Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript

조수연,조수연,허일영,고재수,진성호,강혜진 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.2

Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.

흰쥐에서 안드로젠 및 항안드로젠투여후 대자 고환도내 Cord의 형태학적 관찰

조수연,윤문수 가톨릭대학 (가톨릭신학대학) 대학원 1995 가톨릭大學醫學部 論文集 Vol.48 No.1

용서 집단상담 프로그램의 효과에 대한 메타분석

조수연,권경인,이지현 한국상담학회 2015 한국상담학회 학술대회 논문집 Vol.2015 No.8

급성세균성전립선염의 임상적 특징 및 치료 결과

조수연,배웅진,조용현,이승주 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Acute bacterial prostatitis is an uncommon male urinary tract infection that is the result of severe prostatic infection mainly by gram-negative bacteria. We conducted a retrospective study to report clinical outcomes of patients with acute bacterial prostatitis. Materials and Methods : The clinical records of 49 patients diagnosed with acute bacterial prostatitis were reviewed retrospectively and patients' symptoms, investigations, and treatments were analyzed. Results : All patients presented with fever and voiding symptoms. Some patients (22.4%) had a history of prior manipulation of the lower urinary tract including transrectal prostate biopsy. Urine cultures were positive for 51% of the patients. The most common pathogen was Escherichia coli (60%), followed by Pseudomonas aeruginosa (20%) and Staphylococcus aureus (12%). The ciprofloxacin susceptibility against E. coli was 80%. All patients were treated with parenteral antibiotics in the hospital followed by oral antibiotics for average of three weeks. The major drugs used for empirical treatment were cephalosporins, aminoglycosides, and fluoroquinolones. Prostatic abscess was found in two (4.1%) Patients and chronic pelvic pain syndrome developed in six (12.2%) patients during follow-up. Conclusion : The currently used empirical antibiotics were mostly effective in the treatment of acute bacterial prostatitis. Continuous monitoring on antimicrobial susceptibility of acute bacterial prostatitis was necessary for providing proper treatment guideline.

도로시설물 안전관리 방향과 교통의 역할

조수연,박찬운(PARK, Chanwoon),김옥선,신성일(Sin, Seong-Il) 대한교통학회 2012 대한교통학회 학술대회지 Vol.67 No.-

전자부품을 내장한 시스템의 방사선 영향

조수연,신인철,김진용,유영준,박중우,노영환 제어로봇시스템학회 2014 제어로봇시스템학회 각 지부별 자료집 Vol.2014 No.11

The commercial grade components in the system are severely affected by various kinds of radiation particles. The advanced countries on the radiation hardening technologies for the passive and active components, which are mounted on the system, have been doing research in the field of radiation effects for electronic circuits for space and defense, and are at the level of stabilization. However, our country is the beginning stage of the related technologies. Thus, much research is required regarding these technologies. The electrical components are affected by dose, dose rate, and particle strength, then the electrical characteristics are not satisfied with the specifications, making mal-functions or error. In this paper, TID (Total Ionizing Dose) experiment at the low energy γ rays using 60Co and SEGR (Single Event Gate Rupture) experiment for a MOSFET mounted in DC/DC converter at the cyclotron facility with heavy ions are studied.

