Suppression of ARID1A associated with decreased CD8 T cells improves cell survival of ovarian clear cell carcinoma

정언석,민경환,김동훈,권미정,박호현,장형석 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.1

Objective: AT-rich interactive domain 1A (ARID1A) plays an important role as a tumorsuppressor gene in ovarian clear cell carcinoma (OCCC), but the clinical applicationof ARID1A remains unclear. The aim of this study was to analyze clinicopathologicalparameters, molecular interactions and immune-infiltration in patients with low ARID1Aexpression and to provide candidate target drugs. Methods: We investigated the clinicopathologic parameters, specific gene sets/genes, andimmunological relevance according to ARID1A expression in 998 OCCC patients from 12eligible studies (using meta-analyses); 30 OCCC patients from the Hanyang UniversityGuri Hospital (HYGH) cohort; and 52 OCCC patients from gene set enrichment (GSE)65986 (25 patients), 63885 (9 patients), and 54809 (6 patients and 12 healthy people) of theGene Expression Omnibus (GEO). We analyzed network-based pathways based on gene setenrichment analysis (GSEA) and performed in vitro drug screening. Results: Low ARID1A expression was associated with poor survival in OCCC from the meta analysis, HYGH cohort and GEO data. In GSEA, low ARID1A expression was related to the tumorinvasion process as well as a low immune-infiltration. In silico cytometry showed that CD8 Tcells were decreased with low ARID1A expression. In pathway analysis, ARID1A was associatedwith angiogenic endothelial cell signaling. In vitro drug screening revealed that cabozantiniband bicalutamide effectively inhibited specific hub genes, such as vascular endothelial growthfactor-A and androgen receptor, in OCCC cells with low ARID1A expression. Conclusions: Therapeutic strategies making use of low ARID1A could contribute to betterclinical management/research for patients with OCCC.

Film Session Q&A 2 : 07 ; Laparoscopic Shaving Surgery of Endometriotic Nodule on Anterior Rectal Wall

정언석,최중섭,배재만,이원무,고아라,고정화 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: Demonstrate a new instrument, technique or procedure 방법: Introduction: The aim of the video article is to report a surgical technique of laparoscopic shaving surgery of endometriotic nodule on anterior rectal wall. Methods: The procedure was performed in a 35 year-old Korean primipara with right ovarian endometrioma, who had been suffered from severe dysmenorrhea and dyspareunia for a couple of years. 결과: Results: The first step of the procedure is represented by laparoscopic identification of bilateral ureters and performing ureterolysis using a harmonic scalpel. Then, Left peritonectomy was done from the left infundibulopelvic ligament level to the left uterosacral ligament. The uterosacral ligaments are preserved in terms of hypogastric nerve plexus. We performed laparoscopic shaving surgery of endometriotic nodule by dissecting the line between endometriotic nodule and subserosal fat layer of the rectum using a harmonic shears and dissecting metzembaum with monopolar coagulator. At this time, transanal finger manipulation would be helpful to identify bowel layers during the surgery. The patient`s postoperative course was uneventful and her symptoms were completely relieved after the surgery. 결론: Conclusion: Based on our experience, we propose conservative laparoscopic shaving surgery of endometriotic nodule is feasible and avoids the risk of unfavorable outcomes related to low colorectal resection.

3T3-L1 지방세포에서 RBP-4의 발현에 대한 에스트로겐 수용체의 역할

정언석,이경욱,신정호,이재관,오민정,김탁,김선행,허준용 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-

경계성 난소종양의 복강경적 치료; 강북삼성병원의 경험

정언석 ( Un Suk Jung ),이정훈 ( Jung Hun Lee ),경민선 ( Min Sun Kyung ),이교원 ( Kyo Won Lee ),한종설 ( Jong Sul Han ),최중섭 ( Joong Sub Choi ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.2

