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우리나라 원발성 간세포암 조직에서 중합효소 연쇄반응을 이용한 B 형 간염 바이러스 DNA 의 검출
이계희(Kye Heui Lee),고광철(Kwang Cheol Koh),이효석(Hyo Suk Lee),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Objectives : The advances in molecular biological technique enable us to detect the integrated HBV DNA in the chromosomal DNA of hepatocellular carcinoma (HCC) cells by Southern blot analysis. The recent development of the polymerase chain reaction made possible the detection of single-copy HBV DNA in a hepatocyte. Regarding the oncogenesis of HBV-related HCC, X-gene is highly suggested to be oncogenic in a transgenic mice model. We investigate the detection rate of each HBV subgenome in the HCC tissues to approach to the human hepatocarcinogenesis using the most sensitive polymerase chain reaction (PCR). Methods: Thirteen formalin-fixed paraffin-embedded HCC-tissue blocks which were aseptically obtained by surgical resection in Korea were studied; 10 were positive for serum HBsAg and one was positive for serum anti-HBc alone, and two were negative for all HBV serological markers. Cellular DNA was extracted from a deparaffinized slice of each tissue block, and then each subgenomic HBV DNA was amplified by PCR using a pair of primers corresponding to each subgenome. The amplified HBV DNA subgenomic fragment was detected by Southern blot hybridization. Results : Among 10 HBsAg-positive cases, the s-gene, c-gene and x-gene nucleotide sequences were detected in 5(50%), 4(40%) and 9(90%) cases, respectively, All 3 gene sequences were detectable in 4(40%) cases. However, HBV DNA subgenomic fragment was not found in the anti-HBc-only case and the cases without any HBV serological marker. Conclusion: It was concluded that HBV may not be involved at all in the development of HBsAg-negative HCC while HBV, especially x-gene, played a major etiologic role in HBsAg-positive HCC in human hepatocarcinogenesis.
혈청 제4형 콜라겐 7S Domain 측정에 의한 만성 간염의 섬유화 정도 예측
이계희(Kye Heui Lee),박성훈(Seong Hoon Park),최신은(Shin Eun Choi),김안나(An Na Kim),김성용(sung Yong Kim),임선희(Sun Hee Lim),임용성(Yong Sung Lim),손인(In Son) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A The degree of fibrosis is a major prognostic factor in chronic liver disease. Although liver biopsy is essential to assess the degree of fibrosis, a more simple diagnostic method would be helpful for its invasive nature. Type IV collagen is one of major constituents of basement membrane and serum collagen IV-7S level reflects the degree of fibrosis. To evaluate the usefulness of serum collagen IV-7S in assessing the state of hepatic fibrosis, we compared the level of serum collagen IV-7S in various liver diseases and normal volunteers. The normal value of the serum collagen IV-7S was 3.6+- 1.2 ng/ml. There was no statistically significant difference in serum collagen IV-7S levels among the group of acute hepatitis, fatty liver, chronic persistent hepatitis and the normal controls. And there was no significant difference between the group of chronic active hepatitis and liver cirrhosis, either. But the level of serum collagen IV-7S of the group of chronic active hepatitis and liver cirrhosis was significantly higher than that of the group of acute viral hepatitis, fatty liver and chronic persistent hepatitis. These results suggest that the measurement of serum collagen IV-7S is a valuable aid for evaluating the state of fibrrosis in chronic liver disease.
위 ( 胃 ) 에 발생 ( 發生 ) 한 혈관외피세포종 ( 血管外皮細胞腫 ) ( 例 )
이계희(Kye Heui Lee),박경주(Kyung Joo Park),김동린(Dong Chan Kim),이수영(Su Young Lee),경춘숙(Choon suk Kyoung),최상전(Sang Jeon Choi),손인(In Sohn),박성훈(Seong Hoon Park),전호경(Ho Kyung Chun),최신은(Shin Eun Choi) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
Hemangiopericytoma of stomach is an extremely rare tumor, Recentely we experienced a case of gastric. hemangiopericytoma of a 51-year-old man with massive upper gastrointestinal bleeding, The rarity of thie case is emphasized and the literature reviewed, The hemangiopericytoea of stomach is characteril by mild epigaetric pain, slowly growing mass and upper gaetrointestinl bleeding, In the limited exrience reported so far, partial gastric resection may be an effective form of treitment.
이재용(Jae Yong Lee),성천모(Chun Mo Sung),경춘숙(Choon Suk Kyeong),이수영(Su Young Lee),김동찬(Dong Chan Kim),이계희(Kye Heui Lee),최상전(Sang Jeon Choi),손인(In Son),박성훈(Seong Hoon Park) 대한내과학회 1991 대한내과학회지 Vol.40 No.6
N/A Due to the high propensity of rupture and cardiac death, early diagnosis of pseudoaneurysms of the left ventricle is clinically very important. Diagnosis can be carried out by noninvasive techniques, such as echocardiography and radioisotope gated blood pool scan, if the disease is suspected. We report a case of left ventricular pseudoaneruysm after acute myocardial infarction of the inferoposterolateral wall, with the findings of echocardiography, radioisotope blood pool scan, and chest computerized tomography.
홍소영(Hong So Young),이계희(Lee Kye Heui),이홍수(Lee Hong Soo),이명숙(Lee Myoung Sook),지선하(Jee Sun Ha),정효지(Joung Hyojee) 韓國營養學會 2007 Journal of Nutrition and Health Vol.40 No.8
While metabolic syndrome (MS) is rapidly expanding and dietary pattern, the known risk factor of MS, goes through heavy transition to western diet, not many researches have been done on the association between dyslipidemia and dietary factors in Korean adults. The purpose of this study was to investigate the association between compliance with dietary guidelines and dyslipidemia among Koreans. The subjects of 399 adults who visited health examination center were classified into dyslipidemia (n = 180) and control (n = 219). Diagnosis of dyslipidemia was based on NCEP-ATPⅢ criteria (triglyceride > =150㎎/d, HDL-C < 50 ㎎/㎗ for male, HDL-C < 40 ㎎/㎗ for female). A questionnaire based interview was done to collect information on compliance with dietary guidelines, general characteristics and health related behaviors. Anthropometric variables were measured during the survey. Mean compliance score of dietary guideline was significantly lower in dyslipidemia group than in control. It was associated negatively with waist circumference and positively with serum HDL-cholesterol (p<0.05). Risks of dyslipidemia were significantly decreased in the group with highest dietary guideline score; high serum triglyceride levels (OR = 0.484, 95% CI = 0.268-0.875), abdominal obesity (OR = 0.296, 95% CI = 0.159-0.553), and dyslipidemia (OR = 0.481, 95% CI = 0.266-0.869). These results indicated that increasing compliance with dietary guidelines could be an effective strategy to lower the risk of dyslipidemia among Koreans.
자당분해효소 (蔗糖分解酵素) 측정에 의한 위암에서의 (胃癌) 장형화생의 (腸形化生) 의의
송인성 ( In Sung Song ),오인혁 ( In Hyeog Oh ),이계희 ( Kye Heui Lee ),김해련 ( Hae Ryeon Kim ),정형배 ( Hyeong Bae Jung ),김정룡 ( Chung Young Kim ) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2
Enzyme histochemistry of the gastric surface epithelium has been found to be valuable in diagnosing atrophic lesions with intestinal metaplasia of gastric mucosa. And interest in intestinal metaplasia of gastric mucosa as the origin of gastric carcinoma has increased considerably. To identify the type of intestinal metaplasia of stomach in gastric cancer by direct measurement of surcrase activity from gastric mucosa, we conducted this study. We obtained following results; 1) Intestinal metaplasia in atrophic gastritis showed two types, small intestinal type (46.1%) and colonic type (53.9%). Which was judged by direct measurement of sucrease activities from gastric mucosa. 2)In remnant stomach small intestinal type of metaplasia was observed in 55.6%, and 16.6% of gastric mucosa in benign gastric ulcer showed small intestinal type of metaplasia. 3)In gastric cancer, 37% of non-tumor bearing mucosa showed samll intestinal type of metaplasia. Our results suggest that degree of differentiation of intestinal metaplasia has no direct relationship with malignant potential in stomach.