MLC(다엽콜리메이터) 입력방식에 따른 오차

조수연,유승연,양영란,김진숙,김해영,문은숙,이강식 대한방사선사협회 2003 대한방사선사협회지 Vol.29 No.1

기종성 신우신염의 임상양상 및 사망위험인자

조수연,이호재,조용현,이승주 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Emphysematous pyelonephritis (EPN) is an acute gas forming necrotizing infection of the renal parenchyma with high mortality. Although its incidence is relatively low, it mostly occurs in patients wiith diabetes mellitus. The aim of the study is to identify the risk factors related to mortality and assess the outcome of managements according to the radiologic classification. Materials and Methods : The clinical records of 23 patients diagnosed with EPN were reviewed retrospectively. The cases were grouped into two types on the basis of computed tomography scan. Type 1 EPN was defined as renal necrosis and gas formation with total absence of fluid content. Type 2 EPN was defined as the presence of renal or perirenal fluid in association with bubbly or loculated gas pattern. The patients' symptoms, performed investigations, and treatments were analyzed. Results : All patients had diabetes mellitus. Escherichia coli (78.6%) was the most common pathoqen in urine and blood cultures. The factors showing statistically significant differences between survivors and non-survivors were age (P=0.013), the presence of obstructive uropathy (P= 0.008), and type 1 group (P=0.030). Multivariate logistic regression showed that factor significantly related to death was age (odds ratio=1.20, 95% confidence interval 1.01-1.38, P=0.037). Conservative treatment including antibiotics and percutaneous drainage was successful in type 2 group, Overall mortality was 26.1%; all expired patients were from type 1 group. The mortality of conservative treatment and nephrectomy in type 1 group was 83.3% and 20.0%, respectively. Conclusion : These results suggest that old age is a significant risk factor for mortality in patients with EPN. Nephrectomy should be considered as the main treatment option in patients with type 1 EPN.

Analgesic Effects of Gyejibokryeong-hwan Aqueous Extracts on the Rat Model of Primary Dysmenorrhea

조수연,김동철,Cho, Su-Yun,Kim, Dong-Chul The Society of Korean Medicine Obstetrics and Gyne 2020 大韓韓方婦人科學會誌 Vol.33 No.3

목 적: 이 생체 내 연구의 목적은 인도메타신과 비교했을 때 쥐의 원발성 월경통에 대한 계지 복령환 열수 추출물의 진통 및 개선 효과를 관찰하는 것이다. 방 법: 랫트 PD 모델을 만들기 위해, Estradiol benzoate를 10일간 투여한 다음 마지막 10회 estradiol benzoate 투여 1시간 후 1 U/kg의 oxytocin을 투여하였다. 계지복령환 열수 추출물을 500, 250 및 125 mg/kg 용량으로 매일 1회씩 10일간 투여하였다. 이후 체중 및 실험 기간 동안의 체중 증가량, 자궁 중량 및 육안부검 소견, 진통 활성을 나타내는 abdominal writhing test, 자궁 조직 내 지질 과산화(Malondialdehyde, MDA 함량) 및 항산화 방어 시스템 - glutathione (GSH) 함량, superoxide dismutase (SOD) 및 catalase (CAT) 활성, Nuclear factor-κB (NF-κB) 및 cyclooxygenase (COX)-2 mRNA의 발현, 자궁의 조직병리학적 변화, tumor necrosis factor (TNF)-α 및 inducible nitric oxide synthase (iNOS)로 나타나는 면역조직 화학적 변화를 관찰하였다. 계지복령환 열수 추출물의 결과는 인도메타신 투여 쥐의 결과와 비교하였다. 결 과: Estradiol benzoate 및 oxytocin 투여 결과, 현저한 체중 및 증체량, 자궁 GSH 함량, SOD와 CAT 활성의 감소와 abdominal writhing 반응, 자궁 지질 과산화(MDA 함량), 자궁 중량, NF-κB 및 COX-2 mRNA 발현의 증가가 TNF-α 및 iNOS 면역반응세포와 염증세포 침윤 증가, 자궁의 충혈 및 확대와 함께 관찰되었다. 이는 전형적인 염증 및 산화 스트레스성 원발성 월경통이 잘 유도되었음을 의미한다. 한편 이러한 소견은 계지복령환 열수 추출물의 투여에 의해 용량의존적으로 현저히 억제되었으며, 인도메타신의 억제 효과보다는 낮았다. 결 론: 이 연구에서 얻은 결과는 계지복령환 열수 추출물이 estradiol benzoate 및 oxytocin으로 유도된 원발성 월경통에 용량-의존적으로 유리한 진통 및 개선 활성을 가짐을 시사한다. Objectives: The objective of this in vivo study is to observe the analgesic effects or improvements of Gyejibokryeong-hwan aqueous extracts (GJBRHe) on the Primary dysmenorrhea (PD) in rats as compared to those of Indomethacin (IND). Methods: The rats were administered with estradiol benzoate for 10 days and oxytocin 1 hour after the last 10th administration of estradiol benzoate to make the primary dysmenorrhea rat model. Gyejibokryeong-hwan aqueous extracts 500, 250 and 125 mg/kg were orally administrated, for 10 days once a day. Then the changes on the body weights and gains during experimental periods, uterine weights and gross inspections, abdominal writhing response for analgesic activities, uterus lipid peroxidation (malondialdehyde (MDA) levels), antioxidant defense system - glutathione (GSH) contents, activities of superoxide dismutase (SOD) and catalase (CAT), Nuclear factor-κB (NF-κB) and Cyclooxygenase (COX)-2 mRNA expressions, were monitored with uterus histopathology and immunohistochemistry for tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS). The results of Gyejibokryeong-hwan aqueous extracts were compared to those of Indomethacin adminstered rats. Results: As results of estradiol benzoate and oxytocin treatment, noticeable decreases of body weights and gains, uterus GSH contents, SOD and CAT activities, increases of abdominal writhing responses, uterus lipid peroxidation (MDA level), uterus weights, NF-κB and COX-2 mRNA expressions were observed with increases of TNF-α and iNOS immunolabeled cells, inflammatory cell infiltrations, congestion and enlargement of the uterus at gross and histopathological inspections. These means classic inflammatory and oxidative stress mediated primary dysmenorrhea are relatively well induced. However, these signs were favorably and dose-dependently inhibited by administration of three different dosages of Gyejibokryeong-hwan aqueous extracts, but lesser than those of Indomethacin. Conclusions: The results obtained in this study suggest that Gyejibokryeong-hwan aqueous extracts has favorable analgesic and refinement activities dose-dependently on the estradiol benzoate and oxytocin treatment-induced primary dysmenorrhea signs.

