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대장암에 대한 5 - Flurouracil 지속주입 및 Cisplatin ( FP ) 복합화학요법의 치료효과
서철원(Cheol Won Suh),김시영(Si Young Kim),방영주(Yung Ju Bang),김노경(Noe Kyeong Kim),박재갑(Jae Gahb Park),이건욱(Kuhn Uk Lee),홍성국(Sung Kuk Hong),최국진(Kuk Jin Choe),김수태(Soo Tae Kim),하성환(Sung Hwan Ha),박찬일(Chan Il Park) 대한내과학회 1988 대한내과학회지 Vol.35 No.4
N/A Between August 1986 and February 1988, 60 patients with metastatic or recurrent colorectal cancer were treated with a combination chemotherapy consisting of 5-fluorouracil, 1,000 mg/m² iv continuous infusion over 12 hours on Days 1-5 and cisplatin,.60 mg/m² iv on Day 1; cycled every 3 weeks, Among 36 patients with measurable disease, none achieved complete response and 9 (25%) had partial responses, thus this combination chemotherpay regimen showed modest action on the advanced colorectal cancer. The median duration of response was 20 weeks. Median survival was 52 weeks for all patients who could be evaluated for response and/or toxicity; 61 weeks for patients with response, 48 weeks for those with stable disease and 17 weeks for those with progressive disease. In the analysis of the response according to the various pretreatment characteristics of the patients, those without a history of previous anticancer chemotherapy showed response rate of 36% which is better than 7% for those with prior chemotherapy. The patients with metastatic sites in the liver had a response rate of 47%, which is significantly better than 7 96 for those with metastatic site in the lung and 0% for those with any other sites of metastasis. Toxicity was common, but generally mild to moderate and rapidly reversible.
박인숙,김동섭,최기환,왕소영,임화경,오우용,김소희,강주희,방영주,김주일,Park, In-Sook,Kim, Dong-Seop,Choi, Ki-Hwan,Wang, So-Young,Lim, Hwa-Kyung,Oh, Woo-Young,Kim, So-Hee,Kang, Ju-Hee,Bang, Yung-Jue,Kim, Joo-Il 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.2
The enormous cost, intensive time, and constant efforts are required the drug discovery and development of bringing new drug products to the marketplace. The past several years, KFDA approved new drugs developed by local pharmaceutical industries; that is Sunppla, Factive etc. In addition to, investigational new drug application (IND) was established to accelerate new drug development and harmonize with international standards in 2002. At this point of time it is urgent problem to develop ability of reviewing new drug applications (NDAs) scientifically and appropriately to ensure that new drugs are safe and effective. There are many scientific issues embedded in new drug approval process from non-clinical studies to phase 3 clinical trials; 1) sample size, 2) application of end point, 3) statistical method, and etc. However the overall relation between protocols/reports of clinical trials and the characteristics of domestic medical system has fully not been studied. There is also, no references or data for the point to be considered in drug approval process. On this background, the objectives of this study are introduction of guidelines for the requirement for approval or evaluation of safety/efficacy in other countries and presentation how to practice clinical trial for new oncologic products in the present situation of clinical trial. We hope that the guidelines contribute to providing methods of clinical trials and procedures, and evaluating method to develop chemotherapeutic agents.
신기철 ( Ki Chul Shin ),이윤종 ( Yun Jong Lee ),최영주 ( Young Ju Choi ),강성욱 ( Seong Wook Kang ),이은봉 ( Eun Bong Lee ),방영주 ( Yung Jue Bang ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.4
The coexistence of autoimmune and lymphoproliferative disorders has rarely been reported. We report 3 cases of malignant lymphoma associated with systemic lupus erythematosus(SLE). In one case, Hodgkin`s disease and SLE occurred simultaneously. In the other 2 cases, non-Hodgkin`s lymphoma occurred prior to and after development of lupus, respectively. The clinical courses of the patients are described with review of the literature.
불임환자에서 체외수정시술시 난소내 기질 동맥 Doppler 초음파검사 및 혈청 Glycodelin 측정의 임신 예측인자로서의 임상적 효용성
김선미 ( Sun Mie Kim ),황규리 ( Kyu Ri Hwang ),김진주 ( Jin Ju Kim ),문정애 ( Jung Ae Moon ),방영주 ( Young Joo Bang ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Choi ),김정구 ( J 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
Objective: To assess the clinical efficacy of intraovarian artery stromal Doppler ultrasonography and serum glycodelin (placental protein 14, PP14) as prognostic factors of pregnancy in vitro fertilization and embryo transfer (IVF-ET) cycles. Methods: Fif
Incidence and Significance of Multiple Primary Malignant Neoplasms
최은경(Eun Kyung Choi),조문준(Moon June Cho),하성환(Sung Whan Ha),박찬일(Charn Il Park),방영주(Young Ju Bang),김노경(Noe Kyung Kim) 대한방사선종양학회 1986 Radiation Oncology Journal Vol.4 No.2
한 환자에서 두개 이상의 중복암이 발생하는 경우는 매우 드물게 알려져 왔으나 근래에 들어와 치료법의 발달로 환자의 수명이 연장되고 진단법이 발달되면서 그 보고가 증가되고 또한 관심도 높아지고 있는 상태이다. 따라서 이런 중복암을 가진 환자의 특성을 분석함으로써 발생할 수 있는 2차 3차 암의 조기 발견 및 나아가서는 발암 물질과 유전적 요인 등을 찾아 암의 치료 및 예방에 이응 할 수 있겠다. 이에 1978.7~1986.8까지 8년간 서울 대학교 병원에서 중복암으로 진단되어 치료받은 121예를 대상으로 하여 다음과 같은 결과를 얻었다. 전체 발생율은 0.7%이 있으며 이중 2중복암이 119례, 3중복암이 2례 있었다. 동시성은 (6개월 이내) 51례, 속발성은 (6개월 이상) 70례이었으며 속발성의 경우 70%이상에서 3년내에 2차 암이 발생했다. Moertel분류에 의한 mvlticentriz은 11.6%로 다소 낮은 빈도를 보였으며 다른 장기에 발생한 중복암 중에서는 위암과 간암, 위암과 직장암의 빈도가 가장 높았다. To know the three questions about multiple primary cancers: 1) what are the characteristics of persons having multiple parimary cancer? 2) Does the presence of a single primary concer after the susceptability to multiple primary cancers? 3) Does the location of one multiple primary cancer influence the site of others?, we analysed 121 cases of multiple primary malignant neoplasms registered in Seoul National University Hospital during 8 years from July 1978 to August 1986. Of 121 cases, double primary malignant neoplasms were 119 cases and triples were 2 cases. The incidence of multiple primary malignant neoplasms was 0.7%. The metachronous tumor (>6 months) was found in 70 cases and the median time between the first and the second was 32 months. The most commonly associated tumors were stomach and primary liver carcinoma. Cervix and Lung cancer, Stomach and Rectal cancer, Stomach and Esophagus cancer were also commonly associated.