다양한 원인에 의한 윤부 부전으로 인해 발생한 지속 각막상피결손

정인권,한동진,서지원,이종현,최헌진,이도형 대한안과학회 2022 대한안과학회지 Vol.63 No.4

Purpose: We report the process of treating persistent corneal epithelial defects due to limbal deficiency in a patient who underwent surgery for ptosis, recurrent pterygium, and senile cataract for 3 weeks. Case summary: A 65‐year‐old male patient underwent cataract surgery 4 months ago and visited this hospital with persistent inflammation of the left cornea that started 2 months ago. The patient underwent blepharoplasty and pterygium surgery at the same time 3 weeks before cataract surgery. At the first visit, severe conjunctival injection and an oval‐shaped corneal epithelial defect with a size of 3 × 5 mm in the center of the cornea were seen. As the result of the eyelid eversion test, fibrotic scar tissue due to the non‐absorbable suture used during the upper eyelid blepharoplasty was observed and surgically removed. The corneal epithelial defect site became smaller, but the atrophy of the corneal stroma was sustained, and the amniotic membrane was tripled and permanent amniotic membrane transplantation was performed. Corneal epithelial defects have improved with postoperative best‐corrected visual acuity of 0.15. Conclusions: Sufficient recovery period between serial multiple surgeries is required to reduce the occurrence of complications like persistent epithelial defects.

Structure and properties of Biodegradable Gluten Compounds

정인권,임성욱,이광희 한국고분자학회 1997 한국고분자학회 학술대회 연구논문 초록집 Vol.1997 No.10

Cyclosporine A에 의한 신장기능의 변화

정인권,박양생 고신대학교 의학부 1989 高神大學校 醫學部 論文集 Vol.5 No.1

임상에서 면역억제제로 사용되고 있는 cyclosporine A(CsA)의 신독성 기전을 연구하기 위하여 동물재료로 Sprague-Dawley계 웅성백서를 사용하여 CsA(Sandimmun, Sandoz, Basel, Switzerland)를 25㎎/㎏.day용량으로 4주간 피하주사하여 신독성을 유발하면서 1주 간격으로 각종 신장기능의 병화를 조사하여 대조군(식염수 주입군)의 성적과 비교하였다. 1. 혈장내 creatinine, 요소, K^(+) 및 삼투질 농도는 CsA처지(4주)에 의해 의의잇게 증가 되었으나 Na^(+)농도는 크게 변화되지 않았다. 2. CsA처치 3주 후부터 요배설량은 의의있게 증가했으나 요삼투농도는 감소되었다, 3., 요중으로의 creatinine 배설량은 CsA처치 2주 때까지 급격히 감소되다가 그 후에는 그대로 유지되었으며, 처치 4주 후에 산출한 creatinine제거율(Ccr)은 대조군에 비해 60%정도 낮았다. 4. 요중으로서 Na^(+), K^(+), 요소 및 총 삼투질의 배설량은 CsA처치 1주 후에 모두 의의있게 감소되었으나 2주째부터는 대조군의 수준으로 회복되었다. 5. CsA처치 4주 후에 측정된 물, Na^(+), K^(+) 요소 및 삼투질의 fractional excretion은 대조군의 값보다 의의있게 높았다. 6. CsA처치 3~4주 후에는 신세뇨관의 free water 재흡수가 현저히 감소되었으며, 신수질조직의 Na^(+) 및 요소농도가 의의있게 감소되었다. 7. CsA처치 후에는 Pitressin 주사 후에도 요농축능이 회복되지 않았다. 8. 신피질조직의 산소소모능은 CsA처치로 약 20% 감소되었으나 p-aminohippurate 능동적 이동은 CsA에 의해 영향을 받지 않았다. 이상과 같은 결과는 CsA처치시 사구체여과율이 감소되며, 다뇨증 및 요농축능의 저하가 일어나는데, 다뇨증과 요농축능의 저하 기전은 Henles loop 상행각의 Na^(-) 펌트기능이 억제되어 세뇨관으로부터 free water의 재흡수가 감소되기 때문임을 시사한다. Changes in the renal function were studied in rats (Sprague-Dawley) treated with cyclosporine A (CsA), an immunosuppressive agent, to elucidate the mechanism of CsA-induced nephrotoxicity Animals were subcutaneousely injected with CsA (Sandimmun, Sandoz, Basel, Switzerland) at a dose of 25㎎/㎏?day for 4 weeks. Renal functions were tested at 1-week intervals and compared with those observed in control animals(saline-treated). The results are summarized as below 1. CsA treatment for 4 weeks resulted in a significant elevation of the plasma creatinine, urea and K^(+) concentrations and osmolality with no significant change in the Na^(+) level. 2. The daily urine volume was significantly increased and the urine osmoality was decreased after 3 weeks of CsA treatment. 3. The urinary excretion of creatinine decreased drastically during the first 2 weeks of CsA treatment, and then remained unchanged during the rest of treatment period. The creatinine clearance determined at the end of 4-week treatment of Cs A appeared to be 60% lower than that in the control. 4. The urinary excretions of Na^(+), K^(+), urea and the total osmotic substance decreased significantly after 1-week treatment of CsA, but they returned to the control level thereafter. 5. The fractional excretions of water, Na^(+), K^(+), urea and the total osmotic substances at the end of 4-week treatment of CsA were significantly higher than the control level. 6. The free water reabsorption and renal medullary Na^(+) and urea contents appeared to be significantly reduced by 3-4 weeks of CsA treatment. 7. Injection of Pitressin to CsA-treated rats did not restore urine concentration ability. 8. The renal cortical tissue oxygen consumption was significantly reduced, but the active transport capacity of aminohippurate was not altered in CsA-treated animals. It is concluded from these results that CsA treatment in rats attenuates glomerular filtration rate and impairs the Na^(+) pump system in the ascending Henles loop, and the latter effect leads to a urinary concentrating defect and polyuria.

