궐증(厥證)에 대(關)한 문헌적(文獻的) 고찰(考察)

이화신,김지혁,황의완,Lee Hwa-Sin,Kim Ji-Hyeok,Hwang Ui-Wan 대한한방신경정신과학회 1993 동의신경정신과학회지 Vol.4 No.1

흡연 여대생의 식이섭취 패턴 및 혈청 지질과 혈청 Cu, Zn, Ceruloplasmin 농도에 관한 연구

이화신,김정희 대한지역사회영양학회 1997 대한지역사회영양학회지 Vol.2 No.1

현훈에 (眩暈) 대한 동서의학적 고찰

이화신,정대규 대구한의대학교 제한동의학술원 1990 東西醫學 Vol.15 No.3

N/A

스트레스 궤양에 (潰瘍) 대한 고찰

이화신,정대규 대구한의대학교 제한동의학술원 1991 東西醫學 Vol.16 No.2

N/A N/A

항당뇨 효능이 있는 천연물의 탐색 및 활성물질의 분석

이화신,박보배,유선녕,김민지,배윤진,이이룬,이예은,김시윤,심윤호,안순철 한국생명과학회 2023 생명과학회지 Vol.33 No.10

Modern people have an increased incidence of metabolic diseases due to changed eating habits, and diabetes is considered the most significant metabolic disease. Given that existing diabetes treatments are accompanied by side effects, the aim of this study was to identify traditional natural products that have anti-diabetic activity. The potential anti-diabetic and antioxidant activities of natural products were examined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, α-glucosidase assay, and protein tyrosine phosphatase 1B (PTP1B) inhibition assay. Methanol extracts of Ulmus davidiana var. japonica, Acer tegmentosum branches, Nelumbo nucifera seeds, and Carthamus tinctorius seeds were found to have high anti-diabetic activity and further fractionated with solvents using ethyl acetate and butanol. Consequently, the ethyl acetate fraction of C. tinctorius seeds (MG-11-E) with high α-glucosidase and PTP1B inhibitory activity was selected. MG-11-E was subjected to preparative thin layer chromatography, and fraction #6 showed high α- glucosidase and PTP1B inhibitory activity. Fraction #6 was analyzed and fractionated via high performance liquid chromatography with 50% methanol as the mobile phase, and anti-diabetic activity was observed in the sample that eluted after 4 min as a single peak. The α-glucosidase inhibitory activity exhibited by this sample seemed to be greater than the PTP1B inhibitory activity; thus, it was concluded that a greater anti-diabetic therapeutic effect may be achieved by combining this agent with natural products that inhibit PTP1B activity.

이탈리아 미시사란 무엇인가 : 공백 메우기인가 패러다임의 전환인가

이화신 한국중앙사학회 2000 중앙사론 Vol.14 No.-

즉석 섭취식품의 전자레인지 가열 시 포장재의 열 변형 패턴 조사

이화신,조아름,문상권,윤찬석,이근택 한국포장학회 2015 한국포장학회지 Vol.21 No.3

RTE(ready-to-eat)형 전자레인지 가열용 제품들의 가열 조리시 특정 부위의 열 변형이 발생하여 전자레인지 포장재 의 재질 및 형태별 가열 패턴을 조사하였다. 국내에서 유통되고 있는 시료 9종 중 5개의 시 료에서 열 변형이 발생되었 고, 국외에서 유통되고 있는 시료 11종 중 8종에서 열 변형 이 발생되었다. 국외 시료의 경우 국내 시료보다 열 변형 정 도는 덜 하였지만 일부 발생되는 것을 확인하였다. 또한 트 레이 타입 용기에 열 변형이 발생하는 소스를 담고 전자레 인지로 가열하였을 때도 리드지 및 컵에서 열 변형이 관찰 되었다. 국내외에서 유통되고 있는 전자레인지 가열용 제품 의 염도, 당도, pH 및 점도를 측정한 결과 열 변형 발생 유 무 및 정도에 따른 일정한 경향은 없었다. 하지만 극히 낮거 나 높은 점도를 가진 시료에서 열 변형이 나타나지 않았고 내용물의 형태 및 포장재의 형태에 따라 열 변형의 차이가 있었다. 따라서 제품의 열 전환 및 열전달을 고려하여 포장 재의 깊이 등 설계를 반영하여 포장 내 전자파의 집중을 방 지하는 등의 기술 도입이 필요할 것으로 판단된다. Thermal deformation of packaging materials was observed in some ready-to-eat food products for microwave use. Therefore, the deformation patterns depending on packaging types and shapes of 9 domestic and 11 foreign products after microwave heating were investigated. Among the domestic and foreign products, thermal deformations of packaging material were observed in 5 and 8 samples, respectively. Besides, thermal deformation occurred on the lid and cup body of tray filled with a spicy chicken sauce after having microwaved where previously no deformation had been observed with other food types. No consistent results of thermal deformation were obtained by the analysis of salinity, brix, pH and viscosity of RTE products for microwave heating. However, thermal deformations of packages were less found in the packages used for the RTE foods contained very high or low viscosity than those with medium viscosity. Furthermore, the degree of thermal deformations was dependent on the food composition and shape as well as package type. In order to prevent the thermal deformation of packaging materials, therefore, technological advances and further studies are required to develop the heat-resistant packaging system and to improve the non- uniformity during microwave heating of RTE foods.

