UVB 조사에 의한 Phenothiazine 의 광독성에 미치는 Ascorbic Acid 의 영향

임연일,김종예,김봉희 한국식품위생안전성학회 1998 한국식품위생안전성학회지 Vol.13 No.3

The purpose of this study is to examine the phototoxicity of four phenothiazine derivatives such as chlorpromazine, perphenazine, trifluoroperazine and promethazine, and to investigate the effects of ascorbic acid on their phototoxicity by LTVB irradiation. Effects of the test compounds on RBCs were monitored with a spectrophotometer by the method of Kahn et al. The extent of photohemolysis by tested phenothiazine derivatives were increased with their concentration and toxic photoproducts were formed by chlorpromazine and promethazine with preirradiated UVB. Photohemolysis postirradiated chlorpromazine and perphenazine and preirradiated promethazine were decreased with the use of ascorbic acid significantly.

UVB조사에 의한 Phenothiazine의 광독성에 미치는 Ascorbic Acid의 영향

임연일,김종예,김봉희 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

광독성 및 광알러지를 일으키는 물질인 phenothiazine계 약물중 chlorpromazine(CPZ), perphenazine(PPZ), trifluoperazine(TFZ), promethazine(PMZ)을 택하여 적혈구에서의 광용혈현상을 Kahn 등의 방법에 의해 UVB(UV irradiation RMX-3W, 1.5 J/㎠)을 조사하여 약물 농도별로 측정한 결과 CPZ, PPZ은 UVB 조사에 의해 약물농도에 따라 현저히 적혈구 용혈현상이 증가 되었으며 이는 ascorbic acid에 의해 유의성있게 감소되었고, 각 약물의 광독성 물질 생성 여부와 이에 의한 용혈독성을 조사해보니 CPZ, PMZ에서 관찰되었고 ascorbic acid에 의해 그 현상이 감소되었다. The purpose of this study is to examine the phototoxicity of four phenothiazine derivatives such as chlorpromazine, perphenazine, trifluorperazine and promethazine, and to investigate the effects of ascorbic acid on their phototoxicity by UVB irradiation. Effects of the test compounds on RBCs were monitored with a spectrophotometer by the method of Kahn et al. The extent of photohemolysis by tested phenothiazine derivatives were increased with their concentration and toxic photoproducts were formed by chlorpromazine and promethazine with preirradiated UVB. Photohemolysis postirradiated chlorpromazine and perphenazine and preirradiated promethazine were decreased with the use of ascorbic acid significantly.

요추에서 발생한 골연골종 치험1례 보고

임수재(Soo Jae Yim),김연일(Yon Il Kim),최창욱(Chang Uk Choi) 대한정형외과학회 1990 대한정형외과학회지 Vol.25 No.2

외과 골절에서 가장 적절한 수술법은 무엇인가?

김연일,임수재,이영구,김명회 순천향대학교 순천향의학연구소 2010 Journal of Soonchunhyang Medical Science Vol.16 No.2

Among ankle fractures, lateral malleolar fractures are being treated in various ways. In this study, fracture fixation was conducted using lag screws and neutral plates in lateral malleolar fractures, and its clinical and radiological satisfaction was evaluated. The subjects of this study were 296 cases, who could be followed up for one year at least, among 1,297 patients who had received surgical treatment for ankle fracture from 2000 to 2008. Among total 296 cases, the results were shown to be satisfactory through Meyer’s method, such that their clinical satisfaction was observed in 262 cases and radiological satisfaction in 257 cases. Although there are diversified fracture surgeries, lag screws and neutral plates were used in this study, and it is deemed that rather operational skill than operational method most significantly influences the operational result.

소아에서 발생한 외상성 고관절 탈구 - 1례 보고 -

김연일,서유성,임수재,윤승렬,최중근,정연철 대한골절학회 1999 대한골절학회지 Vol.12 No.2

Traumatic hip dislocation in childhood is rare. Factors predisposing to abnormal results are delayed reduction and severe trauma. We experienced 8 year-old girl with traumatic posterior hip dislocation and treated with immediate closed reduction. At 30 months follow-up, our patient had good functional and good roentgenographic result with no posttraumatic arthritis or posttraumatic avascular necrosis. So we report this case with review of literature.

