자궁근종 치료를 위한 질경유 초음파 유도하 고주파 자궁근종용해술의 장기간 효과에 대한 임상적 연구

이우석,이일한,김동호,이상훈,Lee, Woo-Seok,Lee, Il-Han,Kim, Dong-Ho,Lee, Sang-Hun 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.1

목 적: 질경유 초음파 유도하 고주파 자궁근종용해술의 임상적인 효과 및 안정성에 대해 분석해 보고자 하였다. 연구방법: 2004년 12월부터 2007년 3월사이에 질경유 초음파 유도하 고주파 자궁근종용해술을 시행받은 109명을 대상으로 하였다. 환자의 평균나이는 $42.8{\pm}5.8$세였고 모두 자궁을 보존하기 원하였다. 시술 전에 이학적 검사와 초음파를 이용한 병변의 크기 측정이 이루어졌다. 추적검사는 시술 후 1주일, 1개월, 3개월, 6개월 후 시행되었으며 동일 의사에 의해 크기 및 부피변화를 측정하였고, 방문 때마다 생리과다, 생리통 등의 근종 특이증상의 호전 유무를 추적 관찰하였다. 결 과: 근종의 평균 최대직경은 $6.1{\pm}0.5\;cm$ 이었고, 고주파용해술에 소요된 시간은 평균 $16.3{\pm}8.5$분이었다. 유의 할만한 크기와 부피의 감소는 시술 1개월 이후부터 발생하였으며 근종의 평균 최대직경은 시술 후 1주일, 1개월, 3개월, 6개월에 각각 $29.9{\pm}4.8%$ (p<0.001), $41.5{\pm}1.5%$ (p=0.05), $46.2{\pm}3.9%$ (p=0.003), $54.6{\pm}6.1%$ (p<0.001)의 감소율을 보였으며 평균 부피는 각각 $44.4{\pm}8.3%$ (p=0.001), $68.1{\pm}4.2%$ (p=0.035), $73.9{\pm}4.8%$ (p=0.042), $84.5{\pm}5.1%$ (p<0.001)의 부피 감소를 보였다. 일시적인 하복통과 출혈의 지속이 각각 3명씩 있었으나 모두 교정되었고 위중한 합병증은 발생되지 않았다. 생리통과 생리과다 등의 증상은 시술 3개월 후 유의하게 감소하였다. 결 론: 질경유 고주파 자궁근종용해술은 자궁을 보존하면서 좋은 효과와 조기 회복이 가능한 안전하고 효과적인 시술법이다. Objective: This study was performed to investigate the efficacy and safety of radiofrequency (RF) myolysis under transvaginal ultrasound guidance. Methods: Transvaginal RF myolysis had been performed in one hundred nine women with uterine leiomyoma at Chung-Ang University hospital between Dec. 2004 and Mar. 2007. All patients, mean aged $42.8{\pm}5.8$ years, desired their uterine conservation. Patients underwent physical examination, transvaginal pelvic ultrasound for measurement of the lesions preoperatively. Follow up was done at 1 week, 1 month, 3 months, 6 months after RF myolysis by same physician and measurement of size and volume of myoma and improvement of myoma specific symptoms such as menorrhagia and dysmenorrhea were checked at each visit. Results: The mean maximal diameter of myomas treated by RF myolysis was $6.1{\pm}0.5\;cm$ and average time of the procedure was $16.3{\pm}8.5$ minutes. A significant decrease of myoma size and volume was observed at 1 month after myolysis. Mean reduction in maximal diameter was $29.9{\pm}4.8%$ at 1 week (p<0.001), $41.5{\pm}1.5%$ at 1 month (p=0.05), $46.2{\pm}3.9%$ at 3 months (p=0.003), $54.6{\pm}6.1%$ at 6 months (p<0.001) after RF myolysis respectively. Mean reduction in volume was $44.4{\pm}8.3%$ (p=0.001), $68.1{\pm}4.2%$ (p=0.035), 73.9$73.9{\pm}4.8%$ (p=0.042), $84.5{\pm}5.1%$ (p<0.001) at the same follow up period respectively. Significant improvement of symptom was observed at 3 months after RF myolysis. Transient low abdominal pain and prolonged vaginal bleeding were detected in 3 patients each but spontaneously resolved and no serious complication has been noticed or found. Conclusion: This study shows transvaginal RF myolysis could be a safe and effective method to treat uterine leiomyoma, allowing uterine conservation with significant volume reduction and rapid return to normal activity.

