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고등식물의 엽록체 형질전환: 원핵생물과 진맥생물의 조우
정화지,서영배,정원중,민성란,유장렬,Chung, Hwa-Jee,Suh, Young-Bae,Jeong, Won-Joong,Min, Sung-Ran,Liu, Jang-R. 한국식물생명공학회 2006 식물생명공학회지 Vol.33 No.3
엽록체는 숙주세포에 잡아먹힌 (식균작용) 남세균이 숙주세포와 공생관계를 형성하여 온 것으로 간주된다. 엽록체 게놈은 정적이라고 이해하고 있지만 형질전환을 통하여 상동염기가 도입되면 이와는 반대로 intramolecular homologous recombination에 의해 subgenomic circle을 만드는 등 매우 다이나믹하다는 것이 최근에 증명되고 있다. 고등식물의 엽록체 형질전환은 핵 형질전환에서 기대할 수 없는 여러 이점을 제공한다. 예컨대, transgene의 발현율을 높일 수 있고, transgene들을 polycistronic하게 발현할 수 있으며, 도입된 transgene이 모계유전을 하게 된다는 것 등이다. 담배는 엽록체 형질전환의 모델 식물로 사용되어 왔으나 최근에는 벼, 대두, 면화 등 다른 주요 작물의 형질전환도 가능하게 되었다. 엽록체 형질전환된 작물은 미생물을 이용하여 고부가가치 단백질을 생산하는 생물반응기를 향후 대체할 수 있게 될 것이다. Chloroplasts are believed to be descended from certain cyanobacteria, which were taken up by phagocytosis into a host cell and lived there in a symbiotic relationship. In contrast to the current static concept on the chloroplast genome, its dynamism has been recently demonstrated: the chloroplast genome is active in intramolecular homolgous recombination, producing subgenomic circles when it obtains homolgous sequences via genetic transformation. Chloroplast tranformation in higher plants provides many advantages over nuclear transformation that include higher expression levels of transgenes, polycistronic expression of transgenes, and maternal transmission of transgenes. Tobacco has been used as a model for chloroplast genetic transformation. However, it is recently possible to transform the chloroplasts of other major food and economic crops including rice, soybean, and cotton. Chloroplast-transformed crops will be able to replace bioreactors using microorganisms for production of value-added proteins in future.
Population Stereotypes as a Perceiver's Cognitive Structure on Manipulating Devices for Daily Use
정화식,강정일,정인주,신홍철,정동혁,정유진,Jung, Hwa-Shik,Kang, Jeong-Il,Jung, In-Ju,Shin, Hong-Cheul,Jeong, Dong-Hyuk,Jung, Yu-Jin The Korean Society of Physical Therapy 2008 대한물리치료학회지 Vol.20 No.4
Purpose: This study standardizes the position and direction of devices based on general user expectations and stereotypes. Population stereotypes are cognitive structures that contain the perceiver's knowledge, beliefs, and expectations about human groups. In this paper, the stereotypes that people typically expect when manipulating 'cylindrical key-in-knob locks' and 'lever-type water faucet handles' were investigated and data regarding their expectations were collected. Methods: Two sets of 600 participants, between 13 and over 60 years old, were recruited for the experiment. Each group was evenly subdivided into six age groups. Each participant was presented with cylindrical door locks mounted on a miniature door and actual lever-type water faucet handles mounted on a mockup sink. Results: If the cylindrical lock was positioned 'vertically,' 59.2% of the participants expected the device to be locked, and if the lever type faucet handle was positioned 'up,' 63.0% of the participants expected the device to be turned on. Thus, daily-use devices should be designed consistent with user expectations of operation. There was a significant difference between genders for manipulating the faucet handle between up and down. Conclusion: A more general stereotype may be defined by repetitive measurements under the same test conditions with fixed time intervals, as well as accounting for people with cognitive problems.
저체온 심폐우회로를 채용한 심장수술에서 요골 동맥압 파형분석을 이용한 심박출지수는 신뢰할 만한가?
