만성 혈액투석 환자에서의 대사성 산혈증과 음이온차의 양상

손정일(Chong Il Sohn),김병훈(Byoung Hun Kim),신진호(Jin Ho Shin),양석철(Suck Chul Yang),박용수(Yong Soo Park),한동수(Dong Soo Han),안명주(Myung Ju Ahn),손주현(Ju Hyun Sohn),이인홍(In Hong Lee),김순길(Soon Kil Kim),이정희(Jung Hee Lee 대한내과학회 1996 대한내과학회지 Vol.51 No.2

N/A Objectives: The aim of the present study is to evaluate the prevalence of the various patterns of metabolic acidosis and anion gap among chronic hemodyalysis patients. Methods: Analysis of predialysis arterial blood gases and anion gap patterns was performed in 67 stable chronic outpatient hemodialysis patients(>1 year) with acetate buffer. Blood samples were drawn from the arterial line of the atreriovenous fistula for determination of blood electrolytes, chemistries, and analysis of blood gases at the beginning of hemodyalysis. Results: The degree of metabolic acidosis was mild to moderate with mean pH 7.33±0.039. 82% of a total 67 patients had pH between 7.30 and 7.39 with 18% of them between 7.20 and 7.29. Simple as mixed metabolic acidosis was shown in 49 of 67 patients(73%) and 18 of 67 patients(27%), respectively. In comparison of both groups, the group with mixed metabolic acidosis had significantly lower pH(7.29±0.04 vs 7.34±0.03, p<0.001) with higher pCO₂(38.5±3.4, p<0.005) and anion gap(19.6±4.1 vs 17.6±2.9, p<0.05). The classical high anion gap of end stage renal disease (range, 16 to 29 mEq/L) was also noted in 20 of 67 patients(30%). The linear regression analysis between anion gaps and total serum carbon dioxide contents (TCO₂) didn't show any significant correlation in all patients as well as the two subdivided groups with high and normal anion gap. Furthermore, only 13 of 67 patients(20%) were included between 80 and 120% in the ratio of delta anion gap(ΔAG) over delta TCO₂(dTCO₂). Therefore, the majority of hemodialysis patients (80%) showed the discrepancy between the degrees of d AG and ΔTCO₂. The analysis of unmeasured cations(K, Ca) and anions(albumin, phosphate) in the calculation of anion gap(Na ?Cl ?HCO₃) between two groups of high and normal anion gap of all patients as well as 49 patients of simple metabolic acidosis didn't reveal any discernible contributions to the changes of anion gap. Conclusion- This study therefore showed that the mixed acid-base balance and normal anion gap metabolic acidosis is not an exception in chronic stable hemodialysis patients. Also, the impact of hemodialysis in end stage renal disease patients seemed to lead the changes in values of unidentified anions besides fixed mineral acids and/or in those of unrecognized ionic equivalents of plasma constituents.

골이식재를 사용하지 않은 상악동 거상술

손동석(Dong-Seok Sohn),이지수(Ji-soo Lee),안미라(Mi-ra Ahn),신홍인(Hong-In Shin) 대한치과의사협회 2008 대한치과의사협회지 Vol.46 No.4

Various maxillary sinus floor augmentation techniques were common performed and in the most cases, many kinds of bone graft materials were used. The graft materials are autogenous bone or other biomaterials of human, artimal or synthetic origin. but these cases, report describes a new surgical technique by which dental implants are inserted in a void space created by elevating the sinus membrane without additional graft material in atrophic posterior maxilla. We created lateral bony window using piezoelectric device and elevated the schneiderian membrane in ten patients. Dental implants were simultancously placed and lateral window prepared was covered with non-resorbable membrane in five patients and was repositioned with bony window in five patients, without any bone graft. From the clinical and histological results, it is found there is potential capacity for bone formation and placement of implants in the maxillary sinus without the use of bone grafts or bone substitutes.

내건성 형질전환벼의 토양미생물상 영향

손수인 ( Soo-in Sohn ),오영주 ( Young-ju Oh ),김병용 ( Byung-yong Kim ),장안철 ( Ancheol Chang ),이범규 ( Bumkyu Lee ),윤도원 ( Doh-won Yun ),이강섭 ( Gang-seob Lee ),오성덕 ( Sung-dug Oh ),조현석 ( Hyun-suk Cho ) 한국환경농학회 2016 한국환경농학회 학술대회집 Vol.2016 No.-