Cyclosporine A에 의한 신장기능의 변화

정인권,박양생 고신대학교(의대) 고신대학교 의과대학 학술지 1989 고신대학교 의과대학 학술지 Vol.5 No.1

Changes in the renal function were studied in rats(Sprague-Dawley) treated with cyclosporine A(CsA), an immunosuppressive agent, to elucidate the mechanism of CsA-induced nephrotoxicity. Animals were subcutaneousely injected with CsA(San-dimmun, Sandoz, Basel, Switzerland) at a dose of 25mg/kg·day for 4 weeks. Renal functions were tested at 1-week intervals and compared with those observed in control animals(saline-treated). The results are summarized as below 1. CsA treatment for 4 weeks resulted in a significant elevation of the plasma creatinine, urea and K⁺ concentrations and osmolality with no significant change in the Na⁺ level. 2. The daily urine volume was significantly increased and the urine osmoality was decreased after 3 weeks of CsA treatment. 3. The urinary excretion of creatinine decreased drastically during the first 2 weeks of CsA treatment, and then remained unchanged during the rest of treatment period. The creatinine clearance determined at the end of 4-week treatment of CsA appeared to be 60% lower than that in the control. 4. The urinary excretions of Na⁺, K⁺, urea and the total osmotic substances decreased significantly after 1-week treatment of CsA, but they returned to the control level thereafter. 5. The fractional excretions of water, Na⁺, K⁺, urea and the total osmotic substances determined at the end of 4-week treatment of CsA were significantly higher than the control level. 6. The free water reabsorption and renal medullary Na⁺ and urea contents appeared to be significantly reduced by 3-4 weeks of CsA treatment. 7. Injection of Pitressin to CsA-treated rats did not restore urine concentration ability. 8. The renal cortical tissue oxygen consumption was significantly reduced, but the active transport capacity of aminohippurate was not altered in CsA-treated animals. It is concluded from these results that CsA treatment in rats attenuates glomerular filtration rate and impairs the Na⁺ pump system in the ascending Henle's loop, and the latter effect leads to a urinary concentrating defect and polyuria.

Peripapillary Granuloma with Optic Nerve Head Involvement Associated with Sarcoidosis