포장 소재에 따른 전자레인지 가열 조리 패턴 조사

이화신,조아름,문상권,윤찬석,이근택 한국포장학회 2015 한국포장학회지 Vol.21 No.1

Heating patterns depending on the packaging materials were examined in order to investigate the causes of thermal deformation of packages used for ready-to-eat foods for microwave heating due to the non-uniformity of microwaves. Physical properties including tensile strength, heat-resistance and elongation of four different CPP grades were compared. High retortable CPP had higher sealing strength and heat resistance compared to the conventional CPPs. All CPP samples tested were proved to have melting temperatures around 160oC. However, they were all thermally deformed by microwave heating due to a limited penetration of microwave and non-uniform heating within the spicy sauce of high viscosity contained high salt, especially on the above the filling line and sealing edge of pouches. When the laminated stand-up pouches composed of G-PET/PET/PET/CPP and G-PET/PET/NY/CPP were retorted and microwaved, significant deformations were noticed in both samples after retorting. Besides, pouches contained titanium dioxide showed more intense thermal deformation than the control. When the 10 μm aluminium foil was affixed on the pouch, small thermal deformation was observed only in the bottom layer. More studies are required to prevent the thermal deformation of packaging materials used for RTE foods during microwave heating by developing the technologies to increase the thermal stability of CPP layer and the modification of packaging design to modify the microwave access into the package.

Curcumin-induced Cell Death of Human Lung Cancer Cells

이화신,박보배,유선녕,전호연,김부경,김애리,손동현,김예린,이상율,김동섭,안순철 한국생명과학회 2023 생명과학회지 Vol.33 No.9

Lung cancer is a type of cancer that has the highest mortality rate. It is mainly classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Chemotherapy is used to treat lung cancer, but long-term treatment causes side effects and drug resistances. Curcumin is a bright yellow polyphenol extracted from the root of turmeric. It has biological activities, such as anti-oxidant, anti-cancer, and anti-inflammatory effects. In this study, we observed differential cell death in human lung cancer cells. Based on the results, curcumin at 10, 30, and 50 μM exhibited a dose-dependent inhibition on the cell survival of several lung cancer cells, with minor differential phenotypes. In addition, apoptosis, autophagy, and reactive oxygen species (ROS) regeneration were observed through flow cytometry. Curcumin dose-dependently increased these phenotypes in A549 (NSCLC) and DMS53 (SCLC), which were restored by corresponding inhibitors. Western blotting was performed to measure the level of expression of apoptosis- and autophagy-related proteins. The results indicate that Bax, PARP, pro-caspase-3, and Bcl-2 were dose-dependently regulated by curcumin, with seemingly higher Bax/Bcl-2 ratios in DMS53. In addition, autophagic proteins, p-AKT, p62, and LC3B, were dose-dependently regulated by curcumin. ROS inhibition by diphenyleneiodonium reduced the induction of apoptosis and autophagy generated by curcumin. Taken together, it is suggested that curcumin induces apoptosis and autophagy via ROS generation, leading to cell death, with minor differences between human lung cancer cells.

熱Stress 및 游泳Stress에 對한 歸脾湯과 Ascorbic Acid의 抗Stress效能 比較硏究

이화신,황의완 대한한방신경정신과학회 1995 동의신경정신과학회지 Vol.6 No.1

In order to compare the anti-stress effect of Guibitang with that of ascorbic acid, after these medicines were administered to guinea pigs induced by heating and swimming stress, the changes of the weight of body and organ, and content of plasma catecholamines, serum total cholesterol, free cholesterol, triglyceride, protein, glucose and cortisol were measured. The results were as follows : 1. The weight of the body was increased with statistical significance in the groups administered ascorbic acid and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on both heating and swimming stress. 2. The weight of spleen decreased with statistical significance in the groups administered ascorbic acid, Guibitang and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on heating stress, but in case of swimming stress, the weight of spleen decreased with statistical significance in the groups administered ascorbic acid and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid. The weight of adrenal decreased with statistical significance in the groups administered ascorbic acid and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on heating stress alone. 3. Plasma norepinephrine content decreased with statistical significance not only in the groups administered ascorbic acid and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid but in the group administered ascorbic acid with Guibitang as compared with in the group administered ascorbic acid on heating stress. In case of swimming stress, norepinephrine decreased with statistical significance in the groups administered ascorbic acid, Guibitang and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid. 4. Plasma dopamine content decreased with statistical significance only in the group administered ascorbic acid and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on both heating and swimming stress. 5. Serum total cholesterol content decreased with statistical significance in the groups administered ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on heating stress, but in case of swimming stress, it decreased with statistiscal significance only in the group administered ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid. 6. Serum triglyceride content decreased with statistical significance not only in the groups administered ascorbic acid, Guibitang and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid but in the group administered ascorbic acid with Guibitang as compared with in the group adminstered ascorbic acid on heating stress. In case of swimming stress, triglyceride decrease with statistical significance only in the group administered ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid. 7. Serum glucose content increased with statistical significance in the groups administered Guibitang and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on both heating and swimming stress, particulaly in case of swimming stress, in the group administered ascorbic acid with Guibitang, it increased with statistical significance as compared with in the group administered ascorbic acid. 8. Serum cortisol content decreased with statistical significance only in the group administered ascorbic acid and ascorbic acid with Guibitang as compared with in the group administered non ascorbic acid on heating stress.