대퇴 골두 및 경부 골절에 동반된 고관절의 후방 탈구

이재훈,김연일,서유성,임수재 대한골절학회 2000 대한골절학회지 Vol.13 No.3

Purpose: In the femoral head fracture associated with posterior dislocation of hip, we analyzed the clinical results according to the fracture types and treatment methods to promoting the guide of treatment. Materials and Methods: We used 20 cases of fractured femoral head with posterior dislocation of hip from January 1990 to December 1997, and analyzed the treatment methods and clinical results according to the Pipkin classification. Results: Among the 20 cases, male was 19 cases(95%), motor vehicle accident contributed 15 cases(75%), and the case of type II and IV of Pipkin classification were 7(35%) and 9(45%) cases. Closed reduction performed within 12 hours after injury with good results was conducted in 9 cases(60%) among the 15 cases. According to the treatment methods after closed reduction, good result was showed only 3 of 8 cases(37.5%) in the conservative treatment, whereas 8 of 12 cases(66.7%) in the operative treatment. According to the type of Pipkin classification, good result was showed 3 of 6 cases(50%) in conservative treatment and all of 3 cases in operative treatment among the 9 cases of type I and II, whereas none of 2 cases in conservative treatment and 5 of 9 cases(56%) in operative treatment among the 11 cases of type III and IV. The following complications were encounted; 2 cases of avascular necrosis, 1 case of traumatic arthritis, 1 case of peroneal nerve palsy and 1 case of nonunion Conclusion: Good results were obtained in patients with early, stable, and accurate reduction. The Computed Tomogram was helpful to find the small fragment and check the accurate reduction. Open method that restoration joint congruity seemed to be the better procedure than closed method.

제 1 요추부에 발생한 연골아세포종 : 1예 보고 A Case Report

신병준,윤태경,임강철,이재철,김경제,김동원,김연일 대한척추외과학회 2001 대한척추외과학회지 Vol.8 No.1

연구계획 : 증례 발표 및 문헌 고찰 연구목적 : 제1요추부에 발생한 연골아세포종을 문헌 고찰과 함께 보고하고자 한다. 대상 및 방법 : 36세 여자 환자가 1년 전부터 시작된 요통과 좌측 측복부에 띠 모양의 방사통을 주소로 내원하였다. 하지직거상검사는 제한되지 않았고 지각 신경 및 운동 신경은 정상이었다. 단순방서선 전후면 사진에서 제 1요추 좌측 척추경부터 추체 중간부까지 골흡수 소견을 보이며 T1강조영상에서 저 신호강도, T2강조영상에서 고 신호강도, 가돌리늄 강조영상에서 병벼 내부에 부분적으로 괴사된 저 신호강도를 나타냈다. 결과 : 후방 도달법을 통해 제 1요추부 좌측 횡돌기와 척추경 부근의 종괴를 제거하고 제 12흉추와 제 2요추에 척추걍 나사를 삽입 후에 금속봉으로 연결하였다. 이어 전방 감압술로 제 1요추체를 적출한 후 티타늄 철망을 삽입하여 고정하였다. 적출된 종괴의 크기는 2.3x2x1.5cm 이고, 조직소견상 연골아세포와 유연골 기질로 구성되어 있으면서 특징적인 레이스 모양의 석회화(chicken-wire calcification)가 곤찰 되었다. 술 후 14개월 추시상 신경학적 변화는 없었고 골주사 및 자기공명사진상 재발의 고견은 발결할 수 없었으나 지속적인 요통을 호소하였다. 결론 : 제 1요추부에서 발생한 연골아세포종 1예를 전ㆍ후방 감압술 및 티타늄 철방 내고정으로 1년 이상 추시하여 보고 하는 바이다. Study Design : A case report and review of the literature. Objectives: To discuss the chondroblastoma of the lumbar spine and review the literatures. Materials and Methods : A 36-year-old woman had back pain and pain radiating to the left lateral abdomen. Straight leg raising was not limited. Plain roentgenograms show a small round radiolucent area in left L1 vertebral pedicle and expansile sclerotic margin in L1 vertebral body. Tl-weighted MR images show the lesion displaying low signal intensity. T2-weighted images show high signal intensity. Gadolinium enhanced images show a necrotic area with low signal intensity in the lesion. Results : The mass of left L1 transverse process and pedicle was excised through posterior approach and pedicle screws were inserted T12 and L2 pedicle. L1 vertebral body was excised through anterior approach and a titanium mesh was inserted. It was a ovoid mass. measured 2.3x2x1.5cm in size and histologically diagnosed as chondroblastoma consisting of chondroid matrix and chondroblast. Soft tissue nodule shows chicken-wire calcification. All the symptoms were relieved at 14 months follow-up and no evidence of recurrence on follow-up roentgenogram and bone scan. However, the patient had persistent lower back pain. Conclusions : A case of chondroblastoma in L1 vertebral body was successfully excised by combined anterior and posterior approach and stabilized with a titanium meh.

