aggrecanase-1과 Aggrecanase-2 발현 조절
김형진 ( Hyung Jin Kim ),배은경 ( Eun Kyung Bae ),김진희 ( Jin Hee Kim ),채지영 ( Ji Young Chai ),전찬홍 ( Chan Hong Jeon ),차훈석 ( Hoon Suk Cha ),안광성 ( Kwang Sung Ahn ),고은미 ( Eun Mi Koh ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2
Background: While aggrecanases (aggrecanase-1 and aggrecanase-2) are substantially responsible for cartilage aggrecan breakdown in rheumatoid arthritis (RA), not much information is available on the regulation or expression of the two key aggrecanases in rheumatoid fibroblast-like synoviocytes (FLS). The aim of this study is to determine the effect of hypoxia and several cytokines on the expression of the aggrecanases in rheumatoid FLS. Methods: FLS obtained from RA patients were cultured under hypoxic condition for 24 hours. Quantitative polymerase chain reaction assays for mRNA expression of aggrecanase-1 and aggrecanase-2 were performed on FLS cultured under hypoxia. Additionally, to see the effect of various cytokines, same experiments were conducted after treating FLS with IL-1β, IL-6, EGF, TGF-β and TNF-α, compared with control. Results: Hypoxia significantly increased both aggrecanase-1 and -2 mRNA expression in rheumatoid FLS compared with normoxia. IL-1β, IL-6, EGF, TGF-β and TNF-α upregulated the mRNA expression of aggrecanase-1. Both EGF and TGF-β upregulated the mRNA expression of aggrecanase-2, but TNF-α significantly downregulated the mRNA expression of aggrecanase-2. Conclusions: These results showed upregulation of aggrecanase-1 and -2 by hypoxia and differential regulation of aggrecanase-1 and -2 by various cytokines in rheumatoid FLS. It suggests that hypoxia and cytokines enhance the aggrecanase activity of RA FLS and contribute to joint destruction.(Korean J Med 71:182-188, 2006)
김형진 ( Hyung Jin Kim ),양정채 ( Jeong Chae Yang ),김성해 ( Sung Hea Kim ),채지영 ( Ji Young Chai ),전찬홍 ( Chan Hong Jeon ),차훈석 ( Hoon Suk Cha ),고은미 ( Eun Mi Koh ) 대한내과학회 2005 대한내과학회지 Vol.69 No.2
Behet`s disease is a systemic disorder presenting with recurrent oral and genital ulcerations as well as uveitis often leading to blindness. Although vascular lesions are common complications of this disease, cardiac involvement is extremely rare. A 34-year-old man was admitted to the hospital with intermittent low-grade fever 8 months ago. At that time, the echocardiographic examination revealed a right atrial wall mass that was initially thought to be a vegetation, and surgical excision was performed. Histological finding was consistent with organizing thrombus. The patient was readmitted to the hospital with fever, chill and sore throat for about 4 weeks. His past medical history included recurrent oral and genital ulcerations and uveitis for 5 years. Right atrial mass was seen again on echocardiographic examination. On the basis of the clinical course and the presence of recurrent cardiac thrombus, a diagnosis of Behcet`s disease with recurrent intracardiac thrombosis was made. The patient was treated with prednisolone, colchicine, cyclosporine, and aspirin. Medical therapy resulted in complete resolution of his symptoms and disappearance of the right atrial thrombus.(Korean J Med 69:227-230, 2005)
이유선 ( You Sun Lee ),고은미 ( Eun Mi Koh ),안중경 ( Joong Kyung Ahn ),전찬홍 ( Chan Hong Jeon ),채지영 ( Ji Young Chai ),차훈석 ( Hoon Suk Cha ),정만표 ( Man Pyo Chung ),한정호 ( Joung Ho Han ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.3
Sjogren`s syndrome is an autoimmune exocrinopathy characterised by decreased lacrymal and salivary gland function, resulting in keratoconjunctivitis sicca and dry mouth. The occurrence of malignant lymphoma is the most serious complication of Sjogren`s syndrome. Recent reports have found that MALT lymphoma accounts for 46~56% of the malignant lymphoma that develop in patients with Sjogren`s syndrome. The most common site of MALT lymphoma in patients of Sjogren`s syndrome is parotid gland, but we experienced two cases of MALT lymphoma of lung in patients with Sjogren`s syndrome. We report these cases with review of literature.
급성 신우신염이 선행된 Escherichia coli 농흉 1예
차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5
We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.