The studies about the effect of planted GM crops on soil microorganisms have been continued. Although many studies have been carried out over the past decades, they provided contradictory information about the effect on soil microorganisms even for the same GM crop due to the diversity of soil environment, which means the effect of GM crops on soil microorganisms should be considered in many aspects. In this study, we investigated the effect of the drought tolerant rice, MSRB2-Bar-8 which expresses CaMSRB2 gene on soil microorganisms based on the culture-dependent and culture-independent methods. For this, soil chemical analysis, population density of soil microorganisms, denaturing gradient gel electrophoresis (DGGE) and pyrosequencing were analyzed with rhizosphere soils of GM and the non-GM counterpart of Ilmi rice. There was no significant difference in soil chemicals between GM and non-GM rice. The microbial community densities of the GM soils were found to be within the range of those of the non-GM rice. The DGGE patterns of the total soil microorganisms for GM and non-GM rice were also similar. In the pyrosequencing analyses, Proteobacteria and Cloroflexi were dominant at seedling stage while Cloroflexi showed dominance over Proteobacteria at maturity stage in both soils. In UPGMA dendrogram, two soils were grouped by time period showing difference in soil microorganisms by time period; however, such difference was not the difference in soil microorganisms between GM and non-GM. In conclusion, the results from this study imply that the effect of MSRB2-Bar-8 cultivation on soil microorganisms is not significant.

공공보건의료 연계·협력 추진 현황과 과제

손정인 ( Sohn Jeong-in ) 한국보건사회연구원 2022 보건복지포럼 Vol.311 No.-

공공보건의료 연계·협력은 건강의 사회적 모형, 인구 고령화, 사람 중심 관점에서 필요하며, 그 원칙은 체계적 관점의 포괄적·통합적 대응과 지역사회 중심이다. 2012년 「공공보건의료에 관한 법률」 전부개정과 2018년 ‘공공보건의료 발전 종합대책’에 따라 보편적 개념의 공공보건의료가 등장하고, 지방정부의 책임성이 강화되었으며, 공공보건의료 연계·협력 기반이 마련되었다. 공공보건의료 연계·협력의 주요 실행 주체는 시·도와 함께 시·도 공공보건의료지원단, 책임의료기관이며 2019년부터 확충되어 2022년 기준으로 각각 16곳, 58곳이 운영 중이다. 이들이 주축이 되어 ‘시·도 공공보건의료위원회’ 중심의 정책 거버넌스와 ‘필수 보건의료 원외 협의체’ 중심의 제공 거버넌스를 구축·운영하고 지역 완결적 필수보건의료 제공을 실현하고 자 한다. 이를 위해 중앙정부와 시·도는 지역 현장의 의견을 수렴하고 국가계획과 예산, 건강보험 지불보상, 행정, 인력, 조직, 정보시스템 개선 방안을 마련, 지원할 필요가 있다. The rationale for public health governance consists of the social model of health, population aging, and people-centeredness. The principles of action involved are inclusiveness and comprehensiveness in terms of health system and community-based perspective. The Public Health and Medical Service Act in 2012 and the National Plan of Public Health Care Development in 2018 contributed to the establishment of universal public health care, the strengthening of regional government accountability, and the building of public health governance infrastructures in South Korea. The main actors of public health governance are 17 regional governments, 16 Public Health Care Institutes and 58 Accountable Care Hospitals in South Korea. They support the health care policy governance and oversee service delivery in order to ensure access for residents to essential health care in community. Therefore, central and regional governments in South Korea need to hear the community experts and front-line actors and provide support using the national plans, budgets, health insurance payments, administrations, human resources, organizations, information systems etc.

한반도 남동부 포항-울산지역 심부 지질구조 분석을 위한 중력장 해석

손유진,최승찬,유인창,Sohn, Yujin,Choi, Sungchan,Ryu, In-Chang 대한자원환경지질학회 2020 자원환경지질 Vol.53 No.5