4가지 각막곡률측정 시스템을 이용한 굴절교정수술 후 인공수정체도수계산법 비교

이우석,문상정,이경헌,이동준,Woo Seok Lee,Sang Jeong Moon,Kyung Heon Lee,Dong Jun Lee 대한안과학회 2013 대한안과학회지 Vol.54 No.12

Purpose: To report the evaluation and comparison of true corneal power after corneal refractive surgery through ARK, Orbscan II<SUP>®, Pentacam and IOL master. <br /> Methods: Target IOL (Intraocular lens) power calculated with the SRK/T formula using SMK (Sungmo Eye Hospital keratometry), which is a new method for measuring corneal refractive power, was compared with the back-calculated ideal IOL power after cataract surgery for 30 eyes that required cataract surgery and had previously undergone refractive surgery. Target IOL powers calculated using 4 systems were compared with IOL power calculated using the clinical history method for 64 eyes that had undergone refractive surgery. <br /> Results: Using SMK with the SRK/T formula, the actual refraction was within ±0.5 diopter (D) of the intended refraction for 63.8% of eyes and within ±1.0 D for 90.9% of eyes. Compared with target IOL power calculated with the clinical history method, target IOL power calculated by SMK with the SRK/T formula had a difference of 1.95 ± 0.86 D, which was similar to the results calculated by the Haigis-L formula and by TNP with Haigis. <br /> Conclusions: The difference in characteristics of intraocular lenses subtly affects the vision quality as measured by values such as MTF cut-off and Strehl ratio after cataract surgery. OQAS based on the double-pass technique is considered useful in more objective estimates of the real retinal image quality after cataract surgery which is difficult to explain simply by measuring visual acuity.<br /> J Korean Ophthalmol Soc 2013;54(12):1818-1823

폴리머 몰드를 이용한 금속 나노분말의 미세부품 제조

이우석,김상필,이혜문,배동식,최철진,Lee, Woo-Seok,Kim, Sang-Phil,Lee, Hye-Moon,Bae, Dong-Sik,Choi, Chul-Jin 한국분말야금학회 2007 한국분말재료학회지 (KPMI) Vol.14 No.3

Novel polymer mold process for fabrication of microcomponents using metal nanopowders was developed and experimentally optimized. Polymer mold for forming green components was produced by using a hard master mold and polydimethylsiloxane (PDMS). In the preparation of metallic powder premix for the green components without any defect, 90 wt.% 17-4PH statinless steel nanopowders and 10 wt.% organic binder were mixed by a ball milling process. The green components with very clear gear shape were formed by filling the powder premix into the PDMS soft mold in surrounding at about $100^{\circ}C$. Cold isostatic pressing (CIP) was very potent process to decrease a porosity in the sintered microcomponent. The microgear fabricated by the improved process showed a good dimension tolerance of about 1.2%.

탄소.유황 함유량 분석장치

이우석,Lee, Woo-Seok 한국화재보험협회 2008 방재기술 Vol.45 No.-

펨토초레이저를 이용한 백내장 수술과 고식적 백내장 수술 비교

이우석,한상엽,이경헌,Woo Seok Lee,Sang Youp Han,Kyung Hun Lee 대한안과학회 2013 대한안과학회지 Vol.54 No.8

Purpose: To evaluate the surgical results and efficacy of laser refractive cataract surgery with a femtosecond laser compared with conventional phacoemulsification. Methods: Thirty-one eyes from 31 patients underwent laser refractive cataract surgery (femtosecond laser group), and conventional cataract surgery with phacoemulsification was performed in 30 eyes from 30 patients (conventional group). Best corrected visual acuity, spherical equivalent, surgical induced astigmatism, corneal and ocular astigmatism, total high order aberration, Strehl ratio, objective scatter index, diameter of continuous curvilinear capsulorrhexis (CCC), distance from visual axis to the center of CCC, intraocular lens (IOL) tilt, mean absolute error, effective phaco time, average phaco power and operation time were measured to compare the 2 groups. Results: No significant differences were found between best corrected visual acuity, spherical equivalent, surgical induced astigmatism, corneal and ocular astigmatism, total high order aberration, Strehl ratio, objective scatter index, mean absolute error, effective phaco time, average phaco power or operation time. Significant differences were found in the diameter of CCC, distance from visual axis to the center of CCC, and IOL tilt. Conclusions: Results of laser refractive cataract surgery with a femtosecond laser showed more precise CCC, and more stable IOL position than conventional cataract surgery.

