기술사업화 정책 20년의 진단과 새로운 전환

손수정(Soo J. Sohn),이세준(Se-jun Lee),임채윤(Chae Yoon Lim),안형준(Hyoung Joon An),강민지(Minji Kang),김명순(Myungsoon Kim),이인희,신태옥,최경하,고은영 과학기술정책연구원 2020 정책연구 Vol.- No.-

실증 기반 기술사업화 효율성 제고 방안

손수정(Soo J. Sohn),이세준(Se-jun Lee),우청원(Chungwon Woo),김명순(Myungsoon Kim) 과학기술정책연구원 2019 정책연구 Vol.- No.-

This study examines how to improve the efficiency of technology commercialization through the role of demonstration in the R&D cycle. The main research question is “whether study on demonstration as a bridge between technology and market for technology commercialization is properly conducted?” The sub-questions include 1) the importance of study on demonstration, 2) the characteristics of demonstration by technologies, 3) the adequacy of demonstration level in terms of R&D scale, and 4) the essential resources and systems for demonstration. This study examines the concept, institution, plan, and government projects of R&D demonstration through literature reviews. Then the study analyzed characteristics of R&D demonstration through case studies in different technology fields, and in-depth written interviews with researchers experienced demonstration projects in those fields. The definition of demonstration is the repeated process of identifying and responding R&D achievement to various situation that may occur under the actual environment that could be applied, then supplementing the technical limitations and verifying. So far, demonstration in public R&D has been carried out in terms of increasing R&D efficiency, but budget of demonstration has greatly fluctuated depending on the method of increasing efficiency. Researchers experiencing demonstration projects expressed difficulties in finding and matching with technology demanders, securing specialized projects for demonstration, and lacking adequate resources. As a detailed examples, this study examined sectoral case studies of autonomous vehicles, energy, chemical and environmental industries, and defense and aviation industries, also case studies by countries in the US, Germany, China, Japan and the Netherlands. The policy recommendations based on results of this study are as follows. First, the linkage of demonstration projects and R&D achievements must strengthen. Specific measures include preliminary pre-testing, expansion of follow-up demonstration projects on R&D achievements that are likely to be commercialized, improvement of performance evaluation indicators suitable for demonstration, and incorporating demonstration into the R&D stage. Second, a competition system for demonstration should be established. In order to allow different approaches and to provide opportunities for the development of various solutions, the competition system presents minimum level of expected results and allow the next level of demonstration through the gate upon arrival. Third, mid- and long-term collaborative demonstration by multiple actors should support. If excessive time and cost is needed, multiple stakeholders would work together to prevent the disconnection between R&D and technology commercialization. Fourth, it is necessary to establish a platform for conducting demonstration projects and to specialize the workforce. It is essential to support the demonstration execution platform considering the characteristics of each technical field and to improve the expertise and treatment of technicians in order to cultivate professionals for demonstration.

급진적 혁신에서 살아남기: 자동차 산업의 기술 패러다임 변화와 한국의 대응 전략

김석관(Seok-Kwan Kim),최병삼(Byung-Sam Choi),정일영(Il-Young Chung),윤정섭(Jung-Sup Yoon),엄미정(Mi-Jung Um),손수정(Soo-Jung Sohn),전수경(Soo-Kyung Jun),양희태(Hee-Tae Yang),이제영(Je-Young Lee),차두원(Du-Won Cha),시새롬(Sae-Rom Shi) 과학기술정책연구원 2022 정책연구 Vol.- No.-

인체구강모델을 이용한 구강점막자극 동물대체시험법 개발

임혜림 ( Hye Rim Lim ),이정선 ( Jung Sun Yi ),김태성 ( Tae Sung Kim ),고경육 ( Kyung Yuk Ko ),안일영 ( Il Young Ahn ),김주환 ( Joo Hwan Kim ),이진하 ( Jin Ha Lee ),양송이 ( Song Yi Yang ),김광만 ( Kwang Mahn Kim ),손수정 ( Soo Jun 한국동물실험대체법학회 2015 동물실험대체법학회지 Vol.9 No.1

Ensuring the biological safety of dental materials is important, because people of all ages use them and they stay inside the mouth of a person for years once they are put into it. However, current oral irritation tests bring pain to animals, and there are no internationally accepted alternative test methods. In this study, we have developed a new method to test for oral irritation using three-dimensional (3D) human oral mucosal models in the light of growing needs for alternatives to animal testing in order to ensure the safety of dental materials. The commercially available 3D human oral mucosal models (EpiOral™, HOM™) were cultured, using normal oral epithelial cells, and histologically and phenotypically similar to native buccal tissues. Two controls and three dental materials that are widely used in dentistry were selected for testing. These included a polyethylene film (negative control), 1% Triton X-100 (positive control), resin, denture base resin and impression materials. These three dental materials were prepared according to manufacturers’ instructions, and were turned into 0.7-cm discs in diameter. And then, we directly placed the controls and the three dental materials on the top of each human oral mucosal model for 24 hours and measured tissue viability via the MTT assay and cytokine secretion. When cell viability is less than 50% or cytokine secretion is more than 250 pg/ml, a test material is evaluated as an irritant. The negative control, resin and denture base resin turned out non-irritants while the positive control and the impression materials irritants. Since the results of the oral mucosal irritation test of dental materials using human oral mucosal models matched those of existing cytotoxicity tests, it seems that the oral mucosal test can be a good alternative method. The results of this study suggest that the oral mucosal irritation test employing the 3D human oral mucosal models can be an alternative test method for dental materials. And further validation studies are required in order to take advantage of this method in the future.

