유방암의 감시림프절 검사에서 유방크기와 체질량지수에 따른 검사시간 변화

이다영,남궁혁,조석원,오신현,임한상,김재삼,이창호,박훈희,Lee, Da-Young,Nam-Koong, Hyuk,Cho, Seok-Won,Oh, Shin-Hyun,Im, Han-Sang,Kim, Jae-Sam,Lee, Chang-Ho,Park, Hoon-Hee 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2

유방암 환자의 감시림프절 생검을 위하여 현재 방사성동위원소와 blue dye를 이용한 감시림프절 매핑(Mapping)이 선행되고 있다. 현재 모든 환자에 대하여 일괄적인 검사방법이 적용되므로 환자의 유방의 크기나 비만도와 같은 특성이 고려되지 않아 림프절의 흐름이 느린 환자의 경우, 림프절을 충분히 형성하지 못한 채 검사가 종료되는 경우가 종종 발생한다. 본 연구에서는 환자의 신체적 특성인 체질량지수와 유방의 크기에 따른 림프액의 속도차이를 관찰하였다. 이를 통해 방사성동위원소를 이용한 유방의 감시림프절 신티그래피 에서 환자의 특성을 고려한 최적의 검사시간을 도출하는데 목적을 두었다. 본 연구는 2011년 10월부터 2011년 12월까지 수술직전 유방의 감시림프절 신티그래피를 시행한 100명(여성 100명, 평균연령 $50.34{\pm}10.26$)를 대상으로 하였다. 장비는 감마카메라 Forte (Philips Medical Systems, Nederland B.V.)를 사용하였으며, 방사성의약품은 $^{99m}Tc$-Phytate 18.5 MBq, 0.5 ml를 피내주사하였다. 먼저 80명의 환자를 대상으로 기존의 5분 검사방법대신 충분히 림프절을 형성할 때까지 시간의 제한 없이 영상을 획득하였다. 이를 통해 환자의 유방크기와 체질량지수 별 그룹을 나누어 평균 검사시간을 구하였다. 이 결과를 바탕으로 검사시간을 변화시킨 변형 유방 림프신티그래피를 20명의 환자에게 시행하여 유용성을 확인하였다. 80명의 대상 중 유방의 크기에 따른 평균 검사시간은 A그룹 2.48분, B그룹 7.69분, C그룹 10.43분이었다. 80명의 대상 중 체질량지수에 따른 평균 검사시간은 저 체중 1.35분, 표준 2.56분, 과 체중 5.62분, 비만 15분이었다. 앞서 얻어진 정보를 바탕으로 각 그룹별 적절한 검사시간을 적용하여 검사를 시행하였다. 결과는 20명 중 성공평가를 받은 경우는 17회 실패평가를 받은 경우는 3회로 총 85% 성공률을 나타내었다. 유방의 크기와 체질량지수에 따른 총 검사 시간은 체질량지수가 높을수록, 유방의 크기가 클수록 증가하였으며, 얻어진 정보를 바탕으로 기존 검사방법에서 검사시간만을 변화시킨 변형 유방 림프신티그래피를 적용하였을 때 대부분의 경우 검사시간 내 림프절을 형성할 수 있었다. 이를 통해 모든 환자에게 일괄적으로 적용하던 검사방법보다 개인의 신체적 특성을 고려한 적절한 검사시간을 각각 다르게 적용하였을 때 검사에서 높은 성공률을 보임을 알 수 있었다. Purpose : At this time, the sentinel lymph node mapping using radioisotope and blue dye is preceded for breast cancer patient's sentinel lymph node biopsy. But all patients were applied the same protocol without consideration of physical specific character like the breast sizes and body mass indexes. The purpose of this study is search the optimized scan time in breast sentinel lymphangiography by observing how much the body mass index and breast size influence speed of lymphatic flow. Materials and Methods : The Object of this study was 100 breast cancer patients(Female, 100 persons, average age $50.34{\pm}10.26$ years old)at Severance hospital from October 2011 to December 2011. They were scanned breast sentinel lymphangiography before operation. This study was performed on Forte dual heads gamma camera (Philips Medical Systems, Nederland B.V.). All patients were intra-dermal injected $^{99m}Tc$-Phytate 18.5 MBq, 0.5 ml. For 80 patients, we have scanned without limitation of scan time until the lymphatic flow from the lymph node since injection. We measured how long the lymphatic flow time between departures from injects site and arrival to lymph node using stopwatch. After we calculated patient's Body mass Index and classified as 4 groups. And we measured patient's breast size and classified 3 groups. The modified breast lymphangiography that changing scan time according to comparison study's result was performed on 20 patients and was estimated. Results : The mean scan time as breast size was A group 2.48 minutes, B group 7.69 minutes, C group 10.43 minutes. The mean scan time as body mass index was under weight 1.35 minutes, normal weight 2.56 minutes, slightly over 5.62 minutes, over weighted 5.62 minutes. The success rate of modified breast lymphangiography was 85%. Conclusion : As the Body mass index became higher and breast size became bigger, the total scan time is increased. Based on the obtained information, we designed modified breast lymphangiography protocol. At the cases applying that protocol, most of sentinel lymph nodes were visualized as lymphatic pool. In conclusion, we found that the more success rate in modified protocol considering physical individuality than study carrying out in the same protocol.