노년층의 불안정성 대퇴전자간 골절에서의 양극성 고관절 반치환술

김성태,나수균,최창욱,김연일,서유성,임수재 대한골절학회 2000 대한골절학회지 Vol.13 No.2

Purpose: The purpose of this paper was to present the clinical and roentgenographic results that were obtained with bipolar hemiarthroplasty as a primary treatment for comminuted unstable intertrochanteric fracture in elderly patients with severe osteoporosis. The goal of this treatment is early ambulation with early weight bearing to prevent the complications such as a deep vein thrombosis, pulmonary embolism, pneumonia or atelectasis, and pressure sore. Materials and Methods: Twenty consecutive patients who were more than seventy years old with severe osteoporosis and had an comminuted unstable intertrochanteric fractures were treated by primary bipolar hemiarthroplasty from January 1995 through January 1998 at the Department of Orthopaedic Surgery of Soonchunhyang University Hospital. If there were fractured at the lesser or the greater trochanter, a circlage wire or Dall-Miles system (trochanter cable grip system) was passed through the lesser and the greater trochanter to permit its subsequent fixation to the medial and the lateral side of the femoral component. The functional results were judged according to the hip rating scale of Merle d Aubigne. Results: The mean age at operation was 79.8(70 to 92) years old. The most common type according to the Evans classification system was I-d(10ases, 50%). Singh index was case(5%) of Grade I, 7 cases(35%) of Grade II, 10 cases(50%) of Grade III and 2 cases(10%) of Grade IV. The mean bone mineral density(BMD) was -4.24(-6.95 - -3.17). The functional results in 75% of the patients were rated as excellent, very good, or good and in 25% as fair, poor, or bad. Conclusion: Primary bipolar hemiarthroplasty for the treatment of comminuted unstable intertrochanteric fractures in elderly patients with severe osteoporosis could return these patients to their pre-injury level of activity quickly, thus obviating the postoperative complications caused by immobilization.

농업 신기술 도입여부에 영향을 미치는 요인분석-참외 보온덮개 자동개폐기를 중심으로-

최돈우 ( Don Woo Choi ),연일권 ( Il Kweon Yeon ),도한우 ( Han Woo Do ),임청룡 ( Qing Long Lin ) 한국농촌계획학회 2012 농촌계획 Vol.18 No.2

The objective of this study was to analyze the determinant factors in the new agricultural technology acceptance targeted to the automatic switchgear for heat-retaining mulching used on the oriental melons farms. The probit and the logit models were estimated using survey data. The result indicated that the level of income, innovativeness, and reliability are important factors of the new agricultural technology acceptance. Therefore, it is considered the level of income, innovativeness, and reliability in advance to extend the new agricultural technology quickly.

대퇴 골두 무혈성괴사에서 양극성 고관절 반치환술

서유성(You Sung Suh),권중호(Joong Ho Kwon),임수재(Soo Jae Yim),김연일(Yon Il Kim),최창욱(Chang Uk Choi) 대한고관절학회 1999 Hip and Pelvis Vol.11 No.3

Purpose : To report the analysis of the clinical and radiological results of Bipolar endoprosthesis treatment in patients with avascular necrosis(AVN). Materials and Methods : During 5 years and 7 months from January 1, 1990 to July 31, 1995, Bipolar endoprosthesis treatments, utilizing cementless stem have been performed in patients with AVN. For this study, 25 patients were followed up for 2 years minimum and 9 years and 7 months maximum with the average of 5 years and 1 month. We retrospectively analyzed the clinical results of Harris hip scores, thigh pain, and inguinal pain. In order to provide the statistical foundation for the comparison of acetabular erosion, we used x-rays of the acetabular cartilage from the anteroposterior view that were taken postoperatively each year for 4 years. These pictures were compared with the x-ray picture of the anteroposterior view that was taken immediately after the operation. The thickness of the acetabular cartilages has been measured with a caliper ; we found more than 50% acetabular ero-sion in the area between the acetabulum and the artificial cup. In the cases with more than 50% ero-sion, We investigated the effects of age, disease, process of AVN, type of stem, size and duration of the metal cup after insertion, and the occupation of the patient to determine risk factors for the erosion. Results : After the operation, Harris hip score improved in overall from 46 to 80 points. We found 10 cases of inguinal pain(40%) and 4 cases of thigh pain(16%). Among 17 cases(67%) of more than 50% erosion, 7 cases(40%) had occurred within 1 year after the operation, 4 cases(24%) within 2 years, 4 cases(24%) within 3 years, and 2 cases(12%) within 4 years. Younger age group with relative-ly more active life style showed a faster progress of erosion(p=0.01). We also found that more acetabu-lar erosion occurred with more serious AVN(Ficat stage) ; 1 case(25%) out of 4 at the Ficat stage 2 and 16 cases(76%) out of 21 at Ficat stage 3. Conclusion : We found that the degree of acetabular erosion increases in patients with young age,serious AVN, and longer period after the metal cup insertion.