정화성 ( Hwa Sung Jung ),김창원 ( Chang Won Kim ),김태엽 ( Tae Yop Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.1
Background: Discrepancy of central-peripheral arterial pressure after cardiopulmonary bypass may affect the reliability of arterial pressure waveform derived cardiac index (APCI) monitoring. Methods: In 15 elective cardiac surgeries employing moderate hypothermic cardiopulmonary bypass (CPB), APCI from radial arterial cannula and pulmonary artery catheter derived cardiac index from thermodilution method (PACI) were measured. 1) after anesthesia induction (T1), 2) before CPB (T2), 3) immediately after CPB (T3) and 4) 1 hour after CPB (T4). APCI and PACI were analyzed by using the Bland-Altman analysis. Results: Biases of APCI and PACI at T1, T2, T3 and T4 were 0.093 L/min/m2, -0.053 L/min/m2, 0.485 L/min/m2 and -0.09 L/min/m2, respectively. The limits of agreement (2 SD) at T1, T2, T3 and T4 were from -2.285 to 2.471 L/min/m2, -2.475 to 2.369 L/min/m2, -2.255 to 3.225 L/min/m2 and -2.609 to 2.423 L/min/m2, respectively. Bias of APCI and PACI during entire period (T1-T4) was 0.095 L/min/m2 and 2 SD was from -2.387 to 2.557 L/min/m2. However, mean error % (2 SD/mean) of APCI at T1, T2, T3, and T4 were greater than 30%. Conclusions: Our results were not able to show that APCI measured from radial artery is comparable to PACI for hemodynamic monitoring during cardiac surgery employing moderate hypothermic CPB. Considering the limitations of PACI as a gold standard of hemodynamic monitoring in a certain clinical circumstance, further investigation employing other monitoring method than PACI may be followed to get more definitive conclusion. (Korean J Anesthesiol 2009; 57: 44~9)
재생근관치료의 성공에 영향을 미치는 결정 요인에 대한 후향적 연구
정화경,이난영,이상호,Jeong, Hwakyong,Lee, Nanyoung,Lee, Sangho 대한소아치과학회 2017 大韓小兒齒科學會誌 Vol.44 No.1
본 연구의 목적은 괴사된 미성숙 영구치의 재생근관치료 시 성공에 영향을 미치는 결정적 인자를 평가하고자 함에 있다. 미성숙 영구치의 치수괴사로 진단된 환자 중 재생근관치료를 시행하고 1년 이상 경과 관찰한 증례로서 46개 치아가 선택되었다. 이를 대상으로 성공률과 관련된 변수로서 나이, 성별, 초진 시 치근발육단계, 치수괴사 원인, 치료과정, 임상 및 방사선학적 결과를 조사하고 관련성을 통계 분석하였다. 분석 결과, 치근발육단계는 재생근관치료의 성공률에 영향을 미치지 않았으나, 치수괴사 원인은 치외치, 우식, 외상 순으로 성공률이 높았으며 유의한 차이가 있었다. 근관내 멸균 시 국소적 항생제를 적용했을 때 높은 성공률을 보이며 통계학적 유의차를 보였으며, double과 triple antibiotic paste간에는 유의차가 없었다. 재생근관치료의 성공률을 높이기 위해 치수 괴사 원인, 특히 외상 증례에 있어 신중한 적응증 판단이 선행되어야 하며, 적절한 항생제 적용이 필요하다. This study evaluated critical factors influencing the success of regenerative endodontic treatment for necrotic immature permanent teeth. The study enrolled patients who had regenerative endodontic treatment in a necrotic immature permanent tooth through 1-year follow-up. Possible explanatory variables related to the success rates for 46 teeth were age, gender, dental stage at the initial appointment, etiology, treatment information, and clinical and radiographic outcomes. The dental stage at the time of regenerative endodontic treatment did not influence the success rate. The success rate was significantly related to the etiology of the necrotic immature tooth. The success rate according to etiology decreased in the following order: dens evaginatus, caries, and trauma. There was also a significant difference according to the type of antimicrobial. The success rate was influenced by appropriate disinfection of the root canal system, provision of a scaffold, and coronal sealing. Above all, careful case selection is necessary for treating a necrotic immature permanent tooth, especially in cases of trauma.
정화식(Jung Hwa-Sic),김인용(Kim In-Yong),박종천(Park Chong-Chon) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.5월
The Emergency Exit System is evacuation equipment that operated by crew or passenger when emergency state such as fire, accident, etc in the rolling stock. Generally front emergency exit is installed in the drivers area and it is isolated to passenger area, so its design is little big easy. But front emergency exit that is installed in driverless vehicle have to consider not only anti-vandalism and failure but also its design because it is installed in the passenger area. Therefore, we survey the characteristic, function and needed condition the emergency front exit of driverless vehicle and present the developing system that can be a help to make design.