심방중격류의 수술적 교정

이승진,이석열,장인성,정윤섭,염욱,Lee, Seung-Jin,Lee, Seock-Yeol,Chang, In-Sung,Jeong, Yoon-Seop,Youm, Wook 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.11

A life-long anticoagulation for the prevention of ischemic cerebral events by thromboemboli has been conventionally introduced for the treatment of an atrial septal aneurysm. However, due to the recent decrease of the risks in the open heart surgery, the alternative therapeutic modality has been introduced for the prevention of complications of the anticoagulation. A 41-year old female with dizziness was admitted to our hospital. She was diagnosed a shaving atrial fibrillation and a cerebellar infarction, and an atrial septal aneurysm was detected by transesophagel echocardiography that was not detected by the transthoracic echocardiography. Surgery was approached to the right submammarial anterolateral thoracotomy. The atrial septal aneurysm was obliterated by a purse-string suture and plication. Surgial results were excellent with normal sinus rhythms and esthetically satisfying appearance.

유로키나제와 프로유로키나제의 정제 및 특성 비교

이승진,변상요,Lee, Seung-Jin,Byun, Sang-Yo 한국생물공학회 1999 KSBB Journal Vol.14 No.6

본 연구에서는 인뇨에서 분리 정제한 urokinase와 유전자 재조합 CHO(Chinese Hamster Ovary) 세포 배양액으로부터 분리 정제한 pro-urokinase의 물리화학적 특성과 혈액 내에서의 효소활성을 비교 분석하였다. Two chain form인 urokinase와 single chain form인 pro-urokinase를 각각 순수 분리한 후, electrophoresis한 결과 모두 54 kd의 단일밴드를 나타냈다. 그러나 urokinase는 환원시켰을 때 33 kd과 21 kd으로 나누어짐을 확인하였으나 gel filtration결과 분자량이 54 kd 정도임을 확인되어 용액 내에서 단일분자로 존재함을 알 수 있었다. Urokinase와 pro-urokinase가 물리화학적으로 거의 동일한 구조를 가졌다는 사실은 isoelectro focusing에 의한 pI 값이 모두 8.6으로 동일하다는 점과, 아미노산 조성을 분석한 결과 동일하다는 사실로도 알 수 있었다. N-terminal 아미노산 서열을 분석한 결과, urokinase는 이중사슬구조이므로 N-terminal이 두개 존재하여 pro-urokinase의 서열(Ser-Asn-Glu-Leu-His-Gln-Val-Pro-Ser-Asn)이외에도, 159번째의 Ile다음부터 Ile-Gly-Gly-Glu-Phe-Thr-Thr-Ile-Glu가 같은 peak로 나타남을 확인하였다. 효소활성 조사결과 pro-urokinase와 urokinase는 모두 농도 의존적으로 혈전용해 활성을 보였으나, 특이하게도 짧은 반응시간동안에는 urokinase가 동일 농도 하에서 강한 활성을 보인 반면, 2시간이 지난 오랜 반응조건에서는 pro-urokinase가 혈전용해활성을 나타내었다. Fibrinogen에 대한 분해활성을 조사한 결과, urokinase는 혈장 내 fibrinogen을 상당히 손상시키지만, pro-urokinase는 거의 영향을 주지 않아 혈전선택성이 매우 좋음을 알 수 있었다. Characteristics and enzyme activity comparison was made between urokinase isolated from urine and pro-urokinase separated from CHO(Chinese Hamster Ovary) cell culture broth. Both of purified urokinase and pro-urokinase resulted 54Kd single band in electrophoresis. Urokinase which was proved as a single molecule by gel filtration showed two separated 33Kd and 21Kd bands by 2-mercaptoethanol reduction. Isoelectric forcusing resulted same pl value of 8.6 for both of them. N-terminal amino acid sequence of urokinase after 159th Ile was Ile-Gly-Gly-Glu-Phe-Thr-Thr-Ile-Glu which was different from another N-terminal sequence of Ser-Asn-Glu-Leu-His-Gln-Val-Pro-Ser-Asn. Thrombolytic activities of both of them were propotional to the enzyme concentration. Urokinase showed thrombolytic activities in an short period of reaction time. Pro-urokinase, however, showed high thrombolytic activity for 2 hours or longer period of reaction time.

