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호산구증다증을 동반한 P-ANCA 양성 괴사성 사구체신염
신장열 ( Jang Yel Shin ),강이화 ( Ea Wha Kang ),류동렬 ( Dong Ryeol Ryu ),송정식 ( Jung Sik Song ),이원기 ( Won Ki Lee ),박용범 ( Yong Beom Park ),김루시아 ( Lucia Kim ),정현주 ( Heun Ju Jung ),이수곤 ( Soo Kon Lee ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.1
Antineutrophil cytoplasmic antibodies (ANCAs) are now regarded as a serologic marker for pauci-immune crescentic necrotizing glomerulonephritis either in renal-limited form or in association with systemic vasculitis, such as Wegener`s granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. Two major ANCA antigens have been indentified: proteinase3, which produces a cytoplasmic staining pattern termed C-ANCA, and myeloperoxidase, which produces a perinuclear pattern termed P-ANCA on ethanol-fixed neutrophils by indirect immunofluorescence. In ANCA- associated diseases, eosinphilia in excess of 1.5×10(9)/L has been proposed to be characteristic of Churg-Strauss syndrome and is rare in other forms of ANCA-associated systemic vasculitis and crescentic necrotizing glomerulonephritis. Recently, there were two cases of P-ANCA positive crescentic necrotizing glomerulonephritis with peripheral blood eosinophilia and extrarenal microscopic vasculitis without asthma or granulomas. We experienced a patient with P-ANCA positive pauci-immune necrotizing glomerulonephritis with few eosinophilic infiltration and eosinophilia. He improved with oral prednisolone along with combination of intravenous cyclophosphamide. So we report this case with the review of literature.
이광재,김경희,이관식,문영명,최흥재,정현주,박찬일 대한내과학회 1990 대한내과학회지 Vol.38 No.4
Two cases of primary biliary cirrhosis were diagnosed in a 40-year-old woman and a 61-year-old woman. One case complained of generalized pruritus, easy fatigability and indigestion, and the other case complained of easy fatigability and generalized weakness. They showed an increase in serum alkaline phosphatase and serum IgM, positive antimitochondrial antibody tests, histologic findings of portal expansion with fibrosis, a decreased number of interlobular bile ducts, focal periportal destruction and inflammatory cell infiltration. From the above two cases of primary biliary cirrhosis, we can conclude that we should suspect this disease in patients with pruritus and generalized weakness along with those who show obstructive types of liver function tests but do not display the obstructive lesions of extrahepatic bile ducts and larger intrahepatic bile ducts in U/S, CT or ERCP. It can help us to detect primary biliary cirrhosis that we reconsider the findings of liver biopsy in patients diagnosed as chronic B viral hepatitis or nonAnonB chronic hepatitis who complain of pruritus and show an increase in serum alkaline phosphatase, serum IgM, cholesterol and GGTP, along with positive antimitochondrial antibody test.
김경호,한대석,김영기,이승우,최인준,허갑범,안광진,김미림,정윤석,최규헌,정현주,이호영 대한내과학회 1991 대한내과학회지 Vol.40 No.6
Bartter's syndrome is characterized by hypokalemia, metabolic alkalosis, hyperreninemia, hyperaldosteronism, normal blood pressure, and hyperplasia of the juxtaglomerular apparatus of the kidneys. We experienced a case of Bartter's syndrome in a 30-year-old female adult, along with a successful response to potassium replacement, indomethacin, and spironolactone therapy. The literature is reviewed briefly.
김도영,신장열,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,최규헌,조정래,이준규,남수연,한재호,정현주 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1
Banter's syndrome is characterized by hypokalemia, metabolic alkalosis, hyperreninemia and secondary hyperaldosteronism without hypertension and edema. Histologically, existing hyperplasia of the juxtaglomerular cell occurs mostly in childhood or adolescence, and initial presentation in patients over 40 years old of age is very rare. It has been recorded that Bartter's syndrome is associated with glucose intolerance, but not with overt diabetes mellitus. Whether this association is coincidental or causal is uncertain, although hypokalemia can cause glucose intolerance. We experienced a case of Banter's syndrome in 44 years old non-insulin dependent diabetic woman. She improved with potassium supplements along with combination of prostaglandin synthetase inhibitor and aldosterone antagonist. We report present case with the review of literature.