규모 5 이상의 경주지진과 포항지진이 발생한 이후에도 한반도 남동부에서는 여전히 수백 건의 여진과 미소 지진이 발생하고 있다. 이러한 현상은 응력이 계속 작용하고 있다는 것을 의미하며, 또 다른 큰 지진이 발생할 수도 있음을 암시한다. 따라서 본 연구에서는 한반도 남동부 포항-울산지역의 심부 지질구조를 분석하기 위해 중력장 해석 방법을 사용하였다. 먼저 연구지역의 부족한 중력 데이터를 수집하기 위해, 중력 탐사를 시행하여 기존 자료보다 정밀한 부게 중력이상을 계산하였다. 중력이상 데이터를 바탕으로 역산 방법인 "곡률 분석 (Curvature analysis)"과 "오일러 곱풀기 방법(Euler deconvolution method)"을 이용하여, 한반도 남동부의 심부 단층의 위치 및 방향성과 최대 깊이를 분석하였다. 그 결과, 본 연구지역에는 최소 6개의 심부 단층(C1~C6)이 존재하는 것으로 해석된다. 심부 단층선 C1은 방향성과 위치가 연일구조선과 일치하는 것으로 보아, 연일구조선이 최대 약 4000m 깊이까지 이어져 있는 것으로 해석된다. 심부 단층선 C2는 여러 개의 분절된 단층들로 이루어져 있으며, 지표의 단층들과 잘 대비된다. 심부 단층선 C3, C4와 C5는 북서-남동 방향의 울산단층과 평행한 방향성을 가지는 것으로 분석되며, 초기 백악기에 남북 방향의 응력을 받아 형성되었으나 퇴적물에 덮여 지표에 드러나지 않는 것으로 판단된다. 심부 단층선 C6는 북동-남서 방향성을 가지며, 어일분지의 동쪽 경계단층이 심부로 이어져 있는 것으로 사료된다. 분석한 심부 단층선과 미소 지진 발생 현황을 대비한 결과, 심부 단층선 C1과 2018년~2019년 동안 한반도 남동부에서 발생한 미소 지진의 분포가 대략 일치하는 것을 확인하였다. 이는 심부에 존재하는 단층과 최근 발생하는 지진이 연관이 있다는 것을 시사한다. Even after the Gyeongju earthquake and the Pohang earthquake, hundreds of aftershocks and micro-earthquakes are still occurring in the southeastern part of the Korean Peninsula. These phenomena mean that the stress is constantly working, implying that another huge earthquake may occur in the future. Therefore, the gravity field interpretation method was used to analyze the deep geological structure of the Pohang-Ulsan region in the southeastern Korean Peninsula. First, a gravity survey was performed to collect the insufficient data and to calculate the detailed Bouguer gravity anomaly in the study area. Based on the gravity anomaly data, the location, direction, and maximum depth of deep fault lines were analyzed using the inversion methods "Curvature analysis" and "Euler deconvolution method". As a result, it is interpreted that at least six fault lines(C1~C6) exist in deep depth. The deep fault line C1 is well correlated to the Yeonil Tectonic Line(YTL), suggesting that YTL is extended up to about 4000m deep. The deep fault line C2 consists of several segment faults and well correlated to the fault lines on the surface. Inferred fault lines C3, C4, and C5 have an NW-SE direction, which is parallel to the Ulsan fault. The deep fault line C6 has the direction of NE-SW, and it is interpreted that the eastern boundary fault of Eoil Basin is extended to the deep. Comparing the inferred fault lines with the distribution of micro-earthquakes, the location of the deep fault line C1 is well correlated to the hypocenter of micro-earthquakes. This implies that faults in deep depth are related to the recent earthquakes in the southeastern Korean Peninsula.

개념으로서의 건강권

손정인(Sohn, Jeong-In),김창엽(Kim, Chang-Yup) 비판과 대안을 위한 사회복지학회 2016 비판사회정책 Vol.- No.52

건강권은 문제 상황에 대한 가치판단의 개념적 틀로서 의의가 있다. 국내의 학술적 소통에서 학술 의제로서 건강권의 상황과 건강권에 대한 명명을 분석하기 위해 1990~2014년 동안 국내에서 발표된 건강권에 관한 학술논문(이하, 건강권 논문)의 특성과 추세, 건강권에 대한 명명을 검토하였다. 한국교육학술정보원의 학술연구정보서비스(RISS)를 통해 선정한 386개의 석ㆍ박사학위논문과 학술지논문를 대상으로 내용분석을 수행하였다. 지난 25년 동안 국내 건강권 논문은 전반적으로 증가 추세를 보였고 저자 소속분야도 다양해졌다. 논문 제목에 건강권에 대한 명명이 언급된 논문은 그렇지 않은 논문에 비해 논문 수, 학위논문 비중, 증가 추세의 강도, 저자 소속분야의 다양성, 학술적 엄밀성, 학술지의 KCI 등재(후보) 비율 측면에서 모두 저조하였다. 건강권 명명은 국문 총 39가지, 영문 총 18가지로 사용되었고 각기 ‘건강권’, ‘right to health’의 빈도가 높았다. 개별 논문에서 건강권 명명을 다중 사용했을 때 개념이나 관계 설명을 명시한 경우는 드물었다. 건강권에 대한 국내의 학술적ㆍ실천적 소통을 활성화하기 위해서는 건강권이나 특정 건강권이 주제인 학술 연구의 비중과 학술적 엄밀성을 높이고, 건강권 명명의 개념과 관계에 대한 설명을 제시할 필요가 있다. “The Right to health” is worthy of a conceptual framework for value judgement on economic, social, and cultural issues related to health, although not constructed systematically based on reasoning and communication. To illuminate the use of the right to health as a communicative agenda in South Korea, in research area in particular, this paper explores utilization of concept on the right to health in academic literature published in 1990-2014. The 386 papers consisting of dissertations and journal articles were selected and analysed using a content analysis method. Over the past 25 years, the papers have increased in the number of publications and their authors. However, the papers dealing with the right to health itself have shown poor performance, compared with general trend of total publication, in terms of the number of publication and their authors, attributable proportion among total publication, increasing trend in publication, and scientific soundness and acceptability. With regard to naming of the right to health, 39 names in Korean and 18 names in English were found; the most frequent ones are “건강권” and “right to health”, respectively. Most of publication rarely define the concept of rights to health unconfusingly, also not revealing their relationship, when they apply multiple names to the right to health. To promote communication about the right to health, it needs to facilitate research on the right to health and to improve their quality; and offer more developed concepts and accounts on the right to health.