목적: 경계성 난소종양의 복강경적 치료의 가능성과 효용성을 알아보고자 하였다. 연구방법: 2003년 5월부터 2007년 10월까지 본원에서 16명의 경계성 난소종양 환자에 대해 복강경적 치료를 시행하였다. 임상 기록을 통해 환자 나이, 산과력, 수술 시간, 종양 크기, 입원 기간, 혈색소 변화, 조직학적 종류, 병기, 합병증, 그리고 재발 여부를 분석하였다. 결과: 환자연령의 중앙값은 38세 (27~72세)였고, 출산력은 1회 (0~3회)였으며, 미산부는 6명이었다. 8명에서 보존적 수술을 시행하였고, 나머지는 광범위 수술을 시행하였다. 수술시간은 90분 (50~305분), 입원기간은 5일 (4~16일), 혈색소 변화는 1.4g/dL (0.2~4.5g/dL)이었으며, 종양 크기의 중앙값은 8.5cm였다. 병기는 9명이 Ia기, 2명이 Ib기, 4명이 Ic기, 나머지 1명은 IIIc기였다. 병리학적으로 점액성이 8명, 장액성이 6명이었고, 혼합 상피성과 자궁내막양이 각각 1명이었다. 4명에서 양측 골반 및 대동맥주위 림프절절제술을 시행하였다. 종양 파열로 인한 병기상승은 없었으며, 개복술 전환이나 심각한 합병증은 없었다. 추적관찰 기간은 20개월 (3~53개월)이었고, 재발은 없었다. 보존적 치료를 한 1명의 환자에서 술후 32개월 때 자연임신으로 질식분만을 하였다. 결론: 경계성 난소종양의 수술적 치료에 있어 복강경적 처치가 가능하며, 향후 안정성과 생존률에 관한 대규모의 전향적 임상 연구가 필요하다. Objective: To evaluate feasibility and efficacy of laparoscopic management for borderline ovarian tumors. Methods: From May 2005 to October 2007 in our institution, laparoscopic treatments were performed for 16 patients for borderline ovarian tumors. Through clinical records, the patients` age, parity, operating time, tumor diameter, length of hospital stay, change in hemoglobin level, intraoperative and postoperative complications, and recurrence were analyzed. Results: The median age of the patients was 38 years (27-72 years), the median parity was 1 (0-3), and 6 patients were nulliparous., Eight patients were performed conservative surgery, and radical surgery was performed in the remainder. The median operating time was 90 minutes (50-305 minutes), the median hospital stay was 5 days (4-16 days), the median change of the hemoglobin level was 1.5g/dL (0.2-4.5g/dL), and the median diameter of the tumors was 8.5cm. FIGO stage was Ia for 9 patients, Ib for 2, Ic for 4, and IIIc for the last one. Histopathological results showed mucinous tumor for 8 patients, serous tumor for 6, and mixed type and endometrioid tumor for each remaining. Laparoscopic pelvic and paraaortic lymphadenectomy were performed 4 patients. There was no upstaging by intraoperative cystic rupture. Neither laparoconversion nor intraoperative complication was noted. The median duration of follow-up was 20 months (3-53 months) and none showed recurrence. One of 8 patients who were treated conservatively obtained a baby by vaginal delivery in 32th postoperative month. Conclusion: This preliminary analysis demonstrated patients with borderline ovarian tumor can feasibly and efficiently undergo laparoscopic management.

다양한 크기의 자궁근종 110예에 대한 복강경하 자궁근종절제술의 임상적 효용성에 대한 고찰

정언석 ( Un Suk Jung ),위혜정 ( He Jong Wie ),윤효진 ( Hyo Jin Yoon ),경민선 ( Min Sun Kyung ),이교원 ( Kyo Won Lee ),한종설 ( Jong Sul Han ),최중섭 ( Joong Sub Choi ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.6