상안검에 국한되어 발생한 Merkel 세포 종양 1예

이우석,김상원,노주헌.Woo Seok Lee. MD. Sang Won Kim. MD. Joo Heon Roh. MD. PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To report a case of Merkel cell carcinoma on the left upper eyelid without metastasis and its immunohistochemical features. The carcinoma was successfully treated with excisional surgery and prophylactic radiation therapy. Case summary: A 76-year-old woman presented to the hospital complaining of a 0.6 × 0.9-cm-sized painless and purplish- red colored mass that had grown rapidly on her left upper eyelid margin over the previous two months. An excisional biopsy was performed. On immunohistochemical examination of the lesion, the tumor cells expressed immunoreactivity for synaptophysin and were negative for LAC and cytokeratin, confirming the diagnosis of Merkel cell carcinoma. Additional surgery was performed because the surgical margins were positive. No other primary or metastatic lesions were found. The patient was treated with local prophylactic irradiation and remained disease-free at her 10-month follow-up visit. J Korean Ophthalmol Soc 2012;53(6):856-860

습식 배연탈황공정에서 국내산 석회석의 용해속도 연구

이우석,이형근,조항대,김선근,김인원 ( Woo Seok Lee,Hyung Keun Lee,Hang Dea Jo,Sun Geun Kim,In Won Kim ) 한국화학공학회 1996 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.34 No.6

The rates of dissolution of domestic limestones in the wet type flue gas desulfurization process were measured and the effects of particle size distribution and composition of limestone through the limestone reaction were studied. Five domestic limestone samples of different size distribution(325, 200 and 100 mesh) were tested in both batch and continuous apparatuses. The limestone dissolution rate data measured in the batch experiment system indicated that limestone dissolution rate can be improved by small limestone particles. Relative ranking of limestone dissolution rate was 325 mesh > 200 mesh > 100 mesh. At a fixed size of limestones, the dissolution rates were affected by the composition of limestone, especially MgO. The rates were improved two times by limestone of 3% MgO than pure limestone. But the composition effects to the dissolution rates were reduced as increasing the size of the particles. The continuous type experiments also showed that more limestone was dissolved as the size of limestone decreased.

정상 배란주기의 불임 여성에서 Clomiphene Citrate 단독 사용과 GnRH Antagonist 병합 요법의 임상적 효용성에 관한 연구

이우석,상재홍,김재준,김광준,김동호,이상훈,Lee, Woo Seok,Sang, Jae Hong,Kim, Jae Joon,Kim, Gwang June,Kim, Dong Ho,Lee, Sang Hun 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.3

목 적: 본 연구는 인공 수정 시술에 있어서 정상 배란주기의 여성에서 clomiphene citrate와 GnRH antagonist를 병합하여 임선을 시도한 방법을 기존의 clomiphene citrate 단독으로 사용한 방법과 비교하여 그 임상적 유용성을 알아보고자 하였다. 연구방법: 116명의 환자들 중 43명에게는 자연 배란주기를 이용하여 인공 수정 시술을 시행하였고, 38명과 35명에게 각각 clomiphene citrate 단독 요법과 clomiphene citrate와 GnRH antagonist 병합 요법으로 인공 수정 시술을 시행하여 그 임상 결과를 비교 분석하였다. 결 과: 각각의 군에서 기저 LH, FSH, $E_2$와 배란 유도를 위해 hCG를 투여하는 날의 FSH, $E_2$는 차이를 보이지 않았으나 clomiphene citrate/GnRH antagonist 병합 요법군에서 hCG를 투여한 날의 LH와 자궁 내막 두께는 의미 있게 감소하였으며 유의한 임신율의 증가가 관찰되었다. 결 론: 자연 배란주기법군, clomiphene citrate 단독 요법 사용군에 비해 clomiphene citrate/GnRH antagonist 병합 요법 사용군에서 유의하게 임신율의 향상을 나타냈다. Objective: This study was to investigate the clinical efficiency of clomiphene citrate/GnRH antagonist protocol comparing with the clomiphene citrate only protocol in infertile women with normal ovulatory cycles. Method: Among 116 patients, 43 were received assisted reproductive technologies using natural ovulatory cycle, 38 and 35 were received clomiphene citrate only protocol and clomiphene citrate/GnRH antagonist combined protocol, respectively, and the clinical results were compared and analyzed Results: In each group, basal levels of LH, FSH, $E_2$ and FSH, $E_2$ on hCG day injected were not different, but LH level and endometrial thickness on hCG injected day were decreased significantly and the pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group. Conclusion: The pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group compared with natural ovulatory cycle and clomiphene citrate only group.

Mistral AI 모델을 활용한 특허 명세서의 자동 생성

이우석(Lee Woo Seok),박소현(Park So Hyun),김경재(Kim Gyung Jae),박영연(Park Young Yeon),이지석(Lee Ji Seok),임현우(Lim Hyun Woo),정남주(Jung Nam Joo),성영락(Seong Yeong Rak),박준석(Park Jun Seok) 한국통신학회 2024 한국통신학회 학술대회논문집 Vol.2024 No.1

잡음백색화 과정을 통한 SAMV 알고리즘의 지연시간 추정 성능 개선

이우석(Woo-Seok Lee),박형래(Hyung-Rae Park) 한국통신학회 2018 한국통신학회 학술대회논문집 Vol.2018 No.6