화학, 생물, 방사능 사고의 정신적 영향

이다영,심민영,Lee, Da Young,Sim, Minyoung 대한불안의학회 2017 대한불안의학회지 Vol.13 No.1

We reviewed the scientific literature on psychological effects of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) disaster, which is one of the biggest threat to modern society. CBRNE disaster has the potential to cause specific physical symptoms and psychological distress in victims ; moreover, various toxic symptoms and carcinogenesis/mutation would be an important issue. Bioterrorism can cause localized outbreaks of infectious disease or pandemic disaster. Somatization as well as posttraumatic stress symptoms and depression are the characteristic psychological symptoms in CBRNE disaster's victims. CBRNE disasters could lead to large-scale public fear and social chaos due to the difficulties involved in verifying the extent of exposure and unfamiliar area to the common people. In the evacuation process, problems associated with adjustment and conflict between victims and residents should be considered.

홍삼·복분자 혼합 발효물을 첨가한 치즈의 항비만 효과

이다영,김남석,김하림,김민선,이창현,오미진,오찬호,김종석,김명순,권진,Lee, Da young,Kim, Nam Seok,Kim, Ha Rim,Kim, Min Sun,Lee, Chang Hyun,Oh, Mi Jin,Oh, Chan Ho,Kim, Jong Suk,Kim, Myung Soon,Kwon, Jin 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.2

This study was investigating the anti-obesity effects of diets with a mixture of cheese, red ginseng and fermented mature fruit of Rubus coreanus Miquel. We fed the experimental diets (SC5, SC10) supplemented with 5% or 10% cheese containing of fermented mixture, then orally administered the extract of fermented mixture (RB100, RB300) at a concentration of 100 or 300 mg/kg body weight to SD rats with high fat diet (HFD). The results were as follows: Sample cheese groups decreased visceral fat mass and adipocyte size of stomach compared to that of HFD group. Additionally, lipid droplets of liver in sample cheese groups were smaller than that in HFD group. The serum triglyceride (TG), total cholesterol (tChol), glucose, leptin, and insulin levels in sample cheese group were lower than that in HFD group. But, the serum adiponectin and HDL-cholesterol (cHDL) levels were higher than that in HFD group. These results suggest that fermentation of red ginseng and Rubus coreanus mixed with cheese might be helpful in preventing obesity in high fat diet-fed rats.

메신저 대화에서의 사용자 검증을 위한 전이 그래프와 챗워크

이다영(Da-Young Lee),조환규(Hwan-Gue Cho) 한국콘텐츠학회 2021 한국콘텐츠학회 종합학술대회 논문집 Vol.2021 No.8

작곡 AI의 현재와 쟁점에 따른 국내 음악저작권 논의방향 연구

이다영(Da Young Lee) 한국대중음악학회 2024 대중음악 Vol.33 No.-

작곡 AI는 음악 분야 중 AI기술이 가장 활발하게 적용되는 부문 중 하나로, 본고에서는 음악콘텐츠산업계 최근 소식과 관련 문헌들을 통해 국내 각 계에서 바라보는 작곡 AI의 현황과 저작권적 쟁점 및 논의방향성에 대해 고찰해 보았다. 이는 정책입안자들이 기술 발전과 저작권 보호에 대한 균형적인 시각을 갖도록 유도하고, 음악산업 관계자 및 창작자들로 하여금 저작권 논의방향에 대한 관심과 이해를 촉진하기 위함이다. 이 글에서는 음악콘텐츠의 제작 및 이용 과정상 나타나는 쟁점 사항을 강조 하기 위해 크게 창작 이전 단계와 창작 단계, 기타 부문으로 나누어 살펴보았 다. 먼저 창작 이전 단계는 데이터 학습 단계로, 원 데이터의 복제·전송에 따른 저작권 침해 문제가 쟁점이다. 이에 대해, 학습데이터에 대한 투명한 정보 공개와 더불어 해당데이터 저작권자에 대한 보상의 정도와 방식에 대한 논의의 필요성과, 이러한 합의의 장 마련을 위한 정책적 도움이 필요성을 제시 하였다. 두 번째, 창작이후 단계에 있어 저작권 쟁점사항으로는 작곡 AI의 창작자 인정여부와 소유권 귀속, 보호방식을 들 수 있다. 창작자 인정여부와 관련해서는, 해외 아이바의 경우와 같이 저작권 인정 사례가 증가할 경우 세계 저작권법에 유효한 영향을 미칠 것이므로 이에 대한 대비의 필요성을 제시하 였다. 또한 AI를 창작자로 인정하는 경우 AI의 역할, 참여비중에 따라 분배기준이 필요한데, 음악산업계 내부에서 이러한 분배 기준이 공유·적용되어야 함을 강조하였다. 마지막으로 작곡 AI 음악의 공유와 상업적 이용과 기존작품과의 유사성 여부 판단 역시 논의대상으로 떠오르는데, 특히 표절에 대한 윤리적인 가이드라 인과 이를 객관적으로 판단할 수 있는 시스템의 필요성을 제안하였다. AI composer stands out as one of the most vigorously applied domains of AI technology within the music sector. This study discusses the current status of AI composer as perceived by various stakeholders in Korea through recent issues in the music industry and relevant literature, while also examining the copyright-related issues and directions of discourse. The aim is to encourage policymakers to adopt a balanced perspective on technological advancement and copyright protection, and to facilitate understanding among music industry stakeholders and composers regarding the direction of copyright discussions. To emphasize the contentious issues arising in the process of music content production, this study categorizes them into pre-creation stages, creation stages, and other areas. First, in the pre-creation stages involving data learning, copyright infringement issues arise from the replication and transmission of original data. Thus, we propose the necessity for transparent disclosure of information regarding training data, as well as discussions on the extent and method of compensation for the data copyright holders, and the need for policy support to facilitate such agreements. Second, in the post-creation stages, copyright issues revolve around the recognition of AI composer creators, ownership attribution, and protection methods. Concerning the recognition of creators, as instances of recognizing AI as creators increase globally, this study suggests preparations for potential impacts on international copyright laws. Furthermore, the distribution criteria based on AI’s role and contribution must be established, with an emphasis on the necessity for internal consensus within the music industry. Lastly, the sharing and commercial use of music composed by AI and the determination of similarity with existing works are also discussed. Specifically, ethical guidelines regarding plagiarism and the need for systems enabling objective judgment are proposed.

생활무용프로그램 참여가 노인의 정신건강에 미치는 영향

이다영(Lee, Da-Young),이정일(Lee, Jung-Il),이소정(Lee, So-Jung) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.6

The purpose of this study is to clarify how participating in Practical dancing programs could affect mental health among elderly people in order to search for vitalization measures to create a healthy leisure culture for them. In the pursuit of this purpose, 433 elderly people aged 60 years or over who went to a community center or an elderly housing in D region that held a Practical dancing program were chosen as subjects of study. The researchers and pre-trained investigators visited the participants in person to explain the contents and purpose of the questionnaire. Questionnaires and self-administration were combined in this process. Results were analyzed by using the SPSS 15.0 statistics program for conducting the T-test and one-way ANOVA. The following are conclusions reached from this study. First, the Practical dancing program gave a positive influence on mental health in men by gender, 60-69 years of age, those who had a spouse, those who lived with his/her spouse by family form, those who received pocket money of 300 thousand won or more per month, and those whose education level was high school graduate and higher, depending on general features. Second, according to participation in Practical dancing programs, those who participated at a community center, who have participated for 1 year or longer, took part in 2 programs or more, who participated in silver dance, who participated 4 times or more per week, and who participated for 1 hour or longer appeared to have received positive influence on their mental health. Third, the participation of elderly people in Practical dancing programs positively affected subcomponents of mental health such as anxiety, psychosis, obsessive-compulsive disorder, and interpersonal sensitivity. In conclusion, a significant difference among elderly people was observed depending on whether they participated in Practical dancing programs, which proves that Practical dancing brings excellent effects on mental health. It vitalizes the life of elderly people and also gives positive influence on their mental health. Thus, a healthy leisure culture for the elderly could be created through Practical dancing programs. More various programs that they can cheerfully join in should be developed and popularized.

우주선 : 발달장애 아동의 소근육 발달을 위한 음악치료 에듀테인먼트 서비스

이다영(Lee, Da Young),윤재영(Yun, Jae Young) 한국디자인학회 2017 한국디자인학회 학술발표대회 논문집 Vol.2017 No.06

재조합 미생물 바이오센서를 이용한 chlorotoluene과 nitrotoluene 화합물의 검출

이다영(Da Young Lee),조재호(Jae Ho Cho),임운기(Woon Ki Lim),신혜자(Hae Ja Shin) 한국생명과학회 2014 생명과학회지 Vol.24 No.1

방향족 화합물은 독성 환경오염물질로 생태계와 인간의 건강에 해로운 영향을 미친다. 그중 chlorotoluene과 nitrotoluene 화합물은 수생생물에 독성을 나타내며 인간의 피부, 눈, 호흡기를 자극한다. 본 연구에서는 폐수의 chlorotoluene과 nitrotoluene 화합물을 저렴하고 간단하게 검출하고자 재조합 미생물 바이오센서를 개발하였다. BTEX (benzene, toluene, ethylbenzene, xylene) 분해 조절 유전자 xylR를 Po’ (upstream activating sequences를 제거한 DmpR 조절단백질 promoter Po) 또는 Pu (XylR 고유의 프로모터)::lacZ 유전자(β-galactosidase 유전자)의 upstream에 연결한 플라스미드를 제작한 후, E. coli DH5α에 형질 전환하였다. 유도 화합물 존재 하에서, 아가로스에 고정된 이 재조합 바이오센서 세포는 유도 화합물에 의해 β-galactosidase를 발현하고 기질인 chlorophenol red β-D-galactopyranoside (CPRG)를 분해하여 1~2시간에 붉은색을 나타내었다. BTEX 화합물 중, 특이적으로 o-, m-, p-chlorotoluene (0.1 ㎛-100 mM) 그리고 o-, m-, p-nitrotoluene (0.1 mM-100 mM)에서 높은 반응을 나타내었으며 Po’가 Pu보다 높은 반응성을 보여주었다. 아가로스에 고정된 바이오센서는 4℃에서 21일간 보존 후에도 활성의 큰 변화 없이 안정하였으며, chlorotoluene과 nitrotoluene 화합물들로 spike된 전처리 하지 않은 폐수 시료중에서도 좋은 반응을 보여 주어 폐수 중 chlorotoluene과 nitrotoluene 화합물의 간단한 초기 검출에 활용될 수 있음을 제시하였다. Aromatic hydrocarbons are toxic environmental pollutants that are detrimental to the ecosystem and human health. Among them, chlorotoluene and nitrotoluene are toxic to hydrobios and irritate the skin, eyes, and respiratory organs of humans. We herein report the development of recombinant microbial biosensors for cheap and rapid monitoring of chlorotoluene and nitrotoluene compounds. Plasmids were constructed by inserting the xylR regulatory gene for BTEX (benzene, toluene, ethylbenzene, and xylene) degradation into upstream of Po’ (the DmpR activator promoter Po with the deletion of its own upstream activating sequences) or Pu (the cognate promoter of XylR)::lacZ (the β-galactosidase gene) and transformed into Escherichia coli DH5α. In the presence of inducers, the biosensor cells immobilized in agarose developed a red color in 1-2 h due to the hydrolysis of chlorophenol red β-D-galactopyranoside (CPRG), a substrate of β-galactosidase that was expressed by the inducers. Among BTEX, high responses were specifically observed with o-, m-, p-chlorotoluene (0.1 ㎛-100 mM) and o-, m-, p-nitrotoluene (0.1 mM-100 mM). Po’ demonstrated higher responses than those with Pu. The biosensors immobilized in agarose showed good stability after 21 days’ storage at 4℃, and responses in untreated wastewater spiked with chlorotoluene and nitrotoluene, suggesting they can be used to detect compounds in wastewater.

우주선 : 발달장애 아동의 소근육 발달을 위한 음악치료 에듀테인먼트 서비스

이다영(Lee, Da Young),윤재영(Yun, Jae Young) 한국디자인학회 2017 한국디자인학회 학술발표대회 논문집 Vol.2016 No.10

20대 소비자의 기초화장품 구매 전 이용한 정보원천 활용도에 따른 구매 후 만족도

이다영 ( Da Young Lee ),이승신 ( Seung Sin Lee ),이영희 ( Young Hee Lee ) 대한가정학회 2017 Human Ecology Research(HER) Vol.55 No.6

Cosmetics market information is important due to advances in information communication technology and the growth of cosmetics market. This study analyzed the relationship between the pre-purchase utilization of information (commercial, neutral, personal and experiential) and the post-purchase satisfaction of skin care cosmetics, categorized as functionality, safety, economic feasibility, information reliability, purchase convenience, condition of purchase place, packaging/design of product and service. This study analyzed reliability, frequency, differences, correlation and regression analysis using SPSS ver. 24.0. The study results are summarized as follows. First, gender was a significant variable in the level of information source utilization. Women used commercial, neutral, and experiential information sources more actively than men. However, women had lower post-purchase satisfaction that could be understood through expectation disconfirmation theory. Women have very high expectations that can lower post-purchase satisfaction. Second, information source utilization can improve post-purchase satisfaction for cosmetics. The consumer post-purchase satisfact the lowest in the commercial information source; however, consumers were satisfied when the commercial informationinformation sourceenon and regre. Third, the consumeried itnformation sourceenon and regression analysis ial, neutral,source and reflected the characteristics of experiential goods. Therefore, companies should provide accurate commercial, personal and experiential information to increase consumervide accurate commercial, per as well as conduct experiential marketing