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이교원 대한의사협회 2020 대한의사협회지 Vol.63 No.5
Immunosuppressive medications and regimens have evolved with significant advancements in the understanding of the immunologic process after solid organ transplantation. Medications can block the communication between antigen-presenting cells and T-cells, the activation and proliferation of T-cells, antibody production by plasma cells, and the activation of the complement system by antibodies. T-cell depleting antibodies and interleukin-2 receptor blockers are commonly used during induction therapy. Calcineurin inhibitors, antimetabolites, antiproliferative agents, and corticosteroids are commonly used in maintenance therapy regimens. These medications decrease the rates of rejection episodes and markedly increase the survival rates of short-term grafts. However, in terms of the survival rate of long-term grafts, there is still room for improvement. Opportunistic infections, development of cancer, metabolic diseases, and calcineurin inhibitor toxicity are hurdles in the improvement in survival rates of long-term grafts. Therefore, many efforts are being taken to overcome these hurdles, such as the development of new drugs, individualization of immunosuppression, and induction of immune tolerance.
한국인 다낭성 난포증후군 환자에서 5,10-Methylenetetrahydrofolate Reductase의 677번 유전자 다형성에 관한 연구
이교원,정유미,이숙환,윤태기,곽인평,윤선웅,최중섭,김계현,한종설,김성도,김남근,차광렬,백광현,이수만,Lee, Kyo-Won,Jeong, Yu-Mi,Lee, Sook-Hwan,Yoon, Tae-Ki,Kwak, In-Pyung,Yoon, Seon-Woong,Choi, Joong-Sub,Kim, Kye-Hyun,Han, Jong-Sul,Kim, Sung-Do,K 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.3
Objective: To investigate the association of genetic background between MTHFR C677T genotype and infertile females with polycystic ovarian syndrome. Materials and Methods: We compared 86 infertile females with polycystic ovarian syndrome (PCOS) with 100 healthy fertile females with one or more offspring. Pyrosequencing analysis for MTHFR C677T variation was performed on polymerase chain reaction (PCR) product of study group. To validate pyrosequencing data of C677T variation for randomly selected 50 samples, we compared the pyrosequencing result with the PCR-RFLP (Restriction Fragment Length Polymorphism) result of MTHFR C677T genotype. Results: The prevalence of the C677T mutant homozygous (TT) was significantly lower (p=0.0085) in females with PCOS (8.14%) than in fertile females (21.00%). MTHFR 677 TT genotype had a decreased risk (3.7-fold) of PCOS compared with wild type (MTHFR 677 CC). Conclusion: Our data support a role for MTHFR mutant homozygous (677 TT) genotype in reducing risk in Korean infertile females with Polycystic ovarian syndrome.
BTL사업의 효율성에 관한 연구 : 학교시설을 중심으로
이교원 한국산업경제학회 2008 산업경제연구 Vol.21 No.2
민간이 자금을 투자하여 사회기반시설을 건설하는 BTL사업은 정부재정의 부족으로 지연된 사회기반시설을 건설하기 위해 재원확보의 수단으로 기채를 발행하는 기채발행사업과 유사하나 어느 방법이 효율적인가에 대하여 아직 구체적인 연구가 없다. 따라서 BTL사업과 재정사업으로 시설된 실증자료로 비교분석하고 이용자를 통한 만족도 조사를 하여 결과를 도출하고자 한다. 먼저 BTL사업에 대한 자금조달비용과 건축부문의 건설비용, 시설이용자에 대한 만족도분석을 통해 BTL사업과 기채발행사업을 비교분석하였다. 구조적으로 시설운영상 수익성이 약한 BTL사업이 경제성장으로 인한 국민의질 높은 사회간접시설의 욕구 충족을 위해 민간투자사업에 접목할 수 있는 것으로 현재 대부분의 학교시설에 집중되고 있다. 따라서 양자를 비교분석한 결과 수치상으로는 그 우열을 판별하기 어려우나 재정의 효율적 운영과 민간자본의 활용을 위해 BTL사업의 활성화가 필요하다는 결과를 도출하였다. 다만 도입초기의 시행착오로 인한 부작용을 최소화할 수 있는 정책적 개발이 시급하다. A BTL project in which private sector invests funds to construct the social infrastructure is similar to the bond issuance project in which government sector issues bonds as a means of raising funds to construct the delayed social infrastructure caused by lack of government budget. However, there is no detailed study yet on which method is more efficient. Therefore, I would like to draw the conclusion by doing comparative analysis with proven materials and by analyzing the degree of satisfaction of the end-users. Firstly, I did comparative analysis on the BTL project and the bond issuance project by analyzing the cost of fund raising, the cost of construction and the degree of satisfaction of the end-users. BTL projects whose profitability is low in terms of facility operation may be connected to investment projects by private sector to satisfy higher needs of the people lead by high economic growth and are currently focused mainly on school facilities. Accordingly, as a result of the comparative analysis, it is difficult to decide which method is better in terms of figures but it is necessary to boost the BTL project to use the government budget effectively and utilize investment by private sector. However, it is a matter of urgency that a policy be developed to minimize adverse effects that may arise from trial and error at the introduction stage of the project.
정상 난소 및 난소암조직에서 20 kDa 단백질의 arginine 메칠화 반응에 관한 연구
이교원,류총근,한종설,박길홍 고려대학교 의과대학 2000 고려대 의대 잡지 Vol.36 No.1
A1 protein methylase I(A1 PMI) activity has been well known to increase in highly proliferative cells, intracellular substrate of which, 20 kDa protein, has been discovered recently. Present study intended to investigate the relevance of ovarian cancer development and arginine methylation of the protein, comparing the intensities of 20 kDa protein and A1 protein arginine methylation in normal ovary and ovarian cancer tissues. Normal ovary and ovarian cancer tissues were taken from the same ovarian cancer patient. A1 protein expression was induced 30-40 fold by IPTG in BL21(DES3)LysS E-coli, and A1 protein was purified to apparent homogeneity with an yield of 2.89㎎ per g E-coli. Specific activities of A1 PMI in normal and cancer ovarian tissues were 0.17, 0.2, 1.18 fold higher in cancer tissue for intracellular substrates, and 5.6, 7.0. 1.25 fold higher in cancer tissue for A1 protein. Fluorography revealed methylated 20 kDa protein as an only intracellular substrate of A1 PMI, the intensities of which for normal and cancer ovarian tissues corresponded to enzyme activity measurements. When A1 protein was added as exogenous substrates, methylated A1 was observed, which parelled the enzyme activities in applied samples, and 20 kDa protein was found to disappear. Conclusively, it was confirmed that 20 kDa protein is the most favored intracellular substrate for AlPMI in physiologic condition. and the protein and A1 protein are methylated by the same enzyme competitively.