정인권,신주연,이종현 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.4

군날개 재발에 있어서 자가윤부결막이식술 단독 및 추가 윤부절개술의 장기 결과

정인권,김진형,이종현,이도형 대한안과학회 2018 대한안과학회지 Vol.59 No.12

Purpose: We report the clinical outcomes of patients undergoing additional widening of the limbal incision to prevent disease recurrence after conjunctivo-limbal autograft combined with pterygial excision. Methods: We retrospectively compared 95 eyes with primary and 12 eyes with recurrent pterygia randomized to treatment via two surgical methods: conjunctivo-limbal autograft alone and combined with widening of the limbal incision to allow for pterygial removal. We widened the limbal incisions by 1 mm on both the superior and inferior limbal margins and removed the pterygia. The outcomes were compared between 39 eyes undergoing conjunctivo-limbal autograft alone and 68 eyes undergoing conjunctivo- limbal autograft with widening of the limbal incision. Results: The mean overall postoperative follow-up period was 29.6 ± 10.5 months and conjunctivo-limbal autograft alone group was 27.4 ± 11.5 months, combined with widening of the limbal incision group was 30.7 ± 9.7 months. Six pterygia (15.4%; four primary and two recurrent) developed in those undergoing conjunctivo-limbal autograft alone and two (2.9%; one primary and one recurrent) in those undergoing additional widening of the limbal incision; the recurrence rate differed significantly between the two groups (p < 0.05). In the group treated with conjunctivo-limbal autograft alone, the mean time to development of a new primary pterygium was 6.3 ± 3.4 months and that to development of a recurrent pterygium 4.3 ± 2.5 months; the respective values for the group undergoing additional widening of the limbal incision were 12.1 ± 2.6 and 8.4 ± 4.6 months; the recurrence rates differed significantly (p < 0.05). Conclusions: Conjunctivo-limbal autograft with additional widening of the limbal incision used to treat both new primary and recurrent pterygia was more effective in terms of reducing pterygial recurrence than conjunctivo-limbal aAutograft alone. 목적: 군날개 수술에서 자가윤부결막이식술 시 재발을 억제하기 위하여 시행한 추가 윤부절개술의 임상성적을 보고하고자 한다. 대상과 방법: 총 95안의 원발성군날개와 12안의 재발성 군날개 환자를 대상으로 자가윤부결막이식술 단독 및 추가 윤부절개술을 시행한 두 군으로 나누어 후향적 분석을 시행하였다. 추가 윤부절개술은 군날개를 제거한 각막윤부의 상부 및 하부경계에 각각 1 mm의 추가 절개를 하는 방법으로 시행하였다. 결과는 자가윤부결막이식술 단독 시행 39안, 추가 윤부절개술 시행 68안을 대상으로 비교 분석하였다. 결과: 전체 환자의 술 후 경과관찰 기간은 29.6 ± 10.5개월이었으며, 자가윤부결막이식술 단독 시행 군에서는 27.4 ± 11.5개월, 추가윤부절개술 군에서는 30.7 ± 9.7개월이었다. 재발은 자가윤부결막이식술 단독 시행 군에서는 6안(15.4%; 원발성 4안, 재발성 2안)이 있었으며, 추가 윤부절개술 군에서는 2안(2.9%; 원발성 1안, 재발성 1안)을 나타내었고, 두 군 간에 통계적으로 유의한 차이를 보였다(p<0.05). 재발이 나타날 때까지의 평균 기간은 자가윤부결막이식술 단독 시행 군에서 원발성 군날개인 경우 6.3 ± 3.4개월, 재발성 군날개인 경우 4.3 ± 2.5개월이었으며, 추가 윤부절개술 군에서는 원발성 12.1 ± 2.6개월, 재발성 8.4 ± 4.6개월을 나타내었고, 두 군 간 통계적으로 유의한 차이를 보였다(p<0.05). 결론: 추가 윤부절개술은 자가윤부결막이식술을 단독 시행하였을 때보다 원발성 및 재발성 군날개 모두에서 재발 방지에 유용한 수술법이다.

제10차 춘계 학술대회 초록집 : 구연 21 ; 간세포암에서 경동맥 화학 색전술과 고주파 열치료 병합 치료의 유용성

정인권,박민재,전성우,서향은,이영두,이명권,조창민,탁원영,권영오,김성국,최용환 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.3(S)

단일 결절 간세포암종에서 고주파 열치료 후 예후에 영향을 미치는 인자

정인권,박민재,권기태,박영대,정윤진,전성우,이명권,서향은,이영두,조창민,탁원영,권영오,김성국,최용환 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.4

