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골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구
정영신,변향민,신지영,김정목,정형민,오유경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4
To design gene delivery systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several cultrure conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells and marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 and CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression chemokine receptors generally decreased in most chemokine receptors with the cultivation of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher lever of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased level of receptor-mediated gene delivery into stromal stem cells.
정영신,이정윤,김현수,남은지,김상운,김영태 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.8
Purpose: Outcomes in patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy(NAC) have been widely studied; however, there is limited information on responses to chemotherapy among patients with non-HGSC. The aim of this study was to compare the survival outcomes of patients with advanced-stage non-HGSC and HGSC treatedwith NAC. Materials and Methods: This study was a retrospective analysis of patients with advanced-stage ovarian cancer treated at YonseiCancer Hospital between 2006 and 2017. The demographics, chemotherapy response, and survival rates were compared betweenpatients with non-HGSC and those with HGSC. Results: Among 220 patients who underwent NAC, 25 (11.4%) patients had non-HGSC histologic subtypes, and all received ataxane-platinum combination regimen for NAC. Patients with non-HGSC had lower baseline cancer antigen-125 levels (p<0.001),poorer response rates (p<0.001), lower rates of optimal cytoreduction (p=0.003), and poorer progression-free survival (PFS) (medianPFS 10.3 months vs. 18.3 months; p=0.009) and overall survival (OS) (median OS 25.5 months vs. 60.6 months; p<0.001),compared to those with HGSC. In multivariate analysis, non-HGSC was a negative prognostic factor for both PFS [hazard ratio(HR), 3.19; 95% confidence interval (CI), 1.73–5.88] and OS (HR, 4.22; 95% CI, 2.07–8.58). Conclusion: In this study, poorer survival outcomes were observed in patients who underwent NAC for treatment of non-HGSCversus those treated for HGSC. Different treatment strategies are urgently required to improve survival outcomes for patients withnon-HGSC undergoing NAC.
기후정의운동의 운동사적 맥락에 관한 연구 : 환경정의운동과 지구정의운동을 중심으로
정영신 부경대학교 글로벌지역학연구소 2023 Journal of Global and Area Studies(JGA) Vol.7 No.3
The climate problem is both an environmental-social problem and a global problem. The climate justice movement is a social movement that tries to solve environmental and social problems on a global scale. Therefore, the issue of “systemic change” that the climate justice movement represents, or social movements for transition, needs to combine environmental-social transformation with transition on a global scale, or clarify the relationship between the two. This article examines the climate justice movement in the context of the historical evolution of environmental and global justice movements to rethink the goals of climate justice and regime change that it calls for. The historical experience of the environmental justice movement shows that analyzing and responding to changes in the global economic structure and political power is essential to solving environmental problems, while the experience of the global justice movement shows the need for a global public space and the difficulty of realizing democracy and leadership. By enriching the historical sources and contexts of climate justice movements, the scope and direction of climate justice and regime change will become clearer.
정영신,Yup Kim,Hyun-Soo Kim,이정윤,강원준,김성훈,김상운 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.3
Objective: We investigated the prognostic value of complete metabolic response (CMR) on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/ CT) after 3 cycles of neoadjuvant chemotherapy (NAC) in advanced high-grade serous ovarian cancer (HGSC). Methods: PET/CT at baseline and after 3 cycles of NAC were performed; peak standardized uptakes were measured. PET parameters were compared with NAC parameter: cancer antigen-125 (CA-125) normalization before interval debulking surgery (IDS) and chemotherapy response score (CRS) to predict platinum-sensitivity. Kaplan-Meier analysis was used to determine correlations between PET parameters and survival. Prognostic factors were obtained by multivariate Cox regression analysis. Results: Between 2007 and 2020, 102 patients were recruited: 19 (18.6%) were designated as CMR group and 83 (81.4%) as non-CMR group. CMR after 3 cycles of NAC showed the highest accuracy in predicting platinum-sensitivity (area under the curve [AUC]=0.729; 95% confidence interval [CI]=0.552–0.823; p=0.017), compared with CA-125 normalization before IDS (AUC=0.626; 95% CI=0.542–0.758; p=0.010) and CRS (AUC=0.613; 95% CI=0.490–0.735; p=0.080). CMR demonstrated better prognosis than non-CMR in progression-free survival (PFS) (median PFS, 23.9 months vs. 16.4 months; p=0.021) and overall survival (OS) (median OS, not reached vs. 69.7 months; p=0.025). In multivariate analysis, CMR was associated with a lower risk of recurrence (adjusted hazard ratio [aHR]=0.50; 95% CI=0.27–0.92; p=0.027) and death (aHR=0.23; 95% CI=0.05–0.99; p=0.048). Conclusion: CMR after 3 cycles of NAC can be a prognostic factor for both recurrence and death in advanced HGSC.