목적: 복강경하 자궁근종절제술 (LM)의 유용성과 임상적 효율성에 대해 보고하고자 한다. 연구방법: 2003년 7월부터 2006년 7월까지 강북삼성병원 산부인과에서 한 명의 집도의에 의해 시행된 110예의 복강경하 자궁근종절제술에 대해 후향적인 연구를 진행하였다. 임상기록, 수술기록, 마취기록을 검토하여 환자의 연령, 출산력, 수술 기왕력, 수술적응증, 근종 크기, 수술 시간, 제거된 근종 개수, 입원 기간, 수술 전과 수술 후 1일째의 혈색소 변화, 재원기간, 동반질환, 동반수술, 수술 중, 수술 후 합병증 등을 분석하였다. 결과: 대상 환자 총 110명의 평균 연령은 35.7±5.8세이고, 평균 출산력은 0.8±0.9이었으며, 26명 (23%)에서 기왕 복강내 수술력이 있었다. 수술 적응증 대부분은 하복부 불편감을 포함한 복부 종괴 촉진, 골반통, 질출혈이 대부분이었으며, 그 외에 빈뇨, 불임이 있었다. 평균 수술 소요시간은 82.9±30.8분이었고, 주요 자궁근종의 평균 크기는 7.1±2.3 cm이었으며, 절제된 자궁근종 중 가장 무거운 것은 795 gm이었다. 수술 전, 후의 혈색소치의 평균 변화값은 2.2±1.1 g/dL이었고, 재원일수는 평균 3.5±1.4일이었다. 수술 후 수혈은 11명에서 시행하였고, 1명에서 피하기종, 2명에서 장폐쇄증이 발생하여 보존적 치료 후 회복되었으며, 개복술 전환율은 0.9% (1예)이었다. 결론: 체계적인 수술진, 숙련된 복강경 시술자 그리고 발전된 수술기법을 통해 다양한 크기의 자궁근종의 복강경하 자궁 근종절제술을 성공적이고 효율적으로 시행할 수 있으며, 개복술로의 전환을 줄일 수 있다. Objective: To assess the feasibility and clinical efficacy of laparoscopic myomectomy (LM). Methods: We analyzed retrospectively the data for 110 LM preformed at Kangbuk Samsung Hospital between July 2003 and July 2006. We reviewed their clinical charts and the operative and anesthetic records, and analyzed data on the patients` age, parity, previous operative history, preoperative indication, the diameter of the largest myoma, operating time, number of the removed myoma, hospital stay, change of the hemoglobin concentration from preoperative to postoperative day 1, concomitant procedures, histopathological reports, and complications. Results: The mean age of the patients was 35.7±5.8 years, the mean parity was 0.8±0.9, and 26 (23%) patients had a previous operative history. The most common operative indication was a palpable abdominal mass (46 patients, 41.9%), followed by chronic pelvic pain (32 patients, 29.0%), abnormal uterine bleeding (24 patients, 21.8%), urinary frequency (7 patients, 6.4%), and infertility (1 patient, 0.9%). The mean operating time was 82.9±30.8 minutes, and the mean diameter of the largest myoma was 7.1±2.3 cm. The heaviest of the removed myoma weighed 795 gm. The mean change of the hemoglobin concentration was 2.2±1.1 g/dL, and the mean hospital stay was 3.5±1.4 days. Postoperatively, transfusions were done 10% (11 cases) of patients, and 2 cases of paralytic ileus and a case of subcutaneous emphysema were noted. Conversion rate to laparotomy was 0.9% (1 case). Conclusion: LM for various sized myomas can be performed successfully and effectively by decreasing laparoconversion, if the surgical team and the laparoscopic surgeon are experienced and enhanced equipment is available.

임신 제 3 삼분기 초기 리스테리아 감염증

정언석 ( Un Suk Jung ),이은성 ( Eun Sung Lee ),이경욱 ( Kyong Wook Yi ),민주영 ( Joo Young Min ),이경주 ( Kyoung Ju Lee ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.1

The impact of Laparoscopically-assisted staging surgery for ovarian or tubal cancers: Intermediate-term oncologic outcomes(초)

정언석 ( Un Suk Jung ),( Jung Hun Lee ),( Min Sun Kyung ),( Joong Sub Choi ) 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-

Relation of high sensitivity C-Reactive protein with metabolic syndrome in healthy menopausal women

정언석 ( Un Suk Jung ),Sung Eun Hur,Byoung Woo Jang,Seong Ki Lee,Jong Sul Han 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-

Management of complications of Laparoscopic gynecologic surgery in a single institution

경민선,정언석,이정훈,김계현,이교원,한종설,최중섭 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-

Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?

조금준,정언석,심재영,이유진,배나영,최혜진,박종헌,김해중,오민정 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.4

ObjectiveThis study aimed to determine the association between preeclampsia and the postpartum development of metabolicsyndrome based on the pre-pregnancy status. MethodsKorean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. Allsubjects underwent a national health screening examination conducted by the National Health Insurance Corporation1 or 2 years prior to their first delivery and within 2 years after their first delivery. ResultsAmong the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolicsyndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P<0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had agreater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure,and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women withoutpreeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolicsyndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05–1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancymetabolic syndrome or 2 components of metabolic syndrome. ConclusionIn this study, preeclampsia was associated with the postpartum development of metabolic syndrome in womenwithout pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in thepre-pregnancy period.