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부갑상선 절제술 후 골밀도의 증가를 보인 만성 신부전증에 병발된 신성 골 이영양증 1 예
박한철,김호중,안유헌,박찬현,정파종,박문향,강경원,강종명,장대국,채현기 대한내과학회 1995 대한내과학회지 Vol.48 No.4
$quot;Renal osteodystrophy$quot;, a term introduced over 51 years ago, is still used to describe any bone disease occuring in a patient with renal disease. In actually, a very wide spectrum of bone disease can occur in renal failure patients, ranging from states of makedly impaired bone formation and mineralization (such as low-turnover bone disease, osteomalacia) to states of markedly increased bone turnover (hyperparathyroidism). We had experienced one case of renal osteodystrophy and secondary hyperaparathyroidism, especially combined with advanced renal failure, who was admitted to Hayang University Hospital due to severe bone pain on both lowe extremites. Skull X-ray showed decreased bone density with so called $quot;salt and pepper$quot; appearance. Subperiosteal bone resorptions along the ribs and the proximal medial tibial metaphysis were noted on chest PA and both knee X-rays. Serum calcium level was 8.9mg/ dl, serum phosphorous level was 5.6mg/dl, serum alkaline phosphatase was 1872IU/L, serum parathyroid hormone level was 6.54ng/dl(normal; 0.22-0.66ng/dl). Dual photon bone densitometry showed marked decreased total body bone density. Renal osteodystrophy(osteitis fibrosa) was confirmed by bone biopsy stained with Haematoxylin & Eosin and double tetracycline labelling, and secondary hyperparathyroidism was confirmed by parathroid gland biopsies. She was treated with CaCO3, Al(OH)3, Cholecalcitriol after parathyroidectomy.
방사선 돌연변이 축엽자소와 야생종 축엽자소 초임계 추출물의 항염증 활성 비교
박한철,소양강,김진백,육홍선,진창현 (사)한국방사선산업학회 2016 방사선산업학회지 Vol.10 No.3
In previous study, the radiation mutant Perilla frutescens (L.) Britton with a higher anti-inflammatory activity was selected. The extracts were obtained from the mutant and wildtype using a supercritical carbon dioxide technique. This study aimed to compare the antiinflammatory activities between the mutant supercritical extract (MSE) and wild-type supercritical extract (WSE). The contents of isoegomaketone (IK) of MSE and WSE were measured through an HPLC analysis. MSE contained IK contents approximately 7-fold higher than those of WSE. To compare the anti-inflammatory activities of MSE and WSE, the expression levels of the mRNA and protein of pro-inflammatory mediators were measured in lipopolysaccharide (LPS)-induced RAW264.7 cells. As a result, MSE inhibited the expression levels of the mRNA and protein of pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) to a much greater extent than did WSE. Taken together, MSE had more IK contents and higher antiinflammatory activities than WSE. Therefore, MSE is proposed based on its therapeutic potential in the prevention of inflammatory disease.
박한철,부척량 대한건축학회 1999 대한건축학회논문집 Vol.15 No.4
The architectural education of the People's Republic of China (P.R.C.) has been examined and appraised through a collaboration of experts from both England and the United States since 1990. To the present, fourteen out of 72 architectural institutions in the P.R.C., have received formal recognition. These institutions all have the following common characteristics 1) The most prominent characteristic of the P.R.C.'s architectural institution is their existence as independent architectural colleges, rather than as a departments of universities. Within the architectural college, there are a number of faculties and departments offering different majors. This system enables students a wide choice of study. 2) The P R.C.'s architectural education system includes a course called, $quot;Post Doctor of Architecture$quot; as a supplementary program beyond Ph.D. level. 3) Apart from the major study in architecture, supplementary areas such as electrical and equipment engineering, material science, sociology related to architecture, and even foreign languages are studied m the PRC's architectural institutions. Thus, the pedagogical areas include those bath directly and indirectly relevant to architecture.