결손가정 청소년들의 사회적 지지와 학교적응

조수연,안귀여루 한국심리치료학회 2012 한국심리치료학회지 Vol.4 No.1

본 연구는 일반가정 학생과 결손가정의 학생이 지각하는 사회적 지지 정도의 차이, 가정유형별 학교적응 에 차이가 있는지를 살펴보고 가정유형별 사회적 지지 요인이 학교적응에 어떠한 영향을 미치는지를 알 아 보고자 하였다. 이 연구를 통해 얻어진 결과는 첫째, 인구통계학적 변인에 따라서 일반가정과 결손가정 사이에 성별 비 율, 학업성적에 있어서는 차이가 없었으나 주거형태, 소득 수준에서는 결손가정 학생이 유의하게 낮은 것으로 나타났다. 둘째, 가족형태에 따른 가족, 선생님, 친구의 사회적 지지 정도의 차이를 살펴보면 모 두 일반가정에 비해 결손가정 학생이 사회적 지지를 덜 받는다고 느끼는 것으로 나타났다. 셋째, 가족형 태에 따른 학교적응의 차이를 살펴본 결과 결손가정의 아이들이 일반가정의 아이들에 비해 학교적응을 잘 못하는 것으로 나타났다. 넷째, 사회적 지지가 학교적응에 미치는 영향을 살펴본 결과, 결손가정과 일 반가정의 학생 모두에게 있어서 선생님과 친구의 사회적 지지가 학교 적응을 유의하게 설명해 주는 것으 로 나타났다. 이러한 결과는 가족형태에 따라 사회적 지지 정도와 학교적응 수준에는 차이가 있었지만, 두 집단 모두가 청소년기의 학생들인 점을 봤을 때 학교생활 적응에 가장 큰 영향을 미치는 것은 교사와 친구임을 보여준다. 마지막으로 연구의 시사점과 제한점을 논의하였다.