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LPS로 유도된 RAW 264.7 세포와 마우스 귀 조직에 대한 양파(Allium cepa L.) 껍질 에탄올 추출물의 항염증 효과
안나경(Na-Kyung Ahn),강보경(Bo-Kyeong Kang),김꽃봉우리(Koth-Bong-Woo-Ri Kim),김민지(Min-Ji Kim),배난영(Nan-Young Bae),박지혜(Ji-Hye Park),박선희(Sun-Hee Park),안동현(Dong-Hyun Ahn) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.11
양파 껍질 에탄올 추출물(OPEE)의 in vitro 및 in vivo에서 항염증 효과를 알아보기 위해 lipopolysaccharide(LPS)로 활성화된 RAW 264.7 세포로부터 분비되는 염증 관련 매개인자들의 발현량과 ICR 마우스모델을 이용한 귀 부종 및 조직 분석을 진행하였다. NO 및 염증성 cytokine(IL-6, IL-1β 및 TNF-α)의 분비량이 OPEE에 의해 농도 의존적으로 감소함을 확인하였다. iNOS 및 COX-2의 발현량은 LPS에 의해 증가하였으나, OPEE 처리에 의해 농도 의존적으로 발현량이 감소하였다. 전사인자인 NF-κB의 활성과 인산화효소인 MAPKs(p-38, JNK 및 ERK)에서도 LPS에 의해 증가된 발현량이 OPEE에 의해 억제됨을 확인하였다. 따라서 NO 및 염증성 cytokine의 분비량 감소는 NF-κB와 MAPKs의 활성 저해에 의한 것임을 확인하였다. In vivo 실험에서는 croton oil로 귀 부종을 유발한 마우스에 OPEE를 처리하였을 때 prednisolone 처리구와 유사한 수준으로 귀 부종이 억제되었으며, 귀 조직 관찰에서도 경피 및 진피의 두께와 진피로 침윤된 mast cell의 수도 억제됨을 확인하였다. 이상의 결과 OPEE는 항염증 소재로서 염증을 예방하거나 치료하는 데 이용 가능성이 높음을 제시한다. Inflammation is a complex process involving a variety of immune cells, which defend the body from harmful stimuli. However, pro-inflammatory cytokines and inflammatory mediators can also exacerbate diseases such as cancer. Onion peel contains several phenolic compounds, including quercetin at an amount 20 times greater in peel than edible flesh. Therefore, in this study, the anti-inflammatory effects of onion peel ethanol extract (OPEE) were investigated lipopolysaccharide-induced inflammatory response. In our results, NO production decreased in a dose-dependent manner. Secretion of IL-6, TNF-α, and IL-1β was suppressed by 44%, 53%, and 60% respectively, at 100 μg/mL. Moreover, OPEE also suppressed expression of COX-2, iNOS, NF-κB, and MAPKs in a dose-dependent manner. Formation of mice ear edema was reduced at the highest dose tested compared to the control, and reduction of ear thickness was observed in the histological analysis as well. In the acute toxicity test, no morality was observed in mice administered 5,000 mg/kg body weight of OPEE over a 2-week observation period. These results suggest that OPEE may have significant effects on inflammatory factors and be a potential anti-inflammatory material.
국내 양돈장에서 돼지글래셔병을 동반한 PMWS에 대한 M+ parapac(R)의 방어효과
안나경 ( Na Kyoung Ahn ),서태원 ( Tae Won Seo ),정현규 ( Hyun Kyu Jeong ),윤병일 ( Byung Il Yoon ),한정희 ( Jeong Hee Han ) 한국동물위생학회 2008 한국동물위생학회지 (KOJVS) Vol.31 No.3
The purpose of this study was to evaluate the efficacy and cross-protection of serovar 12 against serovar 4 or 5 of H parasuis with M+Parapac(R). A total of 141 piglets from 2(A and B) farms were used and divided into experimental group and control group in each farm. Farm A has been detected H parasuis serovar 12, whereas farm B has been detected H parasuis serovar 4 or 5 from post-weaned pigs with PMWS. The piglets were vaccinated intramuscularly with 2.0ml of M+Parapac(R) in experimental group or normal saline in control group at 1 week of age. A same booster dose was given at 3 weeks of age. In order to value the antibody titer to H parasuis using by tube agglutination test, blood samples were collected from piglets at the aged of 1 week, 6 and 14 weeks. In experimental group and control group, the average antibody titers were 32.5±21.0, 114.5±34.0, 98.1±55.4 and 32.9±18.6, 25.8±36.9, 746.7±1,215.8 at the aged of 1 week, 6 and 14 weeks, respectively. The cumulative clinical sign indexes by standard guideline of Schering-Plough Animal Health Corp were 486 and 1,069, respectively. The average daily gains and feed conversion rates were 0.553±0.016kg and 0.492±0.004kg, and 1.99 and 2.24, respectively. The average gross lesion scores were 1.0±0.8 and 1.9±0.6, respectively. According to these results, the M+ Parapac(R) containing H parasuis serovar 12 may be induce circulating antibodies that cross-react with serovar 4 or 5 and have a protection of PMWS with H parasuis.