알코올 대사 효소들의 유전적 다형성이 음주 행태 및 간경변증 발생에 미치는 영향
기주영,김민옥,유일영,채지영,홍의실,안성철,김헌,박선미,윤세진,채희복 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.2
목적: 만성적인 다량의 음주에도 불구하고 알코올 중독자의 15%만이 알코올성 간경변증에 이르는데, 유전학적인 차이를 포함한 간질환에 대한 개인적인 감수성의 차이를 포함한 간질환에 대한 개인적인 감수성의 차이가 발병에 중요한 영향으리 미칠 것으로 생각된다. 이에 저자들은 정상 대조군, 과음주력이 있으나 간경변증의 증가가 없는 군, 알코올성 간경변증 환자군 간의 ALDH2, ADH2, CYP2E1, catalase의 네 가지 알코올 대사 효소의 유전자형 빈도 차이가 음주 행태 및 질환 발생을 어느 정도 설명할 수 있는 것인지를 알아보고자 하였다. 대상과 방법: 정상 성인 42명을 정상 대조군(평균연령 52±9세)으로, 임상적 혹은 방사선학적으로 알코올성 간경변증이 확실하게 증명된 30명을 알코올성 간경변증군(평균연령 52±9세)으로, 음주력은 있으나 간질환의 증거가 없는 12명을 과음주자군(평균연령 46±6세)으로 배정하였다. 환자의 말초혈액 백혈구에서 DNA를 추출한 후, ALDH2, CYP2E1, ADH2, catalasel 유전자에 대해 PCR을 시행한 후 제한 효소들로 처리하여 제한 분절길이 다형성으로 유전자형을 나누어 각 유전자형의 출현 빈도를 비교하였다. 결과: 1) 본 연구에서 검사한 정상 성인 남자 42예에서 알코올 대사 효소들의 유전자형 빈도는 ADH2는 (1*1), (1*2)가 38%, 36%, ADLH2 (1*1)(야생형), (1*2), (2*2)이 각각 69%, 28%, 2%의 비율로 나타났다. CYP2E1의 경우 c1/c1(야생형) 유전자형이 55%를 차지하였다. catalase1의 경우 TT(야생형)유전자형이 12%를 차지하였다. 2) 정상 대조군과 음주자군(과음주자군과 알코올성 간경변증 환자군의 합)간에 ALDH2 (1*2) 혹은 (2*2) 유전자형 빈도가 유의하게 음주자군에서 낮음을 알 수 있었다. 음주자군 중에서는 ALDH2 효소의 결핍형 동형접합체 ALDH (2*2)는 한 예도 없었으며 이형접합체만이 5예였으며, 나머지는 모두 야생형 동형접합체(88%)였다. 3) 정상대조군과 음주자 간에 ADH2, CYP2E1, catalase1 유전자의 유전자형 분포의 차이를 관찰할 수 없었다. 결론: ALDH2 결핍 유전자형 존재는 개인의 음주 행태에 영향을 미치는 인자이나, 존재는 개인의 음주 행태에 영향을 미치는 인자이나, 음주자군에서 그 결핍 빈도가 낮아 알코올성 간경변증 발병에 미치는 영향을 임상 연구를 통하여 규명하기에는 제한점이 있었다. ADH2, CYP2E1, CAT1 유전자의 경우에는 세 군간에 서로 의미 있는 차이가 없어 질병 발생과, 음주 행태에 있어서 이 유전자들의 역할은 미미할 것으로 생각된다. Background/Aims: Genetic variations of ethanol-metabolizing enzymes can affect alcohol drinking behavior. The aims of this study were to investigate and compare the distributions of these genetic polymorphisms between a healthy control group and a heavy drinker group which included an alcoholic liver cirrhosis group. Methods: Genotypes of ADH2, ALDH2, CYP2E1, and catalase were identified by polymerase chain reaction and restriction fragment length polymorphism. Genomic DNA was extracted from peripheral leukocytes in 42 healthy controls, 12 heavy drinkers, and 30 alcoholic liver cirrhosis patients. Results: 1) The genotype frequencies of ALDH2 (1*1), ADH2 (1*1), CYP2E1 (c1c1), and catalase1 (TT) were 69%, 55%, 38%, and 12%, respectively in healthy Korean males. 2) There was a significant difference in the distribution of the genetic polymorphism of ALDH2 between the control group and heavy drinker group (12 heavy drinkers and 30 alcoholic liver cirrhosis patients). The genotype frequency of ALDH2 mutant, ALDH2 (1*2) and ALDH2 (2*2) in the heavy drinker group (12%) was significantly lower than that in the control group (30%). 3) We didn’t find anyone with ALDH2 homozygote mutant (DD) in the heavy drinker group. 4) There was no significant difference in the distribution of genetic polymorphisms in ADH2, CYP2E1 and catalase1 between the two groups. Conclusions: These results suggest that the absence of ALDH2 mutant genotype is strongly related to heavy drinking behavior. We can not prove, however, and evidence that the polymorphisms of other ethanol-metabolizing enzymes are associated with the determination of alcohol-drinking behavior.