연구논문 : 인체구강모델을 이용한 구강점막자극 동물대체시험법 개발

임혜림 ( Hye Rim Lim ),이정선 ( Jung Sun Yi ),김태성 ( Tae Sung Kim ),고경육 ( Kyung Yuk Ko ),안일영 ( Il Young Ahn ),김주환 ( Joo Hwan Kim ),이진하 ( Jin Ha Lee ),양송이 ( Song Yi Yang ),김광만 ( Kwang Mahn Kim ),손수정 ( Soo Jun 한국동물실험대체법학회 2015 동물실험대체법학회지 Vol.9 No.1

Ensuring the biological safety of dental materials is important, because people of all ages use them and they stay inside the mouth of a person for years once they are put into it. However, current oral irritation tests bring pain to animals, and there are no internationally accepted alternative test methods. In this study, we have developed a new method to test for oral irritation using three-dimensional (3D) human oral mucosal models in the light of growing needs for alternatives to animal testing in order to ensure the safety of dental materials. The commercially available 3D human oral mucosal models (EpiOral™, HOM™) were cultured, using normal oral epithelial cells, and histologically and phenotypically similar to native buccal tissues. Two controls and three dental materials that are widely used in dentistry were selected for testing. These included a polyethylene film (negative control), 1% Triton X-100 (positive control), resin, denture base resin and impression materials. These three dental materials were prepared according to manufacturers’ instructions, and were turned into 0.7-cm discs in diameter. And then, we directly placed the controls and the three dental materials on the top of each human oral mucosal model for 24 hours and measured tissue viability via the MTT assay and cytokine secretion. When cell viability is less than 50% or cytokine secretion is more than 250 pg/ml, a test material is evaluated as an irritant. The negative control, resin and denture base resin turned out non-irritants while the positive control and the impression materials irritants. Since the results of the oral mucosal irritation test of dental materials using human oral mucosal models matched those of existing cytotoxicity tests, it seems that the oral mucosal test can be a good alternative method. The results of this study suggest that the oral mucosal irritation test employing the 3D human oral mucosal models can be an alternative test method for dental materials. And further validation studies are required in order to take advantage of this method in the future.

단기 유전독성시험법을 이용한 근로작업환경의 위해성 평가에 관한 연구

손수정,김종원,한의식,엄미옥,강혁준,강일현,변은경,장은철,권영준,이수진,길광섭,오혜영 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-

국내 8개 인쇄업체의 혼합 유기용매에 직업적으로 노출된 근로자 51명의 유전독성을 평가하고자 사람 말초혈액을 이용한 염색체이상시험과 세포질 분열억제 소핵시험을 시시하였다. 흡연과 작업기간등을 고려하여 일반직 근무자를 대조군으로 선정하였으며,발암물질인 mitomycin C와 혼합 유기용매의 병용효가도 비교, 관찰하엿다. 혼합 유기용매에 폭로된 작업장 근로자에서 소핵 생셩빈도가 대조군보다 유의하게 증가하엿으며, 이는 작업기간별로 소핵 빈도를관찰하엿을 때에도 유의한 증가를 나타내엿다. 작업장 근로자와 대조군으 ㅣ말초혈애게 mitomycin C를 처리한 결과에서도 작업장 근로자에서 농도 의존적으로 소핵이 유의하게 증가함이 관찰되엇다. 염색체이상시험 결과에서는 작업장 근로자와 대조군 비교 시 유의성 잇은 차이를 나타내지 않앗으며, 작업기간,흡연,mitomycin C 처리 등의 유무에 따라서도 유의한 차이를 나타내지 않았다. The popula'tion monitoring study was performed by using the chromosome aberration assay and the cytokinesis-:blocked micronucleus assay to investigate whether occupational exposure tonixed organic solvents are genotoltic to workers. The blood samples were collected from fifty one malepresser and matched controls in Seoul area. Smoking habits a]Id duration of employment were fatteninto account. Also, we focu.sod on the synergic effects of organfc sotvents and a DHA damaging agentmitomycin C(MMC). The frequencfes of mieroaucleus in periphffral Iymphocytes from worlters erposedto organic sotvents were significantly different in comparision with control subjects. Alse there weresignificant differences in tOe frequencies of micronucleus by duration of exposure. The combined expo-sure of the cells to the organic solvents with MMC showed synergic effect in cytoBtinesis-blocked micro-aucleus assay- The frequency of chromosome aberrations did not show any increase.