목적: 간세포암종 환자에서 고주파 열치료 후 국소 재발에 영향을 미치는 인자로 종양의 크기, 위치 등이 의미가 있다고 알려져 있다. 저자들은 위 두 인자를 포함한 여러 임상적 요소들이 고주파 열치료를 시행한 환자의 예후에 영향을 미치는지 여부를 알아보고자 하였다. 대상과 방법: 1999년 10월부터 2002년 12월까지 본원에서 간세포암종으로 진단되어 고주파 열치료를 시행받은 환자 중 단일 결절의 환자 107명을 대상으로 하였다. 역동성 복부전산화단층촬영으로 시술 후 3개월마다 추적 검사를 시행하였다. 종양의 크기, 위치, 나이, 성별, 원인 질환, 혈소판의 수, Child-Pugh 등급을 누적 생존율, 누적 무병 생존율에 대하여 Cox 회귀분석하였다. 결과: 추적 기간은 4-44개월(평균 20개월)이었다. 종양의 크기는 1.0-5.0 cm (평균 : 2.5 cm)이었으며, 위치는 피막하, 비피막하로 구분하였다. 누적 생존율은 12, 24, 36개월에 각각 90.5%, 67.4%, 46.4%이고, 누적 무병 생존율은 12, 24, 36 개월에 각각 71.4%, 46.7%, 20.9%이었다. 생존율 및 무병 생존율과 통계적으로 의미 있는 인자는 Child-Pugh 등급(P=0.001, P=0.026), 혈소판 수(P<0.001, P=0.002)였으며, 종양의 크기, 위치를 포함한 다른 인자는 생존율 및 무병 생존율과 통계적으로 의미가 없었다. 결론: 고주파 열치료 후 간세포암종의 국소 재발률에 영향을 미치는 것으로 알려진 종양의 크기, 위치는 생존율 및 무병 생존율에는 영향이 없었다. 고주파 열치료 시행 당시의 간기능 상태를 나타내는 Child-Pugh 등급, 혈소판의 수가 누적 생존율 및 누적 무병 생존율에 영향을 미치는 것으로 나타났다. Background/Aims: Several risk factors, such as size and location, are related to local recurrence after radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC). The objectives of this study were to clarify factors related to prognosis. Methods: From October 1999 to December 2002, we performed RFA for 107 consecutive patients with solitary HCC. We evaluated spiral computed tomography and serum alpha-fetoprotein level every 3 months after RFA. Seven possible factors for prognosis were analyzed using the Cox proportional hazards regression model: tumor size, tumor location, age, sex, etiology, platelet count, and Child-Pugh classification. Overall survival and disease free survival rate were estimated using the Kaplan- Meier method, and differences between two groups were compared using the log rank test. Results: The Kaplan-Meier estimates of overall survival after radiofrequency ablation were 90.5% at 12 months, 67.4% at 24 months and 46.4% at 36 months and disease free survival were 71.4%, 46.7% and 20.9%, respectively. Using the Cox proportional hazards regression model, it was shown that with regard to overall survival and disease free survival, Child-Pugh classification (P=0.001, P=0.026) and platelet count (P<0.001, P=0.002) were statistically significant factors. The other factors did not have a statistically significant relationship to overall survival and disease free survival. Conclusions: The size and location known as local recurrence factors were not statistically significant with regard to survival and disease free survival. The Child-Pugh classification and platelet count, that reflect the liver function at the time of RFA, were significant factors for prognosis.

Micronucleus Test of $Scutellariae$ $Radix$ Aqueous Extract in Bone Marrow Cells of Male ICR Mice

정인권,전우현,강수진,구세광,이영준,Chung, In-Kwon,Cheon, Woo-Hyun,Kang, Su-Jin,Ku, Sae-Kwang,Lee, Young-Joon Society of Preventive Korean Medicine 2012 대한예방한의학회지 Vol.16 No.1

Objectives : In this research, the genotoxic effect of $Scutellariae$ $Radix$(SR), the dried roots of $Scutellaria$ $baicalensis$ Georgi has been traditionally used as antipyretic agent, was evaluated using the mouse micronucleus test. Methods : SR aqueous extract(yield = 27.2%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide(CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus(MN) in polychromatic erythrocyte(PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Results and Conclusions : Although significant(p<0.01) increase of the number of PCE with one or more nuclei(MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of SR extracts treated mice with over 0.33 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that SR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels - the limit dosage in rodents.

Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice

정인권,전우현,구세광 한국독성학회 2011 Toxicological Research Vol.27 No.2

In this research, the genotoxic effect of Picrorrhiza Rhizoma (PR) aqueous extract was evaluated using the mouse micronucleus test. PR extract was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2000, 1000 and 500 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control. The appearance of a micronucleus (MN) in polychromatic erythrocyte (PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Although significant (p < 0.01) increase of the number of PCE with one or more nuclei (MNPCE) was detected in cyclophosphamide treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of PR extracts treated mice with over 0.39 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that PR extract shows no genotoxicity effects up to 2000 mg/kg dosing levels.