유로키나제와 프로유로키나제의 정제 및 특성 비료

이승진(Seung Jin Lee),변상요(Sang Yo Byun) 한국생물공학회 2000 KSBB Journal Vol.14 No.6

마우스에서 vitamin E의 장,단기적 항스트레스 효과

이승진 ( Seung Jin Lee ),고민석 ( Min Seok Go ),강상모 ( Sang Mo Kang ) 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.4

Responsiveness of the Korean Version of the Voice Activity and Participation Profile (K-VAPP) after Surgical Intervention

이승진(Seung Jin Lee),임성은(Sung Eun Lim),최홍식(Hong Shik Choi) 한국언어청각임상학회 2017 Communication Sciences and Disorders Vol.22 No.2

배경 및 목적 : ‘음성 활동 및 참여 프로파일-한국판(K-VAPP)’는 타당도 및 신뢰도 측면에서 검증되었으나, 중재 후의 반응도는 아직 연구되지 않았다. 이에, 본 연구에서는 다양한 음성장애 환자의 수술적 중재에 대한 K-VAPP의 반응도를 검증하였다. 방법: 다양한 병인의 음성장애에 대하여 수술적 중재를 받고 수술 전 및 수술 3개월 후 음성검사를 시행한 환자 90명을 대상으로 하였다. 심리측정적 평가로 K-VAPP와 KVHI를, 청지각적 평가로 GRBAS를, 음향학적 검사로 MDVP 및 ADSV를 시행하였으며, EGG와 PAS로 측정된 성대접촉지수 및 공기역학적 측정치를 비교하였다. K-VAPP 하위점수가 다른 측정치와 갖는 상관관계를 분석하고, Grade 변화량과 상관관계가 큰 하위점수를 탐색하였다. 결과: 수술 후 K-VAPP의 총점, 활동 제한 점수와 ‘목소리 문제의 심각한 정도에 대한 본인의 인식’, ‘직업에 대한 영향’, ‘일상 의사소통에 대한 영향’, ‘본인의 감정에 대한 영향’ 점수가 유의하게 감소하였다. 반면, 참여 제약 점수와 ‘사회적 의사소통에 대한 영향’ 점수는 차이가 없었다. 이러한 반응도는 여타 음향학적, 공기역학적 변수의 술 전후 개선과 변화량 간 상관관계에 의해 뒷받침되었다. Grade 변화량과 상관관계가 큰 변화량을 보인 하위영역은 1과 4였다. 논의 및 결론: K-VAPP는 충분한 수준의 반응도를 보였다. 음성의 질이 개선되었음에도 참여 제약 및 사회적 의사소통 영역 점수가 개선되지 않은 점은 장기적인 중재 차원에서 임상적 시사점이 있으며, 각각의 병인집단 또는 수술에 대한 후속연구가 필요할 것으로 보인다. Objectives : The purpose of this study was to confirm the responsiveness of the Korean version of the Voice Activity and Participation Profile (K-VAPP) after surgical intervention for various voice disorders and to explore the correlation between changes in the K-VAPP subscale scores and other measures, focusing on auditory-perceptual estimations. Methods: The K-VAPP was administered to 90 patients with various voice disorders who underwent surgical treatment. Along with the K-VAPP, pre- and post-operative vocal assessment results after 3 months were compared, including psychometric, acoustic (both spectral and cepstral), electroglottographic, and aerodynamic assessment. In addition, a correlation between the differences in the K-VAPP subscale scores and Grade changes of GRBAS (grade, roughness, breathiness, asthenia, strain) scale was explored. Results: After surgery, the total score, activity limitation score, and all the subscale scores except ‘effect on social communication’ decreased significantly. On the other hand, the participation restriction score and ‘social communication’ subscale score did not show significant changes. The responsiveness was supported by improvement in several psychometric, acoustic, and aerodynamic parameters, and correlation between K-VAPP subscale scores and those measures. ‘Self-perceived severity’ and ‘effect on social communication’ subscale scores showed significant correlation with perceived severity by clinician. Conclusion: In sum, the K-VAPP was confirmed to be sufficiently responsive after surgical intervention. It is clinically significant that the participation restriction and effect on social communication did not improve after surgery. Further studies pertaining to each etiological group are needed.

