http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 오동렬(Dong-Yul Oh) (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
도파민 발현 세포주 CV(bDAT) 세포에서 항정신병 약물이 도파민 수송체 활성에 미치는 영향
김영미,이용성,이상훈,오동렬,양병환,조석신,남정현,Kim, Young-Mi,Lee, Yong-Sung,Lee, Sang-Hun,Oh, Dong-Yul,Yang, Byung-Hwan,Cho, Suck-Shin,Nam, Jung-Hyun 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1
CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake activity were investigated. All of antipsychotic drugs tested, inhibited the [$^3H$]dopamine uptake into CV(bDAT) cells with $IC_{50}s$ in the low to mid micromolar range, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.
-
장미윤(Mi Yoon Chang),전대준(Dae Joon Cheon),오동렬(Dong Yul Oh),이용성(Yong Sung Lee),이상훈(Sang Hun Lee) 대한약학회 1999 약학회지 Vol.43 No.6
Human and bovine dopamine transporters (DAT) demonstrate discrete functional differences in the dopamine (DA) transport and cocaine binding. The functional analyses on the chimeras of human and bovine DAT have revealed that the region from the 133rd to 186th residue (encompassing the 3rd transmembrane domain(TM)) is responsible for the substrate transport and cocaine binding. The present studies have been done to find out the specific amino acid(s) which is essential for the binding of cocaine to DAT by interchanging the amino acids in that region between human and bovine DAT. When isoleucine, the 152nd residue of chimera B3 (bovine DAT sequence), was transformed back to valine, the human DAT residue at the identical position, the cocaine binding was remarkably recovered to 98% of the human DAT values. In addition, the cocaine binding of the human DAT was decreased by 57% by substituting isoleucine for valine at position 152. When isoleucine at position 152. When isoleucine at position 152 of the chimera B3 was converted to the other amino acids to provide an possible molecular basis for the functional role of the 152nd residue, only the conversion to alanine among the amino acids tested significantly increased the cocaine binding by 34%, but these effects were not as much as those by the conversion to valine. In conclusion, valine at position 152 is a crucial amino acid for the interaction of cocaine to the DAT.
-
김진훈(Jin-Hun Kim),김길숙(Gil-Sook Kim),오동렬(Dong-Yul Oh),김종우(Jong-Woo Kim) 한국중독정신의학회 2002 중독정신의학 Vol.6 No.2
Objectives:The purpose of this study was to investigate the difference between alcoholic men and normal controls on Temperament and Character Inventory (TCI) scores. Methods: We compared 40 male alcoholic patients who were admitted to Seoul National Hospital with 40 normal controls. All subjects were assessed by drinking pattern questionnaires, Seoul National Hospital Alcoholism Screening Test, and TCI. Results: 1) Alcohol dependent patients showed higher Novelty-Seeking and lower Self-Directedness scores than normal controls. 2) Self-Directedness score was lower in early-onset than in late-onset patients. 3) Persistence score was lower in violent than non-violent patients. Conclusion:The findings of this study suggest that alcoholic dependent patients have higher Novelty-Seeking score and lower Self-Directedness score than normal controls, and that those with specific clinical characteristics such as early-onset and violence have close relationship with a specific TCI profile.
-
-
지연성 운동장애에 대한 Bromocriptine의 치료 효과
吳東烈,金二泳 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.2
In this double-blind clinical trial of bromocriptine, the author tried to evaluate the efficacy of bromocriptine in the treatment of tardive dyskinesia and to prove the relevance of supersensitivity theory of brain dopaminergic system as a hypothesis of pathophysiology of tardive dyskinesia. Research subjects were selected from schizophrenic inpatients of National Seoul Mental Hospital by Schooler and Kane(1982)'s inclusion criteria. Twenty one chronic schizophrenic patients with tardive dyskinesia were finally selected as research samples. The Abnormal Involuntary Movement Scale provided by National Institute of Mental Health in America was used for assessment of severity of dyskinesia and the Brief Psychiatric Rating Scale was used for evaluation of mental symptom change. The results were as follows; 1) There was no significant improvement of involuntary movements could statistically be proved in the bromocriptine-treated group. However, a slight improvement of involuntary movements could be noticed in 8 among 11 cases in bromocriptine group. Thus, possible action of bromcriptine as a partial dopamine agonist could not be excluded. 2) During the research period, many drop-out cases were noticed in placebo group. By this result, antipsychotic evidence of bromocriptine was vaguely suggested. At the present situation, however, theoretical implication of bromocriptine to antipsychotic effect is impossible to formulate. But, it is suggested that since the majority of persistent dyskinesia were the chronic schizophrenics, antidyskinesic agents should either have antipsychotic property or well be tolerated with antipsychotic agents for the successful management of tardive dyskinesia.
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
