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Reduced Glutathione 및 人蔘抽出液이 X線 全身照射를 입은 마우스 肝組織의 蛋白量에 미치는 影響
蔡洙喜,權得基,金容彦,崔聖邱 최신의학사 1974 最新醫學 Vol.17 No.9
In an attempt to clarify the radioprotective effect of reduced glutathione (GSH), and to observe a possible radioprotective effect of Ginseng extract, whole body X-irradiation of 1, 200R was administered to the mouse either independently or immediately following the injection of GSH or Ginseng extract to the mouse intraperitoneally. The protein content of the liver was measured at 30, 60 and 120 minutes, and a comparison was made with the normal. The results obtained are summarized as follows; 1) The normal value of the protein content of the mouse liver was 106.2±2.4 mg/gm wet wt. 2) The protein content of the liver did not change appreciably from the normal by the injections of Ginseng extract or reduced glutathione. 3) When 1,200R of X-irradiation was administered, the protein content of the liver increased moderately at 30 and 60 minutes, but the value returned to the normal at 120 minutes. 4) When GSH was injected prior to the X-irradiation, the liver protein increased slightly . at 30 minutes, but the value was generally within the normal limit. 5) Injection of Ginseng extract prior to the X-irradiation produced a slight increase of the protein content of the liver at 30 minutes but the value did not change greatly from the normal throughout the experiment.
Reduced Glrtathione이 四鹽化炭素 中毒家兎의 肺胞表面活性物質의 活性度에 미치는 影響
蔡洙喜 中央醫學社 1975 中央醫學 Vol.29 No.2
The present study was undertaken to observe a possible damaging effect of carbon tetrachloride (CCl4) on the pulmonary surfactant activities, and to elucidate the effectiveness of reduced glutathione (GSH) on the pulmonary surfactant activities of the CC], intoxicated animal. The rabbit was used throughout the entire experiment, and the mixture of <CC14 and olive oil (1 : 1) in the dose of 0.3m1 or 0.5m1 per Kg BW was administered intraperitoenally twice weekly for one or two weeks, and the changes of the surfactant activities of the lung washings were observed one day after the respective CCl4 administration as a preliminary experiment to determine the appropriate dose of CC14 in the main experiment. All the experimental data obtained from the preliminary study showed decreased surfactant activities from the control, but when CCl4 mixture of 0. 3ml per Kg BW was administered twice weekly for one week, the decrease was not as prominent as when higher doses of CC14 were used, in which cases the decrease -was similar. From the above results, CC14 mixture of 0.3m1 per Kg BW was used twice weekly for two weeks in the main experiment, and the changes of the maximum and minimum surface tension, and stability index were studied on 1, 3 and 5 days after the CC], administration. The changes of the body weight and left lung weight were also measured, and the left lung weight/body weight ratio was thus calculated. GSH in the dose of 20mg per Kg BW was intraperitoneally administered either singularly or in combination with CC14i and the study was performed as in the case of CCLadministration. The results thus obtained are summarized as follows: 1) The maximum and minimum surface tension and stability index of the normal rabbit lung washings was 56.1'2.5 dyne/ cm, 5.5±1.2 dyne/cm and 1.70, respectively. The protein content of the lung washings was 100.3 ' 8.5mg/mI and the body weight, left lung 'eight and left lung weight/body weight ratio was 2.23±0.17 kg, 3.0±0.27gm and 1.35±0.15, respectively in the normal rabbit. 2) When 0.3m1 of the mixture of CC14 and olive oil per Kg BW was admini?stered twice weekly for one week, the surfactant activities of the lung washings did not change noticeably from the control values, but the surfactant activities decreased when 0.3m1 of CCI4 was administered twice weekly for two weeks: and the tendency was similar when the dosage of CCI4 was increased to 0.5m] for one or two weeks. 3) While administration of 0.3m1 of CCI4 alone twice weekly for two weeks, produced a decreased surfactant activities, GSH caused no change from the control. When GSH and CC14 were combined, the surfactant activities were lower than the GSH group, but higher than the CC", group. 4) The decrease of the body weight by CCI4 administration was prominent but left lung weight did not change noticeably. Thus, the left lung weight ratio was elevated from the control throughout the experiment. The protein contents, of the lung washings in the CC14 intoxicated group showed decreased values from the control. When GSH alone was used, the body weight, left lung weight, left lung weight/body weight ratio and protein content of the lung washings did not change from the control, but. the combined administration of GSH and CC14: produced higher values than the CCI4 group. 5) From the above, it may be concluded that CCI4 produces lowered surfactant activities. Also, GSH seems to be effective to some extent to minimize the damaging effect of CCI4 on the pulmonary surfactant activities