태양광 시스템에 적용하는 LC공진 DC차단기의 초전도체 유무에 따른 동작특성 분석

이승진(Seung-Jin Lee),정지솔(Ji-Sol Jeong),김건웅(Geon-Woong Kim),문제필(Je-Pil Moon),박상용(Sang-Yong Park),최효상(Hyo-Sang Choi) 한국조명·전기설비학회 2020 한국조명·전기설비학회 학술대회논문집 Vol.2020 No.11

A Comparison of Cepstral and Spectral Measures according to Measurement Position in a Reading Passage

이승진(Seung Jin Lee),임성은(Sung Eun Lim),최홍식(Hong Shik Choi) 한국언어청각임상학회 2017 Communication Sciences and Disorders Vol.22 No.4

배경 및 목적: 본 연구에서는 음성장애의 중증도를 통제한 상태에서 켑스트럼과 스펙트럼 측정치가 집단 및 문단 내의 측정 위치에 따라 차이가 있는지를 알아보고자 하였다. 또한, 각 위치에서 켑스트럼 및 스펙트럼 측정치를 이용한 중증도 추정치의 진단적 가치를 탐색하였다. 방법: 음성장애 환자군 및 정상 대조군 각 35명으로 하여금 표준문단 ‘가을’을 읽도록 하였다. 26-30 음절 길이의 문장 샘플을 각 문단 샘플 내 세 위치(앞, 중간, 뒤)에서 잘랐으며, 각 샘플에서 켑스트럼 피크 현저성(CPP), L/H 비율(SR), 그리고 각 표준편차를 측정하였다. 청지각적으로는 CAPE-V의 전반적 중증도를 측정하였다. 중증도를 통제한 상태에서 집단 및 위치 간에 켑스트럼 및 스펙트럼 측정치를 비교하였고, 각 위치에서 이들 측정치가 청지각적 중증도와 갖는 관련성을 살펴보았으며, ROC 커브 분석을 통해 청지각적 추정치의 진단적 가치를 탐색하였다. 결과: 뒷부분의 CPP는 중간 부분보다 낮았던 반면, 뒷부분의 SR 표준편차는 앞과 중간 부분보다 높았다. 한편, 청지각적 중증도와 켑스트럼 및 스펙트럼 측정치의 상관관계뿐 아니라, 청지각적 추정치의 진단적 가치 또한 앞부분에서 가장 높게 나타났다. 논의 및 결론: 연구 및 임상 현장에서 문단 내 위치에 따른 CPP 및 SR 측정치의 변이성을 고려할 필요가 있을 것으로 여겨진다. Objectives: The purpose of the present study was to investigate whether cepstral and spectral measures differ according to measurement position in a reading passage, upon controlling for the overall severity of voice disorders. Furthermore, the diagnostic value of perceptual estimates in each position was explored. Methods: Thirty-five patients with voice disorders and 35 normal controls were asked to read the standard passage ‘Ga-eul’. For each sample, sentence samples of 26-30 syllable length were trimmed in 3 positions (front, middle, rear) of the passage, measuring cepstral peak prominence (CPP), L/H spectral ratio, and standard deviations (SDs). Overall severity from the CAPE-V was measured perceptually. Upon controlling for severity, cepstral measures were compared between groups and positions. The association of acoustic measures with overall severity was explored by conducting a multiple regression analysis in each position. The diagnostic value of perceptual estimates derived from acoustic measures was explored using ROC curve analysis. Results: Results indicated that CPP of the rear position was lower than that of the middle position, while SD of the L/H ratio of the rear position was higher than those of the front and middle positions. On the other hand, the relationship between perceptual and cepstral and spectral measures, along with the diagnostic value, was the highest for the front position. Conclusion: It is recommended that the variability of the cepstral and spectral measures among positions be considered in research and clinical practice.

인라인스케이트 선수의 자기관리와 스포츠자신감 및 운동 몰입의 관계

이승진(Lee, Seung-Jin),김지태(Kim, Ji-Tae),정연성(Jung, Yeon-Sung) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.4

The purpose of this study was to analyze the relationship among self-management, sports confidence, and exercise commitment of inline skate players. In order to achieve these goals, a population was selected from male and female inline skate players in teams of the middle and high schools, universities, and businesses in 16 cities and provinces who were registered with the Korea Roller Sports Federation. And a total date of 291 players were collected from the players who competed in the 34th National Male and Female Roller Tournaments according to convenient sampling method. Hypothesis test on collected data was conducted by using SPSS 20.0 and AMOS 20.0. programs. The following are the conclusions of this research. First, self-management of inline skate players had a positively (+) significant effect on sports confidence. Second, self-management of inline skate players had a positively (+) significant effect on exercise commitment. Third, sports confidence of inline skate players had a positively (+) significant effect on exercise commitment. Fourth, self-management of inline skate players had a direct influence on exercise commitment yet through the partially mediating effect of sports confidence.

근골격계 질환의 한,양방협진치료 효과 연구에 대한 체계적 문헌 고찰

이승진 ( Seung Jin Lee ),신병철 ( Byung Cheul Shin ),송근성 ( Geun Sung Song ),황의형 ( Eui Hyoung Hwang ),윤영주 ( Young Ju Yun ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.4

Objectives: This study aims to systematically evaluate the effectiveness of Eastern-Western integrative medicine for musculoskeletal disorders compared with Eastern or Western Medicine. Methods: Systematic searches of 9 major Korean databases were conducted for articles published up to July 2011. Searching keyword was “Integrative Medicine”. Prospective studies dealt with musculoskeletal disorders by Eastern-Western integrative medicine were included. Quality assessment of included studies was evaluated by Cochrane risk of bias tool. Results: 470 studies in total were searched. Among them, 7 studies met our inclusion criteria(3 randomized controlled clinical trials, 2 non-randomized controlled trials and 2 uncontrolled clinical trials). Included studies dealt with lumbar pain(3), shoulder pain(2), pain after traffic injury(1), spinal compression fracture(1). Eastern-Western integrative medicine showed better or equal effect for the treatment of various musculoskeletal disorders compared with Eastern or Western medicine alone. Conclusions: There is very weak evidence for the effectiveness of Eastern-Western integrative medicine for musculoskeletal disorders compared with Eastern or Western medicine alone. Well designed randomized controlled trials with rigorous methodology are needed to evaluate the effectiveness of Eastern-Western integrative medicine objectively in the future.

순환골재가 고유동 콘크리트의 유동특성에 미치는 영향

이승진(Seung-Jin Lee),박상준(Sang-Jun Park) 한국산업기술융합학회(구. 산업기술교육훈련학회) 2023 산업기술연구논문지 (JITR) Vol.28 No.4

본 연구에서는 순환골재를 고유동 콘크리트용 골재로 활용함으로써 순환골재의 활용을 촉진하고자 하였다. 본 연구에 사용된 순환골재는 설계기준강도가 40MPa인 콘크리트를 6개월간 양생한 후, 죠 크러셔로 파쇄한 것이다. 순환 골재를 이용한 고유동 콘크리트의 특성을 평가하기 위해 순환골재 대체율, W/B, 잔골재 부피비(Sr) 등 다양한 콘크 리트 배합조건을 검토하였다. 유동성, 편석 저항성, 충전성을 평가하기 위해 슬럼프 유동시험, L-깔때기 유동시험, 깔대기 시험을 실시하였다. 그 결과 요구성능을 만족할 수 있는 순환골재를 이용한 고유동 콘크리트의 배합조건을찾을 수 있었는데, 순환골재 대체율은 50% 이하, W/B는 37% 이하, 그리고 Sr은 47% 이하인 것으로 나타났다. The purpose of this study was to promote the use of recycled aggregates by using recycled aggregates as aggregates for high flowing concrete. The recycled aggregate used in this study was made by curing concrete with a Fck 40 MPa for 6 months and then crushing it using a Jaw crusher. To evaluate the properties of high flowing concrete using recycled aggregates, various concrete mixture conditions such as replacement rate of the recycled aggregates, W/B and Volume ratio of fine aggregate(Sr) were reviewed. Slump flow test, L-funnel flow test and funneling test were conducted to estimate flowability, resistance to segregation and fillingability. As a result, the mixture conditions of high flowing concrete using recycled aggregate to satisfy the required performance could be found; the replacement rate of the recycled aggregate of below 50%, W/B of below 37% and Sr of below 47%.