정다현,안나경,최연욱,박지혜,배난영,박선희,김민지,김꽃봉우리,안동현,Jeong, Da-Hyun,Ahn, Na-Kyung,Choi, Yeon-Uk,Park, Ji-Hye,Bae, Nan-Young,Park, Sun-Hee,Kim, Min-Ji,Kim, Koth-Bong-Woo-Ri,Ahn, Dong-Hyun 한국미생물·생명공학회 2015 한국미생물·생명공학회지 Vol.43 No.2
본 연구는 BALB/c mice의 등 쪽 부위에 반복적인 DNCB 도포를 통해 유발시킨 아토피 피부염에 있어서 참모자반 물 추출물의 효능에 대해 연구하였다. 참모자반 물 추출물을 2주 동안 지속적으로 처리하고 IL-4 및 IFN-γ cytokine의 분비량, 비장세포 증식능, 혈청 중 총 IgE 함량, 육안 평가 및 skin clinical severity score, 조직관찰을 실시하였다. 그 결과 참모자반 물 추출물을 지속적으로 도포함으로써 IL-4 cytokine과 총 IgE 함량이 현저히 감소하는 것을 확인할 수 있었으며 IFN-γ cytokine은 유의적으로 증가하는 것을 확인하였다. 비장세포 증식능에는 참모자반 물 추출물의 도포처리가 큰 영향을 미치지 않는 것으로 나타났다. 육안평가 및 skin clinical severity score 결과, 참모자반 물 추출물을 2주간 지속적으로 도포 처리하였을 때, 그 증상이 눈에 띄게 완화되는 것을 확인할 수 있었으며 score 또한 DNCB 단독 처리군과 비교 시 유의적으로 감소하였다. 등 조직 관찰에서도 참모자반 물 추출물에 의해 DNCB로 유발된 아토피 동물 실험군의 경피 및 진피 조직 두께 및 진피에서의 mast cell의 침윤 정도가 감소되었음을 확인하였다. 이상 결과를 종합 해볼 때, 참모자반 물 추출물이 아토피 피부염 치료제로서 이용 가능성이 있을 것으로 사료된다. This study was intended to evaluate the anti-atopic effect of Sargassum fulvellum water extract (SFWE). Atopic dermatitis (AD) was induced in BALB/c mice by spreading 2,4-dinitrochlorobenzene (DNCB) to the dorsal skin area. The production of IL-4 and total IgE of the SFWE treated group was significantly less than the DNCB only group. On the other hand, the production of the IFN-γ of SFWE treated group was greater than that of the DNCB only group. In addition, SFWE alleviated the AD symptoms when compared to the DNCB only group and reduced the epidermal thickness and the number of mast cells in histological analysis. In conclusion, these results suggest that the application of SFWE has an anti-atopic activity through the modulation of IL-4 and IFN-γ cytokines, and the total IgE in DNCB-induced BALB/c mice. Therefore, SFWE can be utilized with atopic disease therapies.
RAW 264.7 세포에서의 미역(Undaria pinnatifida)뿌리 에탄올 추출물의 항염증활성
강보경,안나경,최연욱,김민지,박시우,김보람,김꽃봉우리,안동현 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
The anti-inflammatory effects of the ethanol extract ofUndaria pinnatifida root (UPREE) were investigated using the lipopolysaccharide (LPS)-induced inflammatory response in RAW 264.7 cells by measuring the production of nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β, and cell proliferation. We found that NO levels were reduced by 34% at 100 μg/mL. Moreover, the production of IL-6 and TNF-α was suppressed by the UPREE treatment. In particular, the IL-6 production was inhibited by more than 30% at 100 μg/mL UPREE. The proliferation of RAW 264.7 cells was measured by MTT assay, and we found no cytotoxicity in those cells treated with UPREE compared to the control. Our results suggest that UPREE shows promise as a therapeutic anti-inflammatory treatment.