CaO-SiO2-Al2O3-MgO계 슬래그 중 Cu와 Ni의 용해도

한보람 ( Bo Ram Han ),손인준 ( In Joon Son ),손호상 ( Ho Sang Sohn ) 대한금속재료학회(구 대한금속학회) 2015 대한금속·재료학회지 Vol.53 No.11

In this study, the solubility of Cu and Ni, which are the main metal components of waste PCB in a CaO-SiO2-Al2O3-MgO slag system, was investigated by the chemical equilibration technique in the temperature range 1673-1823 K, under a CO-CO2 atmosphere. The concentrations of Cu and Ni in the slag increased with increasing oxygen partial pressure and MgO content in the slag. The concentrations of Cu and Ni in the slag decreased with increasing temperature. The concentration of Cu in the slag decreased with increasing activity of CaO, but that of Ni increased. The dissolution mechanisms of Cu and Ni in the CaO-SiO2-Al2O3-MgO slag could be described by the following equations from the effect of oxygen partial pressure and slag basicity on Cu and Ni dissolution behaviors: From the results obtained, the enthalpy changes from dissolution of Cu into the CaO-SiO2-Al2O3-MgO slag were calculated to be -59.17 kJ/mol, and that for Ni was calculated to be -78.89 kJ/mol.

이중구조 합성 폴리머 차폐막에 위한 골성 회복능 평가

손정오 ( Jung Oh Sohn ),박의균 ( Eui Kyun Park ),이진호 ( Jin Ho Lee ),신홍인 ( Hong In Shin ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.1s

Bone defects occur in a variety of clinical situation, and their reconstruction to provide mechanical integrity to the skeleton is a necessary step in the patient rehabilitation. Bones can regenerate themselves to repair defects up to a certain size but sometimes the suitable implant materials have to be applied to facilitate the bone repair. As a part of the effort to improve the efficiency of bone repair, we evaluated the hydrophilized asymmetric pore sized polydioxanone membrane for guided bone regeneration. The polydioxanone membrane was fabricated to have different pore size at inner (around 50 nm in diameter) and outer surface (around 50 μm in diameter) with an average 0.4 mm thickness. The cytotoxic effect of it was analyzed in vitro and the histocompatibility and guided bone regeneration effects were evaluated in vivo, respectively. The rat tibia bone defects measuring 7 mm×3 mm in size were treated with polydioxanone membrane with or without application of 10 mM LiCl or 100 μg/ml T-CAM. The defects were evaluated at 3weeks after treatment by radiography and histology. The polydioxanone membrane was relatively resilient with some cushion. It was no cytotoxic and evoked neither an immune nor an inflammatory response. It was gradually absorbed by numerous multinucleated giant cells with time and completely disappeared within 8 weeks at rat subcutaneous pouches. The application of polydioxanone membrane at rat tibia bone defects induced more effective bone repair with matured cortical plate regeneration compared to none membrane applied group. In addition, the treatment of 10 mM LiCl and 100 μg/ml T-CAM within polydioxanone membrane facilitated bony healing. These results suggest that the combined application of bioactive molecules such as 10 mM LiCl or 100 μg/ml T-CAM with hydrophilized sized polydioxanone membrane can facilitate the guided bone regeneration.

신규 백금착물 항암제 KBP31705-C127 , KBP30603-901 의 Clsplatn 및 Carboplatin 과의 약동력학적 동태 비교

정인숙(In Sook Jung),이주선(Ju Seon Lee),허수정(Soo Jung Huh),김진숙(Jin Sook Kim),진창배(Chang Bae Jin),김동현(Dong Hyun KIm),김명수(Myung Soo Kim),박경수(Kyung Su Park),손연수(Youn Soo Sohn),백형기(Hyoung Gee Back),조양하(Yang Ha C 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4

The present study examined pharmacokinetic profiles of KBP31705-C127 and KBP30603-901, new platinum coordination complexes synthesized as anticancer candidates, in comparison with two well-known platinum-containing anticancer agents, cisplatin and carboplatin in rats. Under sodium pentobarbital anesthesia of male Sprague-Dawley rats, urinary bladder, and femoral artery and vein were catheterized for urine collection, blood sampling and drug injection, respectively. Following i.v, administration of cisplatin (2 ㎎/㎏), KBP31705-C127 (2 ㎎/㎏), carboplatin (20 ㎎/㎏) or KBP30603-901 (20 ㎎/㎏), blood samples were collected at 2, 4, 6, 8, 10, 15, 20, 30, 45, 60 and 120 minutes. Urine samples were collected at 1-hr interval for 4 hr. Platinum concentrations in plasma and urine were measured using an inductively coupled plasmamass spectrometer. The plasma concentration-time curves were biphasic for all drugs during the time period studied. Compared with cisplatin, KBP31705-C127 showed similar decay patterns in the alpha- and beta-phases with slightly lower plasma concentrations. Urinary platinum excretion for cisplatin and KBP31705-C 127 was 56 and 52% of the administered dose in 4 hr, respectively. With regard to carboplatin and KBP30603-901, a similar decay pattern was also observed in the alpha-phase. The half life of KBP30603-901 in the beta-phase, however, was much longer than that of carboplatin, which was consistent with the urinary excretion results that 46 and 59% of the administered dose were excreted in the urine in 4hr, respectively. The results suggest that platinum coordination complexes are primarily excreted via the renal route and KBP30603-901 can elicit longer duration of action due to slower renal excretion compared to carboplatin.

당뇨병환자에서 뇨중 Fibronection 치에 관한 연구

이인규(In Kyu Lee),박근용(Keun Young Park),조성래(Sung Rae Cho),박기락(Ki Rak Park),진선미(Sun Mi Jin),손건영(Kun Young Sohn),이병헌(Bung Heun Lee),조준승(Joon Seung Jo) 대한내과학회 1995 대한내과학회지 Vol.49 No.4

N/A Objectives: In diabetic nephropathy, thickening of basement membrane in the glomerulus and tubule is a well known finding. Therefore, we evaluated whether the excretion of urinary fibronectin, which is one of important factors of basement membrane, is related with the presence of diabetic nephropathy. Methods: We measured and compared the urinary fibronectin excretion rate(FER) and the albumin excretion rate (AER) in 20 healthy controls and 89 diabetic patients', 44patients without microalbuminuria, 26 patients with microalbuminuria, 19 patients with overt nephropathy, Urinary fibronectin levels were measured by our enzyme linked immunosorbent assay (ELISA) method and urinary microalbumin by radioimmunoassay. Results: Patients with overt proteinuria were characterized by a significantly (p<0.005) longer duration of diabetes (Mean±SD: 97.1±30.8 years, 60.5±74.4 years, 62.2±58.3 years) and by a higher systolic presure (l34.2±19,5mmHg, 120.5±5.8 mmHg, 121.8±14.2mmHg, 127.7±14.5mmHg) compared with control and diabetic patients with or with- out microabluminuria 2) The mean fibronectin excretion rate was significantly (p<0,05) higher in the group with microalbuminuria (277.9+244,6μg/min) than in normoalhuminuria patients(165.7±90.3μg/ min) or in control subjects (184.1±96.9μg/min) and also significantly (p<0.005) higher in the group with overt proteinuria (370.6±331.6μg/min) than in microalbuminuria (277.9±244.6μg/min) or in normoalbuminuria (165.7±90.3μg/min) 3) Significant (p<0.01, p<0.001) degree of correlation were found between urine fibronectin excretion rate and duration of diahetes (r=0.31) or systolic blood pressure(r=0.35), where as AKR significnatly (p<0.01) correlated with duration of disease (r=0,27). 4) Urine fibronectin excretion rate were, significantly ocrrelated with AER(r=0.13, p<0.001) Conclusion: The results of this study suggest that FER is a useful indicator for the occurrence and